This document provides an overview of the Grade 10 Earth and Space science curriculum in the Philippines. It covers two main modules on plate tectonics and Earth's interior. The plate tectonics module describes plate boundaries, processes at boundaries like earthquakes and volcanoes, and activities to teach these concepts. The Earth's interior module covers the internal structure of Earth and evidence that supports plate movement, with additional hands-on activities. The curriculum aims to explain geological phenomena based on the theory of plate tectonics.
This tacklesabout locating epicenter,3 typesof plate boundaries hotspot.
A ppt presentation for module 1 in 1st quarter in grade 10sciencein the Philippines.
Feel free tomessage mefor any corrections/suggestions forimprovement.
This tacklesabout locating epicenter,3 typesof plate boundaries hotspot.
A ppt presentation for module 1 in 1st quarter in grade 10sciencein the Philippines.
Feel free tomessage mefor any corrections/suggestions forimprovement.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
1. K-12 Science Curriculum
Grade 10 Earth and Space
Rovel R. Salcedo Norman S. Valeroso
Merly A. Razon Herma D. Acosta
Cherry Ann D. Into & Eligio C. Obille Jr.
EDITED BY: JEVY DACUNES-CARBONQUILLO
2. Overview
DEPARTMENT OF EDUCATION
What is Science?
• Science- The system of acquiring
knowledge through systematic
experimentation and methodology.
The search for truth and knowledge.
4. Overview
DEPARTMENT OF EDUCATION
Grade 6 Grade 7 Grade 8 Grade 9 Grade 10
Earthquakes
& volcanic
eruptions
The
Philippine
Environment
Earthquakes &
faults
Volcanoes
Plate
tectonics
Weather
patterns
Interactions
in the
atmosphere
Understanding
typhoons Climate
Motions of
the Earth;
The solar
system
Seasons &
eclipses
Other
members of
the Solar
System
Constellations
5. Geology Overview
Grade 3 Grade 4 Grade 5 Grade 6
Describe what makes up the
environment in the
community.
Different landforms
Bodies of water
Focus on two components of the
environment: soil & water.
Classify soils using simple criteria.
Identify the different sources of water
in the community.
Infer importance of water in daily
activities.
Describe ways of using water wisely.
The environment does not stay
the same forever. The surface of
the Earth changes with the
passage of time.
Rocks undergo weathering,
forming soil.
Soil is carried away by erosion.
Other processes that change the
surface of the Earth:
earthquakes & volcanic
eruptions.
Note: only the effects of
earthquakes and volcanic
eruptions are taken up in this
grade level, not the causes
(which will be tackled in Grades 8
and 9).
Grade 7 Grade 8 Grade 9 Grade 10
Focus on the environment of
the Philippines as a whole.
The country’s location near
the equator and along the
Ring of Fire influences what
makes up the Philippine
environment (e.g., climate,
natural resources).
Locate places using a
coordinate system.
Because it is located along the Ring of
Fire, the Philippines is prone to
earthquakes.
Using models, explain how quakes are
generated by faults.
Using PHIVOLCS maps, find out if there
are active faults in the community.
Because it is located along the
Ring of Fire, the Philippines is
home to many volcanoes.
Using models, explain what
happens when volcanoes erupt.
Describe the different types of
volcanoes.
Differentiate active volcanoes
from inactive ones.
Explain how energy from
volcanoes may be tapped for
human use.
Focus on plate tectonics, a
theory that explains many
geologic processes, such as
volcanism, earthquakes, and
mountain building.
Discover that volcanoes,
earthquake epicenters, and
mountain ranges are not
randomly scattered in different
places but are located in the
same areas.
6. Overview
DEPARTMENT OF EDUCATION
Unlike in previous grade levels, there
is only one strand in the Earth and Space
unit of Grade 10: GEOLOGY.
Module 1: PLATE TECTONICS
Module 2: EARTH’S INTERIOR
8. Module 1: Plate Tectonics
DEPARTMENT OF EDUCATION
• Describe the distribution of active
volcanoes, earthquake epicenters,
and major mountain belts.
• Describe the different types of plate
boundaries.
• Explain the different processes that
occur along plate boundaries.
9. Activities in Module 1
DEPARTMENT OF EDUCATION
Activity 1 Find the Center
Activity 2 Let’s Mark the Boundaries
Activity 3 Head-on Collision
Activity 4 Going Separate ways
Activity 5 Slide and Shake
Activity 6 Drop it Like its “Hot Spot”
14. DEPARTMENT OF EDUCATION
2 Types of Plates
• Ocean plates - plates below the
oceans which are relatively
thinner but denser than
continental crust.
