The document provides a history of Good Manufacturing Practices (GMP) regulations from the early 1900s to present day. Key events that prompted increased regulation include children dying from contaminated diphtheria antitoxin in 1902 and Upton Sinclair's The Jungle exposing unsanitary meat packing practices in 1905. Major milestones included the 1906 Pure Food and Drug Act, regulations in the 1960s in response to thalidomide birth defects, and revisions in the 1970s-2000s to address issues with medical devices, drug quality controls, and electronic record keeping. GMP guidelines are now internationally harmonized through organizations like the International Conference on Harmonization.