Grace dislocated and fractured her ankle at age 10 during gymnastics which required surgery and healing. At age 12, a bony bridge had developed in her growth plate requiring another surgery. Follow up showed her ankle was bowing outward and the range of motion was decreasing. Surgery was performed to remove the lateral and medial growth plates to prevent further issues. Four months post-op, her leg and ankle appeared normal and she was able to return to gymnastics with ongoing therapy. The case demonstrates how minimally invasive procedures can resolve issues and allow kids to return quickly to their activities.
Francesca: Anterior Physeal Arrest with Recurvatum Deformity & Shortening Cas...David S. Feldman, MD
Francesca is a competitive level female gymnast who sustained a proximal tibia fracture at the age of 10. The injury damaged her growth plate (physis) which caused it to close prematurely and led to the development of deformities where her right leg was shorter than her left and her right knee bent backwards 16 degrees more than her left knee. Francesca underwent a proximal tibia fibular osteotomy surgical procedure and had a Taylor Spatial Frame applied to her leg. The combination of this surgical procedure with physical therapy resolved her lower limb issues and allowed her to return to gymnastic.
Francesca recently qualified for Nationals and will be competing in the next few days. We wish her the best of luck and we’ll all be rooting for her!
http://www.davidsfeldmanmd.com/patient-education/case-studies/francesca-anterior-physeal-arrest-recurvatum-deformity-shortening
Axel: Arthrogryposis, Clubfeet, & Dislocated Hips and Knees Case StudyDavid S. Feldman, MD
At the time of Axel’s birth, it was apparent to both Axel’s parents and doctors that there was something very wrong with his legs. His pediatrician had never seen a case like his before. I began treating Axel when he was three days old after diagnosing him with bilateral clubfeet, dislocated knees, and subluxated (partially dislocated) hips caused by arthrogryposis.
By the age of one, Axel was doing very well. He was standing and holding on independently and had begun walking with assistance. Axel has had an excellent short term result for a severely involved child with arthrogryposis.
After six years of intermittent groin pain, Nadine sought medical care when her symptoms became worse. An MRI revealed a cartilage tear in her right hip and she was later diagnosed with bilateral hip dysplasia. When Nadine visited me for a second opinion, I found that her right hip was worse than her left and recommended a right hip periacetabular (Ganz) osteotomy.
In the months since her surgery, Nadine’s right hip pain has been resolved and she’s been able to return to her normal activities.
http://www.davidsfeldmanmd.com/patient-education/case-studies/nadine-hip-dysplasia
At the age of 13, Stephanie underwent a posterior spinal fusion to treat her scoliosis which severely affected her lumbar and thoracic vertebrae. Following her surgery, Stephanie was able to recover and return to her activities without any restrictions in a relatively short amount of time.
http://www.davidsfeldmanmd.com/patient-education/case-studies/stephanie-severe-idiopathic-scoliosis
Jordan was born with skeletal issues which included low muscle tone, absent clavicles, and congenital kyphosis. He was later diagnosed with cleidocranial dysostosis, a rare hereditary congenital disorder which causes teeth and bones in the upper torso to develop abnormally. At the age of 13, Jordan’s spine had developed multiple hemivertebrae in addition to scoliosis and kyphosis curves.
Jordan underwent a posterior spinal fusion with Ponte osteotomies to help straighten his spine and expand his ribs. He did very well after surgery and was able to return to playing basketball five months after surgery.
http://www.davidsfeldmanmd.com/patient-education/case-studies/jordan-cleidocranial-dysostosis
Anthony was diagnosed with Legg-Calve-Perthes disease at the age of four and was treated by me until the age of 10. His multi-faceted and individualized course of treatment consisted of therapy, non-weight bearing, and surgery. Five years after his last procedure, Anthony’s Legg-Calve-Perthes is completely resolved and he should continue to enjoy normal hip function for many decades to come.
www.davidsfeldmanmd.com/patient-education/case-studies/anthony-legg-calve-perthes-disease
Shaunak was diagnosed at birth with achondroplasia, a bone growth disorder that causes a form of dwarfism. Shortly before his sixth birthday, he visited my office with his family to discuss options for limb lengthening and correction of his bowed legs. Shaunak’s limb deformities were corrected in stages over the course of eight months.
