Luteolin is a type of flavonoid and a 38, 48, 5, 7-tetra hydroxyl flavone with a yellow crystalline appearance. Luteolin is
widely present in different plant families such as, Lamiacea, Arecaceae, Brassicaceae, Campanulaceae, Asteraceae, Resedaceae and
Scrophulariaceae. Luteolin mostly found in edible plants and most important food based phytochemical. Dietary sources of luteolin such
as, celery, peppers, carrots, peppermint, olive oil, thyme, oregano and rosemary, etc. On the base of luteolin content among other sources
oregano is the better source with 1028.75mg/100g contents. Flavonoids are important component of plants, and widely used in
traditional medicine to cure the different type of diseases. Luteolin has different health benefits such as, anti-inflammatory, sun
protectant, anti-oxidant, improve heart function, neurological impairments, anti-cancer and many more. Luteolin has many possible
mechanisms involved in different biological activities such as, stabilization of p53, modulation of ROS levels, and reduction of NF-
kappaB, reduction of AP-1 activity and inhibition of PI3K.
Pharmacological Applications of Isorhamnetin: A Short Reviewijtsrd
Isorhamnetin (30-Methoxy-3, 40, 5, 7-tetrahydroxyflavone) is a flavonol, and it belongs to a group of plant secondary metabolites known as flavonoids. It is present in mans daily diet and is known for its biological activities such as antioxidant, antiviral, anticancer, antimicrobial, and anti-inflammatory effects. Isorhamnetin has been reported for its antioxidant and antiviral applications hence it is not only used as such, but it also has various derivatized forms which has potentials for development into drugs for the treatment of diseases caused by oxidative stress and lethal viruses. The present review reflects the pharmacological importance of isorhamnetin. S Kandakumar | Dr V Manju"Pharmacological Applications of Isorhamnetin: A Short Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-4 , June 2017, URL: http://www.ijtsrd.com/papers/ijtsrd2202.pdf http://www.ijtsrd.com/biological-science/biochemistry/2202/pharmacological-applications-of-isorhamnetin-a-short-review/s-kandakumar
Alteration in Protein Metabolic Profiles in Liver Tissue of Rats during Dimet...iosrjce
Dimethoate is the widely used organophosphorous insecticides in agriculture. The irrational use of
Dimethoate in Yemen play a crucial role in the occurrence of many diseases affecting plants, animals and man.
Dimethoate (DM) is used to kill mites and aphids among other insects and is applied on citrus, cotton, fruit,
olives, potatoes, tea, tobacco and vegetables. The aim of the present work was to study biochemical changes
that might occur in the liver of albino rats as a result of DM intoxication. In the present investigation the
animals were treated with 1/10th of LD50 of DM via oral gavage (34.5mg/kg body weight. The first group
animals were considered as control animals. Second group of animals were treated with Dimethoate via oral
gavage (34.5mg/kg body weight which is 1/10th of LD50) for 10 days, third and fourth groups of animals were
administered for 20 and 30 days with an interval of 48h respectively. The DM treated groups are AST and ALT
was selected in the present investigation showed an increment. The present findings indicate that chronic
exposure to DM has clear toxic effect on the liver of albino rats.
Pharmacological Applications of Isorhamnetin: A Short Reviewijtsrd
Isorhamnetin (30-Methoxy-3, 40, 5, 7-tetrahydroxyflavone) is a flavonol, and it belongs to a group of plant secondary metabolites known as flavonoids. It is present in mans daily diet and is known for its biological activities such as antioxidant, antiviral, anticancer, antimicrobial, and anti-inflammatory effects. Isorhamnetin has been reported for its antioxidant and antiviral applications hence it is not only used as such, but it also has various derivatized forms which has potentials for development into drugs for the treatment of diseases caused by oxidative stress and lethal viruses. The present review reflects the pharmacological importance of isorhamnetin. S Kandakumar | Dr V Manju"Pharmacological Applications of Isorhamnetin: A Short Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-4 , June 2017, URL: http://www.ijtsrd.com/papers/ijtsrd2202.pdf http://www.ijtsrd.com/biological-science/biochemistry/2202/pharmacological-applications-of-isorhamnetin-a-short-review/s-kandakumar
Alteration in Protein Metabolic Profiles in Liver Tissue of Rats during Dimet...iosrjce
Dimethoate is the widely used organophosphorous insecticides in agriculture. The irrational use of
Dimethoate in Yemen play a crucial role in the occurrence of many diseases affecting plants, animals and man.
