The document discusses drug discovery and development. It begins with definitions of key terms like drug, drug discovery process, and drug development process. It then describes the main stages of new drug development, including drug discovery, preclinical development, and clinical development. Specific examples of discovered drugs are provided, such as artemisinin from Artemisia annua used to treat malaria, and andrographolide from Andrographis paniculata which has anti-inflammatory properties. The biosynthesis process of andrographolide is also summarized. In conclusion, the document provides an overview of the drug discovery and development process from target identification to clinical trials.
ITS AN IMPORTANT TOPIC OF PHYTOCHEMISTRY DEALING WITH THE COMPLETE INFORMATION REGARDING THE BIOSYNTHESISI OF WITHANOLIDES AND UMBELLIFERONE WHICH IS VERY USEFUL FOR THE 1 SEM MPHARM STUDENTS OF THE PHARMACOGNOSY DEPARTMENT.
HOPE EVERYONE WILL MAKE USE OF IT TO LEARN WELL
A purified and standardized fraction with a defined minimum of four bioactive or phytochemical compounds of an extract of a medicinal plant or its part, for internal or external use of human beings or animals for diagnosis, treatment, mitigation, or prevention of any diseases but does not include administration by parenteral route.
Drug discovery is the process through which potential new medicines are identified.
It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases.
Natural products also have challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization.
INDUSTRIAL PHARMACOGNOSTICAL TECHNOLOGY
Herbal drug industry: Infrastructure of herbal drug industry
involved in production of standardized extracts and various
dosage forms. Current challenges in upgrading and
modernization of herbal formulations. Entrepreneurship
Development, Project selection, project report, technical
knowledge, Capital venture, plant design, layout and construction.
Pilot plant scale –up techniques, case studies of herbal extracts.
Formulation and production management of herbals.
Pharamcovigilance of drugs of natural originNiravKumar9
WHO Guidelines on safety monitoring of herbal medicines in Pharmacovigilance system and AYUSHSURAKSHA (Pharmacovigilance of Ayurveda, Unani, Siddha, And Homeopathy) syestem in India.
Plants Drug Cultivation:
General introduction to importance pharmacognosy.
Indian Council of Agricultural Research.
Current good agricultural practices.
Current good cultivation practices
Current good collection practices.
Conservation of medicinal plants-Ex-situ & In-situ conservation of medicinal plants.
ITS AN IMPORTANT TOPIC OF PHYTOCHEMISTRY DEALING WITH THE COMPLETE INFORMATION REGARDING THE BIOSYNTHESISI OF WITHANOLIDES AND UMBELLIFERONE WHICH IS VERY USEFUL FOR THE 1 SEM MPHARM STUDENTS OF THE PHARMACOGNOSY DEPARTMENT.
HOPE EVERYONE WILL MAKE USE OF IT TO LEARN WELL
A purified and standardized fraction with a defined minimum of four bioactive or phytochemical compounds of an extract of a medicinal plant or its part, for internal or external use of human beings or animals for diagnosis, treatment, mitigation, or prevention of any diseases but does not include administration by parenteral route.
Drug discovery is the process through which potential new medicines are identified.
It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases.
Natural products also have challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization.
INDUSTRIAL PHARMACOGNOSTICAL TECHNOLOGY
Herbal drug industry: Infrastructure of herbal drug industry
involved in production of standardized extracts and various
dosage forms. Current challenges in upgrading and
modernization of herbal formulations. Entrepreneurship
Development, Project selection, project report, technical
knowledge, Capital venture, plant design, layout and construction.
Pilot plant scale –up techniques, case studies of herbal extracts.
Formulation and production management of herbals.
Pharamcovigilance of drugs of natural originNiravKumar9
WHO Guidelines on safety monitoring of herbal medicines in Pharmacovigilance system and AYUSHSURAKSHA (Pharmacovigilance of Ayurveda, Unani, Siddha, And Homeopathy) syestem in India.
