Mohammad Ghaderzadeh
Ph.D candidate in Animal Breeding & Genetics, Sari Agricultural Sciences and Natural Resources University, Iran
انتخاب ژنتیکی برای مقاومت در دام و طیور
Infectious diseases of livestock are most costly and hazardous problem facing the Agri-food industry
Adversely affect animal production and economics by increasing the cost of production and decreasing the production rate
Breeding Approaches Towards Disease Resistance In LivestocksSharadindu Shil
a detailed description of instances & methodologies used in livestock breeding for developing disease resistant breeds world wide.specially helpful for veterinary post graduate students for their seminars.
This document discusses correlations between different traits in a population. It defines correlation as a measure of the relationship between two variables. There are three main types of correlations: phenotypic, genetic, and environmental. Phenotypic correlation is observed between traits and is partitioned into genetic and environmental correlations. Genetic correlation is important because selection for one trait will cause changes in genetically correlated traits. Methods like parent-offspring analysis and half-sib analysis are used to estimate genetic correlations. Knowledge of genetic correlations is useful for selection programs and predicting response to selection.
Response to selection is the change in the population mean from one generation to the next due to selection. It is represented by R or the expected genetic gain (ΔG). R is influenced by factors like heritability (h2), selection differential (S), and generation interval. Higher h2, S, and shorter generation intervals result in greater response to selection and genetic gain per year. Selection differential depends on proportion selected and herd size, while generation interval varies by species from 1-2 years in pigs and chickens to 8-12 years in horses.
This document provides an overview of estimated breeding values (EBVs) for sheep and goat producers. EBVs quantify an animal's genetic merit for economically important traits and are calculated by the National Sheep Improvement Program (NSIP). NSIP accounts for environmental effects, heritability, genetic relationships between animals, and genetic correlations between traits to calculate EBVs. Producers can use EBVs to make more informed breeding decisions by selecting animals with above average EBVs for traits important to their operation and production system.
Dr. Sushil Neupane's notes on "Introductory Genetics and Animal Breeding" for the 2nd year, 1st semester of the Diploma in Animal Science (latest syllabus of CTEVT) provide a comprehensive overview of key concepts and principles related to genetics and animal breeding. The notes cover fundamental topics in genetics and their practical applications in livestock production and breeding programs.
This document discusses genetic parameters and their estimation in animal breeding. It defines genetic parameters as quantities that characterize a population's statistics, such as variance and mean, which can be estimated from sample data. The key genetic parameters discussed are heritability, repeatability, and genetic correlation. Heritability quantifies the proportion of phenotypic variation attributable to genetics. Repeatability sets an upper limit for heritability and indicates how early performance predicts later performance. Genetic correlation indicates the extent to which traits are influenced by the same genes. The document outlines methods for estimating these parameters using variance components from experimental data.
Infectious diseases of livestock are most costly and hazardous problem facing the Agri-food industry
Adversely affect animal production and economics by increasing the cost of production and decreasing the production rate
Breeding Approaches Towards Disease Resistance In LivestocksSharadindu Shil
a detailed description of instances & methodologies used in livestock breeding for developing disease resistant breeds world wide.specially helpful for veterinary post graduate students for their seminars.
This document discusses correlations between different traits in a population. It defines correlation as a measure of the relationship between two variables. There are three main types of correlations: phenotypic, genetic, and environmental. Phenotypic correlation is observed between traits and is partitioned into genetic and environmental correlations. Genetic correlation is important because selection for one trait will cause changes in genetically correlated traits. Methods like parent-offspring analysis and half-sib analysis are used to estimate genetic correlations. Knowledge of genetic correlations is useful for selection programs and predicting response to selection.
Response to selection is the change in the population mean from one generation to the next due to selection. It is represented by R or the expected genetic gain (ΔG). R is influenced by factors like heritability (h2), selection differential (S), and generation interval. Higher h2, S, and shorter generation intervals result in greater response to selection and genetic gain per year. Selection differential depends on proportion selected and herd size, while generation interval varies by species from 1-2 years in pigs and chickens to 8-12 years in horses.
This document provides an overview of estimated breeding values (EBVs) for sheep and goat producers. EBVs quantify an animal's genetic merit for economically important traits and are calculated by the National Sheep Improvement Program (NSIP). NSIP accounts for environmental effects, heritability, genetic relationships between animals, and genetic correlations between traits to calculate EBVs. Producers can use EBVs to make more informed breeding decisions by selecting animals with above average EBVs for traits important to their operation and production system.
Dr. Sushil Neupane's notes on "Introductory Genetics and Animal Breeding" for the 2nd year, 1st semester of the Diploma in Animal Science (latest syllabus of CTEVT) provide a comprehensive overview of key concepts and principles related to genetics and animal breeding. The notes cover fundamental topics in genetics and their practical applications in livestock production and breeding programs.
This document discusses genetic parameters and their estimation in animal breeding. It defines genetic parameters as quantities that characterize a population's statistics, such as variance and mean, which can be estimated from sample data. The key genetic parameters discussed are heritability, repeatability, and genetic correlation. Heritability quantifies the proportion of phenotypic variation attributable to genetics. Repeatability sets an upper limit for heritability and indicates how early performance predicts later performance. Genetic correlation indicates the extent to which traits are influenced by the same genes. The document outlines methods for estimating these parameters using variance components from experimental data.
Repeatability refers to the correlation between measurements of the same trait for an individual measured more than once. It ranges from 0 to 1. Repeatability is influenced by both permanent environmental effects, which consistently impact all measurements of an individual, as well as temporary environmental effects that vary between measurements. Heritability instead refers to the degree to which offspring inherit traits from their parents. While heritability estimates the genetic influence, repeatability captures both genetic and permanent environmental influences. Repeatability can be estimated using analysis of variance to partition phenotypic variance into within and between individual components. Higher repeatability means past performance is a better predictor of future performance.
Presented by Raphael Mrode, ILRI, at the workshop on Essential Knowledge for Effective Improvement and Dissemination of Genetics in Sheep and Goats, Addis Ababa, Ethiopia, 3–5 November 2020
This is the 5th and final presentation in a 5-part webinar series on Breeding Better Sheep & Goats. The presenter is Susan Schoenian, University of Maryland Extension Sheep & Goat Specialist.
This document provides information about an animal breeding course taught by Abdirahman Awsamire at the University of Hargeisa. The course covers the historical development of animal breeding, identification of livestock breeds, genetic parameters, methods of selection, breeding programs, and conservation of animal genetic resources. The objective is for students to understand concepts of animal breeding including methods of selection, identification of livestock breeds, genetic parameters, relationship categories, and principles of breeding programs and genetic conservation.
This document discusses principles of animal genetics including Mendelian genetics. It explains Mendel's principles of dominance, segregation, and independent assortment and how they can be used to predict genotypes and phenotypes of offspring through Punnett squares. It describes genetic material including DNA, genes, and chromosomes. It discusses how genetic material is transferred from parents to offspring and defines key genetic terms. It also covers non-Mendelian inheritance patterns like incomplete dominance and codominance.
