SlideShare a Scribd company logo
1 of 21
FORMULATION FACTOR EFFECTING
DRUG ABSORBTION
Presented by
PRIYANKA GRESESS ANAND
M.Pharm
Department of Pharmaceutics
INTEGRAL UNIVERSITY
LUCKNOW U.P
CONTENTS
1)-Introduction
2)-Manufacturing variables
3)- Type of dosage form
4)-Pharmaceutical ingredients/excipients
5)-products life and storage condition
6)-Conclusion
7)-Reference
5/30/2018 2
Introduction
• To gain entry in to the blood circulation,a drug
must be solubilize to pass from the absorbtion
site through biological membranes.
• Permeability of drug through biological
membranes is closely related to the molecular
structure of the drug,physicochemical
characteristics,formulation factor ,and the
physical and biochemical properties of the cell
membrane.
5/30/2018 3
DRUG ABSORBTION
Definition
Drug absorbtion is a pharmacokinetic parameter that
refers to the way a drug is absorbed from a
pharmaceutical formulation in to the bloodstream.
In general,lipid soluble drugs composed of smaller
molecules are more likely to absorbed .
the rate and extent of absorbtion mostly depends on
routes of administration and the way a drug product is
designed and manufactured.
.
5/30/2018 4
Dosage forms like tablet, capsule, powder, solution,
suspension, emulsion may vary the absorption.
Drug products that contain the same drug (active
ingredient) may have different inactive ingredients so
absorbtion of these drug from different products may
flactuate.
Absorbtion play a key role in determining how fast a
drug produces a clinical effect.
5/30/2018 5
Formulation Factor which can slower the rate of
absorbtion of drug are mentioned below –
Formulation Factors:-
Manufacturing variables: -
a). Method of granulation
Wet granulation yields a tablet that dissolves
faster than those made by other granulating
methods. But wet granulation has demerit like
formation of crystal bridge or chemical
degradation.
5/30/2018 6
b)-compression force-Higher compression force
yields a tablet with greater hardness hence have a
long D.T. but on other hand higher compression
force cause crushing of drug particles into
smaller ones with effective surface area which
decreasesD.T..
5/30/2018 7
5/30/2018 8
Drug formulations are designed to provide an
attractive, stable, and convenient use of
products.
Decreasing order dissolution rate of different
dosage forms as :-
solutions>solid solutions>suspensions,
capsules>coated capsules>tablets, and
controlled release formulations.
5/30/2018 9
5/30/2018 10
Solutions
Solutions shows faster absorption as compared to
solid dosage forms.
solutions are frequently used as bioavailability
standards.
Factor effecting absorbtion of solution:-
Viscosity
Solubulizer
Stability
surfactants
5/30/2018 11
Suspensions
• A drug in a suspension is in solid form, but is
finely divided and has a large surface area.
• Drug particles can diffuse readily between the
stomach and small intestine so that absorption
is relatively insensitive to stomach emptying
rate.
• Liquid dosage forms, therefore, have
advantages besides simple dissolution rate.
However, they also have some disadvantages,
including greater bulk, difficulty in handling, and
perhaps reduced stability.
5/30/2018 12
Capsules and tablets
• These formulations differ from each other in
that material in capsules is less impacted than
in compressed tablets.
• Once a capsule dissolves, its contents generally
disperse quickly.
• Tablets generally disintegrate in stages, first into
granules and then into primary particles. As
particle size decreases, dissolution rate
increases due to of increased surface area..
Pharmaceutical
Ingredients/Excipients
 Excipients are added to ensure
1. Stability
2. Uniformity
3. Functionability
4. Bioavailability
5. Acceptability
5/30/2018 13
Diluents
 Diluents are commonly added to tablet and
capsule formulations if the required dose is
inadequate to produce bulk.
 Eg:-Drug-diluent interaction resulting in poor
bioavailability of tetracycline & DCP
5/30/2018 14
Binders and granulating agent
Promote cohesive compacts before & after compression
 Eg polymeric materials like starch, cellulose derivatives, acacia,
PVP, etc.
COLOURANTS
 Very low concentration of water-soluble dye has inhibitory effect on
dissolution.
 E.g. brilliant blue retards dissolution of sulfathiazole
5/30/2018 15
Lubricants
To aid flow of granules
 To reduce interparticle friction
 Sticking of particles to dies & punches
 Eg:- sodium and magnesium stearates &
waxes.
5/30/2018 16
DISINTEGRANTS
 These Agents overcome cohesive strength of tablet & break them on
contact with water which is an important for tablet to dissolve.
eg MCC
BUFFERS
 They create right atmosphere for dissolution
e.g. buffered aspirin tablets
 Buffer containing potassium cations inhibit the drug absorption
e.g. vitamin B2 & sulphanilamide
5/30/2018 17
SURFACTANTS
 They may enhance or retard drug absorption
1. Promotion of wetting & dissolution of drugs
2. Better membrane contact of drug for absorption
3. Enhanced membrane permeability of the drug
5/30/2018 18
Product age and storage conditions
• Product aging and improper storage
conditions adversely affect B.A.
E.g. –precipitation of drug in solution
decrease rate of drug dissolution
& absorption .
5/30/2018 19
CONCLUSION
• Absorption plays an major role to attain the desired
therapeutic action with minimal side effects at the given
period of time.
• Formulation factors influencing drug absorption helps us to
focus on formulating drug with proper attainment of
permeability of drugs to systemic circulation at given time
5/30/2018 20
REFERENCE
• 1. Brahmankar D.M., Jaiswal S.B., First edition,
“Absorption of Drugs” Biopharmaceutics and
Pharmacokinetics – A treatise, Vallabh Prakashan, Delhi
1995, Page No. 5-75.
• 2. Shargel L., Andrew B.C., Fourth edition “Physiologic
factors related to drug absorption” Applied
Biopharmaceutics and Pharmacokinetics, Prentice Hall
International, INC., Stanford 1999. Page No. 99-128.
• 3. Pharmaceutics , the Science of Dosage form Design By
M.E. Aulton
• 4. Swarbrick J., Boylan J.C., “Absorption” Encyclopedia
of Pharmaceutical Technology, Marcel Dekker, INC., New
York 1988:1-32.
5/30/2018 21

