This document discusses earwax, also known as cerumen, and methods for removing impacted earwax. It describes the structure and composition of earwax, noting that it helps clean and lubricate the ear canal while also playing an antibacterial and antifungal role. When earwax becomes impacted, it can cause symptoms like a blocked ear sensation, discomfort, pain, tinnitus, and hearing impairment. The document outlines common techniques for removing impacted earwax, including using cerumenolytic drops to soften the wax, syringing the ear canal with water, and instrumental removal with tools like a cerumen hook. Complications from improper removal are also discussed.
Any deviation in the normal nasal septum is called DNS (Deviated Nasal Septum).
Deviated Nasal Septum may be caused by mechanical trauma and may be
associated with some developmental defects.
Any deviation in the normal nasal septum is called DNS (Deviated Nasal Septum).
Deviated Nasal Septum may be caused by mechanical trauma and may be
associated with some developmental defects.
Bleeding from inside the nose is called epistaxis
Fairly common and is seen in all age groups.
“Epistaxis refers to nose bleed or hemorrhage from the nose”.
It‘s mostly commonly originates in the anterior portion of the nasal cavity.
A hemorrhage from the nose, referred to as epistaxis, is caused by the rupture of tiny, distended vessels in the mucous membrane of any area of the nose.
Most commonly, the site is the anterior septum, where three major blood vessels enter the nasal cavity:
(1) the anterior ethmoidal artery on the forward part of the roof (Kesselbach’s plexus)
(2) the sphenopalatine artery in the posterosuperior region, and
(3) the internal maxillary branches (the plexus of veins located at the back of the lateral wall under the inferior turbinate).
Trauma to the auricle and ear canal
Its Complications
Treatment plan
Ear wax ,its composition, clinical features and management
Foreign body to the ear and its types
Treatment for foreign body in ear
Hematoma of The Auricle
Collection of blood between the auricular cartilage and its perichondrium.
Often result of blunt trauma seen in boxers, wrestlers and rugby players.
Extravasated blood may clot and then organize, resulting in a typical deformity called cauliflower ear (pugilistic or boxer’s ear)
If hematoma gets infected, severe perichondritis may occur.
Bleeding from inside the nose is called epistaxis
Fairly common and is seen in all age groups.
“Epistaxis refers to nose bleed or hemorrhage from the nose”.
It‘s mostly commonly originates in the anterior portion of the nasal cavity.
A hemorrhage from the nose, referred to as epistaxis, is caused by the rupture of tiny, distended vessels in the mucous membrane of any area of the nose.
Most commonly, the site is the anterior septum, where three major blood vessels enter the nasal cavity:
(1) the anterior ethmoidal artery on the forward part of the roof (Kesselbach’s plexus)
(2) the sphenopalatine artery in the posterosuperior region, and
(3) the internal maxillary branches (the plexus of veins located at the back of the lateral wall under the inferior turbinate).
Trauma to the auricle and ear canal
Its Complications
Treatment plan
Ear wax ,its composition, clinical features and management
Foreign body to the ear and its types
Treatment for foreign body in ear
Hematoma of The Auricle
Collection of blood between the auricular cartilage and its perichondrium.
Often result of blunt trauma seen in boxers, wrestlers and rugby players.
Extravasated blood may clot and then organize, resulting in a typical deformity called cauliflower ear (pugilistic or boxer’s ear)
If hematoma gets infected, severe perichondritis may occur.
The Nose and nasal cavity, anatomy, and clinical diseases of nasal cavity and...HamzehKYacoub
Nasal cavity is the most superior part of the respiratory system.
Blood supply of nose and Cavernous Sinus.
Epistaxis causes and locations.
Allergic Rhinitis and Non-allergic rhinitis with eosinophilia (NARES).
Ostiomeatal complex (OMC)
Sinusitis.
Nasal polyps.
Headaches types.
Neuralgia.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
1. EAR WAX ANDEAR WAX AND
SYRINGINGSYRINGING
Dr. Avinash Malekar
2. Histology of EAC
• External canal is lined entirely by keratinising stratified
squamous epithelium. This epithelium is in continuity
with the lateral surface of the tympanic membrane
Bony part (Inner 2/3rd) Cartilageous part (Outer 1/3rd)
The skin lining the bony canal is very
thin, measuring about 30 - 50 microns
in thickness
Skin here is loosely adherent to the
underlying bone, facilitating easy
elevation during surgery
Skin over the cartilagenous canal is
much thicker and more adherent
than the skin of the bony canal
Rete ridges are absent in the skin
lining the bony portion of the
external canal. The skin here lacks
hair and other appendages
It has numerous hairs as well as
sebaceous and ceruminous glands
4. EAR WAXEAR WAX
• Wax is composed of secretion of sebaceous
glands, ceruminous glands, hair, desquamated
epithelial debries , keratin, dirt
• Sebaceous and ceruminous glands open into
space of hair follicle
• Sebaceous glands provide fluid rich in fatty
acids while secretion of ceruminous gland is
rich in lipid and pigment granules
5. • The primary components of earwax are the final
products in the HMG-CoA reductase pathway,
namely, squalene, lanosterol, and cholesterol
6. Wax
WET WAX
• Light or dark brown and
sticky
• High concentration of lipid
(around 50%) and pigment
granules
• Found in Caucasians and
Africans
DRY WAX
• Grey or tan
and brittle
• Contains around 20% lipid
• Found in Asians
and Native Americans
7.
