There are many factors that can influence the toxicity of chemicals. Factors pertaining to the chemical include its physicochemical properties, solubility, concentration, ionic characteristics, and ability to interact with other chemicals. Factors related to exposure include the route of exposure, duration of exposure, and exposure system. The surrounding medium's characteristics like temperature, dissolved oxygen, pH, salinity, and suspended/dissolved substances can also impact toxicity. Finally, characteristics of the organism such as species, sex, age, life stage, size, health, and acclimation level influence its susceptibility to chemicals.
Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms that arise following exposure to toxic substances.
The dynamics of movement of xenobiotics in the living system from its penetration into the blood to its final elimination from the body is termed translocation. Translocation of the toxicants is completed by absorption, distribution, biotransformation and excretion.
Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms that arise following exposure to toxic substances.
The dynamics of movement of xenobiotics in the living system from its penetration into the blood to its final elimination from the body is termed translocation. Translocation of the toxicants is completed by absorption, distribution, biotransformation and excretion.
A bioindicator is any an "indicator species" or group of species whose function, population, or status reveal the qualitative status of the environment.
One of the major factors influencing the toxic effects of a chemical is the dose and concentration. Anything can be toxic if taken enough, and conversely the most toxic substance may not be harmful when taken in low concentration.
INTRODUCTION
Toxicology is the science of the poisons. It also studies the nature, effects, detection, assessment and treatment of their effects on biological material.
Toxicology is a multidisciplinary science. The ultimate objective of the combined research is to determine how an organism is affected by exposure to an agent.
This includes an understanding of:
How the agent moves and interact with living cells and tissues of the organism;
What parts of the organism are affected by its presence and health outcomes of this exposure.
Evaluation of the toxicity of substances whose biological effects may not have been well characterized.
The influence of chemical toxicity is mainly
determined by the dosage, duration of exposure,
route of exposure, species, age, sex, and environment.
The goal of toxicology is to contribute to the
general knowledge and harmful actions of
chemical substances.
2. to study their mechanisms of action,
3. and to estimate their possible risks to humans
HISTORY
Dioscorides, a Greek physician in the court of the Roman emperor Nero, made the first attempt to classify plants according to their toxic and therapeutic effect. Poisonous plants and animals were recognized and their extracts used for hunting or in warfare.
In 1500 BC people used hemlock, opium, arrow poisons, and certain metals to poison enemies or for state executions.
Theophrastus Phillipus Auroleus Bombastus von Hohenheim (1493–1541) (also referred to as Paracelsus, a Roman physician from the first century) is considered "the father" of toxicology.
He stated that "All things are poisonous and nothing is without poison; only the dose makes a thing not poisonous.“
Mathieu Orfila (1813) is considered the modern father of toxicology.
In 1850, Jean Stas became the first person to successfully isolate plant poisons from human tissue.
Hippolyte Visart de Bocarmé used nicotine to kill his brother-in-law. He extracted nicotine from tobacco leaves.
The 20th and 21st Centuries have marked by great advancements in the level of understanding of toxicology. DNA and various biochemicals that maintain body functions have been discovered. Our level of knowledge of toxic effects on organs and cells has expanded to the molecular level.
Induced breeding is a technique where organism is stimulated by particular hormone or other synthetic hormone or by providing condition, introduced to breed in captive condition.
Ecotoxicology is the science devoted to the study of the adverse effects of chemicals on ecosystems structure, functions, and biodiversity. It is a modern discipline, just developed during the last four decades, directly associated to the need to identify, predict, control, and minimize the negative environmental consequences of the recent human industrial development. Ecotoxicology has always been connected to toxicology, and is in part an extension of human/veterinary toxicology to the investigation of effects on wildlife. In parallel, it also linked ecotoxicology to ecology, from both conceptual and methodological viewpoints.
A bioindicator is any an "indicator species" or group of species whose function, population, or status reveal the qualitative status of the environment.
One of the major factors influencing the toxic effects of a chemical is the dose and concentration. Anything can be toxic if taken enough, and conversely the most toxic substance may not be harmful when taken in low concentration.
INTRODUCTION
Toxicology is the science of the poisons. It also studies the nature, effects, detection, assessment and treatment of their effects on biological material.
Toxicology is a multidisciplinary science. The ultimate objective of the combined research is to determine how an organism is affected by exposure to an agent.
This includes an understanding of:
How the agent moves and interact with living cells and tissues of the organism;
What parts of the organism are affected by its presence and health outcomes of this exposure.
