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16/02/2016 1
SASMITA RAUT , COOMUNITY
2
Emerging and re-
emerging infectious
diseases
Presented By:
Mrs. Sasmita Nayak
Tutor, KINS, KIIT, DU, BHUBANESWAR
 Emerging infectious diseases
 Re-emerging infectious diseases
 Factors contributing to emergence and re-emergence of
infectious diseases
 Challenges to prevent the emergence of diseases
3
CONTENT
INTRODUCTION
Infectious diseases are the leading cause of death
worldwide, claiming at least 17 million lives every year. In
the South-East Asia region, 7 million people die from
diseases annually.
During the last 20 years, at least 30 new diseases have
emerged to threaten the health of hundreds of millions of
people. For many of these diseases there is no treatment or
appropriate vaccine and the possibility of preventing or
controlling them is limited
4
5
Infectious diseases remain the leading
cause of death worldwide
Emergence of new infectious
diseases
Re-emergence of old infectious
diseases
Persistence of intractable infectious
Diseases.
• Emerging infectious diseases are “New diseases; new
problem (New threats)”
• An emerging infectious disease is one which is caused
by a newly discovered infectious agent
or
• By a newly identified pathogen, which has emerged
and whose incidence in humans has increased during
the last 2 decades and is threatening to increase in the
near future.
7
Emerging Infectious Diseases
8
Types
• Diseases due to new agents
• Diseases due to new variants of known
pathogens
• Diseases caused by infectious agent but
resulting in non communicable diseases
9
Diseases due to new agents
Year Disease Causative agent
1970 Human monkeypox Monkeypox
1973 Infantile diarrhoea Rota virus
1976 Diarrhoea Cryptosporidium parvum
1977 Diarrhoea Campylobactero jejuni
1977 Legionnaires’ Disease Legionella Pneumophila
1976 Ebola haemorrhagic fever Ebola virus
1981 MRSA infection MRSA
1983 AIDS HIV
1
0
Cont…
Year Disease Causative agent
1988 Hepatitis E Hepatitis E virus
1989 Hepatitis C Hepatitis C virus
1993 Hanta virus
pulmonary syndrome
Hanta vitus
1998 Nipah encephalitis Nipah virus
2002 VRSA infection VRSA infection
2003 SARS SARS-associated
coronavirus
2004 H5N1 influenza H5N1 virus
2012 Middle – East
Respiratory Syndrome
Corona virus
2015 Zika Zika
1
1
Diseases caused by new variants of known
pathogens
Year Disease Causative agent
1982 Diarrhoeal diseases 0157.HF strain of E.
coli
1986 Exanthem Subitum HHV - 6
1992 Cholera 0139 strain of
V.cholerae
1996 -
97
Avian influenza H5N1
1
2
Diseases caused by infectious agent but resulting
in non communicable diseases
Year Disease Causative agent
1982 T – cell lymphoma
(lymphocytic leukemia)
Human T- lymphotropic
virus- 1 (HTLV-1)
1982 Hairy cell leukemia Human T- lymphotropic
virus- 2 (HTLV-2)
1982 Coronary artery disease chlamydia
1989 Non-A, Non-B hepatitis,
(liver cancer)
Hepatitis C
1995 Kaposi’s Sarcoma HHV-8
• 1970 - First discovered – Zire, Africa
• 1996- 97 : second outbreak
• 2003 : small outbreak in US with 79 cases
• 2005 : 49 cases reported from sudan
• Sept. 2017 – may 2019: Nigeria
• September 2018 : UK
• May 2019 : Singapore
HUMAN MONKEYPOX
• 1976 - First discovered – America (182 cases & 29 died)
• 1999: second outbreak in Netherland (318 cases &32 death)
• 2001 : largest outbreak in Spain (449 cases & 6 died)
• 2005: Canada (127 cases & 29 died
• 2014: Portugal (304 cases & 7 death)
• 2015: Northern California (81 cases)
• 2019: Western North Carolina (141 cases & 4 death)
• Every year: 8000-18000 cases occur in US.
