This document provides background on the speaker Jean-Paul Grund and his experience studying drug use through ethnographic research. It outlines his timeline of research from the 1960s studying cannabis, psychedelics, opium and speed through the 2000s doing research in the Netherlands. It discusses the emergence of heroin and cocaine use in the Netherlands and how the social context and drug markets influenced risk behaviors over time, such as the shift from needle sharing to drug sharing practices. It also outlines Grund's research on drug use and HIV risks in Russia and Central and Eastern Europe, including the traditions of group drug preparation and injection in those regions.
E, K, G, BZP, 2CB, 5MeO-DIPT...
“Party Drugs” such as Ecstasy, Ketamine and GHB have not gone away. However, there have been significant changes to purity and associated risks. As well, a proliferation of new substances are quickly appearing.
What are some of the current substances being used and the risk reduction messages we should be sharing, particularly with today’s youth?
We will look at:
Street Drugs --> Party Drugs --> NPS
Specific substances:
- What they are
- How they work
- Immediate risks
- Longer-term concerns
- Risk reduction strategies
E, K, G, BZP, 2CB, 5MeO-DIPT...
“Party Drugs” such as Ecstasy, Ketamine and GHB have not gone away. However, there have been significant changes to purity and associated risks. As well, a proliferation of new substances are quickly appearing.
What are some of the current substances being used and the risk reduction messages we should be sharing, particularly with today’s youth?
We will look at:
Street Drugs --> Party Drugs --> NPS
Specific substances:
- What they are
- How they work
- Immediate risks
- Longer-term concerns
- Risk reduction strategies
A 90 minute presentation to Addiction and Mental Health workers in Ontario, Canada.
Contains many links to useful resources and information.
To provide a background and overview of some of the newer substances we are seeing and people may be consuming.
A focus on:
- MDMA / Ecstasy / Molly
- Drug Checking
- Bath Salts / Cathinones
- Synthetic Cannabinoids
**Unfortunately the speaker notes are not uploading. Please contact us if you would like a copy of these: http://www.ohsutp.ca/contact
11320171Chapter 13 Public Order Crimes-Slides andBenitoSumpter862
11/3/2017
1
Chapter 13: Public Order Crimes
-Slides and data in this outline are from Adler, Mueller, and Laufer (2007, 2013 &
2018); Siegel (2015); and modified by Manning (2007, 2013, 2015 & 2018).
Drug abuse and crime
Alcohol and crime
Sexual morality offenses
Law and Morality
• Public Order Crimes
• Behavior that is outlawed because it threatens the general well-being of
society and challenges its accepted moral principles.
• Sometimes referred to as victimless crimes.
• Drug and alcohol use, prostitution, pornography and even gambling.
• Censorship of those freely choosing to engage maybe a violation of free
speech.
• Which may lead to dissent
• Moral Crusaders say it doesn’t diminish freedom of opinion.
Law and Morality
• Criminal or Immoral?
• Social harm
• Immoral acts can be distinguished from crimes on the basis of the injury they cause:
• Acts that cause harm or injury are outlawed and punished as crimes.
• Acts, even those that are vulgar, offensive, and depraved are not outlawed or punished if they
harm no one.
• 500,000 US deaths per year due to alcohol and tobacco
• Immoral yet legal and regulated by our government.
• Marijuana is nonfatal and sold for medical purposes
• Should laws be applied to shape social morality?
• What about polygamy, or minors and marriage?
• Why is prostitution illegal?
11/3/2017
2
Substance Abuse: when did it begin?
• Egypt – use of opium
• Religion 3,500 BC; Painkiller 1,600 AD
• USE – Use begins for medical purposes
• Opium (Morphine and Codeine)
• Used to treat a wide variety of illness
• Civil War morphine = Soldiers disease
• 1860s cocaine to unblock sinues.
• Alcohol and its prohibition
• January 16, 1920, the 18th Amendment prohibited the manufacture, sale and
transportation of alcoholic beverages.
• Women’s Christian Temperance Union
• American Anti-Saloon League (Carrie Nation).
• December 5, 1933, the 21st Amendment to the Constitution repealed 18th.
Stats on drug abuse
• Extent of substance abuse
• Alcohol abuse in USA national high school studies: approximately 52%
• Binge drinking – 5x once per month 23%
• Heavy drinking – 5 per night 5 x per month 6%
• NHS surveys show:
• Drug abuse declined between 1970-1990
• Increased until 1996
• 2007 till now marijuana rose to an all time high
• Major issues: K2 and spice is synthetic marijuana (not plant based)
• Overall drug used peaked in 1970s, decreased till 1990s and now steady.
