Green coffee bean extract is derived from unroasted coffee beans and is a source of antioxidants like chlorogenic acid. The document discusses the composition of green coffee beans, how extracts are produced, and functional properties of certain compounds. Key compounds - chlorogenic acid, caffeine, and trigonelline - are associated with benefits like weight loss, blood pressure regulation, and improved blood sugar and lipid levels. Research studies are summarized that investigate green coffee bean extract for weight loss, diabetes management, and reducing oxidative stress.

1. Functional properties
of green coffee bean
extract
By
Shweta Priyadarshini

2. What are green coffee bean extract
 As the name implies it is extracted from unroasted green coffee
beans.
 Coffee beans are actually green seeds inside a bright red berry. Roasting them
turns the seeds brown and creates the characteristic aroma and flavor.
 To prepare green coffee bean extract, the seeds are left unroasted. Instead they’re
soaked and then concentrated to create the extract.
 It was first introduced as a weigh loss supplement to the world by Dr. Oz in his
show “Dr. Oz show” back in 2012.

3.  Coffee plants are classified into two types-
Robusta and Arabica
 The green coffee bean extract is made from coffea
Arabica plant’s green beans.
 The Arabica is actually has the best quality.
Also, high in caffeic acids and cholorogenic acid.
These two essential compounds are responsible for
anti-oxidant properties of green coffee beans .

4. Green coffee bean processing in producing industry, Clarke 1976

5. The composition of green and roasted Arabica beans , in % dry
weight
constituent Green Roasted
Caffeine 1.2 1.3
Polysaccharides 49.8 38.0
Amino acids 0.5 0
Proteins 9.8 7.5
Saccharose 8.0 0
Other sugars 1.1 0.3
Trigonelline 1.0 1.0
Quinic acids 0.4 0.8
Lipids 16.2 17.0
Chlorogenic acids 6.5 2.5
Volatile aromatic substances traces 0.1
Caramalized products ……. 25.4
Minerals 4.2 4.5

6. Caffeine
1,3,7-trimethylxanthine
Purine alkaloid that occurs naturally in coffee beans.
evolved in plants as a defense mechanism (it’s toxic to fungi
and insects)
Rapidly and almost completely absorbed within an hour.
enhanced after roasting

7. Trigonelline
N-methyl nicotinic acid
 nitrogenous compound
 pyridine alkaloid that is derived from the methylation of
the nitrogen atom of nicotinic acid.
gives coffee its aroma and bitter taste

8.  It is a Phytochemical.
 Ester of caffeic acid and quinic acid.
 Coffee-derived Chlorogenic acid is a family of conjugated
hydroxycinnamates
 Most abundant phenolic acid in the flesh of eggplant fruits and is
also found in prunes.
 Richest source is green coffee bean extract.
 Most of the chlorogenic acid is removed when coffee is roasted
Chlorogenic acid

10. ward off Alzheimer’s
Reduces risk of type2 diabetes
increases memory
detoxes the liver and cleanses the colon
reduce fatty liver
relieves post work-out muscle pain
ease depression
increases stamina during exercise
Cataracts
Caffeine

11. TRIGONELLINE
 Prevents cavities
 Decreases blood glucose level and lipid levels
 Increase insulin sensitivity index and insulin
content
 Upregulate antioxidant enzymes activity thus
decrease lipid peroxidation

12. Chlorogenic Acid
 It slows down the release of glucose in the body, while
boosting the body’s metabolism at the same time.
 When these two things happen together, they stop the
body from absorbing fat while transforming fatty deposits
into usable energy for the body.
 When this usable energy is burned off, it causes weight
loss.

13. Metabolic pathway of chlorogenic acid

14. Effect on glucose metabolism
Hypoglycemic and Antidiabetic Effect
Stimulation of Insulin Secretion
Improving Glucose Tolerance and
Insulin Resistance.

15. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers
and its effect on body mass when used long-term in overweight and obese people.
E Thom (2007) The Journal of International Medical Research, 35: 900 – 908
Study 1
The study was designed as a three-way double-
blind randomized crossover study with each
subject serving as his or her own control.
Study 2
12-week randomized double-blind study of
thirty overweight subjects.
weight loss in the decaffeinated instant coffee
and normal instant coffee group was 5.4 and
1.7 kg respectively.
6.9% reduction in glucose uptake compared to the
control
To investigate the effects of a single drink
of the different coffee products on the
absorption of glucose
To study effects of the CGA-enriched
decaffeinated instant coffee, when compared to
normal instant coffee for longer time

16. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid
and trigonelline on glucose tolerance.
van DijkAE, Olthof MR, Meeuse JC, Seebus E, Heine RJ and Dam RM. (2009) Diabetes Care. 32(6): 1023-25
This study attempted to shed light on the effects of chlorogenic acid as present
in decaffeinated coffee and when administered alone as a dietary supplement..
This 15-subject, randomized, crossover trial studied the effects of: 12g
decaffeinated coffee (equivalent to 264mg chlorogenic acid), 1g chlorogenic
acid, 500mg trigonelline, and 1g mannitol (as placebo)
Both chlorogenic acid and trigonelline elicited significantly lower insulin and
blood glucose concentrations 15 minutes after the OGTT when compared to the
placebo, with chlorogenic acid resulting in the lowest blood glucose levels. But
decaffeinated coffee did not show any significant effect.

17. Effect on lipid metabolism
Decreases serum and hepatic triglyceride level
Reduces LDL oxidation susceptibility and decreases LDL-
Cholesterol and MDA Levels.
Alters enzymes involved in lipid metabolism
Inhibits lipids’ absorption and transformation, inhibits
cholesterol’s intestinal absorption and hepatic
biosynthesis.
Improvement of antioxidant activity

18. Lipolytic Activity of Svetol®, a Decaffeinated Green Coffee Bean Extract
Flanagan J, Bily A, Rolland Y and Roller M (2013) Phytotherapy research Phytother. Res.
 To study the effects of varying concentrations of Svetol®, a decaffeinated green
coffee bean extract enriched in chlorogenic acids, on the liberation of free fatty
acids from human adipocytes following short-term (2 h) and long-term (192 h)
exposure.
 Normal human adipocytes were freshly isolated from surgical samples of healthy
abdominal skin (34-year-old woman) and was used for acute evaluation and chronic
evaluation of lipolytic activity of chlorogenic acid using caffeine as control
 The results showed that although lipolytic activity observed following short-term
incubation could be tentatively linked to residual caffeine traces in the sample,
longer term exposure clearly showed the effects of Svetol® on release of free fatty
acids, and this effect was not due to caffeine
Objective
Method
Result

19. Possible mechanism of action of regulation carbohydrate
and lipid metabolism

20. Effect on hypertension
Inhibition of NAD(P)H oxidase expression and activity
Directly scavenging free radicals
Stimulation of NO production by the endothelial-dependent
pathway
Inhibition of angiotensin-converting enzyme in the plasma, and
possibly in the organs and tissues

21. Antihypertensive effect of green coffee bean extract on mildly hypertensive
subjects.
Kozuma K, Tsuchiya S, Kohori J, Hase T and Tokimitsu I (2005) Hypertension Research 28(9):711-18.
• To examined the effect of
green coffee bean extract on
117 male volunteers with
blood pressure health goals.
Objective
• Four randomized groups
received either: a placebo or
GCE in doses of 46mg,
93mg, or 185mg per day.
Systolic and diastolic blood
pressures were measured at
study start after 28 days of
GCE administration.
Method • Significant reductions in
systolic and diastolic blood
pressure were seen in the
93mg and 185mg dosage
groups when compared to
the placebo. No adverse
effects were reported
Result

22. Green coffee as a weight loss ingredient
 Chlorogenic and caffeic acids are responsible weight loss
 The caffeic acid is responsible for removal of fatty acids
stored in the body while chlorogenic acids responsibility is
to assist the liver to process the fatty acids in an efficient
manner thereby causing weight loss.

23. The Effect of Green Coffee Bean Extract in Decreasing Oxidative Stress in Overweight and Obese
Patients
Ittichai Wichaporn1 Jarasphol Rintra
 To study the effects of consuming the green coffee bean extract supplement
and whether it could reduce the oxidative stress and body mass index in
overweight and obese patients.
 A prospective, randomized, double blind, experimental clinical trial in forty
male and female subjects, aged between 25 and 45, each with a body mass
index value of at least 23.00 kg/m2 was carried out for a period of 8 weeks.
They were randomly separated into two groups of twenty, to consume either
the green coffee bean extract supplement or a placebo medication. Doses-
400mg/day
 The green coffee bean extract was effective in reducing oxidative stress in
overweight and obese patients, with a statistical significance in comparison to
the placebo medication but no significant reduction in BMI was observed.
Objective
Result
Method