Shortly before his 14th birthday we discussed options for additional lengthening and the correction of a deformity that occurred as he grew. This course of treatment is still in progress and Shaunak’s case study will be updated once treatment is complete.
http://www.davidsfeldmanmd.com/patient-education/case-studies/shaunak-achondroplasia
Nathalie was diagnosed with osteogenesis imperfecta (Type IV) as a toddler. Osteogenesis imperfecta is a congenital genetic condition that causes brittle bones which fracture easily from minor impact and in some cases for no reason. As a result, Nathalie experienced multiple fractures throughout her childhood which required several surgical procedures.
Given the nature of osteogenesis imperfecta, these childhood fractures were to be expected. However, Nathalie’s parents’ diligence in immediately seeking care has helped to limit the long-term effects that could have resulted from her injuries. Nathalie is now in her early teens and doing very well overall.
http://www.davidsfeldmanmd.com/patient-education/case-studies/nathalie-osteogenesis-imperfecta
Francesca: Anterior Physeal Arrest with Recurvatum Deformity & Shortening Cas...David S. Feldman, MD
Francesca is a competitive level female gymnast who sustained a proximal tibia fracture at the age of 10. The injury damaged her growth plate (physis) which caused it to close prematurely and led to the development of deformities where her right leg was shorter than her left and her right knee bent backwards 16 degrees more than her left knee. Francesca underwent a proximal tibia fibular osteotomy surgical procedure and had a Taylor Spatial Frame applied to her leg. The combination of this surgical procedure with physical therapy resolved her lower limb issues and allowed her to return to gymnastic.
Francesca recently qualified for Nationals and will be competing in the next few days. We wish her the best of luck and we’ll all be rooting for her!
http://www.davidsfeldmanmd.com/patient-education/case-studies/francesca-anterior-physeal-arrest-recurvatum-deformity-shortening
Axel: Arthrogryposis, Clubfeet, & Dislocated Hips and Knees Case StudyDavid S. Feldman, MD
At the time of Axel’s birth, it was apparent to both Axel’s parents and doctors that there was something very wrong with his legs. His pediatrician had never seen a case like his before. I began treating Axel when he was three days old after diagnosing him with bilateral clubfeet, dislocated knees, and subluxated (partially dislocated) hips caused by arthrogryposis.
By the age of one, Axel was doing very well. He was standing and holding on independently and had begun walking with assistance. Axel has had an excellent short term result for a severely involved child with arthrogryposis.
After six years of intermittent groin pain, Nadine sought medical care when her symptoms became worse. An MRI revealed a cartilage tear in her right hip and she was later diagnosed with bilateral hip dysplasia. When Nadine visited me for a second opinion, I found that her right hip was worse than her left and recommended a right hip periacetabular (Ganz) osteotomy.
In the months since her surgery, Nadine’s right hip pain has been resolved and she’s been able to return to her normal activities.
http://www.davidsfeldmanmd.com/patient-education/case-studies/nadine-hip-dysplasia
At the age of 13, Stephanie underwent a posterior spinal fusion to treat her scoliosis which severely affected her lumbar and thoracic vertebrae. Following her surgery, Stephanie was able to recover and return to her activities without any restrictions in a relatively short amount of time.
http://www.davidsfeldmanmd.com/patient-education/case-studies/stephanie-severe-idiopathic-scoliosis
Jordan was born with skeletal issues which included low muscle tone, absent clavicles, and congenital kyphosis. He was later diagnosed with cleidocranial dysostosis, a rare hereditary congenital disorder which causes teeth and bones in the upper torso to develop abnormally. At the age of 13, Jordan’s spine had developed multiple hemivertebrae in addition to scoliosis and kyphosis curves.
Jordan underwent a posterior spinal fusion with Ponte osteotomies to help straighten his spine and expand his ribs. He did very well after surgery and was able to return to playing basketball five months after surgery.
http://www.davidsfeldmanmd.com/patient-education/case-studies/jordan-cleidocranial-dysostosis
Anthony was diagnosed with Legg-Calve-Perthes disease at the age of four and was treated by me until the age of 10. His multi-faceted and individualized course of treatment consisted of therapy, non-weight bearing, and surgery. Five years after his last procedure, Anthony’s Legg-Calve-Perthes is completely resolved and he should continue to enjoy normal hip function for many decades to come.
www.davidsfeldmanmd.com/patient-education/case-studies/anthony-legg-calve-perthes-disease
Shaunak was diagnosed at birth with achondroplasia, a bone growth disorder that causes a form of dwarfism. Shortly before his sixth birthday, he visited my office with his family to discuss options for limb lengthening and correction of his bowed legs. Shaunak’s limb deformities were corrected in stages over the course of eight months.
