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Physiotherapy Management of
        Osteoarthritis
             Cameron Bulluss
   Advanced Physiotherapy and Injury
               Prevention
    335 Hillsborough Rd Warners Bay
Physio Facts
 12000 registered Physios in Australia
 1200 of these have a formally recognised specialty
   Musculoskeletal
   Sports
   Neurology
Advanced Physiotherapy
 Warners Bay
 8 full-time Physios
 220 new patients per month, half of these from g.p.s and
    specialists
   Patients range over 10, with average of 46
   Most common reason to seek a visit with us is for an OA knee
   20 % of our patients present with symptomatic OA
   Physio provider for Newcastle Jets Soccer
Osteoarthritis
 The most common musculoskeletal disorder
 The leading cause of pain an disability in the community
Age and Gender
Joint Replacement Trend
Common Sites

               19%




                30%
 41%
Definition
- Clinical definitions
- Radiological definitions
- Anatomical definitions
- All vary and none appear to encompass all aspect of the disease
- These even vary between body parts
Definition
 “The synovial joint is an organ, and OA represents failure of
  that organ and can be initiated by abnormalities arising in any
  of its constituent tissues. “ (Brandt 2008)
These abnormalities are in
                   Articular Cartilage
                   Bone
                   Synovium
                   Periarticular Soft Tissues
                   Muscles
                   Nerves
Articular Cartliage
                       Exposes sub-chondral bone
                       Irritation of synovium via
                        debris
                       Alteration of joint
                        alignment
                       No pain directly possible as
                        it is aneural
The Bony Changes We See Are
 Increased density of subchondral plate
 Bone necrosis
 Bone cysts
 Bone oedema
 Sclerosis
 Osteophytes
Subchondral Bone
 Much of the pain comes from the subchondral bone (Hunter 2009
  Rad Clin North America 2009 (539 -531)
Diagnosis
 Clinical Examination is crucial
 Imaging can be used to confirm the diagnosis and exclude
  other pathology
 X-Rays provide further information but are notoriously
  insensitive
 MRI provides greater insight
   subchondral bone marrow lesions,
   synovitis
   subarticular bone attrition
   Articular cartilage damage
Knee x-ray useful additional view
 A clear x-ray does not exclude osteoarthritis
 Knee X-rays should include Rosenberg view if looking for
  OA


                                    Erect PA view at 45
                                    degrees flexion
Keys to
Management
                     Activity modification and
                           strengthening




                                                  Weight
        Pharmaceutical                           Reduction




                          Psychological
Keys to
Management
                          Activity
                        modification
                        and exercise




                                          Weight
       Pharmaceutical
                                         Reduction


                         Psychological
Keys to Management
Weight Reduction
• For every 2 units of BMI increase there is a 36% increase in the
   risk of developing knee OA
Keys to Management
Weight Reduction
• For every 2 units of BMI increase there is a 36% increase in the
  risk of developing knee OA
• BMI>30 there is a 20 fold increased risk of knee OA
Keys to Management
Weight Reduction
• For every 2 units of BMI increase there is a 36% increase in the
  risk of developing knee OA
• BMI>30 there is a 20 fold increased risk of knee OA
• Body fat % perhaps more important than BMI
      Inflammatory proteins such as cytokinenes may contribute to sensitisation
       of nerve endings, tendon and muscle degeneration
Keys to Management
Weight Reduction
 For every 5 kg decrease in body weight during the
  preceeding 10 years the risk of OA of the knee declines by
  more than 50%. (MJA 2004)
Consider the load in the situation where someone
     30kg overweight walks down 10 steps
• Impact loading will increase with increased body weight
    30 kg overweight will result in over 10 steps
    30 x 4 x 10 =        1200 kg extra accumulated load through
     Patellofemoral joint
Keys to
Management
                     Activity modification and
                              exercise




                                                  Weight
        Pharmaceutical                           Reduction




                          Psychological
Keys to
Management
                         Activity
                     Modification and
                        Exercise


                                           Weight
         Pharmaceutical                   Reduction




                          Psychological
Optimise Loading in       Commence Low Intensity
  Current Activities          Cyclical Exercise