More Related Content

What's hot

EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMSEVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMSSANI SINGH
 
methods of determining drug absorption ppt
methods of determining drug absorption pptmethods of determining drug absorption ppt
methods of determining drug absorption ppttenzin jangchuk
 
Mucoadhesive Drug delivery system
Mucoadhesive Drug delivery systemMucoadhesive Drug delivery system
Mucoadhesive Drug delivery systemsahebrao Boraste
 
microparticles by amruta
microparticles by amrutamicroparticles by amruta
microparticles by amrutashaikhazaroddin
 
P h partition hypothesis
P h partition hypothesisP h partition hypothesis
P h partition hypothesisZahid1392
 
Formulation and evaluation of effervescent tablets.pptx
Formulation and evaluation of effervescent tablets.pptxFormulation and evaluation of effervescent tablets.pptx
Formulation and evaluation of effervescent tablets.pptxParimal Hadge
 
Evaluation of parenterals
Evaluation of parenteralsEvaluation of parenterals
Evaluation of parenteralsGeetaKhillari
 
Co processed excipient
Co processed excipientCo processed excipient
Co processed excipientRutuja Gund
 
Tablet compression student (2)
Tablet compression student (2)Tablet compression student (2)
Tablet compression student (2)mizan00
 
Physics of tablet compression (compression & compaction)
Physics of tablet compression (compression & compaction)Physics of tablet compression (compression & compaction)
Physics of tablet compression (compression & compaction)ROHIT
 
Preformulation stability study
Preformulation stability studyPreformulation stability study
Preformulation stability studyArabinda Changmai
 
ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION
ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION
ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION Ankit Malik
 
Physics of tablet compression
Physics of tablet compressionPhysics of tablet compression
Physics of tablet compressionMahadev Birajdar
 
