Amphetamine is a central nervous system stimulant used to treat ADHD, narcolepsy, and obesity. It exists as two forms, levoamphetamine and dextroamphetamine, and is prescribed orally as tablets, liquids, or orally disintegrating tablets. Amphetamine increases neurotransmitters like norepinephrine and dopamine in the brain by releasing them from nerve terminals. Common side effects include insomnia, anxiety, irritability, and weight loss. Nurses monitor patients taking amphetamine for vital signs, adverse effects, weight changes, and drug interactions.

1. DRUG PRESENTATION
ON
AMPHETAMINE
AKASH S V,
Bsc (N) – III Year,
Meantal Health Nursing – DPT,
SRIPMS-CON.

2. AMPHETAMINE
INTRODUCTION;
Amphetamine is a central nervous
system stimulant is used to treat Attention Deficit
Hyperactivity Disoder(ADHD), narcolepsy and
obesity.
Amphetamine is first discovered in
1887 and exists as two levoamphetamine and
dextroamphetamine.
Amphetamine is also used as an
Atheletic performance enhancer and cognitive
enhancer.

3. COND...
●
AMPTHETAMINE ;
Trade name ; Adderall.
Generic name ; Ampthetamine.

4. DOSAGE ;
Not recommended for children under 3 yrs of
Age .
CHILD DOSAGE : 5mg to 10mg/Day.
ADULT DOSAGE : 5mg to 60 mg/Day in divided doses
Based on body responses.

5. ROUTE ;
●
Amphetamine is a prescription drug it comes as an
oral tablet and extended release orally disintegrating
tabelets, as well as an extended release oral liquid.
●
Oral tablet is only available as the brand name of drug
EVEKEO.

6. MECHANISUM OF ACTION ;
●
Amphetamine, act by
Releasing intracellular stores of
catecholamines,
Also inhibits MAO, high level CAO arerapidly
released into synaptic spaces,
Amphetamine increases monoamine and
excitatory neurotransmitter in brain,
It is most pronounced effects targeting the
norepinephrine and dopamine in neurotransmittor system.

7. PHARMACODYNAMICS ;
●
Ampthetamine increased the activity of
monoaminergic system.The primary mechanism
is by releases of dopamine from the nerve
terminals.
●
Ampthetamine are thought to enter the nerve
terminal via the transporters,distrupt the storage
vesicles of dopamine and reverse the direction
of dopamine.

8. PHARMACOKINETICS
●
Amphetamine may administer through orally,
intranasally, intravenosaly. The peak response
occur 1 to 3 hrs after oral adminstration and
approximately 15 mins after injection. A single
dose maintain an effect for upto 7 to 12 hrs.
●
The half life may increases 18 to 34 hrs.

9. INDICATION ;
●
Attention deficit
●
Hyperkinetic disorder
●
Parkinsonism
●
Narcolepsy
●
Obesity
●
Epilepsy
●
Euphoria

10. CONTRAINDICATION ;
●
Hyperthyroidism
●
Hypertension
●
Arterioselerosis
●
Manic behaviour
●
Psychotic disorder
●
Drug abuse
●
Suicidal thoughts
●
Agitation

11. ADVERSE EFFECT ;
●
Grandiosity
●
Irritability
●
Anxiety
●
Insomnia
●
Weight loss
●
Dry mouth
●
Sleeping distrubance
●
Delirium
●
Palpitation

12. DRUG INTRACTIONS ;
●
In general, there is no significant intraction
when consuming amphetamine with food. But
the (pH) of gastrointestinal content and urine
affects.
●
Due to effects of (pH) gastric acid seceration,
also intract with proton pump inhibitor and H2
receptor and seizure drugs.

13. NURSES RESPONSIBILITIES;
●
Monitor vital signs.
●
Check for respiratory depression.
●
Check for allergy.
●
Instruct client to take drug with meal.
●
Monitor weight for every 2 weeks.
●
Monitor for adverse effects.
●
Maintain patient Input and output chart.

14. THANK YOU