                     Activity
                   Modification
                   and Exercise


Commence Low Impact           Commence Range of
   Strengthening               Motion Exercises
Optimise Loading
   in Current
    Activities

               Activity
             Modification
             and Exercise
Optimise Loading with Current
Activities
 Reduce Loading if excessive
   Reduce pressure on subchondral bone
   Less stress on articular cartilage
 Increase Loading if inadequate
   Improved nutrition of articular cartilage
Change Loading – How?
 Optimise Activity Selection (exercise and recreational)
   An understanding is required of the forces involved
     PFJ 4 -10x body weight in running
     PFJ 1.5x body weight in walking
     3-4x body weight ascending and descending stairs
     6x body weight in squatting
     4x body weight sit-stand
Loading Changes – examples
 Replace running with walking
 Replace walking with low intensity bike
 Commence weekly hydrotherapy
 Reduce BMI
 Reduce hills
 Improve shoes
 Walk on grass rather than concrete
 Provide Supportive Device
Reduce Loading with Bracing
Reducing Load Through the first MTP
Reducing Load with shoes



Brooks Addictions
Reducing Load with a Lateral Heel
Wedge
 Are foot orthotics efficacious for treating painful
  medial compartment knee osteoarthritis? A review
  of the literature R. Marks L. Penton Article first
  published online: 11 FEB 2004
 “These data indicate a strong scientific basis for applying
  wedged insoles in attempts to reduce osteoarthritic pain of
  biomechanical origin. Further research to substantiate their
  efficacy in well-designed clinical trials seems warranted”
American Podiatric Medicine
Association Journal
Commence Low
    Impact
Strengthening

              Activity
            Modification
            and Exercise
Commence Low Impact Strengthening –
Why?
   Load Sharing Occurs Between Joints and Muscles
   Muscle weakness is likely to be present in knees with
    symptomatic Osteoarthrits.
   It is also likely to be a risk factor for the development and
    progression of knee osteoarthritis. (Ann Intern Med. 1997
   Muscle weakness is probably more important in the pathogenesis
    of OA than wear and tear (Br J Sports Med 2004)
Low Impact Strengthening – example open
chain exercise




Open chain means that the distal part is
free to move
Quadriceps Strength
 Pre-operative quadriceps
  strength is a good predictor
  of functional outcomes 1
  year post total knee
  replacement
Commence Low
Intensity Cyclical
    Exercise

                 Activity
               Modification
               and Exercise
Commence Low Intensity Cyclical
Exercise - Why
 Improved nutrition of subchondral bone and articular
  cartilage
 Assist with weight loss
 Assist with range of motion
Commence Low Intensity Cyclical
Exercise - Examples
 Exercise bike
 Hydrotherapy
 Low Impact walking




Bike Set-up is crucial
Commence
Range of Motion
   Exercises
               Activity
             Modification
             and Exercise
Commence Range of Motion Exercises
– Why?
 Increasing flexibility of peri-articular soft tissues is likely to
  improve functional range of motion
   60 degrees knee flexion to walk
   80 degrees knee flexion to climb a step
   10 degrees ankle dorsiflexion to walk
   105 degrees knee flexion to ride a bike
American Academy of Orthopaedic
Surgeons – Clinical Guidelines
Clinical Guidelines
Recommendation 1
 We suggest patients with symptomatic OA of the knee be
 encouraged to participate in self-management educational
 programs such as those conducted by the Arthritis
 Foundation, and incorporate activity modifications (e.g.
 walking instead of running; alternative activities) into their
 lifestyle.
Recommendation 3
 We recommend patients with symptomatic OA of the knee,
 who are overweight (as defined by a BMI>25), should be
 encouraged to lose weight (a minimum of five percent (5%)
 of body weight) and maintain their weight at a lower level
 with an appropriate program of dietary modification and
 exercise
Recommendation 4
 We recommend patients with symptomatic OA of the knee
 be encouraged to participate in low-impact aerobic fitness
 exercises.
Recommendation 5
 Range of motion/flexibility exercises are an option for
 patients with symptomatic OA of the knee.
Recommendation 6
 We suggest quadriceps strengthening for patients with
 symptomatic OA of the knee.
 Recommendation 9
 We are unable to recommend for or against the use of a brace
    with a valgus directing force for patients with medial uni-
    compartmental OA of the knee.
   Grade of Recommendation: Inconclusive
   Recommendation 10
   We are unable to recommend for or against the use of a brace
    with a varus directing force for patients with lateral uni-
    compartmental OA of the knee.
   Grade of Recommendation: Inconclusive
Clinical Trials
 Effects of tai chi exercise on pain, balance, muscle strength, and perceived difficulties in physical functioning in
 older women with osteoarthritis: a randomized clinical trial.The Journal of Rheumatology
 CONCLUSION: Older women with OA were able to safely perform the 12 forms of
 Sun-style tai chi exercise for 12 weeks, and this was effective in improving their
 arthritic symptoms, balance, and physical functioning


 Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysis Source: Arthritis and
 Rheumatism 2008 Method: systematic review
 CONCLUSION: Therapeutic exercise, especially with an element of strengthening, is
 an efficacious treatment for hip OA
Exercise variables - Loading
 Generally low
Exercise Variable – Repetitions or Time
- Generally high
- 15 mins on an exercise bike at 60 RPM=900 knee flexion –
  extensions between 5 and 105 degrees
Exercise Variable - Frequency
 Minimum 3 times per week
Exercise Variable – Trial period
 8 weeks is usually required
Resources

 Useful Websites
   www.aaos.org
   www.arthritisaustralia.com.au
Questions
 Acknowledgements – Jess Fidler

OA Changes to the Synovium
 Hyperplasia
 Fibrosis
 Thickening
 Lymphocytic infiltration
 Inflammation
OA Changes to Nerves
 Changes leading to reduced proprioception
   Loss of mechanoreceptors
 Structural changes leading increased pain
   Disorganisation
   Truncation
Biological Pain Generators in OA

                          Synovium




          Periarticular
           soft tissues




                                     Bone
Risk Factors for Development of OA
 Non-Modifiable        Modifiable
   Age                   Muscle strength
   Dysplasia             Activity type and level
   Joint alignment       Obesity
   Traumatic injury      Traumatic injury
Risk Factors for the Development and
Progression of Osteoarthritis
 Age
 Joint dysplasia e.g.
  FAI of hip
Risk Factors for the Development and
Progression of Osteoarthritis – malalignment
Risk Factors for the Development and
Progression of Osteoarthritis
 Joint Instability or
  Injury Leading to
  Mechanical, Biochemical
  Damage to chondral
  surface
    ACL (50 – 60% greater
     risk of osteoarthritis)
    1st CMC – UCL rupture
    Scapholunate
 Visual Analog Scores before and after Knee Bracing
Pain (mm) 7.9 vs 4.4
Activity level (%) 36 vs 61
References
Pathophysiology of Osteoarthritis
 OA represents abnormalities of any of the constituent tissues
  of the synovial joint
 Breakdown of the dynamic equilibrium between breakdown
  and repair
 Not a degenerative disease in that the cells are normal
The Normal Anatomy of Synovial Joints
The Normal Anatomy Synovial Joints –
Synovium
The Normal Anatomy of Synovial Joints
– Articular Cartilage
Changes to the Articular Cartilage
 Loss of chondrocytes
 Matrix degeneration
What Causes the Pain



       Psychological            Biological


                       Social




                       Pain
Physiotherapy and OA Prevention and
Management
 Modifiable Risk Factors    Non-modifiable Risk
   Impact Loading            Factors
   Obesity                    Previous Injury
   Muscle strength            Joint Dysplasia
   Future injury              Gender
   Attitudes                  Age
Modifiable Risk Factors – Injury Risk
 ACL incidence reduced by 85 – 90% in several studies by use
  of a special preventative program
Treatment
OA Prevention and Management
 Some of the symptoms come from changes to the synovium,
  bone and nerves
   Medical treatment
 Much of the pathology comes from degeneration in the
  articular cartilage
   Irreversible but can be slowed
 Much of the pain comes from the subchondral bone
   Partly reversible
 Much of the loss of range comes from either the pain or from
  the periarticular soft tissues
   This can be improved with an exercise program

