The document summarizes Earth's history from the Precambrian era to the present-day Cenozoic era in four parts. It describes the Precambrian era as spanning 88% of Earth's history, including the early evolution of life. The Paleozoic era saw the first life with hard shells and fossils, as well as plant and animal diversification on land and in the seas. Dinosaurs and other reptiles dominated during the Mesozoic era. Finally, the Cenozoic era is characterized as the time of mammals including humans, as well as flowering plants.
The Paleozoic Era started 542 million years ago with the emergence of complex life forms and ended 251 million years ago with the largest mass extinction the world has ever experienced.
The Paleozoic Era started 542 million years ago with the emergence of complex life forms and ended 251 million years ago with the largest mass extinction the world has ever experienced.
The geologic time scale, or geological time scale, (GTS) is a representation of time based on the rock record of Earth. It is a system of chronological dating that uses chronostratigraphy (the process of relating strata to time) and geochronology (scientific branch of geology that aims to determine the age of rocks). It is used primarily by Earth scientists (including geologists, paleontologists, geophysicists, geochemists, and paleoclimatologists) to describe the timing and relationships of events in geologic history. The time scale has been developed through the study of rock layers and the observation of their relationships and identifying features such as lithologies, paleomagnetic properties, and fossils. The definition of standardized international units of geologic time is the responsibility of the International Commission on Stratigraphy (ICS), a constituent body of the International Union of Geological Sciences (IUGS), whose primary objective[1] is to precisely define global chronostratigraphic units of the International Chronostratigraphic Chart (ICC)[2] that are used to define divisions of geologic time. The chronostratigraphic divisions are in turn used to define geochronologic units.[2]
While some regional terms are still in use,[3] the table of geologic time presented in this article conforms to the nomenclature, ages, and color codes set forth by the ICS as this is the standard, reference global geologic time scale – the International Geological Time Scale.[1][
Earth formed around 4.54 billion years ago, approximately one-third the age of the universe, by accretion from the solar nebula. Volcanic outgassing probably created the primordial atmosphere and then the ocean, but the early atmosphere contained almost no oxygen.
A great landmass which was thought to be in the geological past, splitting into fragments drifting apart and again colliding into one another is called a supercontinent.1. VAALBARA -First ever made continent was Vaalbara which was 3.6 billion years old, it was named after kaapvaal and Pilbara which were the most ancient cratons present on that land mass. Kaapvaal is in Africa and Pilbara is in western Australia.2. UR- A supercontinent which was 3000 m.y.a and it was smaller than modern day Australia.3. KENORLAND- 2700 m.y.a famous events were HURONIAN GLACIATION. Also known as SNOWBALL EARTH.Responsible for formation of phytoplanktons.and VREDEFORT impact.4. COLUMBIA- Also called as NUNA . Period between Snowball Earth and subsequent Oxidation is called as THE BARREN BILLION.5. RODINIA- 1130 m.y.a.SECOND SNOWBALL EARTH.Also known as NEOPROTEROZOIC GLACIATION.6. PANNOTIA- 750 m.y.aThe formation of Pannotia was associated with the breakup of Rodinia into Proto- Gondwana and Proto-Laurasia. Two oceans were PANTHALSSA and Pan-African Ocean.7. PANGEA- One of the Youngest Supercontinent of all time , there are plenty of evidences of this Supercontinent. Like marine fossils from TETHYS OCEAN can be observed in Himalayas.
History of Life on Earth (General Biology 2, 1st Semester, Quarter 1, Week 2A)RheaGulay3
Describe general features of the history of life on Earth, including generally accepted dates
and sequences of the geologic time scale and characteristics of major groups of organisms
present during these periods (STEM-BIO11/12-IIIC-G-8).
Specific Objectives:
1. Identify the date, eon, era, period, epoch and describe the major events base on
Geologic Time Scale.
2. Differentiate the types of fossils.
3. Appreciate the history of life on earth by making a personal timeline.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Comparative structure of adrenal gland in vertebrates
Earth's History Notes
1. CHAPTER 17 EARTH'S HISTORY: A BRIEF SUMMARY
The PRECAMBRIAN - spans about 88% of Earth history, beginning with the formation of Earth
about 4.5 billion years ago and ending approximately 540 million years ago with the
diversification of life that marks the start of the Paleozoic era.
- It is the least understood span of Earth's history because most Precambrian
rocks are buried from view. However, on each continent there is a "core area" of
Precambrian rocks called the SHIELD. The iron ore deposits of Precambrian age
represent the time when oxygen became abundant in the atmosphere and combined
with iron to form iron oxide.
Earth's PRIMITIVE ATMOSPHERE - consisted of such gases as water
vapor, carbon dioxide, nitrogen, and several trace gases.
