Antegrade Approach
Step by Step
Gerald S. Werner, MD, FESC, FACC, FSCAI
Medizinische Klinik I
Klinikum Darmstadt GmbH
Darmstadt, Germany
Conflict of interest
• I, Gerald S. Werner, MD, have no conflict of
interest to declare with regard to the following
presentation
The goal of CTO-PCI
• Ideally: Restore the original anatomy of an
occluded artery
• Open an occluded artery
– with the least damage to the coronary anatomy
– with the least investment of time and material,
reducing procedural risks
• There is no retrograde vs antegrade approach,
there is only the choice of the best strategy for
the specific lesion and patient
Strategic options for CTOs in Europe
Bilateral
Maximal Guide
backup
Antegrade
Fielder XT -> Ultimate
or -> Progress
200T/Conf.Pro 9
Penetration, then
step down
Distal good target
Parallel with stiff
wire
Reentrysystem
BridgePoint
Antegrade
no Stump
IVUS for guided
Penetration ?
Retrograde
With feasible collateral
pathways
Ostial CTO
Long CTO
Re-Attempt
Ideal access
Strategic options for CTOs in Europe
The antegrade spectrum of technical options
Bilateral
Maximal Guide
backup
Antegrade
Fielder XT -> Ultimate
or -> Progress
200T/Conf.Pro 9
Penetration, then
step down
Distal good target
Parallel with stiff
wire
Reentrysystem
BridgePoint
Antegrade
no Stump
IVUS for guided
Penetration ?
Retrograde
With feasible collateral
pathways
J-CTO Score Sheet: Predicting complexity
Morino Y et al. JACC Interv, 2011; 4: 213
Examples not likely to work antegrade
Likely targets for the antegrade approach
Antegrade: Step by Step
• Lesion specific analysis
– Identify the proximal cap
– How long is the lesion
– What is the presumed course of the occluded
segment
– Identify the distal target
• Patient specific considerations
– Previous attempts (which wires, why failed)
– Renal function (limits on contrast use)
Basic Setup
• Two catheters (radial and/or femoral route)
• Guide backup: 7F provides all options, in ostial
locations and with IVUS guidance 8F preferred
• Microcatheter selection:
– Finecross: sleek profile, passes deep into lesions
– Corsair: provides additional support for the guide
– Caravelle: sleek profile with tapered tip
– Others to mention: Nhancer, Vascular Solutions
UB3UB3
Hard plaque
Severe calcification
Stiffer tip
XT-(A)XT-(A)
ASAHI Gaia FirstASAHI Gaia First
ASAHI Gaia SecondASAHI Gaia Second
ASAHI Gaia ThirdASAHI Gaia Third
Miracle12Miracle12
Confianza Pro 12
Hornet 14;
Progress 200T
Confianza Pro 12
Hornet 14;
Progress 200T
XT-RXT-R
2016: Which wire to use when?
The wire selection
• Explore the lesion
– Fielder XT, atraumatic, provides feedback on lesion
rigidity, tracks loose tissue and may even penetrate
noncalcified caps; “you follow the wire”
• Pass the lesion
– Gaia 1-3 to penetrate the cap and steer through the
occluded segment; “the wire follows you”
• Conquer the calcified lesions
– Confianza Pro 12 for penetration
– Others: Hornet 14, Progress 200T
– Pilot 200 to find the soft spots within severe calcium
Advance with in the vessel: work horse
Penetrate the cap
Wire tip shape: adapt to the purpose
Remember always: tip shape is lost rapidly
So reshape, whenever you get stuck
Remember always: tip shape is lost rapidly
So reshape, whenever you get stuck
Pass within the occlusion
Pass a collateral
Which wire to start with ?
Examples from the Live Cases
Case #4
Tapered lesion
My approach:
Fielder XT(-A) on microcatheter
If stuck -> Gaia 1
If distal target missed ->
Proceed to parallel wire
Gaia 1st controlled wire passage
Gaia 1st controlled wire passage
Which wire to start with ?
Examples from the Live Cases
Case #8
Faint notch at side branch
My approach:
Fielder XT(-A) to deliver the
microcatheter to the proximal
cap, exploring, but penetration
unlikely
Gaia 2 as starter
If distal target missed ->
Proceed to parallel wire
The parrallel wire
technique is classic
Crossit
200-400 or
Conquest
3g-6g
N.Reifart/O.Katoh 1996
Why parallel wiring works well in the RCA:
the wire straightens the vessel architecture
Why parallel wiring works well in the RCA:
the wire straightens the vessel architecture
When and why parallel wire works
• If the 1st wire is close to the target, the 1st wire
straightens the vessel course, and allows
passage of the 2nd (stiffer) wire
• If the 1st wire is far from the target, the 2nd
wire needs to find a new course, especially in
bent segments
• Often the entry point into the proximal cap
needs to be changed
• Parallel wire is not a reentry technique
When and why parallel wire may fail
• The distal target is diffusely diseased and
narrow
• The distal target is severely calcified and
prevents entry even with a stiff wire tip
• Failure of the operator to check orthogonal
views frequently: biplane systems are helpful
Which wire to start with ?