Legionnaires’ Disease
EBOLA VIRAL DISEASE
 First discovered in 1976 near the Ebola River. Since then,
outbreaks have appeared sporadically inAfrica.
 The 2014 Ebola outbreak is the largest in history.
 Primarily affecting Guinea, Northern Liberia, and Sierra
Leone.
 Ebola virus disease (EVD), previous known as Ebola
hemorrhagic fever (Ebola HF)
 Fatality rate of up to 90%
 Transmitted by direct contact with the blood, body fluids and
tissues of infected animals or people
1
5
AIDS
1
6
SARS Cases
19 February to 5 July 2003
China (5326)
Singapore
(206)
Hong Kong
(1755)
Viet Nam (63)
Europe:
10 countries
(38)
Thailand (9)
Brazil
(3)
Canada
(243)
USA
(72)
Colombia
(1)
Kuwait
(1)
South Africa
(1)
India
(3)
Australia (5)
New Zealand (1)
Korea Rep. (3)
Macao (1)
Taiwan (698)
Malaysia (5)
Indonesia (2)
Philippines (14)
Mongolia
(9)
Russian Fed. (1)
Total: 8,439 cases, 812 deaths,
30 countries
Source: www.who.int.csr/sars
SARS
The First Emerging Infectious Disease Of The 21st Century
No infectious disease has spread so fast and far as SARS did in 2003
13
1
8
Swine Flu (H1N1)
• Pandemic outbreak since April 2009
• April 15th 2009 CDC identifies H1N1 (swine flu)
• April 25th 2009 WHO declares public health emergency
• By May 5th 2009 more than 1000 cases confirmed in 21
countries
• May 16th 2009 India reports first confirmed case
• Cases of swine flu have been reported in India, with over
31,156 positive test cases and 1,841 deaths up to March 2015
1
9
Highly Pathogenic Avian Influenza (H5N1)
•Since Nov 2003, avian influenza H5N1 in birds affected
60 countries across Asia, Europe, Middle-East &Africa
•>220 million birds killed by this virus or culled to
prevent further spread
•Majority of human H5N1 infection due to direct contact
with birds infected with virus
 1947: First discovered in a monkey,
Uganda.
 In 195: First human cases detected.
 Before 2007 : 14 human cases
documented.
 June 2015:- First case in Brazil.
 2016:- In U.S., over 3,000 cases.
 January 22, 2016, CDC activated its
Emergency Operations Center (EOC)
 On February 8, 2016, CDC elevated
its EOC activation to a Level 1, the
highest level.
2
1
Malaysian Nipah virus epidemic 1998-1999
• An outbreak of Nipah virus in Malaysia & Singapore
• Overcrowding results in viral transmission to pig
handlers
• The virus persists in low numbers in the island flying
fox, a type of fruit bat and Malaysian flying fox.
• Of the 269 human cases of viral encephalitis
associated with Nipah virus infection reported
in Malaysia in 1999, 108 were fatal (Ministry of
Health Malaysia, 2001).
2
2
Emerging Food borne & water borne
disease
•Accounts for 20 million cases in the world annually
(T.D. Chugh-2008)
•Incidence is increasing
•Half of all known food borne pathogens discovered
during the past 25 years
•Most common associated organisms are: Entero
hemorrhagic Escherichia coli, Vibrio cholerae,
Campylobacter sp.
2
3
•Re-emerging infectious diseases are “olddiseases new
problem. (New threats)”.
•A re-emerging infectious disease is a one which was
previously controlled but once again has risen to be a
significant health problem.
•This term also refers to that disease which was
formerly confined to one geographic area, has now
spread to other areas.
Re-emerging Infectious Diseases
2
4
Examples
Malaria
Kala - azar
Dengue fever
Plague
Polio
Yellow fever
Tuberculosis
Factors contributing to the emerging &
re-emerging diseases
AGENT
EVOLUTION OF THE
INFECTIOUS AGENT
Genetic change
Antibiotic resistance
Resistance of vector
HOST
Change in behaviour
Ecological disruption
Increased number of
immunocompromised hosts.