8. Functions of ear wax
• 1. Cleaning
• Cleaning of the ear canal occurs as a result of the "conveyor belt"
process of epithelial migration, aided by jaw movement.
• Cells formed in the centre of the tympanic membrane migrate
outwards from the umbo (at a rate equivalent to that of fingernail
growth) to the walls of the ear canal, and accelerate towards the
entrance of the ear canal.
9. • The cerumen in the canal is also carried outwards, taking
with it any dirt, dust, and particulate matter that may have
gathered in the canal. Jaw movement assists this process
by dislodging debris attached to the walls of the ear canal,
increasing the likelihood of its extrusion.
2. Lubrication
• Lubrication prevents desiccation and itching of the skin
within the ear canal (known as asteatosis).
• The lubricative properties arise from the high lipid content
of the sebum produced by the sebaceous glands
• Lubrication of EAC helps to entrap foreign material
10. • 3. Antibacterial and antifungal roles
• Recent studies have found that cerumen has a bactericidal
effect on some strains of bacteria.
• Cerumen has been found to be effective in reducing the
viability of a wide range of bacteria (sometimes by up to
99%), including Haemophilus influenzae, Staphylococcus
aureus, and many variants of Escherichia coli.
• The growth of two fungi commonly present in otomycosis
was also significantly inhibited by human cerumen. These
antimicrobial properties are due principally to the presence
of saturated fatty acids, lysozyme and, especially, to the
relatively low pH of cerumen (typically around 6.1 in
normal individuals).
11. Symptoms caused by impacted wax
1. Sense of blocked ear
2. Discomfort or pain in ear
-Patient seldom complains pain unless the wax is
pressing on the drum
3. Tinnitus
- Results from impaction of wax
against tympanic membrane
14. CERUMENOLYSIS
•It is usually necessary to soften wax before its removal. This
process is referred to as cerumenolysis, and is achieved using
a solution known as a cerumenolytic agent which is
introduced into the ear canal
•Patient should lie with the affected ear uppermost for 5-10
minutes after the drops have been introduced into the ear
canal. Repeated digital pressure on the tragus encourages
movement of the drops and wax dispersal
•The most common home-remedy for this purpose is olive
oil. Other commercially available and common
cerumenolytics include:
16. Ceruminolytics
Oil based Water based Non-water non-oil
based
Olive oil Sodium bicarbonate
(5-10%)
Carbamide peroxide
Almond oil Hydrogen peroxide
(3%)
Glycerol combination
preparations
Peanut oil Acetic acid (1-3%) 2%
paradichlorobenzene
Docusate sodium
17. SYRINGING
• Irrigation or "syringing" is a standard method of wax
removal
• Indications for syringing:
1. Removal of wax
2. Dried fungal debris
3. Epithelial debris
4. Blunt foreign bodies
18. • Contraindications for syringing
1. Acute inflammatory conditions of the external or middle
ear
2. Discharge from the ear
3. Perforation of the tympanic membrane
4. Previous ear surgeries
5. Impacted hygroscopic foreign bodies
6. Sharp foreign bodies
20. How ear syringing done?
Patient is seated with the ear to be syringed towards the
examiner
A kidney tray placed over the shoulder of the patient
The syringe is held in the right hand. Normal saline,
distilled water or normal water can be used after boiling
and cooling at 37º which is the normal body temperature.
Water has to be cooled to body temperature to prevent
labyrinthine stimulation (Caloric effect)
21. Pinna is pulled upward and backward in adults and
downwards and backwards in younger children to
straighten external ear canal
Stream of water is directed towards the posterio-superior
wall of the meatus. The pressure of the water builds up
deeper to the wax and expels the wax out
The ear is made dry with a cotton swab after the
procedure. At the end of this procedure, the ear canal, and
tympanic membrane must be inspected and dried up with a
cotton pledget.
22. • Complications of syringing can be:
1. Trauma to external canal or tympanic membrane
2. Giddiness usually temporary
3. In the rare instances when there is a perforation, irrigation
may force water and wax into the middle ear, causing a
nidus for infection
4. Vaso-vagal shock
23. INSTRUMENTAL MANUPULATION
• Should be done by skilled hands
• Cerumen hook, Jobson-Horne probe or crocodile forcep
• The instrument is passed alongside and deep to the wax
and drawn carefully outwards, removing the wax deposit