This document discusses ear conditions, focusing on ear wax impaction and otitis externa. It defines the conditions, discusses prevalence and epidemiology, aetiology, clinical features, differential diagnosis, and appropriate over-the-counter treatments. Ear wax impaction is common and usually caused by failed attempts to clean the ear canal. Otitis externa is an inflammation often caused by infection, with Pseudomonas aeruginosa and Staphylococcus as common pathogens. Both conditions present with ear discomfort and possible hearing loss, and are usually treated with cerumenolytics or topical antibiotics without referral.
Chronic otitis media effusion, also known as chronic middle ear fluid, is a condition characterized by the long-term presence of fluid in the middle ear. The middle ear is the space behind the eardrum that contains the tiny bones responsible for transmitting sound vibrations to the inner ear
In this presentation there is complete content regarding its causes, pathophysiology, clinical manifestations, diagnostic evaluations and managements that can be done.
First of all as we know that otitis media is a disease condition related to ear infection and inflammations.
What specific questions you will ask to reach the diagnosis?
Give the differential diagnosis?
Give management plan of your diagnosis?
What complications can develop?
Write the treatment of your diagnosis?
This is an insidious condition characterized by accumulation of nonpurulent effusion in the middle ear cleft.
The effusion is mostly viscid and thick but sometimes it is thin and serous.
This condition is commonly seen in the school going children.
it is also known as;
Secretory otitis media.
Mucoid otitis media.
Glue ear.
Chronic otitis media effusion, also known as chronic middle ear fluid, is a condition characterized by the long-term presence of fluid in the middle ear. The middle ear is the space behind the eardrum that contains the tiny bones responsible for transmitting sound vibrations to the inner ear
In this presentation there is complete content regarding its causes, pathophysiology, clinical manifestations, diagnostic evaluations and managements that can be done.
First of all as we know that otitis media is a disease condition related to ear infection and inflammations.
What specific questions you will ask to reach the diagnosis?
Give the differential diagnosis?
Give management plan of your diagnosis?
What complications can develop?
Write the treatment of your diagnosis?
This is an insidious condition characterized by accumulation of nonpurulent effusion in the middle ear cleft.
The effusion is mostly viscid and thick but sometimes it is thin and serous.
This condition is commonly seen in the school going children.
it is also known as;
Secretory otitis media.
Mucoid otitis media.
Glue ear.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
1. LECTURENO.6 AND 7
EARCONDITIONS
Course Name: Community Pharmacy
Course Code: 0520524
Lecturer: Ms. Asma El-Shara’.
MPH FacultyOf Pharmacy,
Philadelphia University-Jordan
2. Learning outcomes:
Define Ear wax impaction and otitis externa.
Explain the prevalence and epidemiology of Ear wax
impaction and otitis externa.
Describe the aetiology of Ear wax impaction and otitis
externa.
Describe how to achieve differential diagnosis for Ear wax
impaction and otitis externa.
Classify the conditions to eliminate.
Classify evidence base for over-the-counter medication.
2
3. Contents
3
Ear wax impaction and otitis externa.
Prevalence and epidemiology.
Aetiology.
Differential diagnosis.
Conditions to eliminate.
Evidence base for over-the-counter medication.
4. BACKGROUND
Currently, community pharmacists can ONL
Y offer
help to patients with conditions that affect the
external ear
Therefore, concentrates on external ear problems.
However, with appropriate auroscopical training and
further POM to Pderegulation of medicines, it is not
unrealistic to extend the community pharmacists' role
to include middle ear problems.
5. EARANATOMY
PINNA + external auditory meatus (EAM, ear canal) =
collect and transmitsoundto the tympanic membrane
(eardrum).
The pinna consistschiefly of cartilage and has a firm
elastic consistency.
The EAM opensbehind the tragusand curves inwards for
approximately 3 cm; the inner two-thirds is bony and the
outer third cartilaginous.
The skin lining the cartilaginous outer portion has a well-
developed subcutaneouslayer that containshair
follicles, ceruminous and sebaceousglands.
Thetwo portionsof themeatushaveslightly different
directions; the outer cartilaginousportion is upward
and backward where as the inner bony portionis
forward and downward. This is important to know when
examining the ear.