Evaluation of the toxicity of substances whose biological effects may not have been well characterized.
The influence of chemical toxicity is mainly
determined by the dosage, duration of exposure,
route of exposure, species, age, sex, and environment.
The goal of toxicology is to contribute to the
general knowledge and harmful actions of
chemical substances.
2. to study their mechanisms of action,
3. and to estimate their possible risks to humans
HISTORY
Dioscorides, a Greek physician in the court of the Roman emperor Nero, made the first attempt to classify plants according to their toxic and therapeutic effect. Poisonous plants and animals were recognized and their extracts used for hunting or in warfare.
In 1500 BC people used hemlock, opium, arrow poisons, and certain metals to poison enemies or for state executions.
Theophrastus Phillipus Auroleus Bombastus von Hohenheim (1493–1541) (also referred to as Paracelsus, a Roman physician from the first century) is considered "the father" of toxicology.
He stated that "All things are poisonous and nothing is without poison; only the dose makes a thing not poisonous.“
Mathieu Orfila (1813) is considered the modern father of toxicology.
In 1850, Jean Stas became the first person to successfully isolate plant poisons from human tissue.
Hippolyte Visart de Bocarmé used nicotine to kill his brother-in-law. He extracted nicotine from tobacco leaves.
The 20th and 21st Centuries have marked by great advancements in the level of understanding of toxicology. DNA and various biochemicals that maintain body functions have been discovered. Our level of knowledge of toxic effects on organs and cells has expanded to the molecular level.
Induced breeding is a technique where organism is stimulated by particular hormone or other synthetic hormone or by providing condition, introduced to breed in captive condition.
Ecotoxicology is the science devoted to the study of the adverse effects of chemicals on ecosystems structure, functions, and biodiversity. It is a modern discipline, just developed during the last four decades, directly associated to the need to identify, predict, control, and minimize the negative environmental consequences of the recent human industrial development. Ecotoxicology has always been connected to toxicology, and is in part an extension of human/veterinary toxicology to the investigation of effects on wildlife. In parallel, it also linked ecotoxicology to ecology, from both conceptual and methodological viewpoints.
Factors affecting action of Disinfectants and Factors Affecting Choice Of Ant...Ms. Pooja Bhandare
PHARMACEUTICAL MICROBIOLOGY (BP303T)Unit-III. Factors affecting action of Disinfectants and Factors Affecting Choice Of Antimicrobial Agent: Concentration of the disinfectant.
Chemical Structure of the disinfectant.
Formulation of the disinfectant.
Interfering substances in the environment.
pH of the surrounding.
Potentiation and antagonism of the disinfectants.
Surface Tension.
Temperature.
Time of Contact.
Type and no. of microbes present.
FACTORS AFFECTING CHOICE OF ANTIMICROBIAL AGENT:
Properties of chemical agents
Environment
Types of microorganisms
Intended application
Toxicity agents
Culture state
relating to the process of providing or obtaining the food necessary for health and growth.
"genetic engineering can alter the nutritional value of food"
Introduction:
History & Development:
Physicochemical Properties in relation to biological action:
Ionization
Solubility
Partition Coefficient
Hydrogen Bonding:
Protein Binding:
Chelation:
Bioisosterism:
Optical & Geomentrical Isomerism
Drug Metabolism:
Drug Metabolism Principles: Phase I & Phase II
Factors Affecting Drug Metabolism including steriochemical Aspects
Terminology
Introduction of Disinfectants
Classification of Disinfectants
Mode of action of Disinfectants
Factors affecting Disinfection
Evaluation of Anti-microbial agents and Disinfectants
This PowerPoint presentation includes all the necessary points regarding xenobiotics in a well organised and concised way which will help students to frameout before before getting into details.
what is toxicology? what is the difference between poison and toxin? what is toxicity? what are different routes of toxicity? what is meant by dose-response curve?
1 physicochemical properties including the functional groups, (ii) solubility in water and organic solvents, (iii) dose/concentration, (iv) ionic characteristics (v) translocation and biotransformation, (vi) their mode of action, and (vii) interaction with other chemicals. Almost all these characteristics are dependent on the structure of compound.
2 Toxicity of chemicals is greatly affected by various factors pertaining to their exposures to the organisms.
3 The factors of surrounding medium affecting the toxicity of chemicals have been extensively worked out for the aquatic medium. The factors related to the medium are physico- chemical characteristics of the water affecting the toxicity of chemicals
4 the factors related to the organisms are very important in the study of toxicity of xenobiotics.