Plants Drug Cultivation:
General introduction to importance pharmacognosy.
Indian Council of Agricultural Research.
Current good agricultural practices.
Current good cultivation practices
Current good collection practices.
Conservation of medicinal plants-Ex-situ & In-situ conservation of medicinal plants.
Pharmacognosy is the objective study of crude drugs of animal, vegetable and mineral origin, treated scientifically.
Pharmacognosy is the study of medicine derived from natural sources that include plants, animals, and microorganisms, and the scope of the field depends on knowledge about the safety, purity, and efficacy of complex multicompound products.
Herbal pharmacognosy is the application of this science specifically to traditional herbal medicine sources.
This topic covers the notes for unit 1 of phytochemistry in 1st semester in M Pharm of department of pharmacognosy. This includes biosynthesis, characterization, purification and uses of steroids.
Pharmacovigilance of drugs of natural origin.pdfKipaPape
PHARMACOVIGILANCE OF DRUGS OF NATURAL ORIGIN.
WHO AND AYUSH GUIDELINES FOR SAFETY MONITORING OF NATURAL MEDICINE.
SPONTANEOUS REPORTING SCHEMES FOR BIODRUG ADVERSE REACTIONS
BIO DRUG-DRUG AND BIO DRUG-FOOD INTERACTIONS WITH SUITABLE EXAMPLES
Withanolides are a group of at least 300 naturally occurring steroids built on an ergostane skeleton.They occur as secondary metabolites primarily in genera of the Nightshade family, for example in the tomatillo.
Structurally, withanolides consist of a steroid backbone bound to a lactone or one of its derivatives; they are produced via oxidation of steroids. It remains unknown to what end withanolides are produced; they may act as a deterrent for feeding insect larvae and other herbivores
Unit 2. Regulatory requirements for setting herbal drug industry:
Content: Global marketing management.
Indian and International patent law as applicable herbal drugs and natural products.
Export - Import (EXIM) policy, TRIPS.
Quality assurance in herbal/natural drug products.
Concepts of TQM, GMP, GLP, ISO-9000.
Unit I: Plant Drug Cultivation
General introduction to the importance of
Pharmacognosy in herbal drug industry, Indian Council of
Agricultural Research, Current Good Agricultural Practices,
Current Good Cultivation Practices, Current Good Collection
Practices, Conservation of medicinal plants- Ex-situ and Insitu
conservation of medicinal plants.
Marine natural products: General methods of isolation and
purification, Study of Marine toxins, Recent advances in research
in marine drugs, Problems faced in research on marine drugs
such as taxonomical identification, chemical screening and their
solution.
Nutraceuticals chapter of Advance Pharmacognosy 1 of M Pharm syllabus.
This presentation involves Introduction to Nutraceuticals,
Classification of Nutraceuticals, Herbs as a food, Inorganic /mineral supplements, brief benefits of vitamin supplements, digestive enzymes and its example, use of cereals and Grains, importance of Antioxidants and Polyunsaturated fatty acids, an example of formulation and standardization of Multivitamin Tablets, what all regulatory requirement we need to manufacture Nutraceuticals and FSSAI guidelines for Nutraceuticals, sources- mediinal use - marker compound of some usually used Nutraceuticals.
Regulatory requirement for setting herbal drug industryRAGHAV DOGRA
The World Health Organization (WHO) estimates that 80 percent of the population of some Asian and African countries presently use herbal medicine for some aspect of primary health care.Pharmaceuticals are prohibitively expensive for most of the world's population, half of whom lived on less than $2 U.S. per day in 2002. In comparison, herbal medicines can be grown from seed or gathered from nature for little or no cost
patent (/ˈpætənt/ or /ˈpeɪtənt/) is a set of exclusive rights granted by a sovereign state to an inventor or assignee for a limited period of time in exchange for detailed public disclosure of an invention. An invention is a solution to a specific technological problem and is a product or a process. Patents are a form of intellectual property.
