It describes the prevalence of Breast Cancer among BRCA 1/2 mutations with special consideration to biological background, detection and screening, actions taken upon discovering mutation carriers and whether we have a different therapeutic algorithm than sporadic cases. Special emphasis on the role of PARP inhibitors in the management of metastatic disease.
It describes the prevalence of Breast Cancer among BRCA 1/2 mutations with special consideration to biological background, detection and screening, actions taken upon discovering mutation carriers and whether we have a different therapeutic algorithm than sporadic cases. Special emphasis on the role of PARP inhibitors in the management of metastatic disease.
Speaker: Lisette Stork-Sloots, Sr Program Director at Agendia, discusses how their technology, MammaPrint was commercialized.
Part of Dx2010, a workshop at MaRS focused on best practices and regulatory considerations for developing gene-based diagnostic and prognostic tests.
HPV Testing is essential in the triage of ASC-US and/or LSIL cytology. The test helps to clearify the situation after treatment of high-grade CIN and to resolve uncertainties after diagnostic and or consecutive treatment. 2016 up to date information is give by the presentation.
Primary HPV testing or co-testin
Breast Cancer in Young Women and its Impact on Reproductive FunctionApollo Hospitals
Breast cancer is the most common cancer in women in developed countries. Chemotherapy for breast cancer is likely to negatively impact on reproductive function. We review current treatment; effects on reproductive function; breastfeeding and management of menopausal symptoms following breast cancer.
learn more from here... https://goo.gl/kg7116
There was a time when cervical cancer was one of the most common causes of deaths of American women due to cancer. However, over the past three decades, the cervical cancer death rate has shrunk by more than 50%. Increased use of screening tests is the main reason behind all this change. Screening can help you find changes in the cervix before any infection, leading to cancer, develops. It can also diagnose cervical cancer in its early stages – when it’s tiny, has not yet spread, and is easier to cure. Having your children vaccinated against HPV (human papillomavirus) is another way to help them avoid cervical cancer in the future.
Pulse Uniform
Speaker: Lisette Stork-Sloots, Sr Program Director at Agendia, discusses how their technology, MammaPrint was commercialized.
Part of Dx2010, a workshop at MaRS focused on best practices and regulatory considerations for developing gene-based diagnostic and prognostic tests.
HPV Testing is essential in the triage of ASC-US and/or LSIL cytology. The test helps to clearify the situation after treatment of high-grade CIN and to resolve uncertainties after diagnostic and or consecutive treatment. 2016 up to date information is give by the presentation.
Primary HPV testing or co-testin
Breast Cancer in Young Women and its Impact on Reproductive FunctionApollo Hospitals
Breast cancer is the most common cancer in women in developed countries. Chemotherapy for breast cancer is likely to negatively impact on reproductive function. We review current treatment; effects on reproductive function; breastfeeding and management of menopausal symptoms following breast cancer.
learn more from here... https://goo.gl/kg7116
There was a time when cervical cancer was one of the most common causes of deaths of American women due to cancer. However, over the past three decades, the cervical cancer death rate has shrunk by more than 50%. Increased use of screening tests is the main reason behind all this change. Screening can help you find changes in the cervix before any infection, leading to cancer, develops. It can also diagnose cervical cancer in its early stages – when it’s tiny, has not yet spread, and is easier to cure. Having your children vaccinated against HPV (human papillomavirus) is another way to help them avoid cervical cancer in the future.
Pulse Uniform
Is there a role for ovarian cancer screeningMing Cheng
Ovarian cancer is the second most common cancer in the female genital tract. Most of the cases are detected late and thus their survival rate is low. This presentation will tell you on the role of ovarian cancer screening based on the current available evidence.
All in the Family: Hereditary Risk for Gynecologic Cancerbkling
Knowing and understanding your inherited genetics is important for ovarian and uterine cancer patients. Dr. Melissa Frey, gynecologic oncologist at Weill Cornell Medicine, discusses how genetic factors affect women with ovarian and uterine cancer and influence treatment decisions, with a particular focus on BRCA1 & 2 and Lynch Syndrome.
This webinar was being put on in partnership with FORCE.
There are various appraisal methods for a start-up business. it should explore which is the most appropriate method for financial appraisal for a business.
The article is based on the sectarian conflict occurred in western part of Myanmar in 2012. This violence remains smoldering tension that challenges the new democratic government for rules of Law; dirty political plot for resurrection of dictatorship; appearance of terrorism; and judgmental stance among internationals based on unreliable news sources.
Influenza and Cold are sometime difficult to differentiate. Influenza especially type A may cause severe illnesses that lead to death. Prevention is the most effective way of controlling epidemic.
Pricing is not a point; actually a range between the lowest price that a seller willing to sell and the highest price at which a buyer willing to buy. it is an art to set a price at the optimal point that maximize a profit.