Application of genome editing in farm animals: Cattle - Alison Van EenennaamOECD Environment
This document summarizes an expert presentation on animal genomics and biotechnology education. It discusses:
1) Cattle contribute significantly to global animal protein supply and demand for cattle products is projected to increase substantially by 2050. Accelerating genetic gain through breeding programs is needed to meet this demand more sustainably.
2) Genome editing holds promise for introducing beneficial traits into cattle, such as polledness, heat tolerance, and disease resistance. One example discussed was using TALENs to introduce the polled allele into dairy cattle to eliminate painful horn removal.
3) However, regulatory hurdles like the FDA's stance that gene-edited animals are drugs could slow the application of new gene editing
Progeny testing is a technique used to estimate the breeding value of sires based on the average performance of their offspring. Each offspring receives half of its genes from its sire, so evaluating the performance of a large number of progeny provides a better indication of a sire's breeding value. Progeny testing is commonly done for males since they can produce more offspring than females. Primary selection is based on sibling averages, with bulls having the highest averages selected for official progeny testing where their daughters' performances are analyzed to estimate the bull's breeding value. Testing more progeny per sire increases the accuracy by reducing sampling errors.
Conservation of farm animal genetic resourcesIllaya Kumar
India is a vast country, rich in biodiversity. With its geographical area of 329 million hectares, India has almost all the climatic conditions and ecological zones found in different parts of the world, ranging from perpetual snow cover to equatorial and tropical conditions, from mangroves to humid tropics and hot and cold deserts as well as all the intermediate conditions. Before the advent of fossil fuel, animal energy was the only source of farm power and that also mainly from bullocks. In the recent past, a number of native breeds are facing fast genetic degradation and dilution because of intensive production system and unplanned introduction and use of exotic germplasm. This scenario, if continued, might result in depletion of the invaluable native germplasm having better potentiality for production, draught capacity, resistance to diseases and heat tolerance ability. In general, indigenous breeds provide the necessary genetic diversity needed by modern agriculture as a means to ensure stability and are vital building blocks for future livestock breeding programmes. Conservation of indigenous animal is needed for Genetic insurance, Scientific study, Economic potential, Environmental considerations, Cultural and ethical requirements, Energy source by In situ or Ex situ conservation techniques. There are some agencies like NBAGR involved in livestock conservation and the government also implemented projects for breeds conservation. There are many successful stories such as Sabarmathi Ashram goshala in the conservation of native breeds. Many foreign countries have realized the genetic potential of our indigenous breeds and using them for improvement of their germplasm. It is high time to proceed to conserve our germplasm.
This document discusses the economic importance and traits of cattle in Nepal. It describes the seven indigenous cattle breeds found in Nepal, which include Pahadi, Siri, Achami, Yak, Terai, Khaila, and Lulu cattle. It also discusses exotic cattle breeds like Jersey and Holstein that have been introduced. The document outlines breeding policies and improvement strategies recommended by the Department of Livestock Services to upgrade indigenous breeds through crossbreeding while conserving genetic resources. It concludes that indigenous cattle are hardy but have low productivity, so crossbreeding with exotic breeds like Jersey is needed under suitable management conditions in Nepal.
This document discusses heritability, which is defined as the proportion of phenotypic variation that can be attributed to genetic factors rather than environmental influences. It notes there are statistical and more common definitions of heritability. The concept plays a central role in psychology and analyzes the relative contributions of genetic and non-genetic factors to traits. Heritability is estimated using studies of related individuals like twins to determine the similarities between them. Estimates provide the proportion of trait variation explained by genetics within a given population under the prevailing environmental conditions.
This document discusses genetics and animal breeding. It explains how genetics relates to livestock improvement and describes cell division, inheritance of traits, and genetic principles like dominance, sex determination, linkage and mutation. Additive gene effects from many genes cumulatively influence economically important quantitative traits like growth and milk production, while non-additive genes control fewer qualitative traits. Heritability estimates the proportion of variation due to genetics. Selection of superior breeding stock relies on performance records and expected progeny differences to make genetic progress over generations.
community based cattle breeding plan in NepalAnil Sigdel
This document discusses a proposed cattle breeding program in Nepal. It aims to improve milk production while conserving indigenous genetic resources. The program would involve line breeding local breeds to preserve genetic diversity, and crossbreeding selected local cows with Jersey bulls to upgrade milk yield. Over generations, this would increase the Jersey blood level up to 75% for commercial cattle. The program is needed to boost farmers' incomes while protecting native breeds at risk of extinction. Careful selection and breeding strategies tailored to different regions are required to balance conservation and productivity goals.
The document discusses selection methods for breeding poultry flocks. The objectives of poultry breeding are to increase egg and meat production through traits like feed efficiency. Selection methods include individual selection based on phenotype, pedigree selection using family records, and family selection involving progeny or sib testing. Breeding programs aim to improve economic traits like body weight, egg production and quality for layers or broilers. Various government and private organizations in India research and develop high-yielding poultry breeds.
This document discusses different mating systems used in animal breeding including inbreeding, outbreeding, and their various forms. Inbreeding, like intensive inbreeding and linebreeding, is used to concentrate desirable genes and make traits more predictable in offspring. Outbreeding, such as crossbreeding and outcrossing, brings in new genes to increase performance and avoid inbreeding depression. Different mating systems are used for goals like genetic superiority, hybrid vigor, maintaining breed characteristics, or upgrading commercial herds.
This powerpoint gives a clear picture on inbreeding and also about outbreeding of higher organisms. This also explains the advantages and disadvantages of the above said topics. the methods of inbreeding and reasons for inbreeding also given in this powerpoint.
This document discusses animal breeding and selection. It covers several key points:
1) Genetic improvement is the goal of any breeding program and is influenced by both genetics (G) and environment (E).
2) Selection considers the whole population, not just individuals. Tools like EPDs and performance records are used.
3) Traits like growth, reproduction, and longevity should be breeding goals. Methods like individual, family, and progeny testing are used for single or multiple trait selection.
4) Crossbreeding can increase performance through hybrid vigor/heterosis and breed complementarity compared to purebreeding. Organized crossbreeding systems maximize these benefits.
This PowerPoint is from a seminar originally presented at the 2010 Maryland Sheep & Wool Festival by Susan Schoenian, Sheep & Goat Specialist for University of Maryland Extension.
This document summarizes several common respiratory diseases that affect poultry, including chickens, turkeys, ducks, geese and other birds. It describes the clinical signs, transmission, treatment and prevention for each disease. The diseases discussed include: fowl pox, Newcastle disease, infectious bronchitis, quail bronchitis, avian influenza, infectious coryza, infectious laryngotracheitis, and turkey rhinotracheitis. For each disease, the document provides details on the species affected, symptoms, how it spreads, potential treatments, and prevention methods such as vaccination and sanitation practices.