24. Randomized, double-blind, placebo-controlled, linear dose, crossover study to
evaluate the efficacy and safety of a green coffee bean extract in overweight
subjects
Vinson JA, Burnham BR, and Nagendran MV (2012) Diabetes Metab Syndr Obes. 5: 21–27
Result
Methodology
Objective
To examine the
efficacy and safety
of a commercial
green coffee extract
product GCA™ at
reducing weight
and body mass in
16 overweight
adults.
Subjects
received high-
dose GCA (1050
mg), low-dose
GCA (700 mg),
or placebo in
separate six-
week treatment
periods followed
by two-week
washout periods
to reduce any
influence of
preceding
treatment.
Significant
reductions were
observed in body
weight, BMI, and
percent body fat
as well as a small
decrease in heart
rate), but with no
significant
changes to diet
over the course of
the study.

25. Anti-ageing
 The chlorogenic acid has anti-oxidant effects.
 Green coffee has a double rate of absorbing oxygen
radicals as compared to green tea and grape seed
extract.

26. METABOLISM BOOSTER
 Green coffee contains caffeic acids which are responsible
for boosting energy and stimulating the body cells.
 Green coffee extract has been proven to increase the body
metabolism rate

27. Help for Migraines and Muscles
 It increases the effectiveness of pain medication,
including medications for migraines.
 It helps the body burn off a higher rate of fats
compared to carbohydrates that may assist with sore
muscles especially athletes or bodybuilders.

28. Does coffee enriched with chlorogenic acids improve mood and cognition after
acute administration in healthy elderly? A pilot study.
Cropley V, Croft R, Silber B, Neale C, ScholeyA, Stough C, Schmitt J. (2012) Psychopharmacology 219(3):737-49.
Objective
• This pilot study examined the effects of regular caffeinated
coffee, plain decaffeinated coffee, decaffeinated coffee enriched
with additional CGA, and a placebo
Method
• Thirty-nine healthy, mature adults participated in this randomized,
double-blind, placebo-controlled, crossover study. Mood and cognitive
processes were measured by behavioral tasks and event-related
potentials. Performance measurements were taken at baseline and after
the equivalent of three cups of coffee.
Result
• Caffeinated coffee showed the most significant effects on
higher-level mood and attention measurements. However,
the CGA-enriched decaffeinated coffee demonstrated
some improvement in mood and behavioral measures,
when compared to the plain decaffeinated coffee and
placebo.

29. REEN COFFEE

30. Experimental Study of Efficacy of Reducing Lipid in Hyperlipidemia
Persons Comparing between Green Coffee Bean Extract and Green
Tea Extract
Touchatun Ridvichai Wichit Boonyahotra
Objective
• A 6-week randomized control trail was conducted to
examine the efficacy of green coffee bean extract comparing
with green tea extract on 40 hyperlipedemic patients
Methodology
• Subjects received green coffee bean extract 400mg per day ,
or green tea 400mg per day in six-week treatment periods.
Primary measurements were body weight, height, and body
mass index. TG , LDL-c , and HDL-c were also measured.
Result
• Significant decrease in LDL cholesterol and significant
increase in HDL cholesterol with no significant difference
between the effect of green coffee bean extract and green
tea.

32. Insomnia
Green
coffee
bean
extract
Restlessness
Increased
heart rate
and
breathing
Nausea and
vomiting
Headache
Anxiety
Agitation
Irregular
heartbeat

33. STAR BUCKS
NEW
ENERGY
DRINKS

34. FEW PRODUCTS IN MARKET

35. Future research direction and prospects
 Present studies suggest that Chlorgenic acid in green coffee bean , which in vivo
can regulate glucose and lipid metabolism and improves insulin sensitivity, may
be capable of preventing and treating obesity, diabetes mellitus, and metabolic
syndrome.
 However, this needs to be verified through the intervention studies of large-scale
populations.
 Dose-response relationship and mechanisms of action of green coffee bean
extract’s beneficial effects require further research and testification.

36.  The mechanism on glucose and lipid metabolism has not yet been conclusively
elucidated.
 The side effects of chlorogenic acid have not yet been investigated comprehensively
 Future research is required to elucidate both the short- and long-term effects of
Chlorogenic acid on glucose and lipid metabolism.
.