TB is one of the common communicable diseases in Myanmar. it has been trying to reduce the burden but some social barriers deter.the effective reduction.
when start a new business, it needs to calculate how much profit a company would earn. In doing so, it is important to consider "time value money" and some uncertainty factors. Thus return on capital investment should not only rely on rate of return and/or payback.
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
India Clinical Trials Market: Industry Size and Growth Trends [2030] Analyzed...Kumar Satyam
According to TechSci Research report, "India Clinical Trials Market- By Region, Competition, Forecast & Opportunities, 2030F," the India Clinical Trials Market was valued at USD 2.05 billion in 2024 and is projected to grow at a compound annual growth rate (CAGR) of 8.64% through 2030. The market is driven by a variety of factors, making India an attractive destination for pharmaceutical companies and researchers. India's vast and diverse patient population, cost-effective operational environment, and a large pool of skilled medical professionals contribute significantly to the market's growth. Additionally, increasing government support in streamlining regulations and the growing prevalence of lifestyle diseases further propel the clinical trials market.
Growing Prevalence of Lifestyle Diseases
The rising incidence of lifestyle diseases such as diabetes, cardiovascular diseases, and cancer is a major trend driving the clinical trials market in India. These conditions necessitate the development and testing of new treatment methods, creating a robust demand for clinical trials. The increasing burden of these diseases highlights the need for innovative therapies and underscores the importance of India as a key player in global clinical research.
R3 Stem Cells and Kidney Repair A New Horizon in Nephrology.pptxR3 Stem Cell
R3 Stem Cells and Kidney Repair: A New Horizon in Nephrology" explores groundbreaking advancements in the use of R3 stem cells for kidney disease treatment. This insightful piece delves into the potential of these cells to regenerate damaged kidney tissue, offering new hope for patients and reshaping the future of nephrology.
How many patients does case series should have In comparison to case reports.pdfpubrica101
Pubrica’s team of researchers and writers create scientific and medical research articles, which may be important resources for authors and practitioners. Pubrica medical writers assist you in creating and revising the introduction by alerting the reader to gaps in the chosen study subject. Our professionals understand the order in which the hypothesis topic is followed by the broad subject, the issue, and the backdrop.
https://pubrica.com/academy/case-study-or-series/how-many-patients-does-case-series-should-have-in-comparison-to-case-reports/
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
3. Death from Cx Ca in developing countries
80%
85%
90%
95%
100%
2002 2008 2030
GLOBOCAN 2008 report
4. Cx Ca situation at a glance in Myanmar
2nd most common Cancer in women and Asian countries?
15.8 15.4
25.4
World SEA Myanmar
Crude incidence rate (100,000 women/year)
6. What causes Cx Ca?
HPV as main cause Sex as transmission mode
7. Period from HPV infection to cancer
HPV infected
10 – 20 years 10 – 15 years
8. Natural history of CIN
57% 43% 32%
32%
11%
1%
35%
22%
5%
56%
12%
CIN 1
Mild dysplasia
CIN 2
Mod dysplasia
CIN 3
Severe dysplasia
Regress
Persist
Progress to CIS
Progress to invasion
Int J Gyne Path 1993; 12:186-192
9. The consequences of HPV infection
90% heal within 2 years
0.8% develop Ca
HPV into Cx cells
thro’ micro-abrasion
10. Can we prevent the progress to cancer?
If we can detect cervical epithelial abnormality…
and
If we can remove it.
It is called “Screen and Treat” approach.
13. Different screening tests for precancerous Cx
Pap smear
HPV test
VIA
Which is the most suitable for the resource poor?
Correctly identified Correctly excluded
38-84%
50-95%
56-94%
>90%
84%
74-94%
Easy-to-perform
Lab facilities
No Lab
Comprehensive cervical cancer control : a guide to essential practice, WHO, 2006
Lab facilities
14. VIA map (2011)
VIA as National program
VIA as Pilot program
No VIA program
15. If she has no evidence of Ca Cx, will she be
free from Ca Cx throughout her life time?
No!
Risk reduction
1 time per life time
2 time per life time
3 time per life time
Every 3 years
Every 2 years
Every year
17 – 32%
29 – 42%
35 – 55%
75 – 88%
86 – 91%
90 – 93%
20. Treatment options for pre-cancer cervix
Cryotherapy
LEEP
Cold knife cone
Effectiveness Setting Direct medical Cost
86 – 95%
91 – 98%
90 – 94%
Clinic
Hospital
Hospital
16-45$
100-320$
Which is the most suitable for the resource poor?
Comprehensive cervical cancer control : a guide to essential practice Pg 140, WHO, 2006
Cost-effectiveness of Cx Ca in India and Thai, NEJM 353:20, Nov, 2005
210-490$
In a place where there are no electricity and anesthetist