Melanoma and HIV: is there an increase in incidence?
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There is an increased incidence of melanoma in HIV patients compared to the general population. The incidence is 26-28% higher in the pre-HAART era and remains elevated at 26-50% even after the introduction of HAART treatment. While immune deficits associated with HIV increase cancer risks, clinical trials often exclude HIV patients with melanoma. However, treatment of melanoma in HIV patients with a high CD4 count, low viral load, no other illnesses, and slow disease progression may have outcomes similar to HIV-negative patients.
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Dr. Ankit Patel provides a detailed 3 page document summarizing cervical cancer including:
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- Persistent HPV infection is the main cause, and vaccination can prevent infection and thus cancer.
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- FIGO staging criteria are discussed and concurrent chemoradiation is the standard of care for locally advanced stages to improve survival rates.
- Intensity modulated radiation therapy can help reduce toxicity compared to conventional radiation.
Ca cervix—standards of care
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Dec2010 1final ll
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Why cervical cancer prevention need
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3 prof james bently hpv vaccination 2014
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3) Both vaccines were well tolerated and showed cross-protection against non-vaccine HPV types. However, Cervarix demonstrated higher long
Anal cancer video
1) Anal cancer is uncommon, comprising 2.4% of digestive system cancers in the US, with an estimated 7,060 new cases and 880 deaths in 2013.
2) The median age at diagnosis of anal cancer is 60, younger than the median age of 66 for all cancers.
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4) Five-year survival rates range from 71-78% for early stage anal cancer to 20-24% for late stage or metastatic disease. Combined chemoradiation provides local control in 85-90% of cases.
CaCu localizado.pdf
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- Modes of transmission for bloodborne pathogens like HIV, HBV, and HCV
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Cervical cancer is a major health problem, but HPV vaccination and screening can reduce rates. HPV is transmitted sexually and can cause cervical cancer. The vaccine protects against high-risk HPV types 16 and 18, which cause most cancers. Northern Ireland has high HPV vaccination rates. While the vaccine reduces cancer risk, screening is still needed since the vaccine does not protect against all HPV types and cannot help women already infected. In the future, screening may shift to HPV testing as prevalence decreases due to vaccination.
Cervical CANCER Prevention : Update 2017 for Indian Gynecologists Dr. Sharda ...
This document discusses cervical cancer prevention in India. Some key points:
- Cervical cancer is the second most common cancer in women in India, with over 122,000 new cases and 67,000 deaths annually. India accounts for about 23-25% of cervical cancer cases and deaths worldwide.
- Human papillomavirus (HPV) infection, especially types 16 and 18, is the primary cause of cervical cancer. HPV is also linked to other cancers. Screening and HPV vaccination are important prevention strategies.
- Screening through cervical cancer screening programs can reduce cases and mortality, but high coverage is difficult to achieve in India due to limited resources. HPV vaccination has significantly reduced cervical cancer burden in
HPV Diseases More Than Cervical Cancer, Dr. Sharda Jain
HPV Disease . Cervical cancer , prevention cervical cancer , HPV prevention , cancer prevention , Human Papillomavirus (HPV), cervical cancer prevention
Is there a role for ovarian cancer screening
Annual screening for ovarian cancer with CA-125 testing and transvaginal ultrasound does not reduce mortality in average-risk women but does increase invasive medical procedures and harms. Screening higher-risk women shows potential for earlier detection through the UKFOCSS trial, but results are pending. While tumor markers like HE4 show promise in detecting early cancers missed by CA-125, more research is needed to determine an effective screening strategy. Overall, there is currently no established role for population-wide ovarian cancer screening.
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Benz®Metastasic.TNCB.Cancer.2019......................
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- 1. HIV and melanoma Lorenzo Alonso Reunión GEAM
- 2. ¿Why to speak about HIV and melanoma? • There is a deterioration in the immune system in HIV patients. • Immune deficits are associated to an increase in cancer incidence (transplant recipients) • Melanoma is a very immunogenic tumor • Is there an incidence increase of melanoma in HIV patients?
- 3. AIDS. 2009 January 28; 23(3): 385–393. doi:10.1097/QAD.0b013e3283213046. JNCI 2013; 105: 350-360 Arch Dermatol. 2010;146(6):625-632 A B C D E
- 4. A, B , C: Merkel cell carcinoma D.Appendageal carcinoma C: squamous and basal cell carcinoma
- 5. Int. J. Cancer: 13, 187–194 (2008)
- 6. melanoma incidence (registries USA)
- 7. melanoma incidence: Navarra (Spain)
- 8. ASSOCIATION HIV/AIDS and melanoma Situación pRR 95% CI Significado PreHAART 1,26 1,11-1,43 + 26% etnicidad PostHAART etnicidad SIDA 1,28 1,26 1,50 1,07 1,1- 1,49 0,97- 1,64 1,12- 2,01 0,83- 1,39 + 28% +26% +50%
- 9. CLINICAL PRACTICE AND MELANOMA Clinical Trials exclude HIV patients with melanoma CTLA-4: Inverse correlation with CD4 levels and viral load. Upregulated inn HIV. AIDS 2002; 16(4): 519
- 10. Burke M M et al. JCO 2011;29:e792-e794 ©2011 by American Society of Clinical Oncology “MODEL PATIENT FOR TREATMENT” . ECOG 0-1 . Young . Low viral load . CD4>500 mm3 . No bulky disease , Slow clinical agresiveness
- 11. Conclusions • 1. There is a relative increase of the incidence of melanoma(20-50%) in HIV patients. • 2. Melanoma and HIV a diagnosis challenge: other cutaneous tumors and special locations • 3. The uncertainty to treat a patient with melanoma and HIV is very similar to a patient without HIV.