A force is any push or pull that can cause an object to change its motion. Forces have both magnitude and direction. There are two types of forces: contact forces, which require objects to touch, like friction or tension; and non-contact forces, which act over a distance, like gravity or magnetism. A force is measured in Newtons, and the acceleration due to gravity on Earth is 9.81 m/s2. Forces can cause objects to accelerate, decelerate, or maintain a constant velocity depending on whether the net force is nonzero.
force, pull, push, magnetic force, frictional force, direction, formula mass x acceleration, a vector quantity, magnitude, types of forces, muscular force, speed, shape, force, size, unit, newton, position, moving object, assignments1, assignment2
force, pull, push, magnetic force, frictional force, direction, formula mass x acceleration, a vector quantity, magnitude, types of forces, muscular force, speed, shape, force, size, unit, newton, position, moving object, assignments1, assignment2
Force? How force can produce effects on our position or position of any object which is in moving or rest condition. Force can disturb their position by applying it in proper direction and enough magnitude. Different types of force according to their application and point of application. A force system is also defined well with its different segments like - co planer, concurrent,co planer concurrent etc. Spring force, friction force, normal force, air resisting force, gravity force, tension force etc. described briefly.
Almost all the things in our daily life are possible because some sort of force. Presence and even absence of force play important role in different situations. This presentation is about 'Forces'. It describes all the types of forces with appropriate and familiar examples.
This is a summary of the topic "Energy, work and power" in the GCE O levels subject: Physics. Students taking either the combined science (chemistry/physics) or pure Physics will find this useful. These slides are prepared according to the learning outcomes required by the examinations board.
Force? How force can produce effects on our position or position of any object which is in moving or rest condition. Force can disturb their position by applying it in proper direction and enough magnitude. Different types of force according to their application and point of application. A force system is also defined well with its different segments like - co planer, concurrent,co planer concurrent etc. Spring force, friction force, normal force, air resisting force, gravity force, tension force etc. described briefly.
Almost all the things in our daily life are possible because some sort of force. Presence and even absence of force play important role in different situations. This presentation is about 'Forces'. It describes all the types of forces with appropriate and familiar examples.
This is a summary of the topic "Energy, work and power" in the GCE O levels subject: Physics. Students taking either the combined science (chemistry/physics) or pure Physics will find this useful. These slides are prepared according to the learning outcomes required by the examinations board.
In this lesson, students will learn how gravity & friction can take affect on the simple things we do everyday of our lives. Learn the 3 main types of friction, & air resistance, plus a few examples. Finally, learn about terminal velocity & get a basic introduction to magnetic & electric forces with a slight distinction for buoyancy & density.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
12. Examples of contact Forces
Buoyant Forces
Or floating forces
(in water
and in air)
13. Examples of contact Forces
Surface Tension
is a property of
the surface of a
liquid that allows
it to resist an
external force
14. Examples of contact Forces
Surface Tension
is a property of
the surface of a
liquid that allows
it to resist an
external force
15. Examples of contact Forces
Friction is the
Resistance that
one surface or
object encounters
when moving
over another.
16. Examples of contact Forces
Friction is the
Resistance that
one surface or
object encounters
when moving
over another.
17. Examples of contact Forces
Air resistance
or drag, is the
friction that acts
on an object
moving through
the air.
18. Examples of contact Forces
Air resistance
or drag, is the
friction that acts
on an object
moving through
the air.
19. Examples of contact Forces
Spring force
is the force applied
by a compressed or
stretched spring on
any object that is
attached to it.
20. Examples of contact Forces
Tension force
is the force that is
Transferred through
a string, rope, cable
or wire when it is
pulled tight by forces acting
from opposite ends.
28. When you stand on a scale, you do not
measure your weight, you measure
your mass.
Your weight is the force that pulls
you down towards the centre of the
Earth as a result of your mass and the
acceleration due to gravity
29. Weight = mass x g
Weight is measured in Newtons (N)
Mass is measured in kilograms (kg)
g is the acceleration due to gravity
= 9.81 m/s2
30. Mr Coumbe’s weight can be
calculated like this:
Weight = m x g
= 80 kg x 9.81 m/s2
= 784.8 N
What is your weight?
31. When we want to
diagrammatically represent
forces, we use a free body
diagram
32. A free body diagram is a
simple diagram that can
represent anything that
has forces acted on it.
33. Objects can have multiple
forces acted on it.
When the forces are in the
same direction, they add
to each other.
34. Objects can have multiple
forces acted on it.
When the forces are in the
opposite direction, they
take away from each
other.
35. The net force is the sum of
all forces
If the net force = 0 then
then object will not change
its motion.
36. Newton’s 1st Law
An object will stay at rest
or in constant motion,
unless acted on by an
external force
37. The net force is the sum of
all forces
If the net force > 0 then
the object will change its
motion in the direction of
the net force