Herbal drugs are usually considered safe but when taken along with other drugs of chemical origin (allopathic drugs), they do interact with them and cause Bio-drug interaction
coumarin; umbelliferone and its biosynthesis and isolation.
terpenoide; cucurbitacine and its biosynthesis and isolation purification and characterization
Phytochemical Analysis and Antibacterial Activity of Psidium Guajava against ...ijtsrd
The some plants have been good source of drugs for microbial resistance. The research for newer source of antibiotics is a global challenges in pharmaceutical companies. Present time plants are being extensively explored for harboring medicinal properties. Phytochemical are naturally occurring compounds present in the medicinal plants such as flavonoids, steroids, alkaloids and phenolic compounds. Psidium guajava is a phototherapeutic plant used in folk medicine and is believed to have active components that helps in treatment and management of various disease such as wounds, ulcers, etc. Guava extract has exhibited remarkable antimicrobial activity against microorganisms. This study investigates the phytochemical and antibacterial properties of Psidium guajava leaf extracts. Antibacterial activity at the plant extract were determined against K. pneumoniae, S. aureus, E. coli. Psidium guajava leaf extracts provided scientific evidence for the rational use of P. juajava leaves in prevention of disorders due to Presence of some useful phytochemicals and in the treatment of disease caused by some bacterial pathogens such as S. aureus, B. cereus, K. pneumonae, E. coli. The present work demonstrates the antimicrobial potential of Psidium guajava leaves extracts by using various solvents. Pooja Soudawat | Anand Verma "Phytochemical Analysis and Antibacterial Activity of Psidium Guajava against Some Clinical Pathogens" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29134.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/29134/phytochemical-analysis-and-antibacterial-activity-of-psidium-guajava-against-some-clinical-pathogens/pooja-soudawat
Pharmacognosy is the objective study of crude drugs of animal, vegetable and mineral origin, treated scientifically.
Pharmacognosy is the study of medicine derived from natural sources that include plants, animals, and microorganisms, and the scope of the field depends on knowledge about the safety, purity, and efficacy of complex multicompound products.
Herbal pharmacognosy is the application of this science specifically to traditional herbal medicine sources.
This topic covers the notes for unit 1 of phytochemistry in 1st semester in M Pharm of department of pharmacognosy. This includes biosynthesis, characterization, purification and uses of steroids.
Pharmacovigilance of drugs of natural origin.pdfKipaPape
PHARMACOVIGILANCE OF DRUGS OF NATURAL ORIGIN.
WHO AND AYUSH GUIDELINES FOR SAFETY MONITORING OF NATURAL MEDICINE.
SPONTANEOUS REPORTING SCHEMES FOR BIODRUG ADVERSE REACTIONS
BIO DRUG-DRUG AND BIO DRUG-FOOD INTERACTIONS WITH SUITABLE EXAMPLES
Withanolides are a group of at least 300 naturally occurring steroids built on an ergostane skeleton.They occur as secondary metabolites primarily in genera of the Nightshade family, for example in the tomatillo.
Structurally, withanolides consist of a steroid backbone bound to a lactone or one of its derivatives; they are produced via oxidation of steroids. It remains unknown to what end withanolides are produced; they may act as a deterrent for feeding insect larvae and other herbivores
Unit 2. Regulatory requirements for setting herbal drug industry:
Content: Global marketing management.
Indian and International patent law as applicable herbal drugs and natural products.
Export - Import (EXIM) policy, TRIPS.
Quality assurance in herbal/natural drug products.
Concepts of TQM, GMP, GLP, ISO-9000.
Unit I: Plant Drug Cultivation
General introduction to the importance of
Pharmacognosy in herbal drug industry, Indian Council of
Agricultural Research, Current Good Agricultural Practices,
Current Good Cultivation Practices, Current Good Collection
Practices, Conservation of medicinal plants- Ex-situ and Insitu
conservation of medicinal plants.
