This document outlines how rapid technological changes may disrupt drug policy and services. It discusses three key points: 1) Innovations in drug chemistry and internet markets have led to new psychoactive substances (NPS) that are untested and their effects unknown. This poses new risks like overdose. 2) The internet has become a driver of drug trade through darknet markets, cryptocurrencies and anonymous networks. This has atomized drug scenes and made new drug trends harder to predict. 3) Technologies like molecular 3D printing may allow homemade production of drugs and medications, further challenging existing drug policy frameworks. This technological disruption could lead to either new harms or opportunities for more empowered, peer-driven