Shortly before his 14th birthday we discussed options for additional lengthening and the correction of a deformity that occurred as he grew. This course of treatment is still in progress and Shaunak’s case study will be updated once treatment is complete.
http://www.davidsfeldmanmd.com/patient-education/case-studies/shaunak-achondroplasia
Nathalie was diagnosed with osteogenesis imperfecta (Type IV) as a toddler. Osteogenesis imperfecta is a congenital genetic condition that causes brittle bones which fracture easily from minor impact and in some cases for no reason. As a result, Nathalie experienced multiple fractures throughout her childhood which required several surgical procedures.
Given the nature of osteogenesis imperfecta, these childhood fractures were to be expected. However, Nathalie’s parents’ diligence in immediately seeking care has helped to limit the long-term effects that could have resulted from her injuries. Nathalie is now in her early teens and doing very well overall.
http://www.davidsfeldmanmd.com/patient-education/case-studies/nathalie-osteogenesis-imperfecta
Christopher: Knee Pain, Severe Crouch Gait, & Hip Flexion Contracture Case StudyDavid S. Feldman, MD
At the age of 23, Christopher a young man with left hemiplegic cerebral palsy visited me for an evaluation of right knee pain which began eight years prior without any known injury. Christopher was unable to walk independently, had a history of lower limb issues, and had undergone several surgeries prior to and after the occurrence of his knee pain. I found that a combination of a crouched gait, hip contracture, and knee contractures were causing his knee pain.
A series of tenotomies, osteotomies, and a trochlear replacement relieved his pain and improved his ability to walk.
http://www.davidsfeldmanmd.com/patient-education/case-studies/christopher-knee-pain-crouch-gait-hip-flexion-contracture
Vincenzo: Arthrogryposis w/ Lower Limb Deformities, Severe Contractures, & Pt...David S. Feldman, MD
Vincenzo is a young man from Bari, Italy who had been diagnosed with arthrogryposis at birth and had been wheelchair bound since the age of six. His family had sought treatment in Altamura and Milano Italy but doctors had not provided any treatment and told the family that nothing could be done to improve his condition. At age 14, he traveled with his family to America to seek treatment.
During our consultation I found that while Vincenzo’s arthrogryposis had caused severe contractures and lower limb deformities, many of these issues could be resolved with surgery and therapy. Over the course of two years, I performed muscles and tendon releases to allow for improved range of motion. By the end of treatment, Vincenzo was able to walk without assistance and had greater control of his arms which allowed him to use his hands in ways he could not before.
http://www.davidsfeldmanmd.com/patient-education/case-studies/vincenzo-arthrogryposis-lower-limb-deformity-contractures-pterygium
Charlotte has been my patient since she was three years old. Over the years, I’ve collaborated with other medical professionals to treat her for various issues with her right leg. When Charlotte was 13, we began a multifaceted course of treatment to correct a complex lower limb deformity that occurred as a result of her earlier leg issues. These treatments have made it possible for Charlotte to keep her leg while avoiding amputation and prosthetics.
http://www.davidsfeldmanmd.com/patient-education/case-studies/charlotte-complex-lower-limb-deformity
David: Femoral Neck Fracture with Avascular Necrosis of the Hip Case StudyDavid S. Feldman, MD
David is an avid hiker who fell and fractured his femoral neck during a hike. He underwent a successful surgery which fixed his femoral neck but later developed avascular necrosis of the hip. I ultimately recommended a multi-faceted course of treatment that included bisphosphonates, core decompression, BMP/Calcium phosphate, and arthrodiastasis. This course of treatment has successfully resolved his avascular necrosis of the hip and prevented the collapse of his femoral head.
http://www.davidsfeldmanmd.com/patient-education/case-studies/david-femoral-neck-fracture-w-avascular-necrosis-hip
Christopher: Knee Pain, Severe Crouch Gait, & Hip Flexion Contracture Case StudyDavid S. Feldman, MD
At the age of 23, Christopher a young man with left hemiplegic cerebral palsy visited me for an evaluation of right knee pain which began eight years prior without any known injury. Christopher was unable to walk independently, had a history of lower limb issues, and had undergone several surgeries prior to and after the occurrence of his knee pain. I found that a combination of a crouched gait, hip contracture, and knee contractures were causing his knee pain.
