Muscular dystrophy is a genetic disorder that causes progressive muscle weakness. It is characterized by defects in muscle proteins and affects skeletal, heart and smooth muscles. The main symptoms are muscle weakness and deterioration over time, leading to difficulties with movement. There are many types of muscular dystrophy but they all involve degeneration of muscle fibers. Currently there is no cure, but treatment focuses on managing symptoms and slowing disease progression through exercise, physical therapy and other means. Researchers are working on developing new treatments such as gene therapy.
Bruce Hamilton - Classification and Grading of Muscle InjuriesMuscleTech Network
Bruce Hamilton
Sports medicine physician, High Performance Center, Oakland, New Zeeland,
-
Classification and Grading of Muscle Injuries: A Review of the Literature
(6th MuscleTech Network Workshop)
14th October, Barcelona
Starting from a clinical case where a professional soccer player tear your acl with a concomitant ramp lesion and a detatchment of the lateral meniscus and popliteo fibular ligament we spek about the acl rehab and the not usual knee injury rehabilitation.
from the annual The Battle Sports Medicine Congress helded in Cesena (ITA) Technogym Village
Sports Injury Prevention Hygiene and Nutrition in athlete Follball players I Dr.RAJAT JANGIR JAIPUR
#aclsurgeryjaipur #aclsurgeryhindia #aclsurgerytaekwondo
Acl reconstruction in jaipur | Acl reconstruction in taekwondo | Acl injury in football player surgery | Acl reconstruction surgery in football | acl surgery | Acl surgery ke baad physiotherapy | Acl surgery in jaipur | acl surgery recovery | Best acl surgeon in jaipur | Best ligament doctor in hindi | Best acl surgeon in india | Meniscus repair surgery in jaipur | Sports injury doctor | Acl injury in football players | Acl injury in taekwondo | acl tear | Best knee surgeon in jaipur
#allinsideacl #internalbrace #drrajatjangir #bestaclsurgeon #aclexpert #bestkneesurgeon
To Know more about ACL Injury, Click the links below:
1. ACL surgery 7 different Techniques we do at our center - "Not single technique best for all"
https://youtu.be/oWkIr8IXvr8
2. Everything about ACL Injury tear surgery in Hindi I
https://youtu.be/bqpjkAkwZ14
3. Best Screw for ACL tear surgery in Hindi
https://youtu.be/1LGpU1NHiIs
4. ACL Injury Tear Surgery Recovery : All your questions & queries solved by Dr.Rajat Jangir
https://youtu.be/SIAPWiMbOqs
5. Partial ACL Tear Surgery or not ! ACL आधा टूटा हो तो क्या करें ?
https://youtu.be/NEJRPKskJTI
6. 5 Symptoms of ACL Injury tear इंजरी के पांच लक्षण ?
https://youtu.be/EXpgy19Jxzw
7. PRP injection therapy in Partial ACL TEARs
https://youtu.be/qyG1EYgS87E
Dr.RAJAT JANGIR(Asso Prof.)
Senior Consultant Arthroscopy and Joint Replacement
(Specialist in Shoulder Knee Hip Surgery)
Ligament and Joints Clinic
67/34 Mansarovar Jaipur
Whatsapp: shorturl.at/gnAEP
Appointment: +91 8104855900
Email: ligamentsurgeon@gmail.com
Google Page: https://g.page/KNEE-Shoulder-SURGERY?...
Facebook: https://www.facebook.com/Ligamentandj...
* Vast experience and specialisation in the field of Arthroscopy and sports surgery.