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Osteoarthritis lecture to gps

  • 1. Physiotherapy Management of Osteoarthritis Cameron Bulluss Advanced Physiotherapy and Injury Prevention 335 Hillsborough Rd Warners Bay
  • 2. Physio Facts  12000 registered Physios in Australia  1200 of these have a formally recognised specialty  Musculoskeletal  Sports  Neurology
  • 3. Advanced Physiotherapy  Warners Bay  8 full-time Physios  220 new patients per month, half of these from g.p.s and specialists  Patients range over 10, with average of 46  Most common reason to seek a visit with us is for an OA knee  20 % of our patients present with symptomatic OA  Physio provider for Newcastle Jets Soccer
  • 4. Osteoarthritis  The most common musculoskeletal disorder  The leading cause of pain an disability in the community
  • 7.
  • 8. Common Sites 19% 30% 41%
  • 9. Definition - Clinical definitions - Radiological definitions - Anatomical definitions - All vary and none appear to encompass all aspect of the disease - These even vary between body parts
  • 10. Definition  “The synovial joint is an organ, and OA represents failure of that organ and can be initiated by abnormalities arising in any of its constituent tissues. “ (Brandt 2008)
  • 11. These abnormalities are in  Articular Cartilage  Bone  Synovium  Periarticular Soft Tissues  Muscles  Nerves
  • 12. Articular Cartliage  Exposes sub-chondral bone  Irritation of synovium via debris  Alteration of joint alignment  No pain directly possible as it is aneural
  • 13. The Bony Changes We See Are  Increased density of subchondral plate  Bone necrosis  Bone cysts  Bone oedema  Sclerosis  Osteophytes
  • 14.
  • 15. Subchondral Bone  Much of the pain comes from the subchondral bone (Hunter 2009 Rad Clin North America 2009 (539 -531)
  • 16. Diagnosis  Clinical Examination is crucial  Imaging can be used to confirm the diagnosis and exclude other pathology  X-Rays provide further information but are notoriously insensitive  MRI provides greater insight  subchondral bone marrow lesions,  synovitis  subarticular bone attrition  Articular cartilage damage
  • 17. Knee x-ray useful additional view  A clear x-ray does not exclude osteoarthritis  Knee X-rays should include Rosenberg view if looking for OA Erect PA view at 45 degrees flexion
  • 18. Keys to Management Activity modification and strengthening Weight Pharmaceutical Reduction Psychological
  • 19. Keys to Management Activity modification and exercise Weight Pharmaceutical Reduction Psychological
  • 20. Keys to Management Weight Reduction • For every 2 units of BMI increase there is a 36% increase in the risk of developing knee OA
  • 21. Keys to Management Weight Reduction • For every 2 units of BMI increase there is a 36% increase in the risk of developing knee OA • BMI>30 there is a 20 fold increased risk of knee OA
  • 22. Keys to Management Weight Reduction • For every 2 units of BMI increase there is a 36% increase in the risk of developing knee OA • BMI>30 there is a 20 fold increased risk of knee OA • Body fat % perhaps more important than BMI  Inflammatory proteins such as cytokinenes may contribute to sensitisation of nerve endings, tendon and muscle degeneration
  • 23. Keys to Management Weight Reduction  For every 5 kg decrease in body weight during the preceeding 10 years the risk of OA of the knee declines by more than 50%. (MJA 2004)
  • 24. Consider the load in the situation where someone 30kg overweight walks down 10 steps • Impact loading will increase with increased body weight  30 kg overweight will result in over 10 steps  30 x 4 x 10 = 1200 kg extra accumulated load through Patellofemoral joint
  • 25. Keys to Management Activity modification and exercise Weight Pharmaceutical Reduction Psychological
  • 26. Keys to Management Activity Modification and Exercise Weight Pharmaceutical Reduction Psychological
  • 27. Optimise Loading in Commence Low Intensity Current Activities Cyclical Exercise Activity Modification and Exercise Commence Low Impact Commence Range of Strengthening Motion Exercises