• Exceptions: Marijuana and Heroin (US epidemic) has increased since 2011
Drug abuse linked to crime
• Substance abuse appears to be heavily linked to crime.
• Adolescents who use illegal drugs engage in more fights and theft.
• 40% incarcerated adults for violence crimes used alcohol before arrest.
• Alcohol reduces restraint on aggression
• Alcohol reduces awareness of consequences
• Drunk driving
• There are different kinds of drug users but not all commit crimes.
• There are differences in criminality ...
11320171Chapter 13 Public Order Crimes-Slides andSantosConleyha
11/3/2017
1
Chapter 13: Public Order Crimes
-Slides and data in this outline are from Adler, Mueller, and Laufer (2007, 2013 &
2018); Siegel (2015); and modified by Manning (2007, 2013, 2015 & 2018).
Drug abuse and crime
Alcohol and crime
Sexual morality offenses
Law and Morality
• Public Order Crimes
• Behavior that is outlawed because it threatens the general well-being of
society and challenges its accepted moral principles.
• Sometimes referred to as victimless crimes.
• Drug and alcohol use, prostitution, pornography and even gambling.
• Censorship of those freely choosing to engage maybe a violation of free
speech.
• Which may lead to dissent
• Moral Crusaders say it doesn’t diminish freedom of opinion.
Law and Morality
• Criminal or Immoral?
• Social harm
• Immoral acts can be distinguished from crimes on the basis of the injury they cause:
• Acts that cause harm or injury are outlawed and punished as crimes.
• Acts, even those that are vulgar, offensive, and depraved are not outlawed or punished if they
harm no one.
• 500,000 US deaths per year due to alcohol and tobacco
• Immoral yet legal and regulated by our government.
• Marijuana is nonfatal and sold for medical purposes
• Should laws be applied to shape social morality?
• What about polygamy, or minors and marriage?
• Why is prostitution illegal?
11/3/2017
2
Substance Abuse: when did it begin?
• Egypt – use of opium
• Religion 3,500 BC; Painkiller 1,600 AD
• USE – Use begins for medical purposes
• Opium (Morphine and Codeine)
• Used to treat a wide variety of illness
• Civil War morphine = Soldiers disease
• 1860s cocaine to unblock sinues.
• Alcohol and its prohibition
• January 16, 1920, the 18th Amendment prohibited the manufacture, sale and
transportation of alcoholic beverages.
• Women’s Christian Temperance Union
• American Anti-Saloon League (Carrie Nation).
• December 5, 1933, the 21st Amendment to the Constitution repealed 18th.
Stats on drug abuse
• Extent of substance abuse
• Alcohol abuse in USA national high school studies: approximately 52%
• Binge drinking – 5x once per month 23%
• Heavy drinking – 5 per night 5 x per month 6%
• NHS surveys show:
• Drug abuse declined between 1970-1990
• Increased until 1996
• 2007 till now marijuana rose to an all time high
• Major issues: K2 and spice is synthetic marijuana (not plant based)
• Overall drug used peaked in 1970s, decreased till 1990s and now steady.
• Exceptions: Marijuana and Heroin (US epidemic) has increased since 2011
Drug abuse linked to crime
• Substance abuse appears to be heavily linked to crime.
• Adolescents who use illegal drugs engage in more fights and theft.
• 40% incarcerated adults for violence crimes used alcohol before arrest.
• Alcohol reduces restraint on aggression
• Alcohol reduces awareness of consequences
• Drunk driving
• There are different kinds of drug users but not all commit crimes.
• There are differences in criminality ...
Pop Culture Across Cultures Context & DescriptionSouth Kor.docxChantellPantoja184
Pop Culture Across Cultures
Context & Description
South Korean pop artist Psy’s smash hit single “Gangnam Style” is more than just a song. It is a cultural phenomenon. The video has gone viral on YouTube, garnering over 600 MILLION hits in just three months, becoming the third-most viewed video on the website (YouTube.com). “Gangnam Style” has been remade and parodied by hundreds of people all around the world. Psy’s popularity has crossed over from South Korea to many countries including the United States. He has granted interviews to the Today Show and the Ellen DeGeneres Show, danced “Gangnam Style” with Britney Spears, and become one of the most popular Halloween costumes of 2012. And through this buzz in the United States, one thing remains the same: the song is sung in Korean (not English).
