xSpot is a fast, reliable, and easy-to-use intra-operative image registration tool that works with most C-arms. It intuitively brings C-arm images into surgical navigation for an efficient workflow. The autoclavable xSpot is suitable for use in the sterile operating room environment without needing attachment to the C-arm or specific positioning, providing accurate registered images with only minimal orientation of its marker spheres.
Learn more: https://www.brainlab.com/curve
Curve™ Image Guided Surgery challenges conventional navigation utility. Super smart ergonomics, multi-directional touch terminals, digital HD, hi-fi and wifi* (*FDA clearance pending). Together we empower surgeons with the latest image-guided computer technology and navigation information, increasing the power to foster collaboration and potentially improve patient outcomes.
Learn more: https://www.brainlab.com/airo
Designed to function inside existing O.R. suites, Airo boasts an ultra-small
footprint, effectively eliminating the need for construction or custom build-outs. A cohesive imaging, patient positioning and navigation solution, Airo is ideal for cranial, spine and trauma procedures, making it a highly versatile intraoperative imaging system. High CT image quality increases surgeon confidence and supports advanced minimally invasive surgery.
Learn more: https://www.brainlab.com/spinal-navigation
Brainlab Spinal Navigation combines state-of-the-art touch screen based image control with best-in-class registration methods for image-guided surgery. As an open navigation platform, Brainlab Spinal Navigation enables accurate pedicle screw placement as well as drastic reduction of X-Ray exposure to both the surgical team and the patient. Navigation of implants and instruments is possible in 2D images, 3D fluoroscopy scans, MR or CT datasets in all stages of surgery—from incision planning to implant placement.
Brainlab Cranial Navigation. Efficiently combining decisive aspects of neurosurgery.
Brainlab® Cranial 3.0 provides a new user experience on Kick® and Curve™ navigation platforms. Fully
DICOM-based, cranial navigation and Brainlab Elements* can run parallel with instant synchronization
to update navigated image sets with new fusion results, SmartBrush® objects or trajectories.
Learn more: https://www.brainlab.com/traumacad
TraumaCad® Joints—Automatic Hip Replacement Planning automatically aligns implants to their anatomic landmarks, performs a virtual resection and assembles components at their attachment points to calculate the resulting leg length and offset. Leg Length and Offset Optimization allows the physician to vary the component size and position, and see the impact on leg length and offset on the reduced hip. Post Operative Evaluation determines acetabular cup anteversion and inclination as well as femoral neck shaft version and inclination on the post-op AP X-Ray.
Learn more: https://www.brainlab.com/elements
Brainlab Elements brings instant access to a suite of radiotherapy pre-planning solutions that work seamlessly together, delivering capability without complexity. Clinicians define the individual elements they need based on their case load, patient need and departmental infrastructure. Brainlab Elements bridge departments and offer working, scalable connections between clinical subspecialties like neurosurgery, spine surgery, orthopedics and radiation oncology. No other company brings it all together like Brainlab.
My current project deals with bringing perception to ultrasound devices. I work on the application of deep learning to medical imaging. Sounds interesting? drop me a line!
Learn more: https://www.brainlab.com/curve
Curve™ Image Guided Surgery challenges conventional navigation utility. Super smart ergonomics, multi-directional touch terminals, digital HD, hi-fi and wifi* (*FDA clearance pending). Together we empower surgeons with the latest image-guided computer technology and navigation information, increasing the power to foster collaboration and potentially improve patient outcomes.
Learn more: https://www.brainlab.com/airo
Designed to function inside existing O.R. suites, Airo boasts an ultra-small
footprint, effectively eliminating the need for construction or custom build-outs. A cohesive imaging, patient positioning and navigation solution, Airo is ideal for cranial, spine and trauma procedures, making it a highly versatile intraoperative imaging system. High CT image quality increases surgeon confidence and supports advanced minimally invasive surgery.
Learn more: https://www.brainlab.com/spinal-navigation
Brainlab Spinal Navigation combines state-of-the-art touch screen based image control with best-in-class registration methods for image-guided surgery. As an open navigation platform, Brainlab Spinal Navigation enables accurate pedicle screw placement as well as drastic reduction of X-Ray exposure to both the surgical team and the patient. Navigation of implants and instruments is possible in 2D images, 3D fluoroscopy scans, MR or CT datasets in all stages of surgery—from incision planning to implant placement.
Brainlab Cranial Navigation. Efficiently combining decisive aspects of neurosurgery.