Dissolution and drug release testing
Dissolution and drug release testingDissolution and drug release testing
Dissolution and drug release testingRoshan Bodhe
 
Parenteral controlled drug delivery system sushmitha
Parenteral controlled drug delivery system sushmithaParenteral controlled drug delivery system sushmitha
Parenteral controlled drug delivery system sushmithaDanish Kurien
 

What's hot (20)

EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMSEVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
 
methods of determining drug absorption ppt
methods of determining drug absorption pptmethods of determining drug absorption ppt
methods of determining drug absorption ppt
 
Orodispersible tablets
Orodispersible tabletsOrodispersible tablets
Orodispersible tablets
 
Dissolution
DissolutionDissolution
Dissolution
 
Mucoadhesive Drug delivery system
Mucoadhesive Drug delivery systemMucoadhesive Drug delivery system
Mucoadhesive Drug delivery system
 
microparticles by amruta
microparticles by amrutamicroparticles by amruta
microparticles by amruta
 
P h partition hypothesis
P h partition hypothesisP h partition hypothesis
P h partition hypothesis
 
Formulation and evaluation of effervescent tablets.pptx
Formulation and evaluation of effervescent tablets.pptxFormulation and evaluation of effervescent tablets.pptx
Formulation and evaluation of effervescent tablets.pptx
 
Evaluation of parenterals
Evaluation of parenteralsEvaluation of parenterals
Evaluation of parenterals
 
Co processed excipient
Co processed excipientCo processed excipient
Co processed excipient
 
Tablet compression student (2)
Tablet compression student (2)Tablet compression student (2)
Tablet compression student (2)
 
Physics of tablet compression (compression & compaction)
Physics of tablet compression (compression & compaction)Physics of tablet compression (compression & compaction)
Physics of tablet compression (compression & compaction)
 
Preformulation stability study
Preformulation stability studyPreformulation stability study
Preformulation stability study
 
Chronopharmacokinetics..
Chronopharmacokinetics..Chronopharmacokinetics..
Chronopharmacokinetics..
 
ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION
ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION
ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION
 
Ocular inserts
Ocular insertsOcular inserts
Ocular inserts
 
Physics of tablet compression
Physics of tablet compressionPhysics of tablet compression
Physics of tablet compression
 
Dissolution and drug release testing
Dissolution and drug release testingDissolution and drug release testing
Dissolution and drug release testing
 
Parenteral controlled drug delivery system sushmitha
Parenteral controlled drug delivery system sushmithaParenteral controlled drug delivery system sushmitha
Parenteral controlled drug delivery system sushmitha
 
In-Vivo In-Vitro Correlation
In-Vivo In-Vitro CorrelationIn-Vivo In-Vitro Correlation
In-Vivo In-Vitro Correlation
 

Similar to Formulation factor effecting drug absorbtion

Factors Affecting Drug Absorption {BRD}.pptx
Factors Affecting Drug Absorption {BRD}.pptxFactors Affecting Drug Absorption {BRD}.pptx
Factors Affecting Drug Absorption {BRD}.pptxGirijaSoori
 
Pelletizatoin
PelletizatoinPelletizatoin
Pelletizatoinaijazpsd
 
Formulation and processing factors
Formulation and processing factorsFormulation and processing factors
Formulation and processing factorsSayeda Salma S.A.
 
Presentation fACTOR AFFECTING DRUGSABSORPTION by deepak kumar
Presentation fACTOR AFFECTING DRUGSABSORPTION by deepak kumarPresentation fACTOR AFFECTING DRUGSABSORPTION by deepak kumar
Presentation fACTOR AFFECTING DRUGSABSORPTION by deepak kumarDrx Kumar
 
Role of Dosage Forms on absorption.
Role of Dosage Forms on absorption.Role of Dosage Forms on absorption.
Role of Dosage Forms on absorption.Arpitha Aarushi
 
formulation factors influencing drug absorption
formulation factors influencing drug absorptionformulation factors influencing drug absorption
formulation factors influencing drug absorptionsunil kumar paidipati
 