* M.S. orthopaedics from BJ Medical College, Civil hospital, Ahmedabad
* Fellowship in Arthroscopy and Sports injury with Prof Joon Ho Wang at Samsung Medical Center, South Korea
* Diploma in Sports Medicine from InternationaI Olympic Committee
* Invited as Athlete Medical Doctor at Rio Olympic 2016
* Done Rajasthan's first "All Inside Physeal Preserving ACL reconstruction" in 13 year old Athlete
Dr.Rajat is rated as one of the best orthopedic surgeon with with excellence in Knee Shoulder Arthroscopy surgeries as replacements'
Bruce Hamilton - Classification and Grading of Muscle InjuriesMuscleTech Network
Bruce Hamilton
Sports medicine physician, High Performance Center, Oakland, New Zeeland,
-
Classification and Grading of Muscle Injuries: A Review of the Literature
(6th MuscleTech Network Workshop)
14th October, Barcelona
Starting from a clinical case where a professional soccer player tear your acl with a concomitant ramp lesion and a detatchment of the lateral meniscus and popliteo fibular ligament we spek about the acl rehab and the not usual knee injury rehabilitation.
from the annual The Battle Sports Medicine Congress helded in Cesena (ITA) Technogym Village
Sports Injury Prevention Hygiene and Nutrition in athlete Follball players I Dr.RAJAT JANGIR JAIPUR
#aclsurgeryjaipur #aclsurgeryhindia #aclsurgerytaekwondo
Acl reconstruction in jaipur | Acl reconstruction in taekwondo | Acl injury in football player surgery | Acl reconstruction surgery in football | acl surgery | Acl surgery ke baad physiotherapy | Acl surgery in jaipur | acl surgery recovery | Best acl surgeon in jaipur | Best ligament doctor in hindi | Best acl surgeon in india | Meniscus repair surgery in jaipur | Sports injury doctor | Acl injury in football players | Acl injury in taekwondo | acl tear | Best knee surgeon in jaipur
#allinsideacl #internalbrace #drrajatjangir #bestaclsurgeon #aclexpert #bestkneesurgeon
To Know more about ACL Injury, Click the links below:
1. ACL surgery 7 different Techniques we do at our center - "Not single technique best for all"
https://youtu.be/oWkIr8IXvr8
2. Everything about ACL Injury tear surgery in Hindi I
https://youtu.be/bqpjkAkwZ14
3. Best Screw for ACL tear surgery in Hindi
https://youtu.be/1LGpU1NHiIs
4. ACL Injury Tear Surgery Recovery : All your questions & queries solved by Dr.Rajat Jangir
https://youtu.be/SIAPWiMbOqs
5. Partial ACL Tear Surgery or not ! ACL आधा टूटा हो तो क्या करें ?
https://youtu.be/NEJRPKskJTI
6. 5 Symptoms of ACL Injury tear इंजरी के पांच लक्षण ?
https://youtu.be/EXpgy19Jxzw
7. PRP injection therapy in Partial ACL TEARs
https://youtu.be/qyG1EYgS87E
Dr.RAJAT JANGIR(Asso Prof.)
Senior Consultant Arthroscopy and Joint Replacement
(Specialist in Shoulder Knee Hip Surgery)
Ligament and Joints Clinic
67/34 Mansarovar Jaipur
Whatsapp: shorturl.at/gnAEP
Appointment: +91 8104855900
Email: ligamentsurgeon@gmail.com
Google Page: https://g.page/KNEE-Shoulder-SURGERY?...
Facebook: https://www.facebook.com/Ligamentandj...
* Vast experience and specialisation in the field of Arthroscopy and sports surgery.