International travel
ENVIRONMENT
Urbanization &
Industrialization
Improper planning of
township
Overcrowding
Deforestation
Poverty
Long-term impact of
global warming
Climate change
Breakdowns in public
health measures
Lack of health care
services
War & political
conflict
Deterioration in
surveillance system
3
4
• Controlling the reservoir
• Interrupting the transmission
• Protecting the susceptible host
• Strengthening of the disease surveillance system
• Encouraging research initiations for treatment regimens and
diagnostics
• Encouraging research for new methods of control measures
• Establishment of drug resistance
Control of Emerging and Re-emerging Diseases
3
5
Increase knowledge and skill ; Educate the public
Encourage partnerships with consumers and other disciplines
Support health care legislation
Involve in research
Encourage using multidisciplinary efforts.
Influence local and National economic and political options
Continue to advance nursing concern
Role of Doctors in Prevention
3
6
National programme for prevention and control of vector
borne diseases
Legislations for elimination
Communities awareness of the disease
Minimizing transmission of infection: By
• Risk communication to the family members
• Minimizing vector population
• Minimizing vector – individual contact
Reporting to the nearest public health authority
Role of Public Health Authorities
3
7
Safe water
Sewage treatment and disposal
Food safety programme
Animal control programme
Vaccination programme
Public health organization
Public health measures to prevent
infectious diseases
•Developing global and regional strategies
•Appointing Task Force
•Generous grant from WHO regular budget
•Support the World Bank grant
•GOARN (Global Outbreak Alert & Response Network)
• Mechanism for combating international disease outbreaks
• Ensure rapid deployment of technical assistance, contribute to long-term
epidemic preparedness & capacity building
3
8
Response of the WHO
3
9
• Surveillance at national, regional, global level
• epidemiological,
• laboratory
• ecological
• anthropological
• Investigation and early control measures
• Implement prevention measures
• behavioural, political, environmental
• Monitoring, evaluation
Key Tasks in Dealing with Emerging Diseases
Peripheral
laboratories
District
laboratories
Disease
Surveillance unit
Disease
Surveillance unit
Disease
Surveillance unit
National
laboratory
State
laboratories
Disease
Surveillance unit
ACTION
40
LAB SURVEILLANCE
Recommended laboratory testing in emerging infections:
Molecular testing- PCR, Rapid test – for flu, Dengue-NS1 antigen, Antimicrobial
resistance-susceptibility testing , gene detection by PCR
Factors Solution
Migration Proper health screening, vaccination
Travel Immunization, infection control measure
Urbanization Proper sanitation, adequate housing, good
infrastructure
Human behaviour Education, behaviour modification
Antibiotic usage Judicious use of antibiotic
Correct antibiotic for correct pathogen (with
right dosage and route).
Strengthen infection control measures
Solutions
Multiple expertise needed !
Infectious
diseases
Epidemio-
logy
Public
Health
International
field
experience
Information
management
Laboratory
Telecom. &
Informatics
4
2
Skills needed for prevention
16/02/2016 43
SASMITA RAUT , COOMUNITY
HEALTH NURSING
4
4
Conclusion
• The true prevalence of many diseases is not known. Since
we live in a global village, we cannot afford to be
complacent about the tremendous economic, social and
public health burden of these diseases. Effective
surveillance is the key to their early containment.
• There is a need to develop epidemiology improved
diagnostic facilities, a strong public health structure,
effective risk communication, epidemic preparedness and
rapid response.
4
5
Reference
1. Park .k , “ Park text book of Preventive and social
medicine ”, 23rd edition ,2015 , m/s Banarsidas Bhanot
,page no – 355-359
2. Suryakantha . AH ,” Community medicicines with recent
advances”,4th edition , 2017 , Jaypee Brother medical
publishers ,(p)ltd, 4th edition , page no 965-970
3. Dash Bijayalaskhmi, A Comprehensive Textbook of
Community Health Nursing, 1st edition, Jaypee Brothers,
Publisher, 2016, Pp- 540-542.