Respiratory problems application of vaccinesFaisalakram75
This document discusses respiratory problems in poultry and the application of vaccines. It describes the respiratory system of chickens and lists various non-viral and viral respiratory diseases such as mycoplasmosis, Newcastle disease, infectious bronchitis, and avian influenza. It provides details on the symptoms, transmission, and diagnosis of these diseases. It also discusses the types of vaccines available for bacterial diseases and mycoplasmosis, as well as viral diseases like Newcastle disease and infectious bronchitis.
Repeatability refers to the correlation between measurements of the same trait for an individual measured more than once. It ranges from 0 to 1. Repeatability is influenced by both permanent environmental effects, which consistently impact all measurements of an individual, as well as temporary environmental effects that vary between measurements. Heritability instead refers to the degree to which offspring inherit traits from their parents. While heritability estimates the genetic influence, repeatability captures both genetic and permanent environmental influences. Repeatability can be estimated using analysis of variance to partition phenotypic variance into within and between individual components. Higher repeatability means past performance is a better predictor of future performance.
Presented by Raphael Mrode, ILRI, at the workshop on Essential Knowledge for Effective Improvement and Dissemination of Genetics in Sheep and Goats, Addis Ababa, Ethiopia, 3–5 November 2020
This is the 5th and final presentation in a 5-part webinar series on Breeding Better Sheep & Goats. The presenter is Susan Schoenian, University of Maryland Extension Sheep & Goat Specialist.
This document provides information about an animal breeding course taught by Abdirahman Awsamire at the University of Hargeisa. The course covers the historical development of animal breeding, identification of livestock breeds, genetic parameters, methods of selection, breeding programs, and conservation of animal genetic resources. The objective is for students to understand concepts of animal breeding including methods of selection, identification of livestock breeds, genetic parameters, relationship categories, and principles of breeding programs and genetic conservation.
This document discusses principles of animal genetics including Mendelian genetics. It explains Mendel's principles of dominance, segregation, and independent assortment and how they can be used to predict genotypes and phenotypes of offspring through Punnett squares. It describes genetic material including DNA, genes, and chromosomes. It discusses how genetic material is transferred from parents to offspring and defines key genetic terms. It also covers non-Mendelian inheritance patterns like incomplete dominance and codominance.
Application of genome editing in farm animals: Cattle - Alison Van EenennaamOECD Environment
This document summarizes an expert presentation on animal genomics and biotechnology education. It discusses:
1) Cattle contribute significantly to global animal protein supply and demand for cattle products is projected to increase substantially by 2050. Accelerating genetic gain through breeding programs is needed to meet this demand more sustainably.
2) Genome editing holds promise for introducing beneficial traits into cattle, such as polledness, heat tolerance, and disease resistance. One example discussed was using TALENs to introduce the polled allele into dairy cattle to eliminate painful horn removal.
3) However, regulatory hurdles like the FDA's stance that gene-edited animals are drugs could slow the application of new gene editing
Progeny testing is a technique used to estimate the breeding value of sires based on the average performance of their offspring. Each offspring receives half of its genes from its sire, so evaluating the performance of a large number of progeny provides a better indication of a sire's breeding value. Progeny testing is commonly done for males since they can produce more offspring than females. Primary selection is based on sibling averages, with bulls having the highest averages selected for official progeny testing where their daughters' performances are analyzed to estimate the bull's breeding value. Testing more progeny per sire increases the accuracy by reducing sampling errors.
Conservation of farm animal genetic resourcesIllaya Kumar
India is a vast country, rich in biodiversity. With its geographical area of 329 million hectares, India has almost all the climatic conditions and ecological zones found in different parts of the world, ranging from perpetual snow cover to equatorial and tropical conditions, from mangroves to humid tropics and hot and cold deserts as well as all the intermediate conditions. Before the advent of fossil fuel, animal energy was the only source of farm power and that also mainly from bullocks. In the recent past, a number of native breeds are facing fast genetic degradation and dilution because of intensive production system and unplanned introduction and use of exotic germplasm. This scenario, if continued, might result in depletion of the invaluable native germplasm having better potentiality for production, draught capacity, resistance to diseases and heat tolerance ability. In general, indigenous breeds provide the necessary genetic diversity needed by modern agriculture as a means to ensure stability and are vital building blocks for future livestock breeding programmes. Conservation of indigenous animal is needed for Genetic insurance, Scientific study, Economic potential, Environmental considerations, Cultural and ethical requirements, Energy source by In situ or Ex situ conservation techniques. There are some agencies like NBAGR involved in livestock conservation and the government also implemented projects for breeds conservation. There are many successful stories such as Sabarmathi Ashram goshala in the conservation of native breeds. Many foreign countries have realized the genetic potential of our indigenous breeds and using them for improvement of their germplasm. It is high time to proceed to conserve our germplasm.
This document discusses the economic importance and traits of cattle in Nepal. It describes the seven indigenous cattle breeds found in Nepal, which include Pahadi, Siri, Achami, Yak, Terai, Khaila, and Lulu cattle. It also discusses exotic cattle breeds like Jersey and Holstein that have been introduced. The document outlines breeding policies and improvement strategies recommended by the Department of Livestock Services to upgrade indigenous breeds through crossbreeding while conserving genetic resources. It concludes that indigenous cattle are hardy but have low productivity, so crossbreeding with exotic breeds like Jersey is needed under suitable management conditions in Nepal.
This document discusses heritability, which is defined as the proportion of phenotypic variation that can be attributed to genetic factors rather than environmental influences. It notes there are statistical and more common definitions of heritability. The concept plays a central role in psychology and analyzes the relative contributions of genetic and non-genetic factors to traits. Heritability is estimated using studies of related individuals like twins to determine the similarities between them. Estimates provide the proportion of trait variation explained by genetics within a given population under the prevailing environmental conditions.
This document discusses genetics and animal breeding. It explains how genetics relates to livestock improvement and describes cell division, inheritance of traits, and genetic principles like dominance, sex determination, linkage and mutation. Additive gene effects from many genes cumulatively influence economically important quantitative traits like growth and milk production, while non-additive genes control fewer qualitative traits. Heritability estimates the proportion of variation due to genetics. Selection of superior breeding stock relies on performance records and expected progeny differences to make genetic progress over generations.
community based cattle breeding plan in NepalAnil Sigdel
This document discusses a proposed cattle breeding program in Nepal. It aims to improve milk production while conserving indigenous genetic resources. The program would involve line breeding local breeds to preserve genetic diversity, and crossbreeding selected local cows with Jersey bulls to upgrade milk yield. Over generations, this would increase the Jersey blood level up to 75% for commercial cattle. The program is needed to boost farmers' incomes while protecting native breeds at risk of extinction. Careful selection and breeding strategies tailored to different regions are required to balance conservation and productivity goals.
The document discusses selection methods for breeding poultry flocks. The objectives of poultry breeding are to increase egg and meat production through traits like feed efficiency. Selection methods include individual selection based on phenotype, pedigree selection using family records, and family selection involving progeny or sib testing. Breeding programs aim to improve economic traits like body weight, egg production and quality for layers or broilers. Various government and private organizations in India research and develop high-yielding poultry breeds.