Dimethoate (DM) is used to kill mites and aphids among other insects and is applied on citrus, cotton, fruit,
olives, potatoes, tea, tobacco and vegetables. The aim of the present work was to study biochemical changes
that might occur in the liver of albino rats as a result of DM intoxication. In the present investigation the
animals were treated with 1/10th of LD50 of DM via oral gavage (34.5mg/kg body weight. The first group
animals were considered as control animals. Second group of animals were treated with Dimethoate via oral
gavage (34.5mg/kg body weight which is 1/10th of LD50) for 10 days, third and fourth groups of animals were
administered for 20 and 30 days with an interval of 48h respectively. The DM treated groups are AST and ALT
was selected in the present investigation showed an increment. The present findings indicate that chronic
exposure to DM has clear toxic effect on the liver of albino rats.
Toxicological advances of traditional medicine in 2019LucyPi1
Abstract There were many researches concerning toxicology of traditional medicine (TM) and active natural products during the past 12 months. This annual toxicology review summarized target organs of TM like liver, kidney and heart. Safety medication of TM has been concerned to different kinds of people, including infants, children, pregnancy and the postnatal period. Besides rodents, zebrafish embryoes have been regarded as common models to evaluate the safety of TM. New technologies in toxicology focus on rapidly screening and identification of toxins in TM. Multispectral optoacoustic tomography imaging the precise location of TM-induced liver injury with 3D information and integrating serum exosomal microRNA and liver microRNA profiles are used to explain the mechanism of TM-induced hepatotoxicity. Taken together, study on the toxicity mechanism of other target organs, drug safety in elders, new models and methods should be paid attention to in the prevention of TM toxicology in the future.
International Organization of Scientific Research (IOSR)iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Studying the expression of proteins in Chrysichthys nigrodigitatus muscle, is essential to understand the biological, physiological and ecological aspects that may be of advantage in ecotoxicology as a tool for biomonitoring the effects of environmental pollution, as well as food safety. This study was aimed to accomplish a systematic characterization of the muscle proteome as well as to identify a putative set of protein biomarkers in C. nigrodigitatus to environmental pollution in Ologe and Badagry lagoons. Fifteen fi sh samples were used
as representative of the population for proteomics analysis. 116 proteins was expressed with 70 up-regulated, 25 down-regulated from Ologe Lagoon and 30 up-regulated, 17 down-regulated proteins from Badagry Lagoon expressed in the muscle of C. nigrodigitatus in response to environmental stressors using iTRAQ, while 8 protein spots from 2-D gels, representing 8 proteins with 2 up-regulated and 6 down-regulated, have been identifi ed using MALDI TOF/TOF MS. Pearson correlation revealed signifi cant correlation (p < 0.05) betwee environmental variables and protein markers. The investigation revealed that the expressed proteins in the muscle of C. nigrodigitatus served as a prognostic tool to assess the fi sh health and pollution status, which was observed that the fi sh were physiologically perturbed by environmental stressors in Ologe and Badagry lagoons.
Improvement in Poultry Performance through Application of PhytobioticsDr. MAYUR VISPUTE
An attempt to explore the possibilities of future use of Phytogenic feed additives as a green and clean alternative to the conventional feed additives like antibiotic growth promoters in modern poultry production
This presentation from the recent international nutrition conference in Bangkok presents a short overview about several aspects of state-of-the art nutrigenomics & molecular nutrition research.
Conclusion
Nutrigenomics enables us
-To understand how nutrition precisely works (evidence-based nutrition);
-To quantify the nutritional needs for optimized fitness at different life stages (“personalized” nutrition);
-To improve early diagnostics of nutrition related disorders (“challenge tests”);
-To support the development of “smart foods” for modern mankind (healthy and tasty, sustainable, affordable)
-To enable the transition of nutritional science to nutritional science 2.0
Bioinformatics Introduction and Use of BLAST ToolJesminBinti
Hi, I am Jesmin, studying MCSE. I think this file will help you if you want to know the basic information about Bioinformatics and the use of BLAST tool. The BLAST tool is the tool that matches the sequences of DNA,RNA and proteins.