4
6

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Emerging and re emerging diseases

  • 2. 2 Emerging and re- emerging infectious diseases Presented By: Mrs. Sasmita Nayak Tutor, KINS, KIIT, DU, BHUBANESWAR
  • 3.  Emerging infectious diseases  Re-emerging infectious diseases  Factors contributing to emergence and re-emergence of infectious diseases  Challenges to prevent the emergence of diseases 3 CONTENT
  • 4. INTRODUCTION Infectious diseases are the leading cause of death worldwide, claiming at least 17 million lives every year. In the South-East Asia region, 7 million people die from diseases annually. During the last 20 years, at least 30 new diseases have emerged to threaten the health of hundreds of millions of people. For many of these diseases there is no treatment or appropriate vaccine and the possibility of preventing or controlling them is limited 4
  • 5. 5 Infectious diseases remain the leading cause of death worldwide Emergence of new infectious diseases Re-emergence of old infectious diseases Persistence of intractable infectious Diseases.
  • 6.
  • 7. • Emerging infectious diseases are “New diseases; new problem (New threats)” • An emerging infectious disease is one which is caused by a newly discovered infectious agent or • By a newly identified pathogen, which has emerged and whose incidence in humans has increased during the last 2 decades and is threatening to increase in the near future. 7 Emerging Infectious Diseases
  • 8. 8 Types • Diseases due to new agents • Diseases due to new variants of known pathogens • Diseases caused by infectious agent but resulting in non communicable diseases
  • 9. 9 Diseases due to new agents Year Disease Causative agent 1970 Human monkeypox Monkeypox 1973 Infantile diarrhoea Rota virus 1976 Diarrhoea Cryptosporidium parvum 1977 Diarrhoea Campylobactero jejuni 1977 Legionnaires’ Disease Legionella Pneumophila 1976 Ebola haemorrhagic fever Ebola virus 1981 MRSA infection MRSA 1983 AIDS HIV
  • 10. 1 0 Cont… Year Disease Causative agent 1988 Hepatitis E Hepatitis E virus 1989 Hepatitis C Hepatitis C virus 1993 Hanta virus pulmonary syndrome Hanta vitus 1998 Nipah encephalitis Nipah virus 2002 VRSA infection VRSA infection 2003 SARS SARS-associated coronavirus 2004 H5N1 influenza H5N1 virus 2012 Middle – East Respiratory Syndrome Corona virus 2015 Zika Zika
  • 11. 1 1 Diseases caused by new variants of known pathogens Year Disease Causative agent 1982 Diarrhoeal diseases 0157.HF strain of E. coli 1986 Exanthem Subitum HHV - 6 1992 Cholera 0139 strain of V.cholerae 1996 - 97 Avian influenza H5N1
  • 12. 1 2 Diseases caused by infectious agent but resulting in non communicable diseases Year Disease Causative agent 1982 T – cell lymphoma (lymphocytic leukemia) Human T- lymphotropic virus- 1 (HTLV-1) 1982 Hairy cell leukemia Human T- lymphotropic virus- 2 (HTLV-2) 1982 Coronary artery disease chlamydia 1989 Non-A, Non-B hepatitis, (liver cancer) Hepatitis C 1995 Kaposi’s Sarcoma HHV-8
  • 13. • 1970 - First discovered – Zire, Africa • 1996- 97 : second outbreak • 2003 : small outbreak in US with 79 cases • 2005 : 49 cases reported from sudan • Sept. 2017 – may 2019: Nigeria • September 2018 : UK • May 2019 : Singapore HUMAN MONKEYPOX