Disinfection, Definition, classification,Mode of action, factors affecting & ...someshwar mankar
Disinfection, Definition, classification,Mode of action, factors affecting & Evaluation of disinfectant as per bacteriostatic & Bacteriocidal action
Department of Pharmaceutics,PRCOP,Loni
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
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Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
How to Make a Field invisible in Odoo 17Celine George
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Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
2. FACTORS PERTAINING TO THE CHEMICALS
1. The factors pertaining to the chemicals are:
i. Physicochemical properties including the functional groups,
ii. Solubility in water and organic solvents,
iii. Dose/concentration,
iv. Ionic characteristics
v. Translocation and biotransformation,
vi. Their mode of action, and
vii. Interaction with other chemicals.
2
3. FACTORS RELATED TO THE EXPOSURES
2. The factors related to the exposures are:
i. Routes of exposure,
ii. Exposure systems,
iii. Exposure duration
3
4. THE EFFECTS OF PHYSICOCHEMICAL CHARACTERISTICS
OF WATER ON THE TOXICITY OF CHEMICALS
3. These factors are:
i. water temperature,
ii. dissolved oxygen,
iii. pH,
iv. salinity,
v. water hardness, and
vi. suspended and dissolved substances.
4
5. FACTORS PERTAINING TO THE ORGANISMS
4. The factors pertaining to the organisms are:
i. Type of species,
ii. Sex,
iii. Age,
iv. Stage of the life cycle,
v. Weight and size of individual,
vi. Health and nutritional status,
vii. Seasonal physiological state, and
viii.Acclimation of individuals.
5
6. ABIOTIC AND BIOTIC MODIFYING FACTORS
• The toxicity modifying factors related to the chemical, the exposure
and the surrounding medium may be considered together and termed
as abiotic modifying factors.
• The factors related to the organisms may also be termed as biotic
modifying factors.
6
7. FACTORS THAT INFLUENCE TOXICITY
• For the sake of convenience, this topic “FACTORS THAT
INFLUENCE TOXICITY” will be divided into following four
sections:
i. Factors pertaining to chemical,
ii. Factors pertaining to exposure,
iii. Factors pertaining to surrounding medium, and
iv. Factors pertaining to organisms.
7
9. (I) CHEMICAL COMPOSITION:
• The physico-chemical characteristics of a compound, such as
solubility, vapour pressure, ionization, functional groups, etc. are
largely governed by the chemical constitution of the compound. All
these characteristics greatly affect the toxicological properties of the
substance.
• The polar (hydrophilic) chemicals are not easily soluble in lipids.
Therefore, they cannot easily cross the membranous barriers and thus
cannot easily reach the target sites for appropriate action. However,
non-polar or lipophilic substances are highly soluble in lipids and
other organic solvents. They can readily penetrate the lipoprotein
layers of membranes, hence they readily produce their potential effects
9
10. (II) DOSE OR CONCENTRATION OF CHEMICAL:
• A chemical induces toxic effects on account of its interaction with
appropriate receptors. The effect is directly related to concentration of
the chemical at the target site and concentration at the target site is
often directly proportional to dose/concentration of the chemical
exposed.
• The lower doses of chemical cause less effects whereas higher doses
may cause pronounced effects. Thus, toxicity of chemical is directly
proportional to its dose/concentration.
10
11. (III) TRANSLOCATION OF TOXICANT:
• There are two types of toxicants:
(a) those producing local effects, and (b) those producing systemic effects.
• In case of the latter group, effective translocation is a key factor. Unless the
toxicants are readily translocated to the specific sites, they cannot produce
adverse effects. During the course of translocation, some of the toxicants
interact with certain macromolecules present in the body of organisms and
are then stored in certain relatively inactive tissues, i.e. storage depots.
• The inefficient translocation and storage of toxicants in inactive forms
reduces their toxicity, while their effective translocation to the target in
active forms enhances their toxicity.
11
12. (IV) BIOTRANSFORMATION OF TOXICANTS
• Certain chemicals are normally inactive. During translocation such
chemicals are biocatalytically converted into active form in the body
of organisms with the help of certain enzymes. Consequently, the
toxicity of that particular chemical is increased.
• However, in certain other cases active xenobiotics are converted to
their inactive forms during translocation and these forms are often
stored in the nontarget or relatively inactive tissues.
12
13. (V) CHEMICAL INTERACTIONS
• In nature often various chemicals may be present and the organisms
are not exposed to only one chemical, but to a variety of chemicals.