Drug response biomcare webinar - jan 2022Regin Jensen
WEBINAR: The role of the Gut Microbiome for Drug Response
Varying drug response is a key factor in both drug development and clinical practice and result in sub-optimal treatment and failed clinical trials.
Resent years research has detailed how the gut microbiome plays an essential role for drug response, and how the inter-individual variation in the composition of the gut microbiome is an important factor, both in drug trials and treatment.
Elements in the webinar
In this seminar, we will dive into this interesting topic, and take you through
-Key research into how the microbiome can affect drug response
-How microbiome profiling of patients can be used to gain insight and control in clinical trials at all stages,
-How microbiome profiling can be used to detect a novel type of biomarkers.
Biomcare is providing sampling support, sequencing, and data analysis for the microbiome aspects of the large NORDIC-SUN clinical trial of Immune Checkpoint Inhibitors, and we will finish the seminar by introducing this project and our solution for microbiome analysis in clinical studies and trials.
Toxicological advances of traditional medicine in 2019LucyPi1
Abstract There were many researches concerning toxicology of traditional medicine (TM) and active natural products during the past 12 months. This annual toxicology review summarized target organs of TM like liver, kidney and heart. Safety medication of TM has been concerned to different kinds of people, including infants, children, pregnancy and the postnatal period. Besides rodents, zebrafish embryoes have been regarded as common models to evaluate the safety of TM. New technologies in toxicology focus on rapidly screening and identification of toxins in TM. Multispectral optoacoustic tomography imaging the precise location of TM-induced liver injury with 3D information and integrating serum exosomal microRNA and liver microRNA profiles are used to explain the mechanism of TM-induced hepatotoxicity. Taken together, study on the toxicity mechanism of other target organs, drug safety in elders, new models and methods should be paid attention to in the prevention of TM toxicology in the future.
International Organization of Scientific Research (IOSR)iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Studying the expression of proteins in Chrysichthys nigrodigitatus muscle, is essential to understand the biological, physiological and ecological aspects that may be of advantage in ecotoxicology as a tool for biomonitoring the effects of environmental pollution, as well as food safety. This study was aimed to accomplish a systematic characterization of the muscle proteome as well as to identify a putative set of protein biomarkers in C. nigrodigitatus to environmental pollution in Ologe and Badagry lagoons. Fifteen fi sh samples were used
as representative of the population for proteomics analysis. 116 proteins was expressed with 70 up-regulated, 25 down-regulated from Ologe Lagoon and 30 up-regulated, 17 down-regulated proteins from Badagry Lagoon expressed in the muscle of C. nigrodigitatus in response to environmental stressors using iTRAQ, while 8 protein spots from 2-D gels, representing 8 proteins with 2 up-regulated and 6 down-regulated, have been identifi ed using MALDI TOF/TOF MS. Pearson correlation revealed signifi cant correlation (p < 0.05) betwee environmental variables and protein markers. The investigation revealed that the expressed proteins in the muscle of C. nigrodigitatus served as a prognostic tool to assess the fi sh health and pollution status, which was observed that the fi sh were physiologically perturbed by environmental stressors in Ologe and Badagry lagoons.
Improvement in Poultry Performance through Application of PhytobioticsDr. MAYUR VISPUTE
An attempt to explore the possibilities of future use of Phytogenic feed additives as a green and clean alternative to the conventional feed additives like antibiotic growth promoters in modern poultry production
This presentation from the recent international nutrition conference in Bangkok presents a short overview about several aspects of state-of-the art nutrigenomics & molecular nutrition research.
Conclusion
Nutrigenomics enables us
-To understand how nutrition precisely works (evidence-based nutrition);
-To quantify the nutritional needs for optimized fitness at different life stages (“personalized” nutrition);
-To improve early diagnostics of nutrition related disorders (“challenge tests”);
-To support the development of “smart foods” for modern mankind (healthy and tasty, sustainable, affordable)
-To enable the transition of nutritional science to nutritional science 2.0
Bioinformatics Introduction and Use of BLAST ToolJesminBinti
Hi, I am Jesmin, studying MCSE. I think this file will help you if you want to know the basic information about Bioinformatics and the use of BLAST tool. The BLAST tool is the tool that matches the sequences of DNA,RNA and proteins.