Brainlab® Cranial 3.0 provides a new user experience on Kick® and Curve™ navigation platforms. Fully
DICOM-based, cranial navigation and Brainlab Elements* can run parallel with instant synchronization
to update navigated image sets with new fusion results, SmartBrush® objects or trajectories.
Learn more: https://www.brainlab.com/traumacad
TraumaCad® Joints—Automatic Hip Replacement Planning automatically aligns implants to their anatomic landmarks, performs a virtual resection and assembles components at their attachment points to calculate the resulting leg length and offset. Leg Length and Offset Optimization allows the physician to vary the component size and position, and see the impact on leg length and offset on the reduced hip. Post Operative Evaluation determines acetabular cup anteversion and inclination as well as femoral neck shaft version and inclination on the post-op AP X-Ray.
Learn more: https://www.brainlab.com/elements
Brainlab Elements brings instant access to a suite of radiotherapy pre-planning solutions that work seamlessly together, delivering capability without complexity. Clinicians define the individual elements they need based on their case load, patient need and departmental infrastructure. Brainlab Elements bridge departments and offer working, scalable connections between clinical subspecialties like neurosurgery, spine surgery, orthopedics and radiation oncology. No other company brings it all together like Brainlab.
My current project deals with bringing perception to ultrasound devices. I work on the application of deep learning to medical imaging. Sounds interesting? drop me a line!
Learn more: https://www.brainlab.com/surgery-products
Abstract
Introduction “Navigation in surgery” spans a broad area, which, depending on the clinical challenge, can have different meanings. Over the past decade, navigation in surgery has evolved beyond imaging modalities and bulky systems into the rich networking of the cloud or devices that are pocket-sized.
Discussion
This article will review various aspects of navigation in the operating room and beyond. This includes a short history of navigation, the evolution of surgical navigation, as well as technical aspects and clinical benefits with examples from neurosurgery, spinal surgery, and orthopedics.
Conclusion
With improved computer technology and a trend towards advanced information processing within hospitals, navigation is quickly becoming an integral part in the surgical routine of clinicians.
Excerpt:
Over the last three decades, technical advances have significantly changed the way we live. From computers to smartphones, from single purpose to multipurpose devices, technology has become an intrinsic part of our daily routine. Navigation in surgery is an important example of today’s technological capabilities being applied to medicine. It has emerged as one of the most reliable representatives of technology as it continues to transform surgical interventions into safer and less invasive procedures. In surgery, navigation has spurred technical progress, enabled more daring procedures, and unlocked new synergies. What was once a simple localization tool has evolved into a centerpiece of technology in the surgical theater.
“Navigation in surgery” spans a broad area, which, depending on the clinical challenge, may have various interpretations. The meaning of navigation in surgery is most accurately defined by the questions posed: “Where is my (anatomical) target?”, “How do I reach my target safely?”, “Where am I (anatomically)?”, or “Where and how shall I position my implant?”. Apart from these important anatomical orientation questions, surgical navigation is also used as a measurement tool and an information center for providing surgeons with the right information at the right time.
There are examples of technological advances in the medical field, whose benefit to the patient became immediately evident which were rapidly adopted and integrated into the clinical routine—without the need for proper randomized clinical trials. Examples range from the introduction of anesthesia to enable safer surgery and the introduction of microscopy enabling microsurgery. Surgical navigation and its wide range of benefits could be next.
Learn more: https://www.brainlab.com/surgery-products
Abstract
Introduction “Navigation in surgery” spans a broad area, which, depending on the clinical challenge, can have different meanings. Over the past decade, navigation in surgery has evolved beyond imaging modalities and bulky systems into the rich networking of the cloud or devices that are pocket-sized.
Discussion
This article will review various aspects of navigation in the operating room and beyond. This includes a short history of navigation, the evolution of surgical navigation, as well as technical aspects and clinical benefits with examples from neurosurgery, spinal surgery, and orthopedics.
Conclusion
With improved computer technology and a trend towards advanced information processing within hospitals, navigation is quickly becoming an integral part in the surgical routine of clinicians.
Excerpt:
Over the last three decades, technical advances have significantly changed the way we live. From computers to smartphones, from single purpose to multipurpose devices, technology has become an intrinsic part of our daily routine. Navigation in surgery is an important example of today’s technological capabilities being applied to medicine. It has emerged as one of the most reliable representatives of technology as it continues to transform surgical interventions into safer and less invasive procedures. In surgery, navigation has spurred technical progress, enabled more daring procedures, and unlocked new synergies. What was once a simple localization tool has evolved into a centerpiece of technology in the surgical theater.