Marine natural products: General methods of isolation and
purification, Study of Marine toxins, Recent advances in research
in marine drugs, Problems faced in research on marine drugs
such as taxonomical identification, chemical screening and their
solution.
Nutraceuticals chapter of Advance Pharmacognosy 1 of M Pharm syllabus.
This presentation involves Introduction to Nutraceuticals,
Classification of Nutraceuticals, Herbs as a food, Inorganic /mineral supplements, brief benefits of vitamin supplements, digestive enzymes and its example, use of cereals and Grains, importance of Antioxidants and Polyunsaturated fatty acids, an example of formulation and standardization of Multivitamin Tablets, what all regulatory requirement we need to manufacture Nutraceuticals and FSSAI guidelines for Nutraceuticals, sources- mediinal use - marker compound of some usually used Nutraceuticals.
Regulatory requirement for setting herbal drug industryRAGHAV DOGRA
The World Health Organization (WHO) estimates that 80 percent of the population of some Asian and African countries presently use herbal medicine for some aspect of primary health care.Pharmaceuticals are prohibitively expensive for most of the world's population, half of whom lived on less than $2 U.S. per day in 2002. In comparison, herbal medicines can be grown from seed or gathered from nature for little or no cost
patent (/ˈpætənt/ or /ˈpeɪtənt/) is a set of exclusive rights granted by a sovereign state to an inventor or assignee for a limited period of time in exchange for detailed public disclosure of an invention. An invention is a solution to a specific technological problem and is a product or a process. Patents are a form of intellectual property.
Herbal drugs are usually considered safe but when taken along with other drugs of chemical origin (allopathic drugs), they do interact with them and cause Bio-drug interaction
coumarin; umbelliferone and its biosynthesis and isolation.
terpenoide; cucurbitacine and its biosynthesis and isolation purification and characterization
Phytochemical Analysis and Antibacterial Activity of Psidium Guajava against ...ijtsrd
The some plants have been good source of drugs for microbial resistance. The research for newer source of antibiotics is a global challenges in pharmaceutical companies. Present time plants are being extensively explored for harboring medicinal properties. Phytochemical are naturally occurring compounds present in the medicinal plants such as flavonoids, steroids, alkaloids and phenolic compounds. Psidium guajava is a phototherapeutic plant used in folk medicine and is believed to have active components that helps in treatment and management of various disease such as wounds, ulcers, etc. Guava extract has exhibited remarkable antimicrobial activity against microorganisms. This study investigates the phytochemical and antibacterial properties of Psidium guajava leaf extracts. Antibacterial activity at the plant extract were determined against K. pneumoniae, S. aureus, E. coli. Psidium guajava leaf extracts provided scientific evidence for the rational use of P. juajava leaves in prevention of disorders due to Presence of some useful phytochemicals and in the treatment of disease caused by some bacterial pathogens such as S. aureus, B. cereus, K. pneumonae, E. coli. The present work demonstrates the antimicrobial potential of Psidium guajava leaves extracts by using various solvents. Pooja Soudawat | Anand Verma "Phytochemical Analysis and Antibacterial Activity of Psidium Guajava against Some Clinical Pathogens" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29134.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/29134/phytochemical-analysis-and-antibacterial-activity-of-psidium-guajava-against-some-clinical-pathogens/pooja-soudawat
ABSTRACT- The present study was planned to study the antimicrobial activity of different plant extract against selected microorganisms. The plants used in the present study were Ocimum sanctum (Tulsi), Withania somnifera (Ashwgandha), Santalum album (Chandan), Aloe vera (Aloe barbadensis), and shatavari (Asparagus racemosus). The extract from the leaves of these plants (are) used in malaria, bronchitis, gastric disorders, cough, cold etc. To test efficiency of some common plants extract against E. coli, Salmonella typhi, Proteus vulgaris, Staphylococcus aureus. Contrary to the synthetic drugs, antimicrobials of plant origin are not associated with many side effects and have an enormous therapeutic potential to heal many infectious diseases. The present investigation is therefore, undertaken to test the efficiency of some of the common plant extracts against some plants and human pathogens, i.e. E. coli and S. aureus. In this project work, we studied the different parts of medicinal plants of Latur, Osmanabad region used for curing different type of diseases specially skin diseases. Some plants have active components which show antimicrobial activity. These Herbal plants are beneficial to human being in therapeutic practice. Skin diseases are difficult conditions to live with, to save the very least. Though some skin diseases may cause minimal discomfort, the visual effects of the conditions can cause significant self esteem and confidence issues. The majority of skin diseases cause scarring or disfigurement. Skin diseases run the gambit from barely noticeable to fatal.