* M.S. orthopaedics from BJ Medical College, Civil hospital, Ahmedabad
* Fellowship in Arthroscopy and Sports injury with Prof Joon Ho Wang at Samsung Medical Center, South Korea
* Diploma in Sports Medicine from InternationaI Olympic Committee
* Invited as Athlete Medical Doctor at Rio Olympic 2016
* Done Rajasthan's first "All Inside Physeal Preserving ACL reconstruction" in 13 year old Athlete
Dr.Rajat is rated as one of the best orthopedic surgeon with with excellence in Knee Shoulder Arthroscopy surgeries as replacements'
Treatment options of Tendinopathy in Athletes: Tendon Overload
#aclsurgeryjaipur #aclsurgeryhindia #aclsurgerytaekwondo
Acl reconstruction in jaipur | Acl reconstruction in taekwondo | Acl injury in football player surgery | Acl reconstruction surgery in football | acl surgery | Acl surgery ke baad physiotherapy | Acl surgery in jaipur | acl surgery recovery | Best acl surgeon in jaipur | Best ligament doctor in hindi | Best acl surgeon in india | Meniscus repair surgery in jaipur | Sports injury doctor | Acl injury in football players | Acl injury in taekwondo | acl tear | Best knee surgeon in jaipur
#allinsideacl #internalbrace #drrajatjangir #bestaclsurgeon #aclexpert #bestkneesurgeon
To Know more about ACL Injury, Click the links below:
1. ACL surgery 7 different Techniques we do at our center - "Not single technique best for all"
https://youtu.be/oWkIr8IXvr8
2. Everything about ACL Injury tear surgery in Hindi I
https://youtu.be/bqpjkAkwZ14
3. Best Screw for ACL tear surgery in Hindi
https://youtu.be/1LGpU1NHiIs
4. ACL Injury Tear Surgery Recovery : All your questions & queries solved by Dr.Rajat Jangir
https://youtu.be/SIAPWiMbOqs
5. Partial ACL Tear Surgery or not ! ACL आधा टूटा हो तो क्या करें ?
https://youtu.be/NEJRPKskJTI
6. 5 Symptoms of ACL Injury tear इंजरी के पांच लक्षण ?
https://youtu.be/EXpgy19Jxzw
7. PRP injection therapy in Partial ACL TEARs
https://youtu.be/qyG1EYgS87E
Dr.RAJAT JANGIR(Asso Prof.)
Senior Consultant Arthroscopy and Joint Replacement
(Specialist in Shoulder Knee Hip Surgery)
Ligament and Joints Clinic
67/34 Mansarovar Jaipur
Whatsapp: shorturl.at/gnAEP
Appointment: +91 8104855900
Email: ligamentsurgeon@gmail.com
Google Page: https://g.page/KNEE-Shoulder-SURGERY?...
Facebook: https://www.facebook.com/Ligamentandj...
* Vast experience and specialisation in the field of Arthroscopy and sports surgery.
* M.S. orthopaedics from BJ Medical College, Civil hospital, Ahmedabad
* Fellowship in Arthroscopy and Sports injury with Prof Joon Ho Wang at Samsung Medical Center, South Korea
* Diploma in Sports Medicine from InternationaI Olympic Committee
* Invited as Athlete Medical Doctor at Rio Olympic 2016
* Done Rajasthan's first "All Inside Physeal Preserving ACL reconstruction" in 13 year old Athlete
Dr.Rajat is rated as one of the best orthopedic surgeon with with excellence in Knee Shoulder Arthroscopy surgeries as replacements'
Be Your Own Health Expert - OsteoarthritisMogrify Studio
Learn the difference between “osteoporosis,” “osteoarthrosis,” and “osteoarthritis,” and how to manage inflammation in the joints with diet and exercise.
Anthony Shield - does strength in the nhe predict hamstring injury MuscleTech Network
Anthony Shield
Senior lecturer, School of Exercise and Nutrition Science Institute of Health and Biomedical Innovation Queensland University of Technology, Brisbane, Australia.
-
Does strength in the Nordic hamstring exercise predict hamstring injury?
(&th MuscleTech Network workshop)
14th October, Barcelona
Conservative Management of Knee osteoarthritisEsserHealth
Osteoarthritis is a major burden on personal health and international health care expenditures. Learn the basics of osteoarthritis and conservative management options for the physician.
Female athletes are six times as liable as male athletes to be injured playing sport. One of the most common of those is the ACL or anterior cruciate ligament. Dr. Connie Lebrun, MD, sports medicine physician at the Glen Sather Sports Medicine Clinic at the University of Alberta discusses causes and treatment of the injury.