Biopharmaceutic considerations in drug product design
Biopharmaceutic considerations in drug product designBiopharmaceutic considerations in drug product design
Biopharmaceutic considerations in drug product designMOHAMMAD ASIM
 
formulation of Buccal Drug Delivery System.pptx
formulation of Buccal Drug Delivery System.pptxformulation of Buccal Drug Delivery System.pptx
formulation of Buccal Drug Delivery System.pptxPawanDhamala1
 
All about Tablets (Pharma)
All about Tablets  (Pharma)All about Tablets  (Pharma)
All about Tablets (Pharma)Sathish Vemula
 
tablets_part_1.pdf
tablets_part_1.pdftablets_part_1.pdf
tablets_part_1.pdfHebaYassin10
 
Buccal Drug Delivery System
Buccal Drug Delivery SystemBuccal Drug Delivery System
Buccal Drug Delivery SystemMOHAMMAD ASIM
 
Formulation factors affecting drug absorption
Formulation factors affecting drug absorptionFormulation factors affecting drug absorption
Formulation factors affecting drug absorptionshikha singh
 
Relation between biopharmaceutics and Dosage form design
Relation between biopharmaceutics and Dosage form design Relation between biopharmaceutics and Dosage form design
Relation between biopharmaceutics and Dosage form design MdJahangirAlam110
 
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...IOSR Journals
 
Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...
Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...
Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...PRAJAKTASAWANT33
 

Similar to Formulation factor effecting drug absorbtion (20)

Factors Affecting Drug Absorption {BRD}.pptx
Factors Affecting Drug Absorption {BRD}.pptxFactors Affecting Drug Absorption {BRD}.pptx
Factors Affecting Drug Absorption {BRD}.pptx
 
Pelletizatoin
PelletizatoinPelletizatoin
Pelletizatoin
 
Formulation and processing factors
Formulation and processing factorsFormulation and processing factors
Formulation and processing factors
 
Presentation fACTOR AFFECTING DRUGSABSORPTION by deepak kumar
Presentation fACTOR AFFECTING DRUGSABSORPTION by deepak kumarPresentation fACTOR AFFECTING DRUGSABSORPTION by deepak kumar
Presentation fACTOR AFFECTING DRUGSABSORPTION by deepak kumar
 
Role of Dosage Forms on absorption.
Role of Dosage Forms on absorption.Role of Dosage Forms on absorption.
Role of Dosage Forms on absorption.
 
formulation factors influencing drug absorption
formulation factors influencing drug absorptionformulation factors influencing drug absorption
formulation factors influencing drug absorption
 
Gpd unit ii
Gpd unit iiGpd unit ii
Gpd unit ii
 
biopharmaceutics.pptx
biopharmaceutics.pptxbiopharmaceutics.pptx
biopharmaceutics.pptx
 
Biopharmaceutic considerations in drug product design
Biopharmaceutic considerations in drug product designBiopharmaceutic considerations in drug product design
Biopharmaceutic considerations in drug product design
 
formulation of Buccal Drug Delivery System.pptx
formulation of Buccal Drug Delivery System.pptxformulation of Buccal Drug Delivery System.pptx
formulation of Buccal Drug Delivery System.pptx
 
Pharmacokinetics mpharm
Pharmacokinetics mpharmPharmacokinetics mpharm
Pharmacokinetics mpharm
 
All about Tablets (Pharma)
All about Tablets  (Pharma)All about Tablets  (Pharma)
All about Tablets (Pharma)
 
tablets_part_1.pdf
tablets_part_1.pdftablets_part_1.pdf
tablets_part_1.pdf
 
Buccal Drug Delivery System
Buccal Drug Delivery SystemBuccal Drug Delivery System
Buccal Drug Delivery System
 
Formulation factors affecting drug absorption
Formulation factors affecting drug absorptionFormulation factors affecting drug absorption
Formulation factors affecting drug absorption
 
Relation between biopharmaceutics and Dosage form design
Relation between biopharmaceutics and Dosage form design Relation between biopharmaceutics and Dosage form design
Relation between biopharmaceutics and Dosage form design
 
Pelletization
PelletizationPelletization
Pelletization
 
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
Mouth dissolving tablets- A unique dosage form curtailed for special purpose:...
 