Drug response biomcare webinar - jan 2022Regin Jensen
WEBINAR: The role of the Gut Microbiome for Drug Response
Varying drug response is a key factor in both drug development and clinical practice and result in sub-optimal treatment and failed clinical trials.
Resent years research has detailed how the gut microbiome plays an essential role for drug response, and how the inter-individual variation in the composition of the gut microbiome is an important factor, both in drug trials and treatment.
Elements in the webinar
In this seminar, we will dive into this interesting topic, and take you through
-Key research into how the microbiome can affect drug response
-How microbiome profiling of patients can be used to gain insight and control in clinical trials at all stages,
-How microbiome profiling can be used to detect a novel type of biomarkers.
Biomcare is providing sampling support, sequencing, and data analysis for the microbiome aspects of the large NORDIC-SUN clinical trial of Immune Checkpoint Inhibitors, and we will finish the seminar by introducing this project and our solution for microbiome analysis in clinical studies and trials.
chaemoprevention of cancer using dietary phytochemicals awan867
dietary phytochemicals are natural ,non-nutritive ,secondary metabolites .they are mainly for defense system in plants ,also provide colour ,aroma, flavour .they also have anti mutagenic & anti carcinogenic properties . there are 900 phytochemicals but main phytochemicals like curcumin ,gingerol,ECGC, Capsacin and many more . various cell signalling molecules can act as a target for these phytochemicals .
A preliminary study on the effects of ozone on induction of resistance in Cic...iosrjce
The potential for ozone to damage vegetation has been known for over 30 years, but it is only over
the last decade that its impacts have become of concern in India and other countries. It is now clearly
established that ozone, at the ambient concentrations can cause a range of effects including visible leaf injury,
growth and yield reductions, and altered sensitivity to biotic and abiotic stresses. Research in recent years has
advanced our understanding of the mechanisms underlying ozone effects on agricultural crops, and to a lesser
extent on trees and native plant species. A study was conducted to evaluate the consequence of application of
ozone for a diminutive period repeatedly on germinated seedlings of Cicer arietinum and Trigonella foenum.
The seedlings were exposed to different concentrations of ozone (5 ppm and 10 ppm) for different time intervals
(5 min, 10 min, 15 min and 20 min) per day for three days. Ozone exposed and untreated (control) plants were
used for biochemical analysis. These include chlorophyll content, total phenol content and phenylalanine
ammonia-lyase assay (PAL). This study has revealed that increase in the ozone concentration and exposure time
enhances the production of soluble phenol contents, PAL activity and reduces the chlorophyll content compared
to control, seedlings.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
Presentation during the Bureau of Agricultural Research (BAR) Seminar Series on March 23, 2017 at RDMIC Bldg., cor. Visayas Ave., Elliptical Rd., Diliman, Quezon City
Cancer Chemoprevention by Flavonoids, Dietary Polyphenols and Terpenoids Dr Varruchi Sharma
The world population is aging, and cancer is always considered to be one of the major causes of death all over the globe. The advent of recent drug-targeted therapies undoubtedly is going to reduce the incidence of cancer over the coming years. However, the frequency of occurrence of such chronic diseases like cancer would continue to increase. Therefore, the search for a safer and cost-effective treatment is urgently needed. Phytochemicals found in plants, foods, vegetables, tea, etc. have emerged as proven therapeutic compounds modulating signaling pathways involved in cancer. We carried out a structured search of bibliographic databases for peer-reviewed research literature using the keywords: cancer chemoprevention, flavonoids, dietary polyphenols, terpenoids, bioactive, microbiota. Quality of the retrieved papers and characteristic outcomes of the articles included in the study was assessed by employing standard tools and deductive qualitative content analysis methodology. The development of personalized supplements comprising particular phytochemicals has been the key, especially dealing with chronic inflammatory disorders like cancer. Better understanding at the molecular level explains the influence of phytochemicals on human health, which has been extensively covered through this review. Moreover, the wide collection of dietary polyphenols that has significant properties in reference to human health has been highlighted. Furthermore, the etiology of end products of such phytochemicals, especially on the modulation of gut microbiota and the host-microbial interactions thereof, need to be properly understood. The present study summarizes the chemoprevention and treatment of cancer using the bioactive components, including flavonoids, dietary polyphenols, and terpenoids. Likewise, the effect of dietary polyphenols on the human gut microbiota has been realized more recently. However, more research is needed in this field, especially focused on the communications, interlinks between the gut microbiota and polyphenols with the precise mechanism of action.