This document discusses different mating systems used in animal breeding including inbreeding, outbreeding, and their various forms. Inbreeding, like intensive inbreeding and linebreeding, is used to concentrate desirable genes and make traits more predictable in offspring. Outbreeding, such as crossbreeding and outcrossing, brings in new genes to increase performance and avoid inbreeding depression. Different mating systems are used for goals like genetic superiority, hybrid vigor, maintaining breed characteristics, or upgrading commercial herds.
This powerpoint gives a clear picture on inbreeding and also about outbreeding of higher organisms. This also explains the advantages and disadvantages of the above said topics. the methods of inbreeding and reasons for inbreeding also given in this powerpoint.
This document discusses animal breeding and selection. It covers several key points:
1) Genetic improvement is the goal of any breeding program and is influenced by both genetics (G) and environment (E).
2) Selection considers the whole population, not just individuals. Tools like EPDs and performance records are used.
3) Traits like growth, reproduction, and longevity should be breeding goals. Methods like individual, family, and progeny testing are used for single or multiple trait selection.
4) Crossbreeding can increase performance through hybrid vigor/heterosis and breed complementarity compared to purebreeding. Organized crossbreeding systems maximize these benefits.
This PowerPoint is from a seminar originally presented at the 2010 Maryland Sheep & Wool Festival by Susan Schoenian, Sheep & Goat Specialist for University of Maryland Extension.
This document summarizes several common respiratory diseases that affect poultry, including chickens, turkeys, ducks, geese and other birds. It describes the clinical signs, transmission, treatment and prevention for each disease. The diseases discussed include: fowl pox, Newcastle disease, infectious bronchitis, quail bronchitis, avian influenza, infectious coryza, infectious laryngotracheitis, and turkey rhinotracheitis. For each disease, the document provides details on the species affected, symptoms, how it spreads, potential treatments, and prevention methods such as vaccination and sanitation practices.
Respiratory problems application of vaccinesFaisalakram75
This document discusses respiratory problems in poultry and the application of vaccines. It describes the respiratory system of chickens and lists various non-viral and viral respiratory diseases such as mycoplasmosis, Newcastle disease, infectious bronchitis, and avian influenza. It provides details on the symptoms, transmission, and diagnosis of these diseases. It also discusses the types of vaccines available for bacterial diseases and mycoplasmosis, as well as viral diseases like Newcastle disease and infectious bronchitis.
Peste des-ruminants-is-a-rinderpest.doc pdfGudyne Wafubwa
Peste des petits ruminant virus (PPRV) is a disease mostly affecting goats and sheep. Since its first discovery, it has caused massive economic loss to most small pastoralists in Africa and other developing countries. It is the integral role of all stakeholders to join hands so as to eradicate the disease.
The document discusses animal bites and rabies in Kuwait. It describes rabies disease and transmission, the epidemiology of animal bites in Kuwait from 2012-2016 which were mostly from dogs and cats, and the public health burden. It outlines the animal bite surveillance system in Kuwait which monitors post-exposure prophylaxis use, epidemiology, and immunity to help mitigate human risk of rabies. Proper management of animal bites including wound treatment, vaccination, and immunoglobulin can prevent rabies, which without treatment, is almost always fatal.
Transboundary diseases and animal welfare concerns Alex Sabuni
Interest in TAD has been direct towards: Socio economic and, Public Health impacts of these diseases with disregard to the welfare of the animals. Decision to initiate control efforts has always ben dictated by the impacts of these diseases to health and livelihoods. Disease causes pain to animals, which is a welfare issue that requires urgent addressing.
Rabies is entirely preventable, and vaccines,
medicines, tools, and technologies have long
been available to prevent people from dying of
dog-mediated rabies. Nevertheless, rabies still
kills about 60 000 people a year, of whom over
40% are children under 15, mainly in rural areas
of economically disadvantaged countries in Africa
and Asia. Of all human cases, up to 99% are
acquired from the bite of an infected dog.
This document discusses various topics related to veterinary science including zoonotic diseases, antimicrobial resistance, vaccines, eggs and milk as food supplements, and career opportunities in veterinary science. It defines key terms and highlights the importance of vaccination in preventing disease outbreaks and protecting public health. Career opportunities mentioned include working for government organizations, private practice, pharmaceutical companies, and livestock industries. Study tips emphasized include sitting up front in class, reading textbooks, taking good notes, setting a schedule, managing time well, dedicating effort, studying in groups, and balancing commitments while reviewing material regularly.
A pilot study on effects of vaccination on immunity of broiler chickensAlexander Decker
This document summarizes a pilot study that examined the effects of vaccination on the immunity of broiler chickens challenged with Newcastle disease virus (NDV). Twenty broiler chickens were divided into five groups, with four groups receiving different locally produced NDV vaccines and one unvaccinated control group. When challenged with NDV at five weeks old, the vaccinated groups showed no clinical signs of infection while the unvaccinated group had 100% mortality within 48 hours. This indicates that vaccination is important for preventing and controlling poultry diseases, as maternal immunity alone in young chicks is not sufficient to fight infections. Locally produced vaccines should be encouraged for small farmers to manage viral outbreaks.
Livestock diseases cause billions in losses annually in the US. Three main causes of disease spread are poor sanitation, improper management, and introducing new animals. Diseases can be caused by nutritional defects, physiological defects, morphological defects, or pathogenic organisms like viruses, bacteria, fungi and protozoa. Good management practices like isolation of new animals, vaccination programs, clean facilities, adequate rations, limiting visitors, quick diagnosis, and proper handling can help prevent disease spread. Common diseases are described along with their causes, symptoms, and prevention/treatment methods.
The document discusses various animal diseases including their causes, symptoms, prevention and treatment. It provides details on nutritional, physiological, morphological and pathogenic defects that can cause disease. Common viral, bacterial, fungal and protozoan diseases are described along with their characteristics. Key points for prevention include proper sanitation, nutrition, housing and vaccination. Overall, the document emphasizes that following good management practices is essential to controlling the spread of diseases and reducing economic losses for livestock producers.
AH presentaton on disease of cattle causes,symptomsdevharsh2902
This document presents a presentation on cattle diseases given by 8 presenters. It discusses what disease is, defines several common cattle diseases like brucellosis, anthrax, mastitis, black quarter, foot and mouth disease, lumpy skin disease, bovine babesiosis, trypanosomiasis, milk fever, and ruminal tympany. For each disease, it describes the causative agent, symptoms, treatment, prevention, and control measures. In conclusion, it states that cattle diseases have wide-ranging impacts and prevention through vaccination and biosecurity is key to minimizing their effects.
