This document discusses the challenges of percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) of the right coronary artery (RCA) ostium. It notes that RCA ostial CTO PCIs have higher anatomical complexity, longer procedure times, higher radiation exposure, and lower success rates compared to non-ostial CTO PCIs. Retrograde wiring is often needed due to unclear anatomy, and reverse controlled antegrade and retrograde tracking (CART), snaring, or wire trapping techniques may be required when microcatheters cannot cross collaterals antegrade. Rotablation can help with severe calcification. The conclusions emphasize that additional imaging is generally needed due to unclear anatomy,