LITERATURE REVIEW: ROLES OF FLAVONOIDS IN HUMAN HEALTHKayode Kolawole
This paper is based on the importance of phytochemicals in our health. How this nutrients from plants help us combat series of degenerative diseases and mechanism of actions.
Disease can occur due to alterations in many physiological processes. A variety of factorsare known to be involved in the progression of cancer, a chronic diseasethat occurs due to permissible proliferative signaling, avoiding growth suppressors, resisting cell death, allowing replicative immortality, induction of angiogenesis, and inducing invasion and metastasis, along with reprogramming of metabolic pathways involved in energy production and avoiding the host immune response for cell destruction. Treatment of such a multifactorial disease has very less cure rate because of the singular agents tried in the past for targeting. Molecular level studies with deeper insight are urgently neededthat focus on the most promising herbal-derived bioactive substances for which thorough research was carried out in the literature in various data-bases such as PUB-MED, MEDLINE, SCOPUS indexed journals etc. to look for systematic reviews of the protocols or data interpretation, natural drug/immunological properties and validation. As immune system plays avery important role in the proliferation or suppression of cancer and other autoimmune diseases, It is the dire need to study the effect of such natural compound on the immune system so that a possible drug target or epitope can be identified for the treatment of such diseases. In nutshell there are many nonclinical in vitro and in vivo studies on herbal medicines which commonly supports the traditional therapeutic claims. It has been seen from the previos studies in literature that the yield and composition of bioactive compounds derived from plants are dependent upon the production source,culturing conditions and extraction protocols.Therefore appropriate optimization conditions would certainly assist the medical and scientific fraternity to accept herbal products as potential candidates for cancer treatment. In this article we explored the different natural products, their immunological effects concerning cancer with no or negligible side effects. However,one has to look for potential herb–drug or herb-epitope interactions and how immune system responds to such drugs.
Similar to Food based phytochemical luteolin their derivatives, sources and medicinal benefits (20)
Sclerotinia sclerotiorum (Lib.) de Bary is a soil borne plant pathogen, capable of infecting more than 500 host plants
worldwide. It is a major pathogen that plays a crucial role in reducing the yield in economically important crops. It causes stem & crown
rot, wilt, leaf & petiole rot, blossom blight, fruit rot and damping off diseases in crops. The initial mycelia infection at the base of the stem
is an appearance of elongated water soaked lesions that expand rapidly. Ascospore infection is quite general and occurs on the other plant
parts. Effective pathogenesis by the S. sclerotiorum requires the secretion of oxalic acid and lytic enzymes. Germination of overwintered
sclerotia, and release, survival and germination of ascospores are important factors for the development of disease. The capability of
sclerotia to survive for more than 5 years, so it becomes very difficult to manage the Sclerotinia diseases. Management of S. sclerotiorum is
a major challenge, and the best being the integration of various Measures like, cultural practices, chemical, biological and resistance
varieties. The review summarizes current information on morphology, symptomatology, disease cycle and management of the disease. In
addition, current research and management strategies to combat S. sclerotiorum also discuss.