“Gangnam Style” is one of the many K-Pop (Korean Pop) songs in what Chinese journalists called the Korean wave (韓流), “a phenomenon that refers to the onslaught of South Korean entertainment in Asia and, more recently, in other parts of the world” (Valerio). Despite differences in language, Psy’s song is now a mainstay in popular (pop) culture in the United States and beyond. However, Psy’s “Gangnam Style” is definitely not the first K-Pop song to exist: groups like 2NE1 and BIGBANG are certainly popular in Korea, but they did not make as big of a splash as Psy’s hit. What was it that made “Gangnam Style” so popular? Why Psy? Why now? Is it Psy’s appearance? The dance associated with the song? The music itself? The lyrics? The splashy, fun music video? Or is it the catchy concept, “Dress classy and dance cheesy”? And what might be the influence of this song on K-Pop music in the US in the future?
The purpose of this project is to explore the nature of popularity by examining a transnational flow of pop culture--a situation that requires the negotiation of different values, assumptions and tastes. What makes a popular artifact from one culture “cross over” to other cultures? What makes the artifact popular in the first place? Why are people drawn to artifacts from certain countries? Why do people seek alternatives from other cultures? What ideological, social, cultural, political, economic, and/or historical factors affect the popularity of an artifact in different countries? What makes one artifact internationally appealing while other artifacts from the same country do not gain the same kind of popularity? How does the success of one artifact open the door for other artifacts from the same country?
Write a feature magazine article that analyzes a transnational cultural artifact: a song, music video, user-created video, movie, blog, book, fashion style, celebrity, etc. In preparation for this project, explore the criteria that help explain what makes a cultural artifact popular in one context and consider how the same criteria may or may not apply to another context. Then, identify a pop culture artifact. It may be something that has crossed .
This document has been drafted within the framework of the European project Talking about taboos.The project has been funded with support from the European Commission. The document reflects the view only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
This presentation presents an overview of the survey results on the Dutch Black Pete discussion. The survey is being conducted within the framework of the European project TALKING ABOUT TABOOS. The project has been funded with support from the European Commission. The document reflects the view only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
National Drug Early Warning (NDEWS) webinar: A more dangerous heroin: Emergin...Dan Ciccarone
This presentation, to an international web audience, was presented alongside one by Dr Wilson Compton, Deputy Director of the National Institute on Drug Abuse. Sponsored by NDEWS, it explores the structural reasons for the emerging heroin overdose epidemic and ways to address it.
A 90 minute presentation to Addiction and Mental Health workers in Ontario, Canada.
Contains many links to useful resources and information.
To provide a background and overview of some of the newer substances we are seeing and people may be consuming.
A focus on:
- MDMA / Ecstasy / Molly
- Drug Checking
- Bath Salts / Cathinones
- Synthetic Cannabinoids
**Unfortunately the speaker notes are not uploading. Please contact us if you would like a copy of these: http://www.ohsutp.ca/contact
11320171Chapter 13 Public Order Crimes-Slides andBenitoSumpter862
11/3/2017
1
Chapter 13: Public Order Crimes
-Slides and data in this outline are from Adler, Mueller, and Laufer (2007, 2013 &
2018); Siegel (2015); and modified by Manning (2007, 2013, 2015 & 2018).
Drug abuse and crime
Alcohol and crime
Sexual morality offenses
Law and Morality
• Public Order Crimes
• Behavior that is outlawed because it threatens the general well-being of
society and challenges its accepted moral principles.
• Sometimes referred to as victimless crimes.
• Drug and alcohol use, prostitution, pornography and even gambling.
• Censorship of those freely choosing to engage maybe a violation of free
speech.
• Which may lead to dissent
• Moral Crusaders say it doesn’t diminish freedom of opinion.
Law and Morality
• Criminal or Immoral?
• Social harm
• Immoral acts can be distinguished from crimes on the basis of the injury they cause:
• Acts that cause harm or injury are outlawed and punished as crimes.
• Acts, even those that are vulgar, offensive, and depraved are not outlawed or punished if they
harm no one.
• 500,000 US deaths per year due to alcohol and tobacco
• Immoral yet legal and regulated by our government.
• Marijuana is nonfatal and sold for medical purposes
• Should laws be applied to shape social morality?
• What about polygamy, or minors and marriage?
• Why is prostitution illegal?
11/3/2017
2
Substance Abuse: when did it begin?
• Egypt – use of opium
• Religion 3,500 BC; Painkiller 1,600 AD
• USE – Use begins for medical purposes
• Opium (Morphine and Codeine)
• Used to treat a wide variety of illness
• Civil War morphine = Soldiers disease
• 1860s cocaine to unblock sinues.