Granulation - Compression-1.pptx
Granulation - Compression-1.pptxGranulation - Compression-1.pptx
Granulation - Compression-1.pptx
 
Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...
Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...
Biopharmaceutic considerations in drug product design and In Vitro Drug Produ...
 

Recently uploaded

TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...Nguyen Thanh Tu Collection
 
24 ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH SỞ GIÁO DỤC HẢI DƯ...
24 ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH SỞ GIÁO DỤC HẢI DƯ...24 ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH SỞ GIÁO DỤC HẢI DƯ...
24 ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH SỞ GIÁO DỤC HẢI DƯ...Nguyen Thanh Tu Collection
 
e-Sealing at EADTU by Kamakshi Rajagopal
e-Sealing at EADTU by Kamakshi Rajagopale-Sealing at EADTU by Kamakshi Rajagopal
e-Sealing at EADTU by Kamakshi RajagopalEADTU
 
會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽
會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽
會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽中 央社
 
OSCM Unit 2_Operations Processes & Systems
OSCM Unit 2_Operations Processes & SystemsOSCM Unit 2_Operations Processes & Systems
OSCM Unit 2_Operations Processes & SystemsSandeep D Chaudhary
 
MuleSoft Integration with AWS Textract | Calling AWS Textract API |AWS - Clou...
MuleSoft Integration with AWS Textract | Calling AWS Textract API |AWS - Clou...MuleSoft Integration with AWS Textract | Calling AWS Textract API |AWS - Clou...
MuleSoft Integration with AWS Textract | Calling AWS Textract API |AWS - Clou...MysoreMuleSoftMeetup
 
The Story of Village Palampur Class 9 Free Study Material PDF
The Story of Village Palampur Class 9 Free Study Material PDFThe Story of Village Palampur Class 9 Free Study Material PDF
The Story of Village Palampur Class 9 Free Study Material PDFVivekanand Anglo Vedic Academy
 
Contoh Aksi Nyata Refleksi Diri ( NUR ).pdf
Contoh Aksi Nyata Refleksi Diri ( NUR ).pdfContoh Aksi Nyata Refleksi Diri ( NUR ).pdf
Contoh Aksi Nyata Refleksi Diri ( NUR ).pdfcupulin
 
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...Nguyen Thanh Tu Collection
 
Improved Approval Flow in Odoo 17 Studio App
Improved Approval Flow in Odoo 17 Studio AppImproved Approval Flow in Odoo 17 Studio App
Improved Approval Flow in Odoo 17 Studio AppCeline George
 
Personalisation of Education by AI and Big Data - Lourdes Guàrdia
Personalisation of Education by AI and Big Data - Lourdes GuàrdiaPersonalisation of Education by AI and Big Data - Lourdes Guàrdia
Personalisation of Education by AI and Big Data - Lourdes GuàrdiaEADTU
 
male presentation...pdf.................
male presentation...pdf.................male presentation...pdf.................
male presentation...pdf.................MirzaAbrarBaig5
 
8 Tips for Effective Working Capital Management
8 Tips for Effective Working Capital Management8 Tips for Effective Working Capital Management
8 Tips for Effective Working Capital ManagementMBA Assignment Experts
 
Spring gala 2024 photo slideshow - Celebrating School-Community Partnerships
Spring gala 2024 photo slideshow - Celebrating School-Community PartnershipsSpring gala 2024 photo slideshow - Celebrating School-Community Partnerships
Spring gala 2024 photo slideshow - Celebrating School-Community Partnershipsexpandedwebsite
 