These chemicals interact with each other and such chemical
interactions may have great toxicological significance.
• However, in the laboratories, the organisms may be simultaneously or
consecutively exposed to two chemicals. These chemicals interact and
affect the toxicity of each other. These interactions may cause three
types of toxic effects.
13
14. (V) CHEMICAL INTERACTIONS
• (i) The combined effect of two chemicals may be equal to the sum of
the effect of each chemical when given alone. This type of interaction
is considered as additive.
• (ii) The combined effects of two chemicals to the organisms exposed
may be greater than the sum and this type of interaction is designated
as synergistic; for example, effects of carbon tetrachloride and ethanol
on liver; and asbestos exposure and cigarette smoking on the lungs.
• (iii) The combined effect of two chemicals to the organisms exposed
may be less than the sum and this type of interaction is termed as
antagonistic; for example, chelation of heavy metals by dimercaprol.
14
15. (V) CHEMICAL INTERACTIONS
• It may thus be inferred that interaction of one chemical with another
may: (i) have no effect on their toxicity, or (ii) increase their toxicity,
or (i) decrease their toxicity
15
17. (I) EXPOSURE ROUTES
• The toxicant gain access to the body of organisms by dermal, oral and
inhalation exposures or by intraperitoneal, intramuscular,
subcutaneous and intravenous injections. The routes of exposure
largely affect the toxicity of chemicals.
• A chemical produces more rapid and greatest effect when given by
intravenous route, because through this route the chemical directly
reaches in active form to the specific site and thus produces greatest
effects.
• The other exposure routes in descending order of toxicity are:
inhalation> intraperitoneal>subcutaneous>intramuscular>oral>topical.
17
18. (II) EXPOSURE DURATION
• LC50 or LD50 values of toxicants decrease with increase in duration
of exposure. The values evaluated for long-term exposures are much
less than those determined for short-term exposures.
• The exposure for short duration has less effect in comparison to long-
term exposures. This simply indicates that the toxicity of substances
increases with increase in exposure period.
18
19. (III) EXPOSURE SYSTEMS
• A variety of exposure systems may be used for the exposure of toxicants.
For instance, in aquatic medium, various exposure systems are used for the
exposure of toxicants to organisms, such as:
i. Static system: Where toxicant is mixed in the water and the organisms
are exposed to it in still water.
ii. Recirculatory system: Where the toxicant solution is recirculated
through certain pumps.
iii. Renewal system: Where the toxicant solution is renewed after certain
interval.
iv. Flow through system: Where the toxicant solution flows into and out of
test chamber intermittently or continuously.
19
21. (I) WATER TEMPERATURE
• The water temperature is expected to greatly affect the toxicity of
xenobiotics. The increased water temperature increases the solubility
of many substances, affects the chemical form of some and governs
the amounts of dissolved oxygen in water.
• Temperature change in a particular direction may increase or decrease
or cause no effect on the toxicity of chemicals, depending on the
chemical, the species, the response and the particular procedure.
21
22. (II) DISSOLVED OXYGEN
• Freshwater can dissolve 14.6 mg/1 level of oxygen at 0ºC, which
gradually decreases to 9.1 mg/1 with increase in temperature upto
20ºC and reaches to the level 7.5 mg/1 at 30ºC. It is, therefore, obvious
that increase in temperature decreases the dissolved oxygen content of
the water. Oxygen is essentially required for respiration by the
organisms.
• Thus, it might be expected that reduction in dissolved oxygen content
of water imposes stress on the aquatic organisms, which may greatly
increase the toxicity of a chemical in water.
22
23. (iii) pH
• pH may have greater effects on the toxicity of those chemicals that
ionize under the influence of pH. Usually undissociated forms of
chemicals are more toxic to organisms, because they easily penetrate
the cell membranes.
• The toxicity of ammonia is known to be greatly affected by pH of the
water. Unionized form of ammonia (NH3) is highly toxic to fish and
the toxic range is quite low (0.2-0.7 mg/1) for salmonids. In contrast,
ionized form of ammonia (NH4 + ) has very little or no toxicity.
23
24. (IV) SALINITY
• The greatest differences in chemical characteristics of fresh water and
seawater may be expected to enormously affect the toxicity of
chemicals.
• Generally, Euryhaline organisms are more resistant in about one third
seawater (i.e. water containing 30-40% salinity), in salinity close to
their isosmotic level.
