Sayyed Jani, known as Gorlin cyst, is a distinct odontogenic cyst characterized by ghost cell keratinization, first described by Gorlin in 1962. It typically appears as a painless swelling in the maxilla or mandible around the age of 30 and is associated with other odontogenic lesions; it presents as well-defined, unilocular radiolucent lesions on radiographs. The cyst shows a histological feature of ghost cells and has a fibrous connective tissue lining with fluid-filled lumens, while enucleation and recurrence are rare.

1. Sayyed Jani
BDS

2.  Also know as “ Gorlin Cyst ”.
 Gorlin 1962 described it as distinct clinicopathologic entity and a possible oral analogue
of pilomatrixoma of skin ; owing to the presence of ghost cell keratinization.
 Gold 1963 named it as keratinizing and COC.
 It mostly appears as lesion especially solid lesion.

3.  It may develop from
(a) Dental lamina
(b) Reduced enamel epithelium
(c) odontogenic epithelial remants
(d) bone or gingiva

4.  Gender predilection: No gender predilection
 Age predilection: average age around 30 years
 Site predilection: occurs in both maxilla and mandible especially in canine and incisors
region
 Origin : Developmental odontogenic cyst

5.  May be associated with other odontogenic lesions such as odontomas ; AOT and
Ameloblastoma.
 painless swelling
 Extraosseous lesions exhibits painful swelling of gingiva

6.  Well defined unilocular radiolucent lesions with scalloped borders.
 Resorption and displacement of adjacent teeth
 Extraosseous type may have saucer shaped radiolucencies.
 Sometimes radiopacities may present which represents odontomas or calcifications.

7.  Lining epithelium is stratified squamous epithelium with 4 to 10 cells in
thickness.
 The basal layer is made up of cuboidal or palisaded tall colunmar cells .
 The epithelial cells above this layer are many cells thick and may resemble
stellate reticulum.
 Characteristic feature is presence of Ghost cells
 Ghost cells- pale ; eosinophilic ; enlarged ; ballooned ; elongated elliptloid or ovoid
epithelial cells with an indistinct outline and nuclear membrane is faint due to
degeneration of the nuclear content. These cells represent an abnormal
keratinization process and tend to calcify .
 Connective tissue is fibrous and have satellite cysts or odontogenic epithelial
cysts.
 Lumen – fluid filled with masses of ghost cells and calcifications .

8.  Enucleation and reoccurrance is rare .