  • 28. Optimise Loading in Current Activities Activity Modification and Exercise
  • 29. Optimise Loading with Current Activities  Reduce Loading if excessive  Reduce pressure on subchondral bone  Less stress on articular cartilage  Increase Loading if inadequate  Improved nutrition of articular cartilage
  • 30. Change Loading – How?  Optimise Activity Selection (exercise and recreational)  An understanding is required of the forces involved  PFJ 4 -10x body weight in running  PFJ 1.5x body weight in walking  3-4x body weight ascending and descending stairs  6x body weight in squatting  4x body weight sit-stand
  • 31. Loading Changes – examples  Replace running with walking  Replace walking with low intensity bike  Commence weekly hydrotherapy  Reduce BMI  Reduce hills  Improve shoes  Walk on grass rather than concrete  Provide Supportive Device
  • 33. Reducing Load Through the first MTP
  • 34. Reducing Load with shoes Brooks Addictions
  • 35. Reducing Load with a Lateral Heel Wedge
  • 36.  Are foot orthotics efficacious for treating painful medial compartment knee osteoarthritis? A review of the literature R. Marks L. Penton Article first published online: 11 FEB 2004  “These data indicate a strong scientific basis for applying wedged insoles in attempts to reduce osteoarthritic pain of biomechanical origin. Further research to substantiate their efficacy in well-designed clinical trials seems warranted”
  • 38. Commence Low Impact Strengthening Activity Modification and Exercise
  • 39. Commence Low Impact Strengthening – Why?  Load Sharing Occurs Between Joints and Muscles  Muscle weakness is likely to be present in knees with symptomatic Osteoarthrits.  It is also likely to be a risk factor for the development and progression of knee osteoarthritis. (Ann Intern Med. 1997  Muscle weakness is probably more important in the pathogenesis of OA than wear and tear (Br J Sports Med 2004)
  • 40. Low Impact Strengthening – example open chain exercise Open chain means that the distal part is free to move
  • 41. Quadriceps Strength  Pre-operative quadriceps strength is a good predictor of functional outcomes 1 year post total knee replacement
  • 42. Commence Low Intensity Cyclical Exercise Activity Modification and Exercise
  • 43. Commence Low Intensity Cyclical Exercise - Why  Improved nutrition of subchondral bone and articular cartilage  Assist with weight loss  Assist with range of motion
  • 44. Commence Low Intensity Cyclical Exercise - Examples  Exercise bike  Hydrotherapy  Low Impact walking Bike Set-up is crucial
  • 45. Commence Range of Motion Exercises Activity Modification and Exercise
  • 46. Commence Range of Motion Exercises – Why?  Increasing flexibility of peri-articular soft tissues is likely to improve functional range of motion  60 degrees knee flexion to walk  80 degrees knee flexion to climb a step  10 degrees ankle dorsiflexion to walk  105 degrees knee flexion to ride a bike
  • 47. American Academy of Orthopaedic Surgeons – Clinical Guidelines
  • 48. Clinical Guidelines Recommendation 1 We suggest patients with symptomatic OA of the knee be encouraged to participate in self-management educational programs such as those conducted by the Arthritis Foundation, and incorporate activity modifications (e.g. walking instead of running; alternative activities) into their lifestyle.
  • 49. Recommendation 3 We recommend patients with symptomatic OA of the knee, who are overweight (as defined by a BMI>25), should be encouraged to lose weight (a minimum of five percent (5%) of body weight) and maintain their weight at a lower level with an appropriate program of dietary modification and exercise
  • 50. Recommendation 4 We recommend patients with symptomatic OA of the knee be encouraged to participate in low-impact aerobic fitness exercises.
  • 51. Recommendation 5 Range of motion/flexibility exercises are an option for patients with symptomatic OA of the knee.
  • 52. Recommendation 6 We suggest quadriceps strengthening for patients with symptomatic OA of the knee.