Examples from the Live Cases
Case #5
Blunt occlusion at side branch
Possible approach:
Pass wire in side branch, dilate
proximal and advance IVUS
IVUS guided penetration with
Gaia 2
Bailout: retrograde
RCA CTO: Strategic options
Torino. 16.4.15
Retrograde approach in mind as
most likely strategy
Chair of session: “antegrade
approach nonsense”
Agreed, but still we need an
antegrade wire for a successful
retrograde approach
The further the antegrade wire
reaches, the shorter the
retrograde wire needs to
travel….
RCA CTO: Strategic options
Torino. 16.4.15
Puncture of the cap with Gaia 2
Torino. 16.4.15
Then via Finecross wire downgraded to Sion Black
Torino. 16.4.15
Complex long RCA CTO
Torino. 16.4.15
20 years Post CABG: Ostial RCA CTO
Additional information from MSCT
Retrograde options are challenging
Moderate calcification -> medium-strength wire
If parallel wiring fails: StingRay reentry device
H.B. 30.1.15
Parallel fails, then StingRay
H.B. 30.1.15
Strategic options for CTOs in Europe
Bilateral
Maximal Guide
backup
Antegrade
Fielder XT -> Ultimate
or -> Progress
200T/Conf.Pro 9
Penetration, then
step down
Distal good target
Parallel with stiff
wire
Reentrysystem
BridgePoint
Antegrade
no Stump
IVUS for guided
Penetration ?
Retrograde
With feasible collateral
pathways
Ostial CTO
Long CTO
Re-Attempt
Ideal access
Parallel fails, then StingRay
H.B. 30.1.15
Parallel fails, then StingRay
H.B. 30.1.15
StingRay wire passed before the stent
H.B. 30.1.15
Antegrade: Step by Step
• Lesion specific approach
– Start with the softest possible wire
– Step up if necessary
– Use parallel wire as an early and easy bailout
– If retrograde is difficult, early decision for guided
reentry technique (StingRay)
• Patient specific approach
– Select the most likely strategy to solve the lesion
– Do not attempt complex lesions without the
option for retrograde conversion
Antegrade: Step by Step
• Lesion specific approach
– Start with the softest possible wire
– Step up if necessary
– Use parallel wire as an early and easy bailout
– If retrograde is difficult, early decision for guided
reentry technique (StingRay)
• Patient specific approach
– Select the most likely strategy to solve the lesion
– Do not attempt complex lesions without the
option for retrograde conversion

Gerald Werner - AntegradeApproach Step by Step

  • 1.
    Antegrade Approach Step byStep Gerald S. Werner, MD, FESC, FACC, FSCAI Medizinische Klinik I Klinikum Darmstadt GmbH Darmstadt, Germany
  • 2.
    Conflict of interest •I, Gerald S. Werner, MD, have no conflict of interest to declare with regard to the following presentation
  • 3.
    The goal ofCTO-PCI • Ideally: Restore the original anatomy of an occluded artery • Open an occluded artery – with the least damage to the coronary anatomy – with the least investment of time and material, reducing procedural risks • There is no retrograde vs antegrade approach, there is only the choice of the best strategy for the specific lesion and patient
  • 4.
    Strategic options forCTOs in Europe Bilateral Maximal Guide backup Antegrade Fielder XT -> Ultimate or -> Progress 200T/Conf.Pro 9 Penetration, then step down Distal good target Parallel with stiff wire Reentrysystem BridgePoint Antegrade no Stump IVUS for guided Penetration ? Retrograde With feasible collateral pathways Ostial CTO Long CTO Re-Attempt Ideal access
  • 5.
    Strategic options forCTOs in Europe The antegrade spectrum of technical options Bilateral Maximal Guide backup Antegrade Fielder XT -> Ultimate or -> Progress 200T/Conf.Pro 9 Penetration, then step down Distal good target Parallel with stiff wire Reentrysystem BridgePoint Antegrade no Stump IVUS for guided Penetration ? Retrograde With feasible collateral pathways
  • 6.
    J-CTO Score Sheet:Predicting complexity Morino Y et al. JACC Interv, 2011; 4: 213
  • 7.
    Examples not likelyto work antegrade
  • 8.
    Likely targets forthe antegrade approach
  • 9.
    Antegrade: Step byStep • Lesion specific analysis – Identify the proximal cap – How long is the lesion – What is the presumed course of the occluded segment – Identify the distal target • Patient specific considerations – Previous attempts (which wires, why failed) – Renal function (limits on contrast use)
  • 10.
    Basic Setup • Twocatheters (radial and/or femoral route) • Guide backup: 7F provides all options, in ostial locations and with IVUS guidance 8F preferred • Microcatheter selection: – Finecross: sleek profile, passes deep into lesions – Corsair: provides additional support for the guide – Caravelle: sleek profile with tapered tip – Others to mention: Nhancer, Vascular Solutions
  • 11.
    UB3UB3 Hard plaque Severe calcification Stiffertip XT-(A)XT-(A) ASAHI Gaia FirstASAHI Gaia First ASAHI Gaia SecondASAHI Gaia Second ASAHI Gaia ThirdASAHI Gaia Third Miracle12Miracle12 Confianza Pro 12 Hornet 14; Progress 200T Confianza Pro 12 Hornet 14; Progress 200T XT-RXT-R 2016: Which wire to use when?