• Alcohol and its prohibition
• January 16, 1920, the 18th Amendment prohibited the manufacture, sale and
transportation of alcoholic beverages.
• Women’s Christian Temperance Union
• American Anti-Saloon League (Carrie Nation).
• December 5, 1933, the 21st Amendment to the Constitution repealed 18th.
Stats on drug abuse
• Extent of substance abuse
• Alcohol abuse in USA national high school studies: approximately 52%
• Binge drinking – 5x once per month 23%
• Heavy drinking – 5 per night 5 x per month 6%
• NHS surveys show:
• Drug abuse declined between 1970-1990
• Increased until 1996
• 2007 till now marijuana rose to an all time high
• Major issues: K2 and spice is synthetic marijuana (not plant based)
• Overall drug used peaked in 1970s, decreased till 1990s and now steady.
• Exceptions: Marijuana and Heroin (US epidemic) has increased since 2011
Drug abuse linked to crime
• Substance abuse appears to be heavily linked to crime.
• Adolescents who use illegal drugs engage in more fights and theft.
• 40% incarcerated adults for violence crimes used alcohol before arrest.
• Alcohol reduces restraint on aggression
• Alcohol reduces awareness of consequences
• Drunk driving
• There are different kinds of drug users but not all commit crimes.
• There are differences in criminality ...
11320171Chapter 13 Public Order Crimes-Slides andSantosConleyha
11/3/2017
1
Chapter 13: Public Order Crimes
-Slides and data in this outline are from Adler, Mueller, and Laufer (2007, 2013 &
2018); Siegel (2015); and modified by Manning (2007, 2013, 2015 & 2018).
Drug abuse and crime
Alcohol and crime
Sexual morality offenses
Law and Morality
• Public Order Crimes
• Behavior that is outlawed because it threatens the general well-being of
society and challenges its accepted moral principles.
• Sometimes referred to as victimless crimes.
• Drug and alcohol use, prostitution, pornography and even gambling.
• Censorship of those freely choosing to engage maybe a violation of free
speech.
• Which may lead to dissent
• Moral Crusaders say it doesn’t diminish freedom of opinion.
Law and Morality
• Criminal or Immoral?
• Social harm
• Immoral acts can be distinguished from crimes on the basis of the injury they cause:
• Acts that cause harm or injury are outlawed and punished as crimes.
• Acts, even those that are vulgar, offensive, and depraved are not outlawed or punished if they
harm no one.
• 500,000 US deaths per year due to alcohol and tobacco
• Immoral yet legal and regulated by our government.
• Marijuana is nonfatal and sold for medical purposes
• Should laws be applied to shape social morality?
• What about polygamy, or minors and marriage?
• Why is prostitution illegal?
11/3/2017
2
Substance Abuse: when did it begin?
• Egypt – use of opium
• Religion 3,500 BC; Painkiller 1,600 AD
• USE – Use begins for medical purposes
• Opium (Morphine and Codeine)
• Used to treat a wide variety of illness
• Civil War morphine = Soldiers disease
• 1860s cocaine to unblock sinues.
• Alcohol and its prohibition
• January 16, 1920, the 18th Amendment prohibited the manufacture, sale and
transportation of alcoholic beverages.
• Women’s Christian Temperance Union
• American Anti-Saloon League (Carrie Nation).
• December 5, 1933, the 21st Amendment to the Constitution repealed 18th.
Stats on drug abuse
• Extent of substance abuse
• Alcohol abuse in USA national high school studies: approximately 52%
• Binge drinking – 5x once per month 23%
• Heavy drinking – 5 per night 5 x per month 6%
• NHS surveys show:
• Drug abuse declined between 1970-1990
• Increased until 1996
• 2007 till now marijuana rose to an all time high
• Major issues: K2 and spice is synthetic marijuana (not plant based)
• Overall drug used peaked in 1970s, decreased till 1990s and now steady.
• Exceptions: Marijuana and Heroin (US epidemic) has increased since 2011
Drug abuse linked to crime
• Substance abuse appears to be heavily linked to crime.
• Adolescents who use illegal drugs engage in more fights and theft.
• 40% incarcerated adults for violence crimes used alcohol before arrest.
• Alcohol reduces restraint on aggression
• Alcohol reduces awareness of consequences
• Drunk driving
• There are different kinds of drug users but not all commit crimes.
• There are differences in criminality ...