A yeast strain E2 was purified from traditional yeast, and retained for its strongly acidifying, fermentative and saccharolytic
power. In fact, this strain produces a high concentration of acetic acid 105.85 mg / L revealed by using the H.P.L.C DAD technique
during its growth in semi synthetic medium containing sucrose at 5 g /l as only carbon source. The pH of the culture medium increases
from 5.58 to 2.76 after 24 hours of culture and to 2.48 after 48 hours of
Characterization, treatment and recovery of fish byproduct as a stable bio-fe...Skyfox Publishing Group
National fish production reached in 2013 an amount of 1,245,912 tons. Now the pelagic fish industry generates a
significant amount of waste up to 60%. The physicochemical analyses of these fish by-products showed a wealth of organic material
including proteins (87.4% dry weight) and minerals (9% dry weight). These components and others are capitalizing to be used for
agricultural or agri-food. Biotransformation of biotechnologically in fish products was performed in the laboratory. Fresh fish byproducts
were ground and mixed with a carbon-rich source of carbohydrates. The mixture was inoculated with selected fermentation
yeast. The fermentation of evolution was controlled by monitoring chemical parameters (pH, dry matter, ash, total nitrogen) and
microbiological (FMAT, Enterobacteriaceae: fecal and total Coliforms, yeasts). Then the product thus stabilized at a pH of 3.8 has
undergone a second treatment. A hydrolyzate rich in amino acids and trace elements was obtained with excellent hygienic quality after a
total elimination of pathogens. Its use will be as factors for fertilizer and soil amendment. We produced three biostimulants necessary for
plant growth: Rooting fertilizer, Plant elongation fertilizer and production fertilizer. The application tests on these biofertilizers in the
laboratory were performed and have allowed obtaining promising results.
Determination of Opinions and Level of knowledge of Culinary Program Students...Skyfox Publishing Group
This study is conducted to investigate knowledge, attitudes and behavior of university culinary program students about
genetically modified organisms (GMOS). The study is carried out among 214 university students aged (99 female, 115 male).
Demographic characteristics of students, their knowledge, attitude and behavior of Genetically Modified Organisms (GMO) are taken
into consideration in the data collection process. 10 open-ended questions and an attitude scale questionnaire which consists of 30
questions was applied. The data obtained with the SPSS 20.0 program by using frequency (F), percent (%), t-test and one way analysis
of variance (ANOVA). For the question “Have you ever heard of the term GMO?” 32 students (15%) stated that they never heard of
the term. Students from the culinary program, replied the question “In your opinion, is GMO beneficial or harmful? ‘’ 95, 8% replied as
harmful. According to replies of culinary program 1. and 2. year students there was no significant difference between their answers to the
question (p> 0.05). For the question ’’ If it is harmful, why?’’ students stated that GMO causes cancer. The average of female students
answer is 3, 40, while the average of male students is 3,42. T test conducted to these averages gives the result of p=0.389 (p> 0.05). The
averages of their responses to the items and the number of male and female students have been very close to each other. But there is
statistical difference to the reply of 28. Question which is p=0.02 (p<0.05). The analysis demonstrates that students have enough basic
knowledge about genetically modified organisms, but it was observed that they experience conceptual confusion. Most of the students
believe that GMO technology is harmful, and there are some conceptual mistakes. It was concluded that the concept of the course will
increase knowledge and awareness about GMOs in the curriculum topics that will help to eliminate confusion.
E-waste is an end of the life span of electric or electronic appliances which contain the complex heavy metals. It is causing
severe health concerns for millions of people around the world, mostly in the developing nations of India, Africa, Europe, etc. More of
these wastes are ending up in dumping yards and recycling centers, cause a new challenge to the environment. In general electronic
gadgets are intended to make our lives happier and simpler, but their toxicity, removal and recycling becomes a health horrendous. Many
research papers have been reported on microbial remediation of heavy metals present in E-waste. The pioneer work was reported on
1998, bio-dissolution of spent nickel batteries using Thiobacillus ferroxidans, which is the first step to recycle and discarded batteries by
using microbes as eco-friendly method. This review paper provides an insight in to the bioremediation of heavy metals from E-waste by
potential microorganisms, in an eco-friendly way and provide pathway for current researchers.
In-vitro antioxidant and GC-MS analysis ethanolic extract of poly herbal drugSkyfox Publishing Group
Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against
infections and degenerative diseases. Current research is now directed towards natural antioxidants originated from plants due to safe
therapeutics. Poly herbal drugs is used in Indian traditional medicine for a wide range of various ailments. To understand the mechanism
of pharmacological actions, antioxidant properties of the Poly herbal drugs extract were tested using standard in vitro models. The
ethanolic extract of Poly herbal drugs exhibited strong scavenging effect on superoxide, nitric oxide radical and reducing power radical
scavenging assay. The free radical scavenging effect of Poly herbal drugs extract was comparable with that of the reference antioxidants.