PINNA
6. PHYSICALEXAMINATION
1. First, wash your hands.
2. Next inspect the external ear for redness, swelling and
discharge.
3. Then apply pressure to the mastoid area which is
directly behind the pinna (If thearea istender this
suggests mastoiditis, a rare complication of otitis media).
4. 4. Next move the pinna up and down and manipulate
thetragus. If either istender onmovementthenthis
suggests external ear involvement.
7. PHYSICALEXAMINATION (continued)
5. You should finally examinetheEAM. This is
bestperformed usinganotoscope,however
currently mostpharmacistshavenothad
appropriate training in their use. An alternative
way to inspect the E
AM would be to usea pen
torch.Becauseof theshapeof theEAM,when
performing anexaminationthepinna needsto
be manipulated to obtain thebest view of the
ear canal
11. EARWAX IMPACTION (mostlikely cause)
Producedinthe outer third ofthe cartilaginous portion ofthe ear canal bythe
ceruminousglands.
FUNCTIONS:
A- Mechanical protection of the tympanic membrane.
B- T
rapping dirt.
C-R
epelling water.
D- Contributing to a slightly acidic medium that has been reported to exert
protection against bacterial and fungal infection.
COMPOSITION OFCERUMEN:
varies between individuals but can be broadly divided into :
1- 'wet or sticky' type of wax common in Caucasians and African-Americans .
2- 'dry‘ that is common in Asian populations.
12. PREVALENCEAND EPIDEMIOLOGY
The exact prevalence rates of ear wax impaction is not
clear.
2-6% of the general population suffer from impacted wax
oneScottishsurveyof GPsreported anaverage of nine
patients per month (range 5 to 50 patients) requesting ear
wax removal.
However,manymorepatients self-diagnose and medicate
without seekingGP assistance, therefore pharmacistshave
an important role in ensuring that treatment is appropriate.
The high number of presentations may be due to patient
misconception that earwax needs to be removed.
13. PREVALENCEAND EPIDEMIOLOGY (continued)
A number of patient groups appear to be more
prone to ear wax impaction thanthegeneral
population:
Patients with congenital anomalies (narrowed ear
canal).
Patients with learning difficulties and those fitted
with a hearing aid.
The elderly are more susceptible to impaction due
to the decrease in cerumenproducing glands
resulting in drier and harder ear wax.
14. Aetiology
Theskinof thetympanicmembraneisunusual.It isnotsimply
shed as skin is from the rest of the body but is migratory. This
isbecausetheauditory canal isthebody's only 'dead end'
and abrasionof the stratum corneumcannot occur.
Skintherefore movesoutwards away from the ear drumand
outalong theear canal.Thismeansthat theears are largely
self-cleaning as the ear canal naturally shedswax from the
ear. However,thisnormalfunctioncanbe interrupted, usually
by misguided attempts to clean ears. Wax therefore becomes
trapped, hampering its outward migration.
16. CLINICALFEATURESOF EARWAX IMP
ACTION
The key features of ear wax impaction are:
1- A history of gradual hearing loss
2- Ear discomfort (to variable degrees).
3- R
ecent attemptsto cleanears.
Itching, tinnitus and dizziness occur infrequently.
Otoscopical examination should reveal excessive
wax.
17. Conditions to eliminate
A. T
raumaof theear canal
use all manner of implements to try and clean the
ear canal of wax (e.g. cotton buds, hairgrips, and
pens).
Inspection of the ear canal might reveal laceration
of theear canal and thepatient mayexperience
greater conductive deafnessbecause of the wax
becoming further impacted.
Trauma might also lead to discharge from the ear
canal; these cases are probably best referred.
18. B
. Foreignbodies
Symptoms can mimic ear wax impaction but, over
time, discharge and pain is observed.
Children are themostlikely age group to present
with a foreign body in the ear canal and suspected
cases need to be referred to a GP
.
Conditions to eliminate (continued)
20. Evidence base for over-the-
counter medication
Studies:
The findings fromreviewssupport the use of oil-
based softeners, sodium bicarbonate and sterile
water over no treatment at all, but no active
treatment proved more superior over any other.