Pop Culture Across Cultures Context & DescriptionSouth Kor.docxChantellPantoja184
Pop Culture Across Cultures
Context & Description
South Korean pop artist Psy’s smash hit single “Gangnam Style” is more than just a song. It is a cultural phenomenon. The video has gone viral on YouTube, garnering over 600 MILLION hits in just three months, becoming the third-most viewed video on the website (YouTube.com). “Gangnam Style” has been remade and parodied by hundreds of people all around the world. Psy’s popularity has crossed over from South Korea to many countries including the United States. He has granted interviews to the Today Show and the Ellen DeGeneres Show, danced “Gangnam Style” with Britney Spears, and become one of the most popular Halloween costumes of 2012. And through this buzz in the United States, one thing remains the same: the song is sung in Korean (not English).
“Gangnam Style” is one of the many K-Pop (Korean Pop) songs in what Chinese journalists called the Korean wave (韓流), “a phenomenon that refers to the onslaught of South Korean entertainment in Asia and, more recently, in other parts of the world” (Valerio). Despite differences in language, Psy’s song is now a mainstay in popular (pop) culture in the United States and beyond. However, Psy’s “Gangnam Style” is definitely not the first K-Pop song to exist: groups like 2NE1 and BIGBANG are certainly popular in Korea, but they did not make as big of a splash as Psy’s hit. What was it that made “Gangnam Style” so popular? Why Psy? Why now? Is it Psy’s appearance? The dance associated with the song? The music itself? The lyrics? The splashy, fun music video? Or is it the catchy concept, “Dress classy and dance cheesy”? And what might be the influence of this song on K-Pop music in the US in the future?
The purpose of this project is to explore the nature of popularity by examining a transnational flow of pop culture--a situation that requires the negotiation of different values, assumptions and tastes. What makes a popular artifact from one culture “cross over” to other cultures? What makes the artifact popular in the first place? Why are people drawn to artifacts from certain countries? Why do people seek alternatives from other cultures? What ideological, social, cultural, political, economic, and/or historical factors affect the popularity of an artifact in different countries? What makes one artifact internationally appealing while other artifacts from the same country do not gain the same kind of popularity? How does the success of one artifact open the door for other artifacts from the same country?
Write a feature magazine article that analyzes a transnational cultural artifact: a song, music video, user-created video, movie, blog, book, fashion style, celebrity, etc. In preparation for this project, explore the criteria that help explain what makes a cultural artifact popular in one context and consider how the same criteria may or may not apply to another context. Then, identify a pop culture artifact. It may be something that has crossed .
This document has been drafted within the framework of the European project Talking about taboos.The project has been funded with support from the European Commission. The document reflects the view only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
This presentation presents an overview of the survey results on the Dutch Black Pete discussion. The survey is being conducted within the framework of the European project TALKING ABOUT TABOOS. The project has been funded with support from the European Commission. The document reflects the view only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
National Drug Early Warning (NDEWS) webinar: A more dangerous heroin: Emergin...Dan Ciccarone
This presentation, to an international web audience, was presented alongside one by Dr Wilson Compton, Deputy Director of the National Institute on Drug Abuse. Sponsored by NDEWS, it explores the structural reasons for the emerging heroin overdose epidemic and ways to address it.
Diffusion of Drug Trends, NPS, the Internet and Consequences for EpidemiologyJean-Paul Grund
In this presentation I consider the changes in markets for illicit and 'unscheduled' drugs related to the ever growing influence of technology in the last 20 years.
Randomized Controlled Trials in Evaluating Socially Complex Interventions: A ...Jean-Paul Grund
Randomized Controlled Trials in Evaluating Socially Complex Interventions: A Square Peg in a Round Hole?
This lecture will discuss a number of challenges and problems in Randomized Controlled Trials (RCTs), in particular in evaluating interventions aimed at (i) altering complex human behaviour, (ii) in marginalized and stigmatized populations; and, (iii) by socially complex interventions. Using examples from the literature and his own research, Dr. Grund will provide a transdisciplinary perspective on the utility of the RCT model in evaluating interventions aimed at, for example, people who use drugs or homeless people, two very complex “Real World” problems in the Czech Republic and elsewhere.
He argues that the arena of services for PUD, the homeless and other marginalised populations is rife with poorly understood contingencies. Consequently, the complexity of the research environment becomes a function of I, ii and iii above, but with enigmatic mathematical operators. Strategies for addressing this complexity through accompanying process evaluation and qualitative research will be discussed.