• However, appreciable decrease in salinity of water often renders the
marine animals less tolerant. Therefore, it may be concluded that the
toxicity of xenobiotics may increase with appreciable decrease in the
salinity of the surrounding medium.
24
25. (V) WATER HARDNESS
• The total hardness of water has little effect on the toxicity of most of
the chemicals except for metals. The toxicity of ammonia, phenols,
surfactants and pesticides has been reported to be affected the least by
the hardness of water. LAS, a surfactant, has been reported to be 1.5
times as toxic to bluegills in hard water as in soft water.
25
26. (VI) SUSPENDED AND DISSOLVED MATTER
• Natural water often contains suspended and dissolved matter including
organic ligands and chelators. They may partly detoxify some of the
xenobiotic chemicals as a result of sorption or binding. The metals are
chief examples that may be detoxified by this mechanism.
• The toxicity of metals is often greatly decreased by the suspended and
dissolved matters present in water because of sorption and binding
while other xenobiotics are much less affected.
26
28. (I) TEST SPECIES
• The toxicity of xenobiotics greatly varies with variation in test
organisms, as the tolerance to chemicals differs in different groups of
organisms. Among the organisms of same group, the toxicity of
chemical varies with variation in species of the organisms. Even in
different individuals of same species, the toxicity of chemicals varies
because of variation in susceptibility owing to certain genetic factors.
Thus, certain individuals of a species may be susceptible to a chemical
whereas the other may be resistant to the same chemical.
• The toxicity of a chemical may vary among various fish species. Spear
and Pierce (1979) reported that salmonids and minnows are about 15
times more susceptible to copper than that of sunfish.
28
29. (II) SEX
• The toxicity of chemicals differs with respect to sexes, because the
males and females differ in their responses due to hormonal and
metabolic differences. Males in some species biotransform compounds
more rapidly than females, although this is not true for all species.
• For instance, aldrin (an organochlorine pesticide) is much more toxic
to male rats than to female rats.
29
30. (III) AGE
• Generally, the young animals are more susceptible to xenobiotics. For
a majority of chemicals, the young are 1.5 to 10 times more
susceptible than the adults. The main reasons for the susceptibility of
young ones may be less resistance and lack of biotransformation
enzyme systems.
• It has already been reported that the newly born individuals do not
posses the enzyme systems catalyzing the biotransformation reactions.
These enzyme systems develop gradually, reach at peak at a certain
stage, thereafter tend to decline.
30
31. (IV) LIFE-STAGE
• The toxicity of chemicals varies with different stages of the life-cycle.
Generally, the early life-stages or immature stages are more
susceptible to toxicant exposures than the late stages or mature
individuals. The fries and fingerlings of fishes are most sensitive
stages. Omkar (1980-81, unpublished data) has also found juveniles of
freshwater prawns to be more susceptible to pesticide exposures than
those of adult individuals.
• In certain organisms or a group of organisms, a particular stage of the
life-cycle may be particularly susceptible to toxicants and exposure of
toxicants at this stage appreciably affects the results. For instance, the
time of molting is particularly susceptible in case of aquatic
arthropods.
31
32. (V) SIZE
• The toxicity of chemicals is also affected by the size of the organisms.
Often larger sized individuals are more resistant to toxicants and this
has been found true in case of certain fishes.
• Hearth and Sprague (1978) reported that copper tolerance to rainbow
trout gradually increases with increase in size of the fish.
32
33. (VI) HEALTH AND NUTRITION
• The toxicity of chemicals to organisms is affected by the health and
nutritional status of organisms. Generally, the healthy individuals are
more tolerant to toxicants than diseased ones. The diseased and
parasitized individuals have been reported to be more sensitive to
various toxicants than the normal ones.
• For example, unhealthy fishes have been reported to be more
susceptible to sodium chloride and an organophosphate pesticide,
guthion. The toxicity of chemicals is also affected by the nutritional
status of the organisms.
33
34. (V) ACCLIMATION
• The animals acclimated to sub lethal levels of a toxicant may become
more tolerant or more weakened, depending upon the mode of action
of toxicant and the types of detoxifying mechanism of the animals.
• For instance, acclimation of trout to sub lethal (0.22 mg/1) level of
arsenic for three weeks, increased the threshold of LC50 by a factor of
1.5. While acclimation to one-third of the lethal level of cyanide to
fish rendered them to become more sensitive by a factor of one-third
in the first week. The tolerance improved to the original level by the
end of three weeks.
34