A series of tenotomies, osteotomies, and a trochlear replacement relieved his pain and improved his ability to walk.
http://www.davidsfeldmanmd.com/patient-education/case-studies/christopher-knee-pain-crouch-gait-hip-flexion-contracture
Vincenzo: Arthrogryposis w/ Lower Limb Deformities, Severe Contractures, & Pt...David S. Feldman, MD
Vincenzo is a young man from Bari, Italy who had been diagnosed with arthrogryposis at birth and had been wheelchair bound since the age of six. His family had sought treatment in Altamura and Milano Italy but doctors had not provided any treatment and told the family that nothing could be done to improve his condition. At age 14, he traveled with his family to America to seek treatment.
During our consultation I found that while Vincenzo’s arthrogryposis had caused severe contractures and lower limb deformities, many of these issues could be resolved with surgery and therapy. Over the course of two years, I performed muscles and tendon releases to allow for improved range of motion. By the end of treatment, Vincenzo was able to walk without assistance and had greater control of his arms which allowed him to use his hands in ways he could not before.
http://www.davidsfeldmanmd.com/patient-education/case-studies/vincenzo-arthrogryposis-lower-limb-deformity-contractures-pterygium
Charlotte has been my patient since she was three years old. Over the years, I’ve collaborated with other medical professionals to treat her for various issues with her right leg. When Charlotte was 13, we began a multifaceted course of treatment to correct a complex lower limb deformity that occurred as a result of her earlier leg issues. These treatments have made it possible for Charlotte to keep her leg while avoiding amputation and prosthetics.
http://www.davidsfeldmanmd.com/patient-education/case-studies/charlotte-complex-lower-limb-deformity
David: Femoral Neck Fracture with Avascular Necrosis of the Hip Case StudyDavid S. Feldman, MD
David is an avid hiker who fell and fractured his femoral neck during a hike. He underwent a successful surgery which fixed his femoral neck but later developed avascular necrosis of the hip. I ultimately recommended a multi-faceted course of treatment that included bisphosphonates, core decompression, BMP/Calcium phosphate, and arthrodiastasis. This course of treatment has successfully resolved his avascular necrosis of the hip and prevented the collapse of his femoral head.
http://www.davidsfeldmanmd.com/patient-education/case-studies/david-femoral-neck-fracture-w-avascular-necrosis-hip
Gymnastics Association of Texas 2010 conference: Presentation geared toward gymnastic coaches on common causes of wrist injuries in gymnast. Biomechanics of loading the wrist. Training exercises to prevent and decrease wrist injuries in gymnast.
Hip dysplasia describes a condition where the hip becomes partially or fully dislocated and/or the hip’s ball (femoral head) and socket (acetabulum) are misaligned. The condition primarily affects children but is also commonly diagnosed in adulthood. Treatment options range from simple bracing to extensive surgery and should be determined based on the patient’s age and the severity of their condition.
http://www.davidsfeldmanmd.com/specialties/hip-dysplasia
Gymnastics Association of Texas 2010 conference: Presentation geared toward gymnastic coaches on preventing and addressing ankle injuries. Biomechanics of loading mechanics on the ankle. Training exercises to improve loading mechanics and prevent or address ankle injuries in gymnast.
Avascular necrosis (AVN) or Aseptic Necrosis of the hip is caused by a disruption to the hip’s blood supply which results in the deterioration and often collapse of the ball of the thigh bone (femoral head). Early identification and treatment of the condition increases the likelihood that a patient’s hip will recover. Surgery may be required in severe cases to repair or revascularize (restore circulation) the hip or to replace the hip in neglected/end stage cases.
http://www.davidsfeldmanmd.com/specialties/avascular-necrosis-hip
comminuted fracture of left patellar with displacement case presentationJOEL RAJAN U
A patella fracture is a break of the kneecap. Symptoms include pain, swelling, and bruising to the front of the knee. A person may also be unable to walk. Complications may include injury to the tibia, femur, or knee ligaments. It typically results from a hard blow to the front of the knee or falling on the knee.
A spinal fusion surgery is a procedure that is used to join two or more vertebrae together. Spinal Fusion Surgery India has a high success rate and you can be one of the many people who recover from a serious illness and live a long and happy life.