The Effect of Animal Agriculture Housing Conditions on the Emergence of the A...Carrie Ducote
This document discusses the housing conditions of commercial poultry and their role in the recent avian influenza outbreak. It argues that keeping large numbers of birds in crowded, stressful conditions allows viruses to easily spread and mutate, making them highly contagious and deadly. The document provides background on avian influenza, outlines the life of commercial poultry, and gives a timeline of the 2014-2015 outbreak in the US that impacted poultry in several states. It ultimately concludes that animal agriculture practices contribute to the emergence and spread of infectious diseases.
The document discusses antibiotic resistance and how it develops through natural selection. It explains that when antibiotics are used, only bacteria that are resistant to the antibiotic will survive and pass on the resistant genes. This can lead to epidemics if the bacteria become resistant to multiple antibiotics. The document also discusses the H5N1 bird flu virus and efforts to develop a vaccine against it.
Stomoxys is a genus of flies belonging to the family Muscidae, commonly known as stable flies. These flies are widely distributed across different regions of the world and are of significant economic and veterinary importance. The genus includes several species, with Stomoxys calcitrans being the most common and well-known species encountered.
This document summarizes information about bovine tuberculosis, a zoonotic disease caused by the bacterium Mycobacterium bovis. It primarily affects cattle but can infect many other species. Humans can contract it through ingesting unpasteurized dairy or inhaling infected aerosols. Control relies on test and slaughter programs along with pasteurization. Outbreaks in wildlife pose challenges. While treatable in humans, it remains an occupational hazard for farmers and abattoir workers in areas where bovine tuberculosis is endemic.
Salmonellosis is caused by Salmonella bacteria and is a major cause of foodborne illness worldwide. There are over 2,500 serotypes of Salmonella but less than 100 cause infections in humans. Salmonella enterica serovar Typhi and Paratyphi cause enteric fever, resulting in systemic illness with symptoms like sustained fever. Nontyphoidal Salmonella generally cause self-limiting gastroenteritis. Diagnosis is made by isolating the bacteria from stool culture. Treatment involves rehydration and sometimes antibiotics. Prevention relies on safe food/water handling and hygiene practices.
This document discusses zoonotic and vector borne diseases. It begins with an introduction to zoonotic diseases, which are diseases that can spread between animals and humans. These diseases are caused by viruses, bacteria, parasites or fungi. The document then discusses the main mechanisms of infection such as direct contact, indirect contact, vector-borne transmission, foodborne transmission, and waterborne transmission. It identifies populations that are at high risk of zoonotic diseases such as children, elderly adults, immunocompromised individuals, and pregnant women. The document also examines the environmental and anthropogenic factors that contribute to the emergence and spread of zoonotic diseases. Finally, it provides examples of major zoonotic diseases and discusses Malaysia's mult
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(GenAI with Milvus)
https://ml.dssconf.pl/user.html#!/lecture/DSSML24-041a/rate
Discover the potential of real-time streaming in the context of GenAI as we delve into the intricacies of Apache NiFi and its capabilities. Learn how this tool can significantly simplify the data engineering workflow for GenAI applications, allowing you to focus on the creative aspects rather than the technical complexities. I will guide you through practical examples and use cases, showing the impact of automation on prompt building. From data ingestion to transformation and delivery, witness how Apache NiFi streamlines the entire pipeline, ensuring a smooth and hassle-free experience.
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Population Growth in Bataan: The effects of population growth around rural pl...
Genetic selection for disease resistance (animal breeding). اصلاح دام
1. In the name of God
Genetic Selection for Disease Resistance: Challenges and Opportunities
Supervisor: Professor G. Rahimi Mianji
By: M. Ghaderzadeh
November, 2014
1
2. The objectives of this presentation
1. Importance of animal health
2. Animal health symptoms and animal welfare
3. Introduction Livestock diseases
4. Challenges of selecting for disease resistance
5. Genetic selection for disease resistance
6. Future prospects and conclusion
2
3. Importance of animal health
Whether it is a herd of cattle, a flock of sheep or goats, a pen of chickens or a group of
weaned pigs, poor animal health decreases the performance of the animals leading to
lower production and financial losses.
Inputs such as feed, water, proper housing and good management practices and record
keeping are essential to your outputs and financial gain. Without proper animal health
practices there will be reduce efficiency and optimal profits.
only healthy animals are delivered for anti-mortem inspection and meat production
ensuring safe and wholesome meat for public consumption. (1)
3
4. Importance of animal health
In order to have a successful farm operation, livestock farmers should seek to do the
following:
1.Seek good genetically sound animals with good reproductive ability.
2. Provide adequate land space for farm operation in order to reduce overcrowding.
3. Provide proper housing with adequate temperature control for the newborn and young
animals.
4. Ensure adequate feed supply in order to provide proper nutrition for the animals.
5. Potable and clean water should be provided at all times for the animals.
6. Have proper animal identification records and include financial and inventory records on
the animals and the farm.
7. Have sufficient pastures for your cattle, sheep and goats and practice proper pasture
rotation to prevent parasite build up and reduce pasture destruction ( 2).
4
5. Animal health symptoms and animal welfare
Healthy Livestock:
Alertness
Chewing of cud
Sleek coat
Bright eyes
Normal feces and urine
Normal temperature
Normal pulse rate
Normal respiration
Unhealthy Livestock:
Loss of appetite
Rough hair coat
Abnormal feces
Dull eyes
High temperature
Discolored urine
Ruminants not chewing their cud (2).
5
6. What Is Animal Welfare?
‘The physical and
psychological state of an
animal’
Is it fit?
Is it healthy?
Is it free from suffering?
(4, 5)
6
7. 7
Animal welfare is the well-being of animals.
The standards of "good" animal welfare vary
considerably between different contexts.
These standards are under constant review
and are debated, created and revised by
animal welfare groups, legislators and
academics worldwide (3) (4). Animal welfare
science uses measures such as longevity,
disease, immunosuppression, behavior,
physiology, and reproduction although there
is debate about which of these indicators
provide the best information (5).
Animal welfare
8. Introduction Livestock diseases
8
Mastitis in dairy cattle is the
persistent, inflammatory reaction of
the udder tissue. This potentially fatal
mammary gland infection is the most
common disease in dairy cattle in the
United States. It is also the most
costly to the dairy industry (6).
Mastitis
9. 9
Bovine spongiform encephalopathy (BSE),
commonly known as mad cow disease, is a
fatal neurodegenerative disease
(encephalopathy) in cattle that causes a spongy
degeneration in the brain and spinal cord. BSE
has a long incubation period, about 30 months
to 8 years, usually affecting adult cattle at a
peak age onset of four to five years, all breeds
being equally susceptible (7). In the United
Kingdom, the country worst affected, more
than 180,000 cattle have been infected and 4.4
million slaughtered during the eradication
program (8).
BSE
Introduction Livestock diseases
10. Introduction Livestock diseases
Pinkeye in Cattle
Infectious bovine keratoconjunctivitis, more
commonly known as pinkeye, is a contagious
bacterial infection of the eye in cattle. The
infection causes inflammation of the tissue
lining of the eyelid and the eyeball itself.