“Navigation in surgery” spans a broad area, which, depending on the clinical challenge, may have various interpretations. The meaning of navigation in surgery is most accurately defined by the questions posed: “Where is my (anatomical) target?”, “How do I reach my target safely?”, “Where am I (anatomically)?”, or “Where and how shall I position my implant?”. Apart from these important anatomical orientation questions, surgical navigation is also used as a measurement tool and an information center for providing surgeons with the right information at the right time.
There are examples of technological advances in the medical field, whose benefit to the patient became immediately evident which were rapidly adopted and integrated into the clinical routine—without the need for proper randomized clinical trials. Examples range from the introduction of anesthesia to enable safer surgery and the introduction of microscopy enabling microsurgery. Surgical navigation and its wide range of benefits could be next.
Jambey Clinkscales gave presentation on "The Value of Cloud in the Business Technology Ecosystem" at the 2011 BDPA Technology Conference in Chicago.
Jambey shared his thoughts on the workshop during BDPA iRadio Show interview held on August 28, 2011 --> http://www.blogtalkradio.com/bdpa/2011/08/29/bdpa-iradio-workshop-presenters
Workshop Presenter:
Jambey Clinkscales
Capabilites and Program Manager, HP Enterprise Services
Topic: The Value of the Cloud in the Business Technology Ecology
BDPA New York Chapter
Middle East and North Africa Internet Technologies (MenaITech).
is the first software company in the Arab region specialized in the development and distribution of Human Resources solutions to top public and private organizations of various countries operating in the Middle East and North Africa.
Founded in 2003 by a group of talented and experienced HR and IT professionals, MenaITech helps organizations implement best practices in recruitment cycles, employment offerings, performance management, skills inventory, employee development and relations, and much more.
El Máster Social Media / Gestión de Redes de la Cámara de ÁlavaSMÁlava junto a su partner académico la Asociación Española de Responsables de Comunidad Online y Profesionales Social Media AERCO-PSM comienza el 2 de marzo de 2017. El programa contempla 128 horas de formación, 1 Masterclass, 1 Taller de Experiencias, 2 Workshops, 2 Business Cases, 250 horas de prácticas y Trabajo Fin de Master.
Evaluación preliminar de los recursos prospectivos de hidrocarburos convencio...Shale Gas España
España es un país poco explorado, pero con gran potencial para generar recursos energéticos propios, tanto en el terreno del gas convencional y no convencional, como en el del petróleo. Así lo confirma el informe presentado por la Asociación Española de Compañías de Investigación, Exploración y Producción de Hidrocarburos y Almacenamiento Subterráneo (ACIEP) en colaboración con GESSAL, compañía española de referencia internacional en la exploración del subsuelo. Según el informe “Evaluación preliminar de los recursos prospectivos de hidrocarburos convencionales y no convencionales en España”, los recursos prospectivos potenciales de gas (convencional y no convencional) en España ascienden a 2.500 BCM (miles de millones de m3 de gas) –en su estimación media-. Esta cantidad equivale a 70 años de consumo en España, tomando como base los estándares de hoy en día. Con la cotización actual del gas, su valor en el mercado alcanzaría los 700.000 millones de euros.
Estudio estructural del mito aplicando las funciones de Propp y comparando su contenido con el cuento "La bella y la Bestia" de Madame Leprince de Bearmount, la pelicula de Disney "La Bella y la Bestia" y la pelicula "La bestia" estrenada en el 2007 y el libro en el que se basa "Bestial" de Alex Flinn
Addressing all major perimetry needs, the Octopus 900 is the visual field analyser of choice for anyone who wants the diagnostic flexibility to analyse, assess and track patients’ visual fields.
Advanced diagnostic ultrasound system with eHD technology and CrystaLine configuration.
What is CrystaLine?
Improved imaging
in difficult to scan
patients.
Major technical improvements
provided by CrystaLine include the
CPI Technology to increase depth
of field, improving the imaging of
deep structures in difficult-to scan
individuals.
iScan80, the high-speed 80kHz OCT that sets the
standard for efficiency - perfect for ECPs seeking an affordable and versatile OCT system. It’s ideal for
practices with limited staff since iScan80 delivers consistent scan acquisition with minimal training and
vocally guides patients through an entire exam in any of 12 languages.
Introducing a 2D (X-Y) Joystick controlled stage I designed and built for Optical Tweezers, but could be used with any inverted microscope. This was a low budget stage system composed of parts from different vendors.
arivis Vision4D - IMAGE ANALYSIS WHICH FITS YOUR DATA (2 pages, 2020)Johannes Amon
arivis Vision4D is the leading software for exploring and analysing large multi-dimensional image datasets created by confocal, Light Sheet, Multi-Photon or Electron Microscopy. arivis Vision4D can handle several hundred Gigabytes or terabytes of such image data as easily as if they were just a few megabytes in size.