Oil-based products to be significantly better than
saline but again showed no differencesbetween
each other.
25. Background
Otitis externa refers to generalised inflammation
throughout the EAM and isoften associated with
infection.
It usually occurs as an acute episode but may
become chronic (greater than 3 months) in children.
26. Prevalence and epidemiology
The lifetime prevalence of acute otitis externa is
10% and a GP will see approximately 16 new
cases per year.
It ismorecommoninhotand humidclimatesand in
westernsociety the number of episodes increasesin
the sum
mer months.
P
eople who swim are FIVE times more likely than
non-swimmers to contract it.
It iscommonerinadults and reported to be slightly
more common in women than men.
27. AETIOLOGY
Primary infection, contact sensitivity or a
combination of both causes otitis externa.
Pathogensinclude
Pseudomonasaeruginosa.
Staphylococcusspp.
Streptococcuspyogenes.
Fungal overgrowth with Aspergillus niger is also seen
especially after prolonged antibiotic treatment.
28. AETIOLOGY (continued)
Certain local or general factorscanprecipitate
otitisexterna.
Local causes include trauma or discharge from
the middle ear
General causes include seborrhoeic
dermatitis, psoriasis and skin infections.
31. CLINICAL FEATURESOF OTITIS EXTERNA
A- Otitis externa is characterised by itching andirritation,
which, depending on the severity, can become intense.
B- This provokes the patient to scratch the skin of the
EAM, resulting in trauma andpain.
C- Otorrhoea (ear discharge) follows and the skin of the EAM
can become oedematous, leading to conductivehearing
loss.
D- On examination, the ear canal or external ear, or both,
appear red, swollen, or eczematous.
32. CLINICAL FEATURESOF OTITISEXTERNA(continued)
Notes:
Patients might not present until pain becomes a
prominent feature.
There should be a period when irritation is the
only symptomapparent.
Chewing and manipulation of the tragus and
pinna can exacerbate pain.
33. CONDITIONS TO ELIMINATE
Likely causes
ACUTEOTITISMEDIA
A rapidly accumulating effusion in the middle ear (acute otitis
media) is most common in children aged 3 to 6 years old.
In older children, ear pain/earache is the predominant feature
and tends to be throbbing.
In young children this is often manifested as irritability or
crying with characteristic ear tugging/rubbing.
Systemic symptoms can also be present suchas fever and loss
of appetite.
Examination Reveal a red/yellow and bulging tympanic
membrane.
34. CONDITIONS TO ELIMINATE (continued)
Pain resolves on rupture of the tympanic membrane, which
releases a mucopurulent discharge.
Treatment
Over three-quarters of episodesresolvewithin 3 days without
treatment and current UK guidelines do not advocate the routine
use of antibiotics.
Patients should be managed with analgesia (paracetamol or
ibuprofen) unless they are systemically unwell or are under 2
years of age and have discharge. These cases should be
referred for GP consideration of antibiotics.
35. CONDITIONS TO ELIMINATE(continued)
Childrenmaydeveloprecurrentotitis media and
isknown as'glue ear'.
Theconditionissymptomlessapart fromimpaired
hearing,butcanhave a negative impact ona
child'slanguageandeducationaldevelopment.
36. CONDITIONS TO ELIMINATE (continued)
Unlikely Causes
DERMA
TITIS
Allergic, contact, seborrhoeic and atopic forms of
dermatitis can occur on the external ear.
Itch is a prominent symptom and could be mistaken for
otitis externa
however there should be no ear pain or discharge
associated with dermatitis.
In addition, in seborrhoeic and atopic formsskin
involvement elsewhere should be obvious.
37. CONDITIONS TO ELIMINATE (continued)
Very Unlikely Causes
A. PERICHONDRITIS
In severe cases of otitis externa the inflammation can
spread from the outer ear canal to the pinna,
B.TRAUMA
Recent trauma (e.g. blow to the head) can cause an
auricular haematoma (cauliflower ear) non-urgent
referral.
C.MALIGNANT TUMOURS
Any elderly patient presenting with an ulcerative or
crusting lesion needs referral.