Genetic engineering technology called Synthetic Genetic Incompatibility (SGI) uses a dCas9-based programmable transcription activator to drive lethal overexpression of a target gene early in embryo development from the mating of an SGI organism and a wild type organism. This creates a genetic barrier to sexual reproduction that could be used to control invasive carp species in US Midwest lakes and rivers. The document describes past demonstration of SGI in yeast and current efforts to demonstrate it in zebrafish and common carp through identification of gene targets and modifications to prevent premature gene activation.