The data obtained in the present study suggests that the extract of Poly herbal drugs have potent Invitro antioxidant and Anti Diabetic
activity against free radicals, prevent oxidative damage to major biomolecules and afford significant protection against oxidative damage.
Nutritional significance of cereals and legumes based food mix- A reviewSkyfox Publishing Group
Tertiary processed foods are commercially formulated foods designed for the ease of consumption. These foods are
mainly formulated using the refined flour which are lacking in one or more nutrients. Whole cereals and legumes found to possess
immense nutritional potentials which could complement one another if accurately processed and combined. Therefore, it is essential to
formulate composite blends and carry out scientific research to ascertain the nutritive adequacy of the cereal and legumes for possible
use as tertiary foods. The present study is therefore a part of an exploratory work towards this goal. The study emphasis on formulation
of tertiary processed foods with application of processing and drying methods using multicereals and legume combination. Successful
utilization of cereals and legumes with added functionality in snack food sector will definitely open up new dimensions to the food
industries.
Effect of cooking temperature on some quality characteristic of Almond milkSkyfox Publishing Group
Processing of almond was done at different temperatures (80, 90, 100 and 110°C), to produce almond milk samples (A, B,
C and D). The almond milk sample (C) processed at normal boiling temperature (100°C) kept as reference standard. Using different
standard analytical methods, almond milk were analyzed for physiochemical, microbiological, and sensory attributes. Due to increase in
temperature the crude fat and moisture content decreased significantly (p<0.05)><0.05)><0.05) from 2.24-1.33×103 CFU/ml for sample A to D processed at 80-110°C, while yeast and mold from 1.22-0.35×102 CFU/ml.
The mean value score awarded to all sensory attributes increase from A to C but decrease in D. Almond milk products were acceptable,
highest acceptability score (8.33) awarded to milk sample C processed at 100°C followed by samples B, A and D. Processing of almond
milk at 100°C provide the better milk product with all measured characteristics suggested for almond milk processing.
Human Noroviruses (HuNoVs) are important enteric pathogens, which affect the stomach and intestines, leading to
gastroenteritis or more commonly called the "stomach flu" or “winter vomiting bug". HuNoVs are mainly transmitted by the fecal-oral
route, either by directly infected person-to-person contact or directly via contaminated foods, water and surface areas. The virus is highly
contagious as 10-100 virus particles are sufficient to cause diseases. HuNoVs can spread easily and cause prolonged outbreaks. This is
due to their environmental persistence, high infectivity, being resistance to disinfection and difficulty in preventing transmission.
HuNoVs are the most common causative agent leading to acute gastroenteritis among infectious diseases worldwide and poses a serious
public health problem, especially among children being the most susceptible. In developing countries, the highest cost of medical care
after respiratory infections is listed for acute gastroenteritis. In this study, Norovirus outbreaks, precautions, its identification and
struggles were informed and some suggestions were made about this case.
Quality evaluation of soy milk ice cream prepared with ipomoea batatas starch...Skyfox Publishing Group
Stabilizers are used in ice cream preparation for viscosity, air incorporation, melt down and texture improvement to attain
attractive end product. Soybeans were used to produce soy milk. Soy milk used as a milk replacer due to its some important health
aspects such protein, vitamin C, isoflavones, dietary fiber, omega-3-fatty acid and oligosaccharides. Starch was extracted form Ipomoea
Batatas. Meteroxylon Sagu powder and Ipomoea Batatas starch analyzed against some quality characteristics such as pH, swelling power
and solubility, water holding capacity, moisture, ash protein and viscosity. Ice cream was prepared by using soy milk with different
concentration such as 0.25, 0.5 and 0.75% of starch and powder. Commercially used stabilizing agent Cremodan was kept as reference
standard. Prepared ice cream mix was analyzed against some physicochemical and sensory parameters. Ice cream sample that contain
ipomoea batatas starch 0.75% showed significant (P<0.05) outcomes against overrun, standup time, viscosity and melt-ability. Soy milk
ice cream development with natural stabilizers such as starches can be cost effective and provide more health benefits.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.