  • 14. • 1976 - First discovered – America (182 cases & 29 died) • 1999: second outbreak in Netherland (318 cases &32 death) • 2001 : largest outbreak in Spain (449 cases & 6 died) • 2005: Canada (127 cases & 29 died • 2014: Portugal (304 cases & 7 death) • 2015: Northern California (81 cases) • 2019: Western North Carolina (141 cases & 4 death) • Every year: 8000-18000 cases occur in US. Legionnaires’ Disease
  • 15. EBOLA VIRAL DISEASE  First discovered in 1976 near the Ebola River. Since then, outbreaks have appeared sporadically inAfrica.  The 2014 Ebola outbreak is the largest in history.  Primarily affecting Guinea, Northern Liberia, and Sierra Leone.  Ebola virus disease (EVD), previous known as Ebola hemorrhagic fever (Ebola HF)  Fatality rate of up to 90%  Transmitted by direct contact with the blood, body fluids and tissues of infected animals or people 1 5
  • 17. SARS Cases 19 February to 5 July 2003 China (5326) Singapore (206) Hong Kong (1755) Viet Nam (63) Europe: 10 countries (38) Thailand (9) Brazil (3) Canada (243) USA (72) Colombia (1) Kuwait (1) South Africa (1) India (3) Australia (5) New Zealand (1) Korea Rep. (3) Macao (1) Taiwan (698) Malaysia (5) Indonesia (2) Philippines (14) Mongolia (9) Russian Fed. (1) Total: 8,439 cases, 812 deaths, 30 countries Source: www.who.int.csr/sars SARS The First Emerging Infectious Disease Of The 21st Century No infectious disease has spread so fast and far as SARS did in 2003 13
  • 18. 1 8 Swine Flu (H1N1) • Pandemic outbreak since April 2009 • April 15th 2009 CDC identifies H1N1 (swine flu) • April 25th 2009 WHO declares public health emergency • By May 5th 2009 more than 1000 cases confirmed in 21 countries • May 16th 2009 India reports first confirmed case • Cases of swine flu have been reported in India, with over 31,156 positive test cases and 1,841 deaths up to March 2015
  • 19. 1 9 Highly Pathogenic Avian Influenza (H5N1) •Since Nov 2003, avian influenza H5N1 in birds affected 60 countries across Asia, Europe, Middle-East &Africa •>220 million birds killed by this virus or culled to prevent further spread •Majority of human H5N1 infection due to direct contact with birds infected with virus
  • 20.  1947: First discovered in a monkey, Uganda.  In 195: First human cases detected.  Before 2007 : 14 human cases documented.  June 2015:- First case in Brazil.  2016:- In U.S., over 3,000 cases.  January 22, 2016, CDC activated its Emergency Operations Center (EOC)  On February 8, 2016, CDC elevated its EOC activation to a Level 1, the highest level.
  • 21. 2 1 Malaysian Nipah virus epidemic 1998-1999 • An outbreak of Nipah virus in Malaysia & Singapore • Overcrowding results in viral transmission to pig handlers • The virus persists in low numbers in the island flying fox, a type of fruit bat and Malaysian flying fox. • Of the 269 human cases of viral encephalitis associated with Nipah virus infection reported in Malaysia in 1999, 108 were fatal (Ministry of Health Malaysia, 2001).
  • 22. 2 2 Emerging Food borne & water borne disease •Accounts for 20 million cases in the world annually (T.D. Chugh-2008) •Incidence is increasing •Half of all known food borne pathogens discovered during the past 25 years •Most common associated organisms are: Entero hemorrhagic Escherichia coli, Vibrio cholerae, Campylobacter sp.