The Octopus 900 is the only perimeter that retains the capabilities and specifications of the original Goldmann standard. With its true Goldmann-sized cupola, it performs accurate manual and automated Goldmann perimetry.
Whether you need fast screenings, early detection, general thresholding or kinetic testing for neuro and end-stage pathologies, the Octopus 900 provides astounding flexibility.
The GE Logiq E9, is a premium shared service ultrasound machine capable of top of the line women's health and 4D imaging along with top notch imaging for radiology, cardiac and vascular applications.
Similar to xSpot Intraoperative Image Registration for C-arm Navigation Flyer (20)
Learn more: https://www.brainlab.com/traumacad
VoyantMark™—Accurately calibrate images and measure patient anatomy. VoyantMark is a single marker X-Ray calibration and marking device. Designed specifically to work with TraumaCad® surgical planning software, VoyantMark aids in accurately measuring patient anatomy—hip, knee, shoulder, ankle and foot.
iPlan BOLD MRI Mapping Clinical White PaperBrainlab
Learn more: https://www.brainlab.com/fibertracking-software
With iPlan BOLD MRI Mapping, anatomical images are enhanced with functional maps showing areas of the brain that are responsible for important motoric or cognitive functions. iPlan BOLD MRI Mapping can be easily combined with iPlan FiberTracking to provide a powerful and comprehensive functional package with information about vital functional areas and significant white matter structures.
Stereotactic Radiosurgery and Radiotherapy of Pituitary Adenomas Clinical Whi...Brainlab
Learn more: https://www.brainlab.com/iplan-rt
Pituitary adenomas (PAs) are the third most common intracranial tumors in surgical practice, accounting for approximately 10 to 25% of all intracranial neoplasms. Radiological series suggest that unsuspected PAs may be present in one out of six people and autopsy specimens reveal a prevalence of 14%. Histopathologically, PAs are mostly benign lesions located on the anterior lobe of the pituitary gland. Because of their invasive growth tendency, these adenomas may cause significant morbidity in affected patients, expressed by visual, endocrinologic and neurologic symptoms.
Monte Carlo Dose Algorithm Clinical White PaperBrainlab
Learn more: https://www.brainlab.com/iplan-rt
Conventional dose calculation algorithms, such as Pencil Beam are proven effective for tumors located in homogeneous regions with similar tissue consistency such as the brain. However, these algorithms tend to overestimate the dose distribution in tumors diagnosed in extracranial regions such as in the lung and head and neck regions where large inhomogeneities exist. Due to the inconsistencies seen in current calculation methods for extracranial treatments and the need for more precise radiation delivery, research has led to the creation and integration of improved calculation methods into treatment planning software.
Stereotactic Radiotherapy of Recurrent Malignant Gliomas Clinical White PaperBrainlab
Learn more: https://www.brainlab.com/intraoperative-mri
Tumors of the central nervous system (CNS) represent approximately 176,000 newly diagnosed cases worldwide per year, with an estimated annual mortality of 128,000. Malignant gliomas comprise 30% of all primary CNS tumors and remain one of the greatest challenges in oncology today, despite access to state-of-the-art surgery, imaging, radiotherapy and chemotherapy.
Stereotactic Radiosurgery and Radiotherapy of Brain Metastases Clinical White...Brainlab
Learn more: https://www.brainlab.com/iplan-rt
Brain metastases are a common manifestation of systemic cancer constituting as much as 30% of all intracranial malignant tumors. Each year, 15 to 30% of cancer patients develop brain metastases, yielding an incidence of over 100,000 patients in the US. Development of brain metastases leads directly to the patient’s death in the majority of cases.
Stereotactic Radiosurgery of Arteriovenous Malformations Clinical White PaperBrainlab
Learn more: https://www.brainlab.com/radiosurgery-products/
Despite the low prevalence—between 0.04% and 0.52%—in the general population, intracranial arteriovenous malformations (AVMs) are the leading cause of nontraumatic intracerebral hemorrhage in people younger than 35 years old. Intracranial AVMs are congenital anomalies developing between the fourth and eighth week of intrauterine life. They consist of the persistence of connections between an artery and a vein without the interposition of a capillary bed, typically under a high-flow regimen.