Basic Civil Engineering notes on Transportation Engineering & Modes of Transport
Basic Civil Engineering notes on Transportation Engineering & Modes of TransportBasic Civil Engineering notes on Transportation Engineering & Modes of Transport
Basic Civil Engineering notes on Transportation Engineering & Modes of TransportDenish Jangid
 
PSYPACT- Practicing Over State Lines May 2024.pptx
PSYPACT- Practicing Over State Lines May 2024.pptxPSYPACT- Practicing Over State Lines May 2024.pptx
PSYPACT- Practicing Over State Lines May 2024.pptxMarlene Maheu
 
Major project report on Tata Motors and its marketing strategies
Major project report on Tata Motors and its marketing strategiesMajor project report on Tata Motors and its marketing strategies
Major project report on Tata Motors and its marketing strategiesAmanpreetKaur157993
 
Trauma-Informed Leadership - Five Practical Principles
Trauma-Informed Leadership - Five Practical PrinciplesTrauma-Informed Leadership - Five Practical Principles
Trauma-Informed Leadership - Five Practical PrinciplesPooky Knightsmith
 

Recently uploaded (20)

TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
TỔNG HỢP HƠN 100 ĐỀ THI THỬ TỐT NGHIỆP THPT TOÁN 2024 - TỪ CÁC TRƯỜNG, TRƯỜNG...
 
24 ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH SỞ GIÁO DỤC HẢI DƯ...
24 ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH SỞ GIÁO DỤC HẢI DƯ...24 ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH SỞ GIÁO DỤC HẢI DƯ...
24 ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH SỞ GIÁO DỤC HẢI DƯ...
 
e-Sealing at EADTU by Kamakshi Rajagopal
e-Sealing at EADTU by Kamakshi Rajagopale-Sealing at EADTU by Kamakshi Rajagopal
e-Sealing at EADTU by Kamakshi Rajagopal
 
會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽
會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽
會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽會考英聽
 
OSCM Unit 2_Operations Processes & Systems
OSCM Unit 2_Operations Processes & SystemsOSCM Unit 2_Operations Processes & Systems
OSCM Unit 2_Operations Processes & Systems
 
MuleSoft Integration with AWS Textract | Calling AWS Textract API |AWS - Clou...
MuleSoft Integration with AWS Textract | Calling AWS Textract API |AWS - Clou...MuleSoft Integration with AWS Textract | Calling AWS Textract API |AWS - Clou...
MuleSoft Integration with AWS Textract | Calling AWS Textract API |AWS - Clou...
 
The Story of Village Palampur Class 9 Free Study Material PDF
The Story of Village Palampur Class 9 Free Study Material PDFThe Story of Village Palampur Class 9 Free Study Material PDF
The Story of Village Palampur Class 9 Free Study Material PDF
 
Contoh Aksi Nyata Refleksi Diri ( NUR ).pdf
Contoh Aksi Nyata Refleksi Diri ( NUR ).pdfContoh Aksi Nyata Refleksi Diri ( NUR ).pdf
Contoh Aksi Nyata Refleksi Diri ( NUR ).pdf
 
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
ĐỀ THAM KHẢO KÌ THI TUYỂN SINH VÀO LỚP 10 MÔN TIẾNG ANH FORM 50 CÂU TRẮC NGHI...
 
Improved Approval Flow in Odoo 17 Studio App
Improved Approval Flow in Odoo 17 Studio AppImproved Approval Flow in Odoo 17 Studio App
Improved Approval Flow in Odoo 17 Studio App
 
Personalisation of Education by AI and Big Data - Lourdes Guàrdia
Personalisation of Education by AI and Big Data - Lourdes GuàrdiaPersonalisation of Education by AI and Big Data - Lourdes Guàrdia
Personalisation of Education by AI and Big Data - Lourdes Guàrdia
 
male presentation...pdf.................
male presentation...pdf.................male presentation...pdf.................
male presentation...pdf.................
 
VAMOS CUIDAR DO NOSSO PLANETA! .
VAMOS CUIDAR DO NOSSO PLANETA!                    .VAMOS CUIDAR DO NOSSO PLANETA!                    .
VAMOS CUIDAR DO NOSSO PLANETA! .
 