Ultimately, the cornea may become ulcerated,
resulting in pain and possible blindness. A
1997 report by the National Animal Health
Monitoring System (NAHMS) found pinkeye
to be the second most prevalent infection in
nursing calves more than three weeks old (9).
10
11. 11
Introduction Livestock diseases
Foot-and-mouth disease
is an infectious and sometimes fatal viral
disease that affects cloven-hoofed animals,
including domestic and wild bovids.(10)
(11). The virus causes a high fever for two
or three days, followed by blisters inside
the mouth and on the feet that may rupture
and cause lameness. Foot-and-mouth
disease (FMD) has severe implications for
animal farming, since it is highly
infectious and can be spread by infected
animals through aerosols, through contact
with contaminated farming equipment,
vehicles, clothing, or feed, and by
domestic and wild predators (13).
12. Introduction Livestock diseases
Avian influenza
12
Bird flu" is a phrase similar to "swine
flu," "dog flu," "horse flu," or "human
flu" in that it refers to an illness caused
by any of many different strains of
influenza viruses that have adapted to a
specific host. While its most highly
pathogenic strain (H5N1) had been
spreading throughout Asia since 2003,
avian influenza reached Europe in 2005,
and the Middle East, as well as Africa,
the following year (13). On January 22,
2012, China reported its second human
death due to bird flu in a month
following other fatalities in Vietnam
and Cambodia (14).
13. Introduction Livestock diseases
Avian infectious bronchitis is an
acute and highly contagious
respiratory disease of chickens.
The disease is caused by avian
infectious bronchitis virus, a
coronavirus, and characterized by
respiratory signs including
gasping, coughing, sneezing,
tracheal rales, and nasal discharge
(15 ,16).
Avian infectious bronchitis
13
14. Introduction Livestock diseases
Newcastle disease is a contagious viral
disease of birds and considered one of
the most important poultry diseases
worldwide. The disease can vary from
mild to severe. A highly contagious
and severe form of the disease, called
exotic Newcastle disease (END), is so
deadly that many birds die suddenly
without showing any signs of disease.
Signs of severe illness include swelling
of the tissues of the head, muscle
tremors, drooping wings, twisted head,
circling, paralysis or sudden death
(17).
14
Newcastle Disease
15. Introduction Livestock diseases
The disease is characterized by the presence of T cell
lymphoma as well as infiltration of nerves and organs by
lymphocytes (18). Viruses related to MDV appear to be
benign and can be used as vaccine strains to prevent
Marek's disease. For example, the related Herpesvirus of
Turkeys (HVT), causes no apparent disease in turkeys
and continues to be used as a vaccine strain for
prevention of Marek's disease. Birds infected with
GaHV-2 can be carriers and shedders of the virus for life.
Newborn chicks are protected by maternal antibodies for
a few weeks. After infection, microscopic lesions are
present after one to two weeks, and gross lesions are
present after three to four weeks. The virus is spread in
dander from feather follicles and transmitted by
inhalation (19).
Marek's disease
15
16. Challenges of selecting for disease resistance
For below reasons, new approaches or alternatives to addressing animal diseases are
needed:
Animal health and important issues for animal producers and consumers.
Animal diseases causing morbidity and mortality significantly decrease profitability
of animal production.
consumer fears of residual drugs in meat products and microbial resistance to
commonly used antibiotics.
Current fear of a worldwide human influenza pandemic caused by transmission of
avian.
influenza virus to humans has increased public awareness of a need to control
animal diseases.
Therapeutic treatment costs for sick animals have continued to increase.
Breeding for improved disease resistance has become perhaps the
major challenge facing animal geneticists.
16
17. 17
Challenges of selecting for disease resistance
One approach for these problems is genetic selection for animals resistant to disease.
Animal health is influenced by many factors including:
Genetics
Nutrition
Age
Stress
Management system
Season
Pathogen dosage
Immunological background
Epidemiology
Animal biological status
Many other variables and interact these factors
18. Challenges of selecting for disease resistance
What is Disease Resistance?
Animal disease resistance protects animals from pathogens in two ways: by preformed
mechanisms and by infection-induced responses of the immune system.
Disease resistance is the reduction of pathogen growth on or in the animal, while the term
disease tolerance describes animals that exhibit little disease damage despite substantial
pathogen levels (21).
18
19. 19
Challenges of selecting for disease resistance
Resistance and Tolerance
Resistance is best understood from an ecological Consideration of
the interaction between the host and the Pathogen species may be
defined as the ability of the host to exert some degree of control
over the pathogen life cycle (22).
This broad definition encompasses the many ways a host species
may be more resistant (e.g., less likely to become infected, reduced
pathogen proliferation once infected, reduced shedding or
transmission of infection), and it also inherently recognises that
resistance is usually relative rather than absolute .(22)
20. Challenges of selecting for disease resistance
Resistance and Tolerance
20
Tolerance may be defined as the net impact on performance of a given
level of infection, i.e. the regression of performance on (a function of)
pathogen load. A related concept, resilience, may be defined as the
productivity of an animal in the face of infection. Whereas resistance
implies a host exerting a deleterious influence on the fitness of the
pathogen, hosts with a greater tolerance are those able to maintain a
greater fitness as pathogen load increases. Definitions are presented
diagrammatically in Fig. 1.(22).
21. Challenges of selecting for disease resistance
Resistance and Tolerance
Fig. 1. Definitions used in the paper are: Resistance is the ability of the host
animal to exert control over the parasite or pathogen life cycle; Tolerance is the
net impact on performance of a given level of infection; Resilience is the
productivity of an animal in the face of infection.The figure (from Bishop, 2012)
show saschematic representation of perfor mance and level of infection(or some
function that linearises the relationship between level of infection and
performance).The regression slope represents Tolerance, point A indicates
Resistance and point B represents Resilience (22).
21
22. 22
Challenges of selecting for disease resistance :
Identifying the phenotype for disease resistance is difficult.
It is a false assumption that in a population of sick and healthy animals all healthy
animals are disease resistant.
Some susceptible animals may not have been sufficiently exposed to the disease
organism to get sick.
Animals that appear healthy may have sub-clinical infections and represent pathogen
reservoirs.
Often the clinical expression of a disease can be confounded with a similar disease.
Accurate disease diagnosis is costly and time consuming.
23. Challenges of selecting for disease resistance :
The success of selection for disease resistance is dependent on correctly
identifying the phenotype for disease resistance.
Selection for disease resistance is much more complicated than selecting for
production traits which can be measured directly or indirectly on each animal.
Before breeding schemes for disease resistance can be developed,
consideration of many different scientific areas such as microbiology,
epidemiology, immunology, host-pathogen interaction, host biology, livestock
production systems, etc., must be understood (23).
23
24. Challenges of selecting for disease resistance :
Keeping the host’s immune defense system in homeostasis may be
difficult.
Also, selection for immunity without leading to autoimmunity may be a
difficult balance to achieve.
Justification for including disease resistance in breeding programs can be
challenging to establish. Most importantly, the economical cost of the disease
must be sufficiently high to rationalize selecting for resistance (23).
