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Cervical Cancer Prevention
Incidence rate per 100,000 females (2005)
Death from Cx Ca in developing countries
80%
85%
90%
95%
100%
2002 2008 2030
GLOBOCAN 2008 report
Cx Ca situation at a glance in Myanmar
2nd most common Cancer in women and Asian countries?
15.8 15.4
25.4
World SEA Myanmar
Crude incidence rate (100,000 women/year)
Myanmar women at risk
13-million
What causes Cx Ca?
HPV as main cause Sex as transmission mode
Period from HPV infection to cancer
HPV infected
10 – 20 years 10 – 15 years
Natural history of CIN
57% 43% 32%
32%
11%
1%
35%
22%
5%
56%
12%
CIN 1
Mild dysplasia
CIN 2
Mod dysplasia
CIN 3
Severe dysplasia
Regress
Persist
Progress to CIS
Progress to invasion
Int J Gyne Path 1993; 12:186-192
The consequences of HPV infection
90% heal within 2 years
0.8% develop Ca
HPV into Cx cells
thro’ micro-abrasion
Can we prevent the progress to cancer?
If we can detect cervical epithelial abnormality…
and
If we can remove it.
It is called “Screen and Treat” approach.
The age to get screening
+
25 – 65 years
The screening tests
Cytology
HPV test
VIA
Different screening tests for precancerous Cx
Pap smear
HPV test
VIA
Which is the most suitable for the resource poor?
Correctly identified Correctly excluded
38-84%
50-95%
56-94%
>90%
84%
74-94%
Easy-to-perform
Lab facilities
No Lab
Comprehensive cervical cancer control : a guide to essential practice, WHO, 2006
Lab facilities
VIA map (2011)
VIA as National program
VIA as Pilot program
No VIA program
If she has no evidence of Ca Cx, will she be
free from Ca Cx throughout her life time?
No!
Risk reduction
1 time per life time
2 time per life time
3 time per life time
Every 3 years
Every 2 years
Every year
17 – 32%
29 – 42%
35 – 55%
75 – 88%
86 – 91%
90 – 93%
The treatment options
LEEP
Conization
Cryotherapy
Loop Electrosurgical Excision Procedure
Electricity or Battery
Specialist
Anesthesia (Local)
Bleeding
Cold Knife Cone (Conization)
Electricity
Specialist
Anesthesia (General)
Bleeding ↑↑
Cryosurgery
Electricity
Specialist
Anesthesia
Bleeding
X
X
X
↓
Treatment options for pre-cancer cervix
Cryotherapy
LEEP
Cold knife cone
Effectiveness Setting Direct medical Cost
86 – 95%
91 – 98%
90 – 94%
Clinic
Hospital
Hospital
16-45$
100-320$
Which is the most suitable for the resource poor?
Comprehensive cervical cancer control : a guide to essential practice Pg 140, WHO, 2006
Cost-effectiveness of Cx Ca in India and Thai, NEJM 353:20, Nov, 2005
210-490$
In a place where there are no electricity and anesthetist
Single Visit Approach
Total time for the service - <20 minutes
(Screen & Treat)
Thanks
If we can effectively “screen & Treat”

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Why cervical cancer prevention need

  • 2. Incidence rate per 100,000 females (2005)
  • 3. Death from Cx Ca in developing countries 80% 85% 90% 95% 100% 2002 2008 2030 GLOBOCAN 2008 report
  • 4. Cx Ca situation at a glance in Myanmar 2nd most common Cancer in women and Asian countries? 15.8 15.4 25.4 World SEA Myanmar Crude incidence rate (100,000 women/year)
  • 5. Myanmar women at risk 13-million
  • 6. What causes Cx Ca? HPV as main cause Sex as transmission mode
  • 7. Period from HPV infection to cancer HPV infected 10 – 20 years 10 – 15 years
  • 8. Natural history of CIN 57% 43% 32% 32% 11% 1% 35% 22% 5% 56% 12% CIN 1 Mild dysplasia CIN 2 Mod dysplasia CIN 3 Severe dysplasia Regress Persist Progress to CIS Progress to invasion Int J Gyne Path 1993; 12:186-192
  • 9. The consequences of HPV infection 90% heal within 2 years 0.8% develop Ca HPV into Cx cells thro’ micro-abrasion
  • 10. Can we prevent the progress to cancer? If we can detect cervical epithelial abnormality… and If we can remove it. It is called “Screen and Treat” approach.
  • 11. The age to get screening + 25 – 65 years
  • 13. Different screening tests for precancerous Cx Pap smear HPV test VIA Which is the most suitable for the resource poor? Correctly identified Correctly excluded 38-84% 50-95% 56-94% >90% 84% 74-94% Easy-to-perform Lab facilities No Lab Comprehensive cervical cancer control : a guide to essential practice, WHO, 2006 Lab facilities
  • 14. VIA map (2011) VIA as National program VIA as Pilot program No VIA program
  • 15. If she has no evidence of Ca Cx, will she be free from Ca Cx throughout her life time? No! Risk reduction 1 time per life time 2 time per life time 3 time per life time Every 3 years Every 2 years Every year 17 – 32% 29 – 42% 35 – 55% 75 – 88% 86 – 91% 90 – 93%
  • 17. Loop Electrosurgical Excision Procedure Electricity or Battery Specialist Anesthesia (Local) Bleeding
  • 18. Cold Knife Cone (Conization) Electricity Specialist Anesthesia (General) Bleeding ↑↑
  • 20. Treatment options for pre-cancer cervix Cryotherapy LEEP Cold knife cone Effectiveness Setting Direct medical Cost 86 – 95% 91 – 98% 90 – 94% Clinic Hospital Hospital 16-45$ 100-320$ Which is the most suitable for the resource poor? Comprehensive cervical cancer control : a guide to essential practice Pg 140, WHO, 2006 Cost-effectiveness of Cx Ca in India and Thai, NEJM 353:20, Nov, 2005 210-490$ In a place where there are no electricity and anesthetist
  • 21. Single Visit Approach Total time for the service - <20 minutes (Screen & Treat)
  • 22. Thanks If we can effectively “screen & Treat”