Stereotactic Radiotherapy for the Treatment of Acoustic Neuromas Clinical Whi...Brainlab
Learn more: https://www.brainlab.com/radiosurgery-products/
Acoustic neuromas (AN) have an annual incidence of approximately one per 100,000 people and may account for up to 8% of all new tumors presenting to a neurosurgical referral practice. Acoustic neuromas are benign tumors arising from Schwann cells from the vestibular branch of the eighth cranial nerve. Nevertheless, they can pursue a potentially aggressive course, with uncontrolled local growth resulting in compression of the brainstem and fourth ventricle, cranial nerve and other neurological deficits.
Learn more: https://www.brainlab.com/iplan-rt
iPlan® Monte Carlo dose calculation offers fast, accurate dose calculations for more precise treatment of extracranial indications—expanding SBRT treatment possibilities. iPlan Monte Carlo performs dose calculations within seconds for conformal beam and dynamic arc treatments and within minutes for complex IMRT cases. Seamless integration allows for use with all major linear accelerators and multi-leaf collimator (MLC) types. This advanced calculation method eliminates treatment area restrictions of conventional dose calculation algorithms for highly precise treatment delivery to inhomogeneous regions including lung and head & neck indications.
Learn more: https://www.brainlab.com/iplan-rt
HybridArc™ intelligently combines two proven, conformal treatment methods for radiosurgery with automated and optimized blending—in seconds—of modulated dynamic conformal arcs and discrete IMRT technology. As part of the iPlan® family of planning and treatment software, HybridArc enables rotational volumetric dose shaping and streamlines both simple and complex treatment planning. Flexible integration makes HybridArc ideal for both the latest advancements in linac technology, as well as established linear accelerators.
Learn more: https://www.brainlab.com/iplan-rt
Less aggressive surgical resection. More functional preservation. Adaptive Hybrid Surgery defines where surgery stops and radiosurgery begins. Today more than half of all cranial benign neoplasms are surgically mitigated with preservation techniques. Combining surgery with radiosurgery offers the best and most durable tumor control while offering the same low surgical risks as preservation surgery on its own.
Stereotactic Radiosurgery for the Treatment of Trigeminal Neuralgia Clinical ...Brainlab
Learn more: https://www.brainlab.com/iplan-rt
Trigeminal neuralgia (TN) is well defined and one of the most common causes of facial pain, especially in the elderly. It usually occurs as one-sided, severe, brief, recurrent episodes of spontaneous or stimulation triggered facial pain in the territory of one or more branches of the trigeminal nerve.
Learn more: https://www.brainlab.com/quentry
Quentry® is an online service by Brainlab for image transfer, sharing and collaboration. It provides physicians a safe environment to access, control and share diagnostic images and documents. Built on a secure, HIPAA-compliant infrastructure, Quentry supports clinicians throughout the referral, diagnosis, planning and treatment workflow. Physicians can join and connect with each other for free and build a medical referral network, either for individual or hospital use.
Learn more: https://www.brainlab.com/traumacad
VoyantMark is a single marker X-ray calibration and marking device.
Designed specifically to work with TraumaCad® surgical planning software,
VoyantMark aids in accurately measuring patient anatomy— hip, knee, shoulder, ankle and foot.
TraumaCad Orthopedic Digital Templating BrochureBrainlab
Learn more: https://www.brainlab.com/traumacad
TraumaCad® provides orthopedic surgeons with digital tools to perform
preoperative planning and simulates the expected results prior to surgery.
Using digital images on-screen, you can perform measurements, fix prostheses, simulate osteotomies and visualize fracture reductions.
Learn more: https://www.brainlab.com/intraoperative-ultrasound
Brainlab Ultrasound Integration fuses intra-operative ultrasound information with navigated patient data. Brainlab® neuronavigation features live anatomical updates that are overlaid directly onto pre-operative data, offering clinicians advanced resection control and brain shift compensation. Neuronavigation provides ultrasound probe orientation for easy image interpretation. Surgeons are also aided by composite views of intra-operative ultrasound and reformatted CT and MR images.
Learn more: https://www.brainlab.com/microscope-integration
Recognizing that neurosurgeons perform most of their procedures while looking through a microscope and not the navigation screen, Brainlab Cranial Navigation Software supports all major neurosurgery microscopes with improved image integration. Passive markers attached to the microscope enable positional tracking, allowing for ergonomic position orientation, as well as Autofocus on the navigated tool.
Buzz Digital O.R. Technical Specifications Brainlab
Learn more: https://www.brainlab.com/buzz
A complete and detailed list of the technical specifications of Buzz Digital O.R. Next-generation OR Integration platform based on computer and network technology rather than classical rack-based hardware. Efficiently designed to
route medical images, patient data and video sources to be viewed within an
OR environment.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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