Key-words- Medicinal plants, Antimicrobial activity, Antifungal activity
Usefulness of Rare and Lesser Known Medicine Gaultheria Procumbens A Clinical...ijtsrd
Background Homoeopathic medicines known for its utility in wider spectrum of pathological conditions. Homoeopathic Science adds new medicines in the system through drug proving and explores additional features of already existed medicines through clinical verification. Gaultheria Procumbens is among those medicines having broader application but lesser known due to limited Clinical Experience with the medicine. Clinical verification of this Medicine will explores many new insights in its healing power and ultimately its utility in day to day practice. Aims The Main Objective was to study to verify the Clinical Utility of Rare and Lesser Known Medicine Gaultheria Procumbens. Another important objective is to prepare a Remedy Profile of Gaultheria Procumbens from clinical verified Symptoms during study. With research question, Will the verification of rare and lesser known medicine Gaultheria Procumbens helpful in Homoeopathic Practice Setting and Design The study was Prospective Analytical and Interventional Clinical Verification study. A clinical study had been conducted in which total 30 experimental samples were Purposively selected from the 3 project sites, Smt. S. I. Patel Ipcowala Homoeopathic Hospital, Amul Dairy Road, Anand and Rural as well as O.P.D. centers situated at Dharmaj, Napad and Anand Agriculture university Health centre.Materials and Methods 30 samples were selected through Purposive Sampling method with fulfillment of inclusion and exclusion criteria. Data collection was done with the Personal Interview Method According to guidelines given in Organon of medicine, book by Dr. Hahnemann. Remedy Profile of Gaultheria Procumbens from available data during Review of Literature with specially Prepared Case Performa and Scoring systems were selected as tools for data collection. Potency Selection, Repetition and Follow ups were decided according to need of particular case. Statistical Analysis Paired t test was done in Microsoft Excel using Pre Treatment and Post Treatment Score from Subjective Scoring System MYMOP Measure Yourself Medical Outcome Profile .Result Most of the cases 11 36.67 were seen in the age group 51 60 that suggest this age group have more Prevalence of the diseases affect the Locomotor system during this era and Female sex having slightly more Predominance than Male sex. Most of cases in this study with Acute phase or Acute Excerbations of Chronic than the Chronic one. Other variables like potency and diagnosis were also observed.Conclusion This study helps to verify the medicine Gaultheria Procumbens and Explore its utility in Practical Homeopathy. Some characteristic symptoms as well as sphere of action were also found during this study which will be helpful in prescribing as well as studying the medicine Gaultheria Procumbens. This Primary research will be a good base for further research with Gaultheria Procumbens. Dr. Jalpa P. Atri "Usefulness of Rare and Lesser Known Medicine Gaultheria Procumbens: A Clinic
Anacyclus Pyrenthrum An Unexplored Ethanomedicinal Plantijtsrd
Anacyclus pyrenthrum most widely growing species of the family Asteraceae. The plant having several pharmacological actions such as antidiabetic, immunostimulant , inhibitory effects, antidepressant activity, anticonvulsant activity, memory enhancing activity, aphrodisiacs, antimicrobial activity, antioxidant, local anesthetic effect, insecticidal effect, action on COX and LOX, interactions with testosterone, interaction with libido, and it interaction with testicles. mostly the root is having phytochemical components which shows above pharmacological activity. M B Narkhede | V B Patond | N G Ratnaparkhi | S D Mhaske "Anacyclus Pyrenthrum: An Unexplored Ethanomedicinal Plant" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd31913.pdf Paper Url :https://www.ijtsrd.com/biological-science/microbiology/31913/anacyclus-pyrenthrum-an-unexplored-ethanomedicinal-plant/m-b-narkhede