24
25. 25
Challenges of selecting for disease resistance :
When genetic selection is helpful?
If antibiotics and other drugs have become inefficient because of
microbial resistance, selection for disease resistance may be logical.
Genetic selection for disease resistance may be useful against diseases
for which neither vaccines nor therapeutics have been found.
Selection may also be of interest for diseases due to a variety of
pathogens infecting the host in a similar manner or pathway.
Organic meat production systems that cannot use vaccines or therapeutics may
also find it economically important to select for disease resistance (23).
26. 26
Challenges of selecting for disease resistance :
When Genetic Selection is undesirable?
If the genetic factors that improve disease resistance reduce production traits such as
growth or feed efficiency then selection for disease resistance will decrease production.
Examples:
Milk yield in dairy cattle has a positive correlation with many disease traits (24).
Selection for growth rate in turkeys increased their susceptibility to Newcastle disease
(25).
In beef cattle, the genetic correlations of disease resistance with growth
and feed efficiency traits are unknown.!!!!???
27. 27
Challenges of selecting for disease resistance :
However, with all these conflicts, what is the solution ?
If these genetic correlations are unfavorable, then a selection index for total merit
may be feasible to maintain production levels while selecting for disease
resistance (23).
I = b1x1 + b2x2 + …+ b m x m
(Hazel 1943)
Definition selection Index:
28. 28
Challenges of selecting for disease resistance :
Biggest challenge
The biggest challenge of selecting for disease resistance is to accurately
identify the phenotype for disease resistance and/or to have reliable
genetic markers with high predictive values for a disease phenotype. For
some diseases, disease resistance may include sub clinical and clinical
infection while for other diseases only the clinical expression may be
considered (23).
29. 29
Challenges of selecting for disease resistance :
Understanding the Immune System
The pathogen must penetrate host cell barriers in sufficient numbers, attack
target cells and replicate (23).
Immune defenses animal
Natural
Innate
Acquired
immunity
30. 30
Understanding the Immune System
Natural immunity: is the first barrier and is comprised of skin, hair,
mucous membranes, secretions (tears, urine, stomach, saliva, mucous,
skin secretions, etc.), grooming behavior (licking, dust rolling, tail
swishing, etc.) and favorable microorganisms that compete directly or
indirectly against pathogens (23).
Innate immunity: refers to the immune system one is born with and is the initial
response by the body to eliminate microbes and prevent infection. It commonly
involves white blood cells (natural killer cells, neutrophils, eosinophils, monocytes,
and macrophages), complement proteins (C1 - C4) that adhere to pathogens, and
cytokines(interferons and chemokines) that attract immune cells to the site of
infection. The innate immune system constantly searches for antigens(bacteria,
fungi, and viruses). When an antigen is discovered, the innate system can attack it or
illicit inflammation to attract immune cells (23).
31. 31
Understanding the Immune System
Acquired immunity: occurs in two forms: passive and active. Passive or
maternal immunity is passed from the cow to the calf via colostrum
containing high levels of antibodies. Passive immunity is temporary.
Disease resistance of very young calves is highly dependent on passive
immunity.
The acquired immune system is comprised of T and B cells, which are
specialized white blood cells. The T cells destroy pathogen-infected cells. The
B cells develop into specific antibody producing cells (23).
32. 32
Genetic Selection for Disease Resistance
From a genetic perspective, understanding the natural, innate, and acquired immune
systems is crucial in developing selection programs for disease resistance. For example,
if the breeding goal is to reduce bacterial diarrhea in young calves, then selection traits
might include the dam’s genetic potential for producing specific colostrum antibodies
(passive immunity) and the calf’s genetic potential for developing an innate and
acquired immune system early in life that responds to the diarrhea causing pathogen.
There may be further problems because negative genetic correlations
between the dam and calf resistance to some diseases have been estimated.
Selection for disease resistance is costly. Potential costs associated with
measuring disease resistance include reduced production, mortality,
decreased longevity, diagnostic costs, and therapeutic expenses.
33. 33
Genetic Selection for Disease Resistance
Direct selection
Direct selection for disease resistance can occur in three different scenarios:
a) First, animals may be observed in a given production system or environment
for lack of clinical expression of a disease. Under this selection approach, it is
assumed that the disease pathogen is constantly present.
Animals with clinical expression of the disease may be identified with relative
accuracy but not all healthy animals may be exposed to the pathogen or
challenged equally. Diseases often occur in clusters of time (years, seasons,
production cycles, etc.) and space (herd, pasture, farm, region, etc.). In years
when the disease incidence is high, there can be an increase in the accuracy of
identifying animals with a high probability of being disease resistant but in
years of low incidence the accuracy will be diminished (23).
34. Genetic Selection for Disease Resistance
Direct selection
b) The second direct approach is to uniformly challenge all
breeding stock with infection. This approach can be costly
depending upon the pathogen’s virulence and clinical expression
of the disease but is a reliable measure of disease resistance. This
may require isolation of the population to prevent transmission
to non-breeding stock (23).
34
35. Genetic Selection for Disease Resistance
Direct selection
c) A third approach is to challenge relatives or clones of the breeding
stock, especially if the disease has a high mortality rate. This latter
approach is also a reliable method of determining genetic resistance.
The latter two approaches are not without error because
immunological background (previous exposure to the pathogen) may
vary among animals (23).
35
36. Genetic Selection for Disease Resistance
Direct selection
Researchers will have to determine the significance of immunological
background for biasing the observed animal response to a disease
challenge. In cattle, direct selection for reducing brucellosis had a
favorable response. Templeton et al., (1990) increased natural
resistance to brucellosis in calves from 20% to59% after breeding cows
to a naturally resistant bull.
36
37. Genetic Selection for Disease Resistance
Indirect selection
Indirect selection for disease resistance can also be achieved by selecting
for indicators of disease resistance. Indicators of disease resistance include
pathogen products (i.e., pathogen reproductive rates, pathogen by products),
and biological or immunological responses of the host.
Examples:
One of the most successful approaches of indirect selection for disease
resistance has been reported in sheep by selecting for low fecal internal
parasite egg count. In dairy cattle, somatic cell count has been used as a
selection criteria for reducing mastitis (23).
37
38. Genetic Selection for Disease Resistance
Indirect selection
Hernandez et al. (2003) suggested that immune responsiveness would be a
useful indicator of disease resistance in cattle. Selection for immune response
is generally beneficial when a single disease is targeted. However, studies in
swine have indicated that selection for immune responsiveness can improve
disease resistance to other diseases while, at the same time, increasing
susceptibility to others ( Wilkie and Mallard, 1998) (23).
38
39. Genetic Selection for Disease Resistance
Indirect selection
39
For effective selection, indicator traits must be heritable, highly genetically
correlated with resistance to the disease or diseases of interest, accurate to
measure, and affordable.
Interactions between the genetics of the animal and the environment commonly
exist. If the genetic by environmental interaction is significant, animals selected
for improved disease resistance in one environment may be more susceptible to
the same disease in a different environment. Therefore, selection programs may
have to be environment specific with the selection environment matching the
commercial production environment.