  • 23. 2 3 •Re-emerging infectious diseases are “olddiseases new problem. (New threats)”. •A re-emerging infectious disease is a one which was previously controlled but once again has risen to be a significant health problem. •This term also refers to that disease which was formerly confined to one geographic area, has now spread to other areas. Re-emerging Infectious Diseases
  • 24. 2 4 Examples Malaria Kala - azar Dengue fever Plague Polio Yellow fever Tuberculosis
  • 25. Factors contributing to the emerging & re-emerging diseases
  • 26. AGENT
  • 27. EVOLUTION OF THE INFECTIOUS AGENT Genetic change Antibiotic resistance Resistance of vector
  • 28. HOST
  • 29. Change in behaviour Ecological disruption Increased number of immunocompromised hosts. International travel
  • 31. Urbanization & Industrialization Improper planning of township Overcrowding Deforestation
  • 32. Poverty Long-term impact of global warming Climate change Breakdowns in public health measures
  • 33. Lack of health care services War & political conflict Deterioration in surveillance system
  • 34. 3 4 • Controlling the reservoir • Interrupting the transmission • Protecting the susceptible host • Strengthening of the disease surveillance system • Encouraging research initiations for treatment regimens and diagnostics • Encouraging research for new methods of control measures • Establishment of drug resistance Control of Emerging and Re-emerging Diseases
  • 35. 3 5 Increase knowledge and skill ; Educate the public Encourage partnerships with consumers and other disciplines Support health care legislation Involve in research Encourage using multidisciplinary efforts. Influence local and National economic and political options Continue to advance nursing concern Role of Doctors in Prevention
  • 36. 3 6 National programme for prevention and control of vector borne diseases Legislations for elimination Communities awareness of the disease Minimizing transmission of infection: By • Risk communication to the family members • Minimizing vector population • Minimizing vector – individual contact Reporting to the nearest public health authority Role of Public Health Authorities
  • 37. 3 7 Safe water Sewage treatment and disposal Food safety programme Animal control programme Vaccination programme Public health organization Public health measures to prevent infectious diseases
  • 38. •Developing global and regional strategies •Appointing Task Force •Generous grant from WHO regular budget •Support the World Bank grant •GOARN (Global Outbreak Alert & Response Network) • Mechanism for combating international disease outbreaks • Ensure rapid deployment of technical assistance, contribute to long-term epidemic preparedness & capacity building 3 8 Response of the WHO
  • 39. 3 9 • Surveillance at national, regional, global level • epidemiological, • laboratory • ecological • anthropological • Investigation and early control measures • Implement prevention measures • behavioural, political, environmental • Monitoring, evaluation Key Tasks in Dealing with Emerging Diseases
  • 40. Peripheral laboratories District laboratories Disease Surveillance unit Disease Surveillance unit Disease Surveillance unit National laboratory State laboratories Disease Surveillance unit ACTION 40 LAB SURVEILLANCE Recommended laboratory testing in emerging infections: Molecular testing- PCR, Rapid test – for flu, Dengue-NS1 antigen, Antimicrobial resistance-susceptibility testing , gene detection by PCR
  • 41. Factors Solution Migration Proper health screening, vaccination Travel Immunization, infection control measure Urbanization Proper sanitation, adequate housing, good infrastructure Human behaviour Education, behaviour modification Antibiotic usage Judicious use of antibiotic Correct antibiotic for correct pathogen (with right dosage and route). Strengthen infection control measures Solutions
  • 42. Multiple expertise needed ! Infectious diseases Epidemio- logy Public Health International field experience Information management Laboratory Telecom. & Informatics 4 2 Skills needed for prevention
  • 43. 16/02/2016 43 SASMITA RAUT , COOMUNITY HEALTH NURSING
  • 44. 4 4 Conclusion • The true prevalence of many diseases is not known. Since we live in a global village, we cannot afford to be complacent about the tremendous economic, social and public health burden of these diseases. Effective surveillance is the key to their early containment. • There is a need to develop epidemiology improved diagnostic facilities, a strong public health structure, effective risk communication, epidemic preparedness and rapid response.
  • 45. 4 5 Reference 1. Park .k , “ Park text book of Preventive and social medicine ”, 23rd edition ,2015 , m/s Banarsidas Bhanot ,page no – 355-359 2. Suryakantha . AH ,” Community medicicines with recent advances”,4th edition , 2017 , Jaypee Brother medical publishers ,(p)ltd, 4th edition , page no 965-970 3. Dash Bijayalaskhmi, A Comprehensive Textbook of Community Health Nursing, 1st edition, Jaypee Brothers, Publisher, 2016, Pp- 540-542.
  • 46. 4 6