Vocal cord paralysis and evaluation of hoarseness
Slides prepared and compiled by highly experienced ENT teacher, Dr. Krishna Koirala from Nepal, for teaching undergraduate and postgraduate ENT students in the field of otorhinolaryngology.
A clear and concise explanation of the basic concepts in the subject matter concerned.
He is the Head of department with a sound knowledge in the field of ENT to teach both undergraduate and postgraduate ENT students
Vocal cord paralysis and evaluation of hoarseness
Slides prepared and compiled by highly experienced ENT teacher, Dr. Krishna Koirala from Nepal, for teaching undergraduate and postgraduate ENT students in the field of otorhinolaryngology.
A clear and concise explanation of the basic concepts in the subject matter concerned.
He is the Head of department with a sound knowledge in the field of ENT to teach both undergraduate and postgraduate ENT students
ear assessment is the examination of the ear and related diagnosis evaluation for ear which all nurses can use for their learning purpose and can use as a tool for assessment for detection and diagnosis of all the disease condition related to ear
The ppt is about anatomy of middle ear which has the following sub headings:
1.Ossicles of ear
2.Intratympanic muscles
3.Nerve supply
4.Lining of middle ear
5.Lymphatic drainage of middle ear
hope this ppt is helpful and any suggestions are welcomed
The common ENT disorders includes Ear Disorder: Ear Infections,Hearing Disorders and Deafness, Meniere's Disease. acute otitis media, tonsillopharyngitis, sore throat, adenoid disorders, epistaxis, nasal congestion and rhinorrhea, sinusitis, and ear foreign bodies and nasal foreign bodies etc.
Anatomy of ear for undergraduate students ( MBBS ) .
Basic anatomy of ear with its clinical importance
nerve supply of ear
blood supply of ear
middle ear ossicles
malleus incus stapes
muscles of middle ear
mastoid air cells
pinna tympanic membrane
lymphatics of ear
walls of middle ear
organ of corti
middle ear cleft
facial recess
sinus tympani
chorda tympani
embryology of ear
Anatomy of ear and mastoid is a must know topic for undergraduate and postgraduate ENT students. In this lecture, Dr Krishna Koirala will be explaining about the anatomy of ear and mastoid in a clear and simplified way.
Understanding Hearing Loss by Jed Kwartler, MD & Marykate Vaughn, AUD - Livin...Summit Health
People of all ages experience gradual hearing loss, often due to the natural aging process, long exposure to loud noise or other medical conditions. Learn about ear anatomy, how the hearing sense works, and the most advanced surgical practices and technology for treating hearing loss.
Common: 200 000 TC/an, 12 000 death
Neuroimaging plays a critical role in the evaluation of patients with traumatic brain injury
CT: first-line of imaging
MR imaging being recommended in specific settings
MR imaging DTI, blood oxygen level–dependent fMRI, MR spectroscopy, perfusion imaging are of particular interest in identifying further injury CT and MRI are normal, as well as for prognostication in patients with persistent symptoms
However, it is an invasive procedure that is not straightforward to perform so is often reserved as a problem-solving tool when both the aortic root and valve are the prime source of interest.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. • 3 distinct parts
• The acoustic meatus
• Pinna
• External acoustic meatus
• Acoustic wave propagation
• Protection of the middle ear and resonance
Anatomy and physiology
of hearing
3. • Eardrum
• Middle ear
• Contents:
• Auditory ossicles Amplify the
vibration of the eardrum
• Malleus, uncus and stapes
• Eustachian tube: connecting the
middle ear to the rhinopharynx:
equalizing air pressure on both
sides of the eardrum
• Adaptation of impedance
• Transformation vibration wave
to mechanical energy
Middle ear
6. • Vestibule and semi circular
canals: Balance
• Cochlea
• Hearing part of the inner ear
• 35mm long
• Spiral around a bony
structure
• 2 spires 1/2
• 2 scala separated by the
spiral lamina
• Filled with peri lymph
Stapes
Fenestra vestibuli
Apex of cochlea
Scala vestibuli
Scala Tympani
Organe of
Corti
Inner ear
7. • Scala Media
• Triangular-shaped duct
• contain the organ of
hearing: Organ of Cort
• Filled with endolymph
Organe of
Corti
Scala vestibuli
Scala tympani
Inner ear
12. Inferior Colliculus
Ø Crossroad between acsending and descending
fibers
Ø Complex auditory information
Ø located just below the visual processing centers
16. SOUND:
Air pressure vibration
Vibration of the eardrum
MAE
Sound =Mechanical
Energy
focus
Ossicles amplification
Endolymph fluid agitation
Hydraulic pressure
OHC: amplification
IHC: frequency
Cochlear nerve =
Electrical energy
Electrochemical signals to
brain
Physiology of Audition
17. • Cochlea tonotopy:
• Cochlea is capable of exceptional sound analysis, in
terms of both frequency and intensity.