• Continental plates - plates below
the continents which are thicker
but less dense.
15. DEPARTMENT OF EDUCATION
The crust is made of a variety of
solid rocks like sedimentary,
metamorphic, and igneous. It has
an average density of 2.8 g/cm3
and its thickness ranges from 5 to
50 km.
16. DEPARTMENT OF EDUCATION
The crust is thickest in a part where
a relatively young mountain is
present and thinnest along the
ocean floor.
17. DEPARTMENT OF EDUCATION
According to the plate tectonics
model, the entire lithosphere of
the Earth is broken into
numerous segments called
plates.
20. Activity 1: Find the Center
DEPARTMENT OF EDUCATION
Objective:
Locate the epicenter of an
earthquake using the triangulation
method.
21. Activity 1: Find the Center
DEPARTMENT OF EDUCATION
Materials:
• hypothetical records of earthquake
waves
• Philippine map
• drawing compass and ruler
• Scissors
• Pentel pens ( black, blue, red)
22. Activity 1: Find the Center
DEPARTMENT OF EDUCATION
Procedure:
1. Study the data showing the
difference in the arrival time of P-
wave and S-wave on three seismic
recording stations.
25. Activity 1: Find the Center
DEPARTMENT OF EDUCATION
3. Choose one of the recording
stations and measure the computed
distance on the map scale (the scale
of the map in Figure 3 is 1.5 cm:
200 km). Set your compass for that
computed distance.
26. Activity 1: Find the Center
DEPARTMENT OF EDUCATION
4. Center your compass on the
station you have chosen. Draw a
circle.
5. Repeat steps 3 and 4 for the rest
of the stations. You should get three
circles that intersect or nearly
intersect at a point. This intersection
is the epicenter.
27. Activity 1: Find the Center
DEPARTMENT OF EDUCATION
In the previous activity, the
hypothetical earthquake happened
locally, that is why we use the
formula stated in the procedure. But,
if the earthquake took place at a far
greater distance, seismologists use
the distance-time graph similar to the
figure below in determining the
location of the epicenter.
29. Activity 1: Find the Center
DEPARTMENT OF EDUCATION
The distance-time graph above
shows that the S-P interval is about
10 minutes.
Q3. What is the distance of the
epicenter from the seismic station?
Q4. What do you think is the
importance of determining the
epicenter of an earthquake?
30. Activity 1: Find the Center
DEPARTMENT OF EDUCATION
Determining the location of
earthquake epicenters plays a vital
role in laying the foundations of
plate tectonics. Let us see how
early geologists used the plotted
positions of earthquake epicenters
throughout the world in
conceptualizing crustal
movements.
31.
32. Activity 2: Let’s Mark the Boundaries
DEPARTMENT OF EDUCATION
Materials
Figure 5 Map of Earthquake distribution
Figure 6 Map of Active Volcanoes of the
world.
Figure 7 Mountain ranges of the world
transparent plastic sheet used for book
cover, same size as a book page (2
sheets)
marking pens (two different colors).
33. Activity 2: Let’s Mark the Boundaries
DEPARTMENT OF EDUCATION
1. Trace the locations of the earthquake
epicenters on a plastic sheet using a
marking pen.
2. On another plastic sheet, trace the
locations of volcanoes using the other
marking pen.
3. Place the earthquake plastic sheet on top
of the volcano plastic sheet.
4. Place the two plastic sheets on top of the
map of mountain ranges.
34. Activity 2: Let’s Mark the Boundaries
DEPARTMENT OF EDUCATION
5. Study the map of plate boundaries.
What do you think is the basis of
scientists in dividing the Earth’s
lithosphere into several plates?
44. Activity 3: Convection Currents
DEPARTMENT OF EDUCATION
Materials
300 mL cooking oil
powdered colored chalk
paper funnel
500 mL beaker
stirring rod
alcohol lamp
tripod
match
Procedure
45. Activity 3: Convection Currents
DEPARTMENT OF EDUCATION
1. Describe step-by-step what happens.
2. Use illustrations to record what
happened.
3. Give an explanation for your
observations.
62. Module 2: Earth’s Interior
DEPARTMENT OF EDUCATION
• Describe the internal structure of
the Earth.
• Describe the possible causes of plate
movement.
• Enumerate the lines of evidence that
support plate movement.
63. Activities in Module 2
DEPARTMENT OF EDUCATION
Activity 1 Amazing Waves!
Activity 2 Our Dynamic Earth
Activity 3 Let’s Fit It!
Activity 4 Drifted Supercontinent!
Activity 5 Split and Separate!
Activity 6 How fast does it go!
Activity 7 Push me up and aside!