- OUTGASSING – a process wherein these gases were
released in volcanic emissions.
The first life forms on Earth, probably ANAEROBIC BACTERIA, did not
require oxygen. As life evolved, plants, through the process of
PHOTOSYNTHESIS, used carbon dioxide and water and released oxygen into the atmosphere.
Once the available iron on Earth was oxidized (combined with oxygen), substantial quantities of
oxygen accumulated in the atmosphere. About 4 billion years into Earth's existence, the fossil
record reveals abundant ocean-dwelling organisms that require oxygen to live.
STROMATOLITES - The most common middle Precambrian fossils.
- Microfossils of bacteria and blue-green algae, both primitive PROKARYOTES
whose cells lack organized nuclei, have been found in chert, a hard, dense, chemical
sedimentary rock in southern Africa (3.1 billion years of age) and near Lake Superior
(1.7 billion years of age).
- EUKARYOTES, with cells containing organized nuclei, are among billion-year-
old fossils discovered in Australia. Plant fossils date from the middle Precambrian, but
animal fossils came a bit later, in the late Precambrian. Many of these fossils are
TRACE FOSSILS, and not of the animals themselves.
The PALEOZOIC ERA - extends from 540 million years ago to about 248
million years ago. The beginning of the Paleozoic is marked by the
appearance of the first life forms with hard parts such as shells.
- Therefore, abundant Paleozoic fossils occur and a far
more detailed record of Paleozoic events can be constructed.
2. During the early Paleozoic (the Cambrian, Ordovician, and Silurian periods) the vast
southern continent of GONDWANALAND existed.
- Seas inundated and receded from North America several times, leaving thick
evaporite beds of rock salt and gypsum.
- Life in the early Paleozoic was restricted to the seas and consisted of several
invertebrate groups.
- During the late Paleozoic (the Devonian, Mississippian, Pennsylvanian, and
Permian periods), ancestral North America collided with Africa to produce the original
northern Appalachian Mountains, and the northern continent of LAURASIA formed.
- By the close of the Paleozoic, all the continents had fused into the
supercontinent of PANGAEA.
- During most of the late Paleozoic, organisms diversified dramatically. Insects
and plants moved onto the land, and amphibians evolved and diversified quickly.
- By the Pennsylvanian period, large tropical swamps, which became the major
coal deposits of today, extended across North America, Europe, and Siberia. At the
close of the Paleozoic, altered climatic conditions caused one of the most dramatic
biological declines in all of Earth history.
The MESOZOIC ERA - often called the "age of dinosaurs,"
- begins about 248 million years ago and ends approximately 65 million years
ago.
- Early in the Mesozoic much of the land was above sea level. However, by the
middle Mesozoic, seas invaded western North America.
- As Pangaea began to break up, the westward-moving North American plate
began to override the Pacific plate, causing crustal deformation along the entire
western margin of the continent.
- Organisms that had survived extinction at the end of the Paleozoic began to
diversify in spectacular ways.
- GYMNOSPERMS (cycads, conifers, and ginkgoes) quickly became the
dominant trees of the Mesozoic because they could adapt to the drier climates.
- Reptiles quickly became the dominant land animals, with one group
eventually becoming the birds.
- The most awesome of the Mesozoic reptiles were the DINOSAURS. At the
close of the Mesozoic, many reptile groups, including the dinosaurs, became extinct.
The CENOZOIC ERA - or "era of recent life,"
- begins approximately 65 million years ago and continues
today.
- It is THE TIME OF MAMMALS, including humans.
3. - The widespread, less disturbed rock formations of the Cenozoic provide a
rich geologic record.
- Most of North America was above sea level through out the Cenozoic.
- Because of their different relations with tectonic plate boundaries, the eastern
and western margins of the North American continent experienced contrasting
events.
- The stable eastern margin was the site of abundant sedimentation as
isostatic adjustment raised the eroded Appalachians, causing the streams to
downcut with renewed vigor and deposit their sediment along the continental margin.
- In the west, building of the Rocky Mountains was coming to an end, the Basin
and Range Province was forming, and volcanic activity was extensive.
- The Cenozoic is often called "THE AGE OF MAMMALS" because these
animals replaced the reptiles as the dominant land life. Two groups of mammals, the
MARSUPIALS and the PLACENTALS, evolved and expanded to dominate the era.
One tendency was for some mammal groups to become very large.
- However, a wave of late PLEISTOCENE EXTINCTIONS rapidly eliminated
these animals from the landscape. Some scientists believe that humans hastened
the decline of these animals by selectively hunting the larger species.
- The Cenozoic could also be called the "AGE OF FLOWERING PLANTS." As
a source of food, flowering plants strongly influenced the evolution of both birds and
herbivorous (plant-eating) mammals throughout the Cenozoic era.