Dutch drug policy - coffee shops & compromise (2014)Jean-Paul Grund
Full text can be downloaded in English and Polish at: http://www.opensocietyfoundations.org/reports/coffee-shops-and-compromise-separated-illicit-drug-markets-netherlands
Though famous for its coffee shops, where cannabis can be purchased and consumed, the Netherlands has accomplished many enviable public health outcomes through its drug policy. These include low prevalence of HIV among people who use drugs, negligible incidence of heroin use, lower cannabis use among young people than in many stricter countries, and a citizenry that has generally been spared the burden of criminal records for low level, nonviolent drug offenses.
Coffee Shops and Compromise: Separated Illicit Drug Markets in the Netherlands tells the history of the Dutch approach and describes the ongoing success of the country’s drug policy. This includes the impact of the Dutch “separation of markets,” which potentially limits people’s exposure and access to harder drugs.
Though coffee shops have traditionally commanded the most media attention, the Netherlands also pioneered needle exchange and safer consumption rooms, decriminalized possession of small quantities of drugs, and introduced easy-to-access treatment services.
These policies, coupled with groundbreaking harm reduction interventions, have resulted in the near-disappearance of HIV among people who inject drugs and the lowest rate of problem drug use in Europe.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. Drugs, bugs and the things that unite them.
A former ethnographer's view of
drug policy and public health.
Jean-Paul Grund, PhD
CVO-Addiction Research Center, Utrecht
Department of Epidemiology, Municipal Health Service, The Hague
Summer Institute on Alcohol, Drugs and Addiction, University of
Amsterdam, 15-07-2008, Amsterdam, The Netherlands
2. The Replacement Speaker’s Dilemma
• My presence today is more determined by the odds
than intent
• What to Present?
• What do I want to convey?
• Who is the audience and what have other speakers
told them?
• “Do something with your past ethnographic work”
3. (My) Ethnographic Timeline
•
•
•
•
•
•
•
•
•
1960s Cannabis, psychedelics, opium and speed
1970s Street Heroin culture developed in major Dutch cities
– From injecting to chasing
1980s House addresses and Cocaine
– 1981: My first practice: the Rotterdam Junkie Union
– Activism, and needle exchange
– 1985: Outreach and “collective” needle exchange
– 1988: Research
– Observations of heroin and cocaine users
– Rituals of regulation
– From needle sharing to drug sharing (Frontloading)
– Rocking up cocaine: cooked cocaine
1990s Back to the streets
– Increased repression of until then tolerated house addresses in neighborhoods
– Platform Zero next to Central Railway Station
– From chasing to basing
– From self produced “cooked coke” to “crack”
1993 UCONN, USA
1995 International Harm Reduction Development Program at OSI/Soros
1999 Research: evaluation of needle exchange in CEE & Russia; Roma, drugs & HIV risks
2001 UNAIDS Policy Advisor; consultant to Yale Liquid Drugs Study
2005 Back to base: research in NL
4. Today’s Timeline
• A short history of wit & bruin
• 25 years of cocaine smoking: a history of unanticipated
and unintended consequences
• A case of serendipity that illustrates the complex
relationship of drug policy and risk behaviors
• Exercise: Drug injection in Russia
• Drug use and social context in CEE
• On interventions (what to do with all that knowledge)
5. Problem Drug Use in the Netherlands
• Drugs: (1960s: Amphetamine, Opium); Heroin (1971); Cocaine (±
1980)
• B4 1980: City center street drug markets in
Amsterdam (capital), Rotterdam (harbor)…
• After 1980: diffusion into low income
neighborhoods & smaller towns;
“House Address” market/scenes
• 1990s: Back to the Streets (diffuse street
markets)
• 2000s: Mobile Phones (meetings,
home delivery)
• Mode of administration:
– 1960s: IDU (white, div. background)
– 1970s: shift to smoking (IDUs: white,
Chasers: Surinamese, Moroccan)
– 1980 – present: smoking dominates
9. Cocaine Smoking in the Netherlands
Example: Rotterdam
• 1980s:
– Cocaine hydrochloride sold at house addresses;
consumed on the spot by smoking (majority)
or injecting (small minority)
– Users cooked C-HCL into C-B themselves
– Majority chased cocaine-base
– Part of social interaction within
constraints of house address
– Collective use, social ritual in relaxed
café-like atmosphere
Shift to non-IDU use
• 1990s:
– 1989: “Smoking over glass,”
– Around 1990: crackdowns on house addresses
– February 1990: first observation of
“cooked coke” at Central Railway Station;
Lighter & Antenna pipes.