Treatment options of Tendinopathy in Athletes: Tendon Overload
#aclsurgeryjaipur #aclsurgeryhindia #aclsurgerytaekwondo
Acl reconstruction in jaipur | Acl reconstruction in taekwondo | Acl injury in football player surgery | Acl reconstruction surgery in football | acl surgery | Acl surgery ke baad physiotherapy | Acl surgery in jaipur | acl surgery recovery | Best acl surgeon in jaipur | Best ligament doctor in hindi | Best acl surgeon in india | Meniscus repair surgery in jaipur | Sports injury doctor | Acl injury in football players | Acl injury in taekwondo | acl tear | Best knee surgeon in jaipur
#allinsideacl #internalbrace #drrajatjangir #bestaclsurgeon #aclexpert #bestkneesurgeon
To Know more about ACL Injury, Click the links below:
1. ACL surgery 7 different Techniques we do at our center - "Not single technique best for all"
https://youtu.be/oWkIr8IXvr8
2. Everything about ACL Injury tear surgery in Hindi I
https://youtu.be/bqpjkAkwZ14
3. Best Screw for ACL tear surgery in Hindi
https://youtu.be/1LGpU1NHiIs
4. ACL Injury Tear Surgery Recovery : All your questions & queries solved by Dr.Rajat Jangir
https://youtu.be/SIAPWiMbOqs
5. Partial ACL Tear Surgery or not ! ACL आधा टूटा हो तो क्या करें ?
https://youtu.be/NEJRPKskJTI
6. 5 Symptoms of ACL Injury tear इंजरी के पांच लक्षण ?
https://youtu.be/EXpgy19Jxzw
7. PRP injection therapy in Partial ACL TEARs
https://youtu.be/qyG1EYgS87E
Dr.RAJAT JANGIR(Asso Prof.)
Senior Consultant Arthroscopy and Joint Replacement
(Specialist in Shoulder Knee Hip Surgery)
Ligament and Joints Clinic
67/34 Mansarovar Jaipur
Whatsapp: shorturl.at/gnAEP
Appointment: +91 8104855900
Email: ligamentsurgeon@gmail.com
Google Page: https://g.page/KNEE-Shoulder-SURGERY?...
Facebook: https://www.facebook.com/Ligamentandj...
* Vast experience and specialisation in the field of Arthroscopy and sports surgery.
* M.S. orthopaedics from BJ Medical College, Civil hospital, Ahmedabad
* Fellowship in Arthroscopy and Sports injury with Prof Joon Ho Wang at Samsung Medical Center, South Korea
* Diploma in Sports Medicine from InternationaI Olympic Committee
* Invited as Athlete Medical Doctor at Rio Olympic 2016
* Done Rajasthan's first "All Inside Physeal Preserving ACL reconstruction" in 13 year old Athlete
Dr.Rajat is rated as one of the best orthopedic surgeon with with excellence in Knee Shoulder Arthroscopy surgeries as replacements'
Be Your Own Health Expert - OsteoarthritisMogrify Studio
Learn the difference between “osteoporosis,” “osteoarthrosis,” and “osteoarthritis,” and how to manage inflammation in the joints with diet and exercise.
Anthony Shield - does strength in the nhe predict hamstring injury MuscleTech Network
Anthony Shield
Senior lecturer, School of Exercise and Nutrition Science Institute of Health and Biomedical Innovation Queensland University of Technology, Brisbane, Australia.
-
Does strength in the Nordic hamstring exercise predict hamstring injury?
(&th MuscleTech Network workshop)
14th October, Barcelona
Conservative Management of Knee osteoarthritisEsserHealth
Osteoarthritis is a major burden on personal health and international health care expenditures. Learn the basics of osteoarthritis and conservative management options for the physician.
Female athletes are six times as liable as male athletes to be injured playing sport. One of the most common of those is the ACL or anterior cruciate ligament. Dr. Connie Lebrun, MD, sports medicine physician at the Glen Sather Sports Medicine Clinic at the University of Alberta discusses causes and treatment of the injury.
