A randomized, double-blind, placebo-controlled, linear dose, crossover study evaluated the efficacy and safety of a green coffee bean extract for weight loss in overweight subjects. The study involved 16 overweight adults who were given varying doses of a green coffee extract or placebo over 22 weeks in a crossover design. The background notes that adult weight gain and obesity are global problems, and overweight individuals often try nutraceuticals for weight loss rather than prescription drugs due to costs and side effects. Green coffee extract contains chlorogenic acids that can influence metabolism and may aid weight loss.

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Retraction NoticeDiabetes Metab Syndr Obes.Randomized, double-blind, placebo-controlled,
linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in
overweight subjects [Retraction]. Metab Syndr Obes. 2014]
Abstract
BACKGROUND:
Adult weight gain and obesity have become worldwide problems. Issues of cost and potential
side effects of prescription weight loss drugs have led overweight and obese adults to try
nutraceuticals that may aid weight loss. One promising nutraceutical is green coffee extract,
which contains high concentrations of chlorogenic acids that are known to have health benefits
and to influence glucose and fat metabolism. A 22-week crossover study was conducted to
examine the efficacy and safety of a commercial green coffee extract product GCA™ at reducing
weight and body mass in 16 overweight adults.