  • 53.  Recommendation 9  We are unable to recommend for or against the use of a brace with a valgus directing force for patients with medial uni- compartmental OA of the knee.  Grade of Recommendation: Inconclusive  Recommendation 10  We are unable to recommend for or against the use of a brace with a varus directing force for patients with lateral uni- compartmental OA of the knee.  Grade of Recommendation: Inconclusive
  • 54. Clinical Trials Effects of tai chi exercise on pain, balance, muscle strength, and perceived difficulties in physical functioning in older women with osteoarthritis: a randomized clinical trial.The Journal of Rheumatology CONCLUSION: Older women with OA were able to safely perform the 12 forms of Sun-style tai chi exercise for 12 weeks, and this was effective in improving their arthritic symptoms, balance, and physical functioning Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysis Source: Arthritis and Rheumatism 2008 Method: systematic review CONCLUSION: Therapeutic exercise, especially with an element of strengthening, is an efficacious treatment for hip OA
  • 55. Exercise variables - Loading  Generally low
  • 56. Exercise Variable – Repetitions or Time - Generally high - 15 mins on an exercise bike at 60 RPM=900 knee flexion – extensions between 5 and 105 degrees
  • 57. Exercise Variable - Frequency  Minimum 3 times per week
  • 58. Exercise Variable – Trial period  8 weeks is usually required
  • 59. Resources  Useful Websites  www.aaos.org  www.arthritisaustralia.com.au
  • 61. OA Changes to the Synovium  Hyperplasia  Fibrosis  Thickening  Lymphocytic infiltration  Inflammation
  • 62. OA Changes to Nerves  Changes leading to reduced proprioception  Loss of mechanoreceptors  Structural changes leading increased pain  Disorganisation  Truncation
  • 63. Biological Pain Generators in OA Synovium Periarticular soft tissues Bone
  • 64. Risk Factors for Development of OA  Non-Modifiable  Modifiable  Age  Muscle strength  Dysplasia  Activity type and level  Joint alignment  Obesity  Traumatic injury  Traumatic injury
  • 65. Risk Factors for the Development and Progression of Osteoarthritis  Age  Joint dysplasia e.g. FAI of hip
  • 66. Risk Factors for the Development and Progression of Osteoarthritis – malalignment
  • 67. Risk Factors for the Development and Progression of Osteoarthritis  Joint Instability or Injury Leading to  Mechanical, Biochemical Damage to chondral surface  ACL (50 – 60% greater risk of osteoarthritis)  1st CMC – UCL rupture  Scapholunate
  • 68.
  • 69.  Visual Analog Scores before and after Knee Bracing Pain (mm) 7.9 vs 4.4 Activity level (%) 36 vs 61
  • 71. Pathophysiology of Osteoarthritis  OA represents abnormalities of any of the constituent tissues of the synovial joint  Breakdown of the dynamic equilibrium between breakdown and repair  Not a degenerative disease in that the cells are normal
  • 72. The Normal Anatomy of Synovial Joints
  • 73. The Normal Anatomy Synovial Joints – Synovium
  • 74. The Normal Anatomy of Synovial Joints – Articular Cartilage
  • 75. Changes to the Articular Cartilage  Loss of chondrocytes  Matrix degeneration
  • 76. What Causes the Pain Psychological Biological Social Pain
  • 77. Physiotherapy and OA Prevention and Management  Modifiable Risk Factors  Non-modifiable Risk  Impact Loading Factors  Obesity  Previous Injury  Muscle strength  Joint Dysplasia  Future injury  Gender  Attitudes  Age
  • 78. Modifiable Risk Factors – Injury Risk  ACL incidence reduced by 85 – 90% in several studies by use of a special preventative program
  • 80. OA Prevention and Management  Some of the symptoms come from changes to the synovium, bone and nerves  Medical treatment  Much of the pathology comes from degeneration in the articular cartilage  Irreversible but can be slowed  Much of the pain comes from the subchondral bone  Partly reversible  Much of the loss of range comes from either the pain or from the periarticular soft tissues  This can be improved with an exercise program