8 Tips for Effective Working Capital Management
8 Tips for Effective Working Capital Management8 Tips for Effective Working Capital Management
8 Tips for Effective Working Capital Management
 
Spring gala 2024 photo slideshow - Celebrating School-Community Partnerships
Spring gala 2024 photo slideshow - Celebrating School-Community PartnershipsSpring gala 2024 photo slideshow - Celebrating School-Community Partnerships
Spring gala 2024 photo slideshow - Celebrating School-Community Partnerships
 
Basic Civil Engineering notes on Transportation Engineering & Modes of Transport
Basic Civil Engineering notes on Transportation Engineering & Modes of TransportBasic Civil Engineering notes on Transportation Engineering & Modes of Transport
Basic Civil Engineering notes on Transportation Engineering & Modes of Transport
 
PSYPACT- Practicing Over State Lines May 2024.pptx
PSYPACT- Practicing Over State Lines May 2024.pptxPSYPACT- Practicing Over State Lines May 2024.pptx
PSYPACT- Practicing Over State Lines May 2024.pptx
 
Major project report on Tata Motors and its marketing strategies
Major project report on Tata Motors and its marketing strategiesMajor project report on Tata Motors and its marketing strategies
Major project report on Tata Motors and its marketing strategies
 
Including Mental Health Support in Project Delivery, 14 May.pdf
Including Mental Health Support in Project Delivery, 14 May.pdfIncluding Mental Health Support in Project Delivery, 14 May.pdf
Including Mental Health Support in Project Delivery, 14 May.pdf
 
Trauma-Informed Leadership - Five Practical Principles
Trauma-Informed Leadership - Five Practical PrinciplesTrauma-Informed Leadership - Five Practical Principles
Trauma-Informed Leadership - Five Practical Principles
 