• Higher frequencies cause movement in the base
of the cochlea, and deeper frequencies work at
the apex.
• Cochlear nuclei tonotopy
• Apex fibers: surface of nucleus
• Base fibers: depth of nucleus
Physiology of Audition
18. Physiology of Audition
Auditory messages are
conveyed permanently to
the brain via two types of
pathway:
the primary auditory
pathway which exclusively
carries messages from the
cochlea
the non-primary pathway
(also called the reticular
sensory pathway) which
carries all types of sensory
messages.
19. a
b
c
d
e
Neurophysiology of audition
• Primary auditory cortex: tonotopic
representation. Topographic map of
cochlea
• Stimulation:auditory hallucinations
contralateral ear
• Secondary auditory cortex: spatial
localisation of sound, memory audition
• Stimulation: auditory illusions
• Broca’s area: articulation of speech
• Wernicke’s area: speech perception
20. Neurophysiology of audition
• Some examples in music:
• Left hemisphere : rythm
• Right hemisphere : Melody et
Harmony
• Primary auditory cortex: height and
sound volume
• Secondary auditory cortex: Harmony,
Melody and Rythm
• Motor cortex: vocals and playing an
instrument
• Hippocampus: memory
• Cerebellum: rythm pathways (beat the
measure, tapping the feet to the beat)
Corpus callosum
23. • Medical history
• Uni or bilateral deafness
• Acquired, evolutive
• Otoscopy
• Tympanometry
• Acoustic reflex (if recruitment: endo cochlear lesion)
• Audiometric tests:
• Rinne CA>CO Nl ou SP
CO>CA ST
• Weber: Nl: vibration both ear
ST: sick side
SP: healthy side
Clinical diagnosis
24. • Audiogram:
• Tonal : graph
• Vocal : patient’s ability to understand
words
AEP: Electric activity cochlea
Clinical diagnosis
ST
SP
S Mixte
Unconformity tonal and
vocal: retro cochlear lesion
brainstem
25. HEARING LOSS
• A number of pathological, genetic and epigenetic factors
can cause hearing loss
• May involve any part of the sensory structure
• 3 types Conductive earing loss
EAM
ME
Sensorineural : Inner ear, IAM, central
Mixed : SP + Conductive
34. Central deafness
• Surdité Verbale:
• Impossibilité de reconnaître les mots entendus.
• Possibilité de parole spontanée
• Atteinte bilatérale cortex temporal.
• Agnosie auditive:
• Impossibilité de reconnaître les sons et bruits
environnants.
• Infarctus capsules externes ou corps genouillés
• Amusie
• Impossibilité de reconnaître la musique
35. • The auditory system has a complex organization
• It revolves around a dual relationship :
• Anatomical structure with perceptual function
• Complex structure combining perception and cognition.
• The deafness causes are many and varied and a good knowledge of anatomy ,
physiological , clinical and para-clinical and etiological diagnostic will
approach adapted diagnosis to a single symptom but with multiple etiologies.