– No one knew where to buy “crack”
– Individual use, quick pull from pipe in (often hostile) public places
10. From self produced “wit” (white)
to “cooked coke” (crack)
• A market environment adjusting to a changing social policy
• Cooked cocaine as an adaptive respons to increased repression
(closure of house addresses), resulting in more users on the streets
• Sold for very pragmatic reasons:
– "You don't have to prepare it.“
– "It is ready for smoking."
– "It's a gain of time."
"It is not so conspicuous when you don't have to prepare before smoking.“
– "You don't have to search for a place to cook the stuff anymore.“
– "You don't need a spoon and ammonia.“
• Pushed cocaine HCL out of the street markets; wiped out
preparation ritual;
• result: decreased self-regulation, increased cocaine-related
morbidity and problems
11.
12. Frontloading…
…or the case of the Serendipitous researcher
Frontloading
or
Syringe-Mediated-Drug-Sharing
13. Definition of Serendipity
• Serendipity (noun): That quality which,
through good fortune and sagacity*, allows a
person to discover something good while
seeking something else.
* Sagacity (noun): personal alertness, awareness, and
understanding;
sagacious (adjective): having or showing understanding and
the ability to make good judgments; wise
14. Field work 1988
• Publications on HIV among IDUs in USA
• Needle sharing identified as risk behavior
• Observations at house addresses:
– Few occurrences of needle sharing in Rotterdam
– Drugs often shared, social lubricants
• Both among smokers and injectors
18. Field note of Frontloading
“Richard puts the spoon in front of him, empties the heroin package in the
spoon and adds some lemon and water. Meanwhile Chris opens two
injection swabs and puts them on the rim of the ash-tray. When
Richard is ready he nods, which Chris takes as a sign to light the
swabs. Richard now holds the spoon above the flame to boil the
contents. Chris carefully watches the spoon and says: "I hope it's
enough that we feel it." It takes more then 2 minutes to dissolve the
heroin. Then Richard puts in the cocaine almost immediately. Cotton is
used to make a filter, and Richard draws the cocktail in the syringe
barrel.
Richard also divides the cocktail. He puts the needle back on his syringe.
Chris gives him his syringe after removing the needle. Richard inserts
his needle in Chris' syringe, eyeballs the amount of liquid drug and
devides it. He compares each’s content holding the two syringes side
by side. In one of them is a little more. That one he gives to Chris. ”
20. Frontloading
• Syringe-Mediated-Drug-Sharing (Frontloading, backloading) is an
important route of HIV and other viral transmission
• The technique of frontloading and similar techniques are known in
many countries
• Frontloading observed in the Bronx, Los Angeles, Baltimore,
South Florida, Barcelona, Spain, Basel, Bern and Zürich (1993)
• Backloading documented in New York, San Francisco and Denver
in the USA, in London, Great Britain
and in Barcelona, Spain (1993)
• Frontloading is the most efficient and honest
way to split a certain amount of drugs in
two or more portions
• "We share everything; social benefit,
food, dope, etc."
• Drug Sharing serves both instrumental and
symbolic purposes
21. Synopsis
• Introduction of heroin, 1971; cocaine in 1980
• Emergence of chasing heroin and cocaine and related
decrease of IDU
• From chasing to basing
• Syringe-Mediated-Drug-Sharing
• Social context of use: both protection and risk
• Drug use as a social ritual
• Impact of policy (street vs. house address-based markets)
on Risk Environment (Rhodes, 2002)
• Drug, Set & Setting (Zinberg, 1982)
41. Frequency of Group Injecting among
Russian Syringe Exchange Participants1
N. N.
N=236
Pskov
N=205
R-N-D
N=199
St. Petersb.
N = 236
Volgograd
N = 221
Total
N=1,097
30 Days Prior to SEP Use(%)
Group Injecting in Last 30 days Before Interview:
Never
9
5
13
4
15
9
11
2
• Never 1-3 Times/Month-Less 12 27 14
Inject inWeek 10 16 10
Groups
14% 13
Once a
10
6
10
2-6 Times a Week
31
31
32
29
20
29
O c regular
13
14
23
19
• Group use is nae a Day 18occurrence
61% 18
More than Once a Da y /
Al most Ever y Da y
21
8
17
23
37
22
11
36
13
31
4
5
20
15
17
28
10
12
7
8
6
26
32
22
20
5
7
19
16
33
14
14
10
26
17
18
– 2 - 6 times a week
26%
Last OnceDuring SEP Use (%)
– 30 Days to several times a day/almost every day 35%
Never
14
1-3 Times/Month-Less
11
Once a Week
10
2-6 Times a Week
26
Once a Day
20
More than Once a Day /
19
Almost Every Day
Totals may not equal 100% due to rounding or
Clearly, Using in Groups is Normative Behavior
among Russian IDUs.