In his Master of Science in Osteopathy (M.Sc.O) thesis for London College of Osteopathy and Health Sciences (LCO), Dr. Arun Vijayan explores the potential benefits of osteopathic treatment techniques on symptoms related to Multiple Sclerosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
Senior Project Research paper
1. Courtney Wintzell
October 18, 2011
1st period
Muscular Dystrophy Disease
Muscular Dystrophy is a number of disorders that decrease the function of the muscles and
others that control the internal organs. The meaning of muscular dystrophy means that the
nourishment for the muscles is defective (Abramovitz 15-29). All muscular dystrophy diseases
have three things in common: they are all hereditary, they are all progressive; and each have
characteristics and continue weakness. The word dystrophy comes from the Greek words “dys,”
meaning abnormal, and “trophe,” which means nourishment (Abramovitz 15-29). Many of these
diseases are very critical to a person’s ability to be mobile. Muscular Dystrophy is caused by
gene mutations and is first shown at birth or later in childhood. Many doctors are trying to find
the treatment and cure for muscular dystrophy by doing research.
How the body works is with two different types of muscles. The types of muscles are
voluntary, smooth, and heart muscles. The human body contains 434 voluntary muscles, also
known as skeletal muscles (Abramovitz 15-29). How we move our muscles is by moving or
relaxing them. Our others muscles on the other hand such as smooth and heart muscles, do not
have to constantly control them. This disease only has to consist with voluntary muscles, but you
can also end up having heart and smooth muscle problems. When a person has a disease like
muscular dystrophy, their muscles lose the ability to contract and relax and begin to get weak
(Abramovitz 15-29).
2. Courtney Wintzell
October 18, 2011
1st period
Diagnosis of any type of Muscular Dystrophy can sometimes be difficult because many of
them resemble each other (Abramovitz, 15-29). Muscular Dystrophy was first described in 1830
by a Scottish surgeon Sir Charles Bell (Abramovitz 15-29). When a doctor tries to figure out
what kind of muscular dystrophy, he or she will send you to what is called neurologists. A
neurologist is a specialist in the nerves and muscle diseases (Abramovitz 15-29). If you have a
smaller aged child your doctor may tell you to go to a pediatrician who specializes in these kinds
of disorders in children. The doctor may also tell you that you will have heart weakness and
breathing problems so you would have to get more medical care for your disease. Your doctor
may also take your information on medical history in your family to see if MD runs in your
family. Your doctor may also perform a number of EMG tests that measures electrical activity in
the muscles (Abramovitz, Melissa). Muscular Dystrophy is diagnosed by a physical exam,
family history, and tests. This may also include a muscle biopsy, DNA testing, blood enzyme
testing, or nerve conduction tests (Web MD, 2011). If your doctor suspects you have Duchenne
or Becker Muscular Dystrophy, the muscle biopsy will show whether dystrophin protein is
missing or abnormal. Genetic testing is also used for some forms of muscle dystrophy (Web MD,
2011). There is no cure for Muscular Dystrophy, but therapy and medication slows the process of
the disease. Studies for gene therapy are being researched as we speak. For instance, scientists
are researching ways to insert a working dystrophin gene into muscles of boys with Duchenne
and Becker muscular dystrophies.
3. Courtney Wintzell
October 18, 2011
1st period
There are many different types of Muscular Dystrophy. One of the common kinds is Duchenne
Muscular Dystrophy Disease. DMD is one of the 10 muscular dystrophies that mainly affect
boys (Children’s Hospital of Boston). In DMD, the combination of not enough dystrophin and
inflammatory reactions causes the muscles to weaken and waste over time. This type of
Muscular Dystrophy is very fatal towards boys and young men and is dependent towards a
wheelchair and decline in cardiac and respiratory function (Children’s Hospital of Boston). One
team at Harvard medical school came up with a model for a cure for this type of Muscular
Dystrophy. Using a zebra fish model of DMD, Dr. Kunkel and his team set out to screen 1,200
chemicals already approved for human use for any that might restore muscle tissue (Children’s
Hospital of Boston). For this experiment, students tested 1,200 chemicals and only seven had the
restoration affect for a cure for DMD. DMD is characterized by severe pain, loss in ability to be
mobile, and possibly death. This affliction affects one and 3500 males, making it most prevalent
of Muscular Dystrophies (Children’s Hospital of Boston). The cause of this type of MD is a
mutation in the gene in the person’s chromosomes. Most affected boys do not survive beyond
their teens or early adulthood (Abramovitz 15-29). In older boys the first symptoms are falling,
having trouble running, and simple things such as getting up the stairs. Your child’s calf muscles
might eventually be enlarged because of the replacement of muscle tissue. Soon, the boy will
walk on his toes with the abdomen pushed forward because of the pelvic muscle weakness
(Abramovitz 15-29). Eventually the boy’s shoulders may be pushed back due to weakness
process of the disease.