Formulation factor effecting drug absorbtion

  • 1. FORMULATION FACTOR EFFECTING DRUG ABSORBTION Presented by PRIYANKA GRESESS ANAND M.Pharm Department of Pharmaceutics INTEGRAL UNIVERSITY LUCKNOW U.P
  • 2. CONTENTS 1)-Introduction 2)-Manufacturing variables 3)- Type of dosage form 4)-Pharmaceutical ingredients/excipients 5)-products life and storage condition 6)-Conclusion 7)-Reference 5/30/2018 2
  • 3. Introduction • To gain entry in to the blood circulation,a drug must be solubilize to pass from the absorbtion site through biological membranes. • Permeability of drug through biological membranes is closely related to the molecular structure of the drug,physicochemical characteristics,formulation factor ,and the physical and biochemical properties of the cell membrane. 5/30/2018 3
  • 4. DRUG ABSORBTION Definition Drug absorbtion is a pharmacokinetic parameter that refers to the way a drug is absorbed from a pharmaceutical formulation in to the bloodstream. In general,lipid soluble drugs composed of smaller molecules are more likely to absorbed . the rate and extent of absorbtion mostly depends on routes of administration and the way a drug product is designed and manufactured. . 5/30/2018 4
  • 5. Dosage forms like tablet, capsule, powder, solution, suspension, emulsion may vary the absorption. Drug products that contain the same drug (active ingredient) may have different inactive ingredients so absorbtion of these drug from different products may flactuate. Absorbtion play a key role in determining how fast a drug produces a clinical effect. 5/30/2018 5
  • 6. Formulation Factor which can slower the rate of absorbtion of drug are mentioned below – Formulation Factors:- Manufacturing variables: - a). Method of granulation Wet granulation yields a tablet that dissolves faster than those made by other granulating methods. But wet granulation has demerit like formation of crystal bridge or chemical degradation. 5/30/2018 6
  • 7. b)-compression force-Higher compression force yields a tablet with greater hardness hence have a long D.T. but on other hand higher compression force cause crushing of drug particles into smaller ones with effective surface area which decreasesD.T.. 5/30/2018 7
  • 9. Drug formulations are designed to provide an attractive, stable, and convenient use of products. Decreasing order dissolution rate of different dosage forms as :- solutions>solid solutions>suspensions, capsules>coated capsules>tablets, and controlled release formulations. 5/30/2018 9
  • 10. 5/30/2018 10 Solutions Solutions shows faster absorption as compared to solid dosage forms. solutions are frequently used as bioavailability standards. Factor effecting absorbtion of solution:- Viscosity Solubulizer Stability surfactants
  • 11. 5/30/2018 11 Suspensions • A drug in a suspension is in solid form, but is finely divided and has a large surface area. • Drug particles can diffuse readily between the stomach and small intestine so that absorption is relatively insensitive to stomach emptying rate. • Liquid dosage forms, therefore, have advantages besides simple dissolution rate. However, they also have some disadvantages, including greater bulk, difficulty in handling, and perhaps reduced stability.
  • 12. 5/30/2018 12 Capsules and tablets • These formulations differ from each other in that material in capsules is less impacted than in compressed tablets. • Once a capsule dissolves, its contents generally disperse quickly. • Tablets generally disintegrate in stages, first into granules and then into primary particles. As particle size decreases, dissolution rate increases due to of increased surface area..
  • 13. Pharmaceutical Ingredients/Excipients  Excipients are added to ensure 1. Stability 2. Uniformity 3. Functionability 4. Bioavailability 5. Acceptability 5/30/2018 13
  • 14. Diluents  Diluents are commonly added to tablet and capsule formulations if the required dose is inadequate to produce bulk.  Eg:-Drug-diluent interaction resulting in poor bioavailability of tetracycline & DCP 5/30/2018 14
  • 15. Binders and granulating agent Promote cohesive compacts before & after compression  Eg polymeric materials like starch, cellulose derivatives, acacia, PVP, etc. COLOURANTS  Very low concentration of water-soluble dye has inhibitory effect on dissolution.  E.g. brilliant blue retards dissolution of sulfathiazole 5/30/2018 15
  • 16. Lubricants To aid flow of granules  To reduce interparticle friction  Sticking of particles to dies & punches  Eg:- sodium and magnesium stearates & waxes. 5/30/2018 16
  • 17. DISINTEGRANTS  These Agents overcome cohesive strength of tablet & break them on contact with water which is an important for tablet to dissolve. eg MCC BUFFERS  They create right atmosphere for dissolution e.g. buffered aspirin tablets  Buffer containing potassium cations inhibit the drug absorption e.g. vitamin B2 & sulphanilamide 5/30/2018 17
  • 18. SURFACTANTS  They may enhance or retard drug absorption 1. Promotion of wetting & dissolution of drugs 2. Better membrane contact of drug for absorption 3. Enhanced membrane permeability of the drug 5/30/2018 18
  • 19. Product age and storage conditions • Product aging and improper storage conditions adversely affect B.A. E.g. –precipitation of drug in solution decrease rate of drug dissolution & absorption . 5/30/2018 19
  • 20. CONCLUSION • Absorption plays an major role to attain the desired therapeutic action with minimal side effects at the given period of time. • Formulation factors influencing drug absorption helps us to focus on formulating drug with proper attainment of permeability of drugs to systemic circulation at given time 5/30/2018 20
  • 21. REFERENCE • 1. Brahmankar D.M., Jaiswal S.B., First edition, “Absorption of Drugs” Biopharmaceutics and Pharmacokinetics – A treatise, Vallabh Prakashan, Delhi 1995, Page No. 5-75. • 2. Shargel L., Andrew B.C., Fourth edition “Physiologic factors related to drug absorption” Applied Biopharmaceutics and Pharmacokinetics, Prentice Hall International, INC., Stanford 1999. Page No. 99-128. • 3. Pharmaceutics , the Science of Dosage form Design By M.E. Aulton • 4. Swarbrick J., Boylan J.C., “Absorption” Encyclopedia of Pharmaceutical Technology, Marcel Dekker, INC., New York 1988:1-32. 5/30/2018 21