Important Notice
40. Genetic Selection for Disease Resistance
40
Gene Mapping
Most genes related to disease resistance have been discovered using
inbred strains of mice.
Only a few genes have been linked to disease resistance in cattle. The
Nramp1 gene (natural resistance-associated macrophage protein) is
associated with the innate immune system. Nramp1 has been linked
with resistance to brucellosis (Harmon et al., 1989), tuberculosis, and
salmonellosis (Qureshi et al. 1996).
The major histocompatibility complex (MHC) genes are linked to
specific immunological responses. MHC genes were some of the first
mapped and sequenced genes related to disease resistance (23).
41. Genetic Selection for Disease Resistance
Gene Mapping
In dairy cattle, the bovine MHC complex has been linked to disease
resistance of economically important traits (Batra et al., 1989). In
chickens, MHC has been linked to resistance to Marek’s disease
and fowl cholera (Lamont, 1989).
Other examples of recently discovered single genes influencing
disease resistance in livestock include the fimbriae F4 (K88) gene
in swine for reducing e. coli intestinal infection (Moon et al., 1999),
the prion protein (PrP) gene related to scrapie susceptibility in
sheep (Bossers et al., 1996), and the TNC gene related to
salmonellosis in chickens (Hu et al., 1997).
41
42. Genetic Selection for Disease Resistance
42
Polygenic Effects
The complexity of the immune system clearly infers that many genes are involved in
disease resistance. It is highly doubtful that many single genes will be discovered
and associated with major diseases. Chromosome mapping may lead to quantitative
trait loci or regions related to disease resistance. Most recently, a region on
chromosome 1 was associated with infectious keratoconjunctivitis (pinkeye) in cattle
(Casas et al., 2006).
As the human and mice genomes are further investigated for disease related genes, it
ishighly plausible that quantitative trait loci(QTL) associated with disease resistant
inlivestock may also be identified in the near future (23).
43. Genetic Selection for Disease Resistance
Polygenic Effects
Micro array technology is advancing rapidly to enable association of
livestock DNA with human ( Chitko- McKown et al., 2004) and mice
DNA. Comparative genomics may make the identification of disease
loci easier and more affordable. It may be possible to identify similar
genes associated with disease susceptibility/resistance among human,
mice, and livestock (23).
43
44. Genetic Selection for Disease Resistance
44
Using genetic tools
Gene transfer technologies
Current major advances in gene transfer technologies, in parallel with the significant new
genetic information provided by genomic technologies, have made it possible to
investigate the host-pathogen interaction in more detail than ever before. Major advances
in our understanding of disease are likely to be achieved within the next few years. These
technologies will lead to new opportunities for diagnosis, intervention and the selective
breeding of animals for resistance. The combination of advanced gene transfer
technologies and traditional disease control measures, should allow for more effective and
sustainable disease control (26).
45. Genetic Selection for Disease Resistance
Using genetic tools
Gene transfer technologies
Genetic modification offers alternative strategies to traditional animal breeding. This
technology is likely to have specific application where genetic variation does not exist in
a given population or species and where novel genetic improvements can be engineered.
With either approach, the intention would be to enhance the ability of the animals to
mount an appropriate immune response against the pathogen (which could require
dampening down the immune system at strategic stages) or to generate an effective
system that would directly block pathogen entry or directly destroy the pathogen.
Indeed, a combination of strategies may prove to be the most successful approach (26).
45
46. Genetic Selection for Disease Resistance
46
Using genetic tools
Marker-assisted selection (Candidate gene)
The strategy of improving the immune response (a new strategy for which
experimental examples are only now being tested) could be used in instances
where specific gene alleles that confer resistance are present in a species but
have been lost from commercial populations. The Mx genes of vertebrates were
first discovered in mice because of the ability of functional alleles to induce a
potent antiviral state in response to infection by specific groups of viruses,
including influenza. Chickens also have an Mx gene, but the allele present in
most commercial lines is apparently not functional, due to a single amino acid
substitution (26).
47. Genetic Selection for Disease Resistance
47
Genetically modified technology
a)Dominant-negative proteins: the introduction of mutant versions of key factors in
pathogen infection, such as cell surface receptors, can block disease progression.
b) Ribonucleic acid interference (RNAi): this strategy relies on the ability of
specific short RNA sequences to anneal with the RNA of the pathogen, causing
destruction of the foreign RNA. RNAi requires access to the target RNA, which may
limit this approach to viruses (26).
49. Genetic Selection for Disease Resistance
Genetically modified technology
49
c) Ribonucleic acid decoys: expression of RNA sequences that mimic specific
sequences within a pathogen can disrupt the activity of the pathogen’s replication
machinery. Again, this approach is probably restricted to specific viruses, with
influenza being a good candidate (26).
d) Antibodies: the transgenic production of antibodies in the host animal may act
in an analogous manner to vaccination (26).
50. 50
Future prospects and conclusion
Other, less prominent diseases of livestock are also of concern because of their
effect on human health, animal welfare and/or the economics of livestock
production. There is a need to reexamine the best ways of controlling disease
outbreaks in farm animals, not just in the case of the diseases that have captured the
headlines but across the board. Perhaps the most important targets are those
endemic diseases that blight the economy and society of developing countries.
Diseases in farm animals can be controlled by vaccination, the use of drugs,
improved husbandry and by breeding animals for improved resistance. Successful
management of disease is likely to include a combination of approaches.
51. Future prospects and conclusion
51
The researchers propose that the use of GM animals will complement these more
traditional tactics, and provide novel intervention strategies that are not possible
through the established approaches. They do not anticipate that GM will be the
primary tool in the fight against disease, but rather that its use will be restricted to
specific diseases. More cooperation is required, and the decision making bodies
have to find the confidence to support what is both an exciting scientific frontier
and one that may bring huge benefit to animals and humans through combating
disease.
52. Future prospects and conclusion
52
We do not know at this time to predict whether or not selection for disease resistance can
be effective in livestock. Basic research into the complexities underlying diseases will
likely reveal effective approaches for many disease problems. It may be possible to select
directly against the disease, select for indicator traits(indirect selection), to select directly
for the gene(s) that confer resistance or some combination of these approaches
Certainly, genetic selection will not solve all of our livestock disease problems.
Therefore, management, nutrition, vaccination, culling, therapeutic treatment, stress
reduction practices and other measures must accompany genetic approaches to reduce
the impact of livestock disease on profitability and animal well being.
53. 53
My offers for be effective Disease Resistance
Management, feeding, herd health and hygienics
Write Records all animals and direct selection
Definition economic selection index for all animal triats
Considering interaction effects between different phenotyps and
environments in different areas
ییییی یییی ییی یی
ییی یییی ییییی
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Hazard Specific Plan.
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RS21747. August 29, 2006.
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Bishop The Roslin Institute and Royal (Dick) School of Veterinary Studies University
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