An unusual cause of small bowel obstruction in a 49-year-old male was found to be mesenteric panniculitis, an inflammatory process involving the fatty tissue of the mesentery. He was also diagnosed with chronic myelomonocytic leukemia (CMML-2), an aggressive form of CMML. Treatment with high-dose steroids provided some improvement in symptoms but he continued to have persistent obstruction, malnutrition, and infections. He was transferred to the Mayo Clinic but passed away shortly after from complications of hemophagocytic syndrome.