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When you go to the doctor, your doctor asks you what your symptoms for your sickness are.
Symptoms in Muscular Dystrophy may be muscle weakness, apparent lack of coordination, and
progressive crippling resulting in fixations (Mayo Clinic Staff). Symptoms vary with different
types of Muscular Dystrophy. Each type of Muscular Dystrophy is different in age. Symptoms
for Muscular Dystrophy is frequent falls, large calf muscles, difficulty getting up, weakness of
the lower legs, waddling gait, and mild retardation in some cases (Mayo Clinic Staff). In the late
stages in this disease, fat and muscle tissue often replace with muscle fibers (Mayo Clinic Staff).
Before you go to the doctor, make a list of family history. Muscular Dystrophy may run in your
family, which may have caused your child to have this disease. Muscular Dystrophy is noticed at
birth but the symptoms aren’t present until the ages 3-5 years old (University of Maryland
Medical Center). If you are having suspicions about your child having MD, please call your
doctor right away to find out the results.
Doctors have been trying to find a way to develop new treatments for Muscular Dystrophy.
Today there is not much for MD. Once a doctor has diagnosed a patient with MD, he or she will
provide a treatment plan to the patients needs (Abramovitz 30-44). The conventional methods
include exercise, drugs that slow down or eliminate muscle wasting, anabolic steroids and
supplementation (Muscular dystrophy. N.P., 2007).This process is to help slow down the disease
or to reduce the symptoms. Researchers are trying to create gene therapies to treat MD.
Symptoms can be reduced by exercise, physical therapy, respiratory care, surgery and
rehabilitative devices (Muscular Dystrophy. N.p, 2007). When you go to the doctor for
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treatment, he or she will try to prevent you from having joint or spinal deformities. Another
person that your doctor might send you to is a physical therapist. A physical therapist that
specializes in designing appropriate exercise programs for people with disabilities (Abramovitz
30-44).
Living with Muscular Dystrophy is difficult in so many ways. When your child gets diagnosed
with MD, you might think to yourselves what I could have to done to prevent this or you just
blame yourselves. Psychologists encourage patients and families to talk about their feelings and
thoughts at each stage of the coping process in order to gain acceptance of the situation
(Abramovitz 60-74). Your psychologists help you to cope with your child having this disease
and finds ways to help to overcome the grief. One of the difficult decisions to make for example
to whether or not to have surgery or not to have surgery or to just let your child have a curved
spine for the rest of his or her life. The surgery has the potential to make the child more
comfortable and to preserve lung function by removing pressure on the lungs exerted by a curved
spine (Abramovitz 60-74). Another obstacle parents may face is whether or not to tell their child
a lot about the disease they have. The best way to tell your child about this disease is to tell
information a little at a time so it is not too much to handle at once. Many parents who have a
child who has this disease they may treat their child different than a normal kid. Adolescents
with MD face many of the same educational and social challenges as affected children do, but
during the teen years these challenges intensify as the individuals struggle to become adults
while dealing with the day to day burden of a severe medical condition (Abramovitz 60-74). If
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you are a parent with a child with MD, do not treat them like they are different because then your
child may think he or she is an outcast.
In conclusion, Muscular Dystrophy is a very harmful disease that is not only deadly but also is
very challenging at times. Muscular Dystrophy is a group of disorders that weaken muscles in
the body, including those that make the body move and others that control certain internal organs
(Abramovitz 15-29). Kids who have MD struggle to be able to walk and normal like other kids.
The meaning of Muscular Dystrophy means that the nourishment for the muscles is defective
(Muscular Dystrophy 15-29). Today doctors have been trying to find a cure for MD, but we can
fight against this disease.