Salmonellosis is caused by Salmonella bacteria and is a major cause of foodborne illness worldwide. There are over 2,500 serotypes of Salmonella but less than 100 cause infections in humans. Salmonella enterica serovar Typhi and Paratyphi cause enteric fever, resulting in systemic illness with symptoms like sustained fever. Nontyphoidal Salmonella generally cause self-limiting gastroenteritis. Diagnosis is made by isolating the bacteria from stool culture. Treatment involves rehydration and sometimes antibiotics. Prevention relies on safe food/water handling and hygiene practices.