  • 12.
    The wire selection •Explore the lesion – Fielder XT, atraumatic, provides feedback on lesion rigidity, tracks loose tissue and may even penetrate noncalcified caps; “you follow the wire” • Pass the lesion – Gaia 1-3 to penetrate the cap and steer through the occluded segment; “the wire follows you” • Conquer the calcified lesions – Confianza Pro 12 for penetration – Others: Hornet 14, Progress 200T – Pilot 200 to find the soft spots within severe calcium
  • 13.
    Advance with inthe vessel: work horse Penetrate the cap Wire tip shape: adapt to the purpose Remember always: tip shape is lost rapidly So reshape, whenever you get stuck Remember always: tip shape is lost rapidly So reshape, whenever you get stuck Pass within the occlusion Pass a collateral
  • 14.
    Which wire tostart with ? Examples from the Live Cases Case #4 Tapered lesion My approach: Fielder XT(-A) on microcatheter If stuck -> Gaia 1 If distal target missed -> Proceed to parallel wire
  • 15.
    Gaia 1st controlledwire passage
  • 16.
    Gaia 1st controlledwire passage
  • 17.
    Which wire tostart with ? Examples from the Live Cases Case #8 Faint notch at side branch My approach: Fielder XT(-A) to deliver the microcatheter to the proximal cap, exploring, but penetration unlikely Gaia 2 as starter If distal target missed -> Proceed to parallel wire
  • 18.
    The parrallel wire techniqueis classic Crossit 200-400 or Conquest 3g-6g N.Reifart/O.Katoh 1996
  • 19.
    Why parallel wiringworks well in the RCA: the wire straightens the vessel architecture
  • 20.
    Why parallel wiringworks well in the RCA: the wire straightens the vessel architecture
  • 21.
    When and whyparallel wire works • If the 1st wire is close to the target, the 1st wire straightens the vessel course, and allows passage of the 2nd (stiffer) wire • If the 1st wire is far from the target, the 2nd wire needs to find a new course, especially in bent segments • Often the entry point into the proximal cap needs to be changed • Parallel wire is not a reentry technique
  • 22.
    When and whyparallel wire may fail • The distal target is diffusely diseased and narrow • The distal target is severely calcified and prevents entry even with a stiff wire tip • Failure of the operator to check orthogonal views frequently: biplane systems are helpful
  • 23.
    Which wire tostart with ? Examples from the Live Cases Case #5 Blunt occlusion at side branch Possible approach: Pass wire in side branch, dilate proximal and advance IVUS IVUS guided penetration with Gaia 2 Bailout: retrograde
  • 24.
    RCA CTO: Strategicoptions Torino. 16.4.15 Retrograde approach in mind as most likely strategy Chair of session: “antegrade approach nonsense” Agreed, but still we need an antegrade wire for a successful retrograde approach The further the antegrade wire reaches, the shorter the retrograde wire needs to travel….
  • 25.
    RCA CTO: Strategicoptions Torino. 16.4.15
  • 26.
    Puncture of thecap with Gaia 2 Torino. 16.4.15
  • 27.
    Then via Finecrosswire downgraded to Sion Black Torino. 16.4.15
  • 28.
    Complex long RCACTO Torino. 16.4.15
  • 29.
    20 years PostCABG: Ostial RCA CTO Additional information from MSCT Retrograde options are challenging
  • 30.
    Moderate calcification ->medium-strength wire
  • 31.
    If parallel wiringfails: StingRay reentry device H.B. 30.1.15
  • 32.
    Parallel fails, thenStingRay H.B. 30.1.15
  • 33.
    Strategic options forCTOs in Europe Bilateral Maximal Guide backup Antegrade Fielder XT -> Ultimate or -> Progress 200T/Conf.Pro 9 Penetration, then step down Distal good target Parallel with stiff wire Reentrysystem BridgePoint Antegrade no Stump IVUS for guided Penetration ? Retrograde With feasible collateral pathways Ostial CTO Long CTO Re-Attempt Ideal access
  • 34.
    Parallel fails, thenStingRay H.B. 30.1.15
  • 35.
    Parallel fails, thenStingRay H.B. 30.1.15
  • 36.
    StingRay wire passedbefore the stent H.B. 30.1.15
  • 37.
    Antegrade: Step byStep • Lesion specific approach – Start with the softest possible wire – Step up if necessary – Use parallel wire as an early and easy bailout – If retrograde is difficult, early decision for guided reentry technique (StingRay) • Patient specific approach – Select the most likely strategy to solve the lesion – Do not attempt complex lesions without the option for retrograde conversion
  • 38.
    Antegrade: Step byStep • Lesion specific approach – Start with the softest possible wire – Step up if necessary – Use parallel wire as an early and easy bailout – If retrograde is difficult, early decision for guided reentry technique (StingRay) • Patient specific approach – Select the most likely strategy to solve the lesion – Do not attempt complex lesions without the option for retrograde conversion