If you have ever treated runners, having them stop or modify activity during rehabilita- tion is nearly impossible. As someone who specializes in the treatment of endurance
athletes, I am always looking for an edge
to return them to activity as soon as possible.
I was at lunch the other day with my medical biller. I am not her only client and she has a long list of specialties that she serves. I found out over salads that she has been suffering with lower back pain for two to three years. When she asked for my opinion, I requested that she give me a little history.
Effectiveness of Progressive Inhibition of Neuromuscular Structures (PINS) an...MusaDanazumi
Abstract- Background and aim: Lumbar disc herniation with radiculopathy has been one of the most difficult conditions to manage in orthopedic manual therapy. While there are many clinical studies concerning the standardization of surgical treatment, there is to date no standardized literatures for the most effective non-operative care for lumbar disc herniation with radiculopathy which suggest that extreme measures to ameliorate lumbar disc herniation with radiculopathy are urgently warranted. In this study, a 35 year old man who was diagnosed with lumbar disc herniation and was planned for lumbar surgery due to failure of medical interventions was successfully treated using non-operative management.
Method: The management of the patient included Progressive Inhibition of Neuromuscular Structures (PINS), Spinal Mobilization with Leg Movement (SMWLM) and Therapeutic exercises inform of lumbar stabilization and stretching exercises. The patient was seen three times in a week over the period of 6 weeks after which the patient was discharged home without having lumbar surgery. Patient was assessed before and after treatments and during one and two year follow-ups using; Visual Analogue Scale (VAS) in the back and leg, Sciatica Bothersome Index (SBI), Sciatica Frequency Index (SFI) and Rolland-Morris Disability Questionnaire (RMDQ) for sciatica.
Results: After six weeks of management the patient had decreased in functional limitation (from 19 to 6), back pain (from 8 to 0), leg pain (from 10 to 2), sciatica frequency (from 18 to 8) and sciatica bothersomeness (from 18 to 8). These outcomes were maintained after one and two year follow-ups.
Conclusion: Progressive inhibition of neuromuscular structures and spinal mobilization with leg movement are effective in the management of patients diagnosed with lumbar disc herniation with radiculopathy.
Implication: Progressive inhibition of neuromuscular structures and spinal mobilization with leg movement may be considered as useful therapeutic non-operative measures for patients diagnosed with lumbar disc herniation with radiculopathy.
Index Terms- Progressive Inhibition of Neuromuscular Structures; Spinal Mobilization with Leg Movement; Lumbar Disc Herniation with Radiculopathy.
juliet Nnaji Review of Case study 2Top of FormEpisodicFoc.docxLaticiaGrissomzz
juliet Nnaji
Review of Case study 2
Top of Form
Episodic/Focused SOAP Note
Patient Information:
JO, 46-year-old female, African American
S.
CC: Pain in both ankles, but more concerned about her right ankle.
HPI: The patient is a 46-year-old African American female who presents to the clinic with complaint of bilateral ankle pain, but more concerned about her right ankle. Patient reports that she heard a pop come from her right ankle while playing soccer 3 days ago over the weekend, and ever since her right ankle has become increasingly uncomfortable. She is able to bear weight but it is uncomfortable when standing or walking. Patient described the pain as a dull uncomfortable pain and she rates the pain as 7/10 to the right ankle and 3/10 to the left ankle. She believes that the right ankle is bruised and swollen. She reports that she takes Ibuprofen and Tylenol alternately for pain and swelling and it makes it tolerable. Pain is aggravated whenever she puts weight on it to stand or walk but feels better when she is seated with her right foot raised.
Current Medications:
Ibuprofen 600mg every 8 hours as needed for the pain
Tylenol 1000mg every 4 hours as needed for pain
One-A-Day Women’s Multivitamins one tablet daily
Ferrous Sulfate 325mg once daily
Allergies: Denies any drug, food, latex or seasonal allergies
PMHx: Osteoarthritis (diagnosed 7 years ago), Type 11 DM and HTN (diagnosed 3 years ago). Right total knee replacement (3 years ago). Received influenza vaccine this season, Current on Covid and other vaccines. Last Tdap 11/25/2020. No recent hospitalizations
A.