1
missing data.
46. Injection-Related HIV Risk Behaviors of
Russian Syringe Exchange Participants1
Last 30 days
Before SEP Use
Collective use of Works
S-M-D-S
82%
58%
Last 30 days
B4 Interview
73%
48%.
The Russian risk environment, results in a very high
prevalence of collective drug paraphernalia use
and Syringe-Mediated-Drug-Sharing
47. Social Setting of the First Hit, Ukraine
“Who was present at your first injection?”*
Company
%
Friends or good acquaintances
80
Person I did not know very well
20
Sexual partner
17
Stranger
7
Alone
5
* More than one answer was possible.
48. Social Setting of the First Hit , Ukraine
“Who gave you the first injection?” by gender (%)
64
Friend, acquantance
55
67
13
Self-made
4
15
8
Sexual partner
32
3
6
Drug dealer
2
7
5
Running body
4
5
1
O ther persons
3
3
0
10
20
Men
30
40
Women
50
60
All
70
80
56. IDUs’ Relationships with Law Enforcement
and other Agencies of State Control
“The relations with
the police are good,
they do a lot of
mutual work.”
(Psychologist @ N.D.
South Russia)
59. Ignore that drug injecting is a
behavior that cuts across
communities…
60. Injecting Drug Use is not a Population
Characteristic, but a Behavioral One,
Overlapping Various Vulnerable Populations
•
•
•
•
Many Occasional Users
Sex work
Gay Community
National & Ethnic Minorities, e.g. Russians in the
Baltics; Roma throughout CEENIS
• Prisoners
64. New HIV & AIDS Cases in Lithuania,
1988 - August 20, 2002
400
344
Alytus Prison Camp: 284 Cases
350
300
250
200
HIV
AIDS
150
100
65
66
52
72
31
50
11
1
81
11
51
4
92
11
1
12 5
8
3
6
9
7
ug
us
t2
00
2
20
01
A
20
00
19
99
19
98
19
97
19
96
19
95
19
94
19
93
19
92
19
91
19
90
19
89
19
88
0
18
65. The Solution of the Prison Department &
Lithuanian AIDS Center
66.
67. What to do?
“The most effective responses to the epidemic
grow out of people’s action within their own
community and national context.”
Handbook for Legislators on HIV/AIDS,
Law and Human Rights (UNAIDS/IPU, 1999)
70. Not the individual IDUs,
but Networks
• IDU networks organized around exchange of critical
commodities (e.g. drugs)
• Secondary syringe
distribution taps into
existing exchange patterns
• Drugs, HIV travel along
natural links in drug
using networks
• So should syringes and
harm reduction information
71. Drug Use Characteristics of Russian
Syringe Exchange Participants N = 1,076
N. N.
Pskov R-N-D St. Petersb. Volgograd
N = 236 N = 201 N = 199
N = 221
N = 219
Age First IDU1 (Mean/SD)
Total
N = 1,076
19 (4)
21 (5)
21 (5)
18 (3)
19 (4)
20 (4)
< 3 years
3+ – 6 years
6+ – 10 years
>10 years
22
33
33
12
47
31
10
12
18
22
25
35
43
27
16
14
26
41
26
6
30
32
23
15
Powder Heroin
Amphetamine
47
9
53
61
5
24
96
9
90
4
59
20
Reported Secondary Exchange (%)
40
46
40
43
48
44
Years Injecting1 (%)
Almost half of Russian Syringe Exchange Participants
reported Secondary Exchange (40-48%), whether the
Drug Injected (%)
program encouraged it83or not. 84
Homemade opiates
15
6
21
42
1,2
72. Peer Driven Interventions,
Respondent Driven Sampling
• Peers are rewarded to conduct the same tasks as outreach
workers;
– Primary incentive for participation in a series of health
education sessions (accent on being taught);
– Secondary incentive for engaging peers in intervention and
educating them in the community (accent on teaching);
• Recognizes that peers know best about peers, peers are
better to convince peers than professional workers
• Peer driven intervention superior to traditional outreach
work intervention in HIV prevention among IDUs
– Superior performance on recruitment power, representation,
and in reducing risk behaviours, while being about 30 times
less costly.
77. Some quick conclusions
• Drug policy has more impact on drug related
harm than on drug use prevalence (eg. MOA)
• Drug users are interested in their health
• Drug users engage in social networks and exercise
collective harm reduction action
• Policy makers should better consider intended and
unintended consequences of policy and
interventions