Since the rise of the internet, traditional models of how new drug trends diffuse are less reliable. The internet has increased access to drug information and enabled online markets where buyers and sellers can meet. As a result, new drug trends have emerged and spread much faster, making geographic diffusion patterns harder to distinguish. The combination of e-commerce and new psychoactive substances allows drugs to be purchased 24/7 from anywhere, making new trends less predictable and uniform and presenting challenges for public health and policy.