Differential Diagnoses
1)Primary Diagnosis is Ankle Sprain:
An ankle sprain is an injury to one or more ligaments in the ankle with symptoms such as pain, swelling, soreness, bruising, limited range of motion and joint stiffness (Dains, Baumann, & Scheibel, 2019). It is an inversion-type twisting of the foot, followed by pain and swelling (Young, 2019). This type of injury is often associated with physical activities or sports. Sports injuries occur when running, cutting, landing from a jump, or from direct contact which can produce an audible tear or pop causing pain and swelling that are immediate, but ecchymosis may lag a day or two behind (American Orthopedic Foot & Ankle Society, 2021). JO has most of these symptoms and is able to bear weight which rules out a more complex structural injury or fracture.
2) Bursitis: Bursitis can be described as the acute or chronic inflammation of a bursa that results in localized pain, tenderness, and swelling over the bursa (Maffulli, et al, 2018). Other symptoms that are associated with this condition is low-grade temperature, the warmth of overlying skin, and a palpable bump over heel (Maffulli et al., 2018).
3) Plantar fasciitis: This affects women twice as often as men. It is caused by chronic weight-bearing stress when laxity of the foot structures allows the talus to slide forward and.
Similar to Grace: Varus Ankle & Medial Physeal Bar Case Study (16)
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Grace: Varus Ankle & Medial Physeal Bar Case Study
1. Case Study: Grace
Varus Ankle & Medial Physeal Bar
12 years to 13 years
David S. Feldman, MD
Chief of Pediatric Orthopedic Surgery
Professor of Orthopedic Surgery & Pediatrics
NYU Langone Medical Center & NYU Hospital for Joint Diseases
3. At the age of 10, Grace dislocated and
fractured her right ankle during gymnastics.
She underwent surgery at another facility to
repair the injury which had also affected her
growth plate (physis) and heel. After surgery,
she was placed in short leg casts for six
weeks, made a full recovery, and was able
to return to gymnastics.
4. A few months before her 12th birthday,
Grace’s mother noticed her right foot had
begun to turn outward. Her pediatrician
ordered CT scans and MRIs for evaluation
and found that a bony bridge had developed
in her physis (physeal bar).
5. Another surgery was performed to remove a
portion of her fibula along with the bony
bridge as it would have likely delayed or
prevented further growth of the bone. She
was able to return to gymnastics after
surgery but began to feel pain in her instep
along with ongoing numbness and tingling in
her heel.
6. A few months after her second surgery,
Grace visited me for a second opinion on
her right ankle.
8. During our first appointment, I examined
Grace and reviewed her medical films. I
found that her physis seemed to have
stopped growing and as a result of her
previous surgeries, there was only a small
distal fibula remaining near her ankle and it
was not attached to the rest of her fibula.
9. An x-ray of Grace’s lower limbs. Note the right limb’s lack of space
around the physes and the disconnected parts of the fibula.
10. I was concerned that this small amount of
bone would be insufficient to buttress and
protect her ankle. In addition, the ankle was
bowing (varus) and surgery would become a
necessity if it continued to drift into a more
varus position.
12. Grace began physical therapy for treatment
of muscle atrophy in her ankle which helped
to decrease her pain and stopped the
tingling in her heel. However, over the next
few months her ankle varus increased and
the range of motion in her ankle mildly
decreased. The physeal bar also
reappeared in her ankle and required
surgical intervention to prevent bone growth
issues in her leg.
14. Distal Tibia Epiphysiodesis
A small incision was made at the distal tibia
and the entire lateral distal tibial physis as
well as the physis of the medial and lateral
fibula were removed. The surgical site was
irrigated, closed in layers, and dry sterile
dressings were applied.
15. Post-op Care
Grace’s surgical wounds healed within a few
weeks but she had to wear a cam walker
fracture boot and was not allowed to
participate in any sports for six weeks.
16. Grace’s ankle after the sutures
and pins were removed.
Grace’s leg in a cast
after surgery.
Grace’s ankle after surgery with the
dressings removed but sutures and
pins still in place.
18. Four months after surgery, x-rays showed
that Grace’s right leg and ankle were normal
and within a year her ankle had full range of
motion with no pain or tenderness.
19. Since then, Grace has been doing very well
and has returned to gymnastics and track.
Grace still receives ongoing strengthening
therapy and remains under observation for
lower limb issues that might arise as a result
of her previous injuries.
20. As this case shows, in some instances big
problems can be resolved with minimally
invasive procedures that allow kids to
quickly recover and return to their sports and
activities.
21.
22. David S. Feldman, MD
Pediatric Orthopedic Surgeon
www.davidsfeldmanmd.com