A Study of Central Nervous System CNS Effect of Xanthium Strumarium in Swiss ...ijtsrd
Xanthium strumarium L. Family Asteraceae, a common weed in North America, Brazil, China, Malaysia, and the drier regions of India, is a medicinal plant. The herb has historically been used to treat a variety of illnesses. Traditional medicine has used extracts of the entire plant, particularly the leaves, roots, fruits, and seeds, to treat conditions like leucoderma, epilepsy, salivation, chronic malaria, rheumatism, tuberculosis, allergic rhinitis, sinitis, urticaria, rheumatoid arthritis, constipation, diarrhoea, leprosy, lumbago, pruritis, bacterial infections, and fungal infections. In this present study, we investigated neurobehavioral activity of ethanol extract of Xanthium strumarium L in mice as a part of a psychopharmacological screening of this plant. The effects of the plant extract on CNS were studied by using Elevated plus maze test, Hole board test, Hole cross test, open field test. The overall results suggest that the ethanol extract of Xanthium strumarium have significant effect on CNS. However, future efforts should concentrate more on in vitro and in vivo studies in order to confirm traditional insight in the light of a rational phytotherapy. Majedul Hoque | Md Mahabur Rahman | Md Nasir Uddin "A Study of Central Nervous System (CNS) Effect of Xanthium Strumarium in Swiss Albino Mice" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-4, August 2023, URL: https://www.ijtsrd.com/papers/ijtsrd59832.pdf Paper Url:https://www.ijtsrd.com/pharmacy/pharmacognosy-/59832/a-study-of-central-nervous-system-cns-effect-of-xanthium-strumarium-in-swiss-albino-mice/majedul-hoque
Invasive Alien Plants: Valuable Elixir with Pharmacological and Ethnomedicina...ijtsrd
Use of herbal medicines is propagating day-by-day and several tribes still rely upon this green treasure against their ailments. Being unfortunate to the environment, invasive plants species hold supreme remedies that are unique. Besides ethnoremedial uses they embrace anticancerous, antidiabetic, antimicrobial, antitubercular and other pharmacological attributes in them. In the present review, authors aimed to compile the segregated ethnomedicinal information of invasive plant species. The literature study revealed a significant ethnoremedial importance of invasive alien weeds that may serve to establish a ground for future researchers to explore in pharmacognostic field with safe and natural drug resource. Shaiphali Saxena | P. B. Rao"Invasive Alien Plants: Valuable Elixir with Pharmacological and Ethnomedicinal Attributes" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-3 , April 2018, URL: http://www.ijtsrd.com/papers/ijtsrd11636.pdf http://www.ijtsrd.com/pharmacy/pharmacognosy-/11636/invasive-alien-plants-valuable-elixir-with-pharmacological-and-ethnomedicinal-attributes/shaiphali-saxena
Phytochemical Screening and Antimicrobial Effects of Leaf and Root Extracts o...inventionjournals
Crotalaria brevidens (slenderleaf) leaves and shoots are used as food and have medicinal properties when consumed by human beings. It also acts as an agent in promotion of suicidal germination of striga, a parasitic plant that is a major problem weed for maize and millet growers. In view of its medicinal importance, and there being increased tolerance of many microorganisms towards known antibiotics, there is a need to establish the anti microbial properties of extracts obtained from its roots, stem, leaf and other body parts against pathogenic microorganism. Even though this plant is reported to have immense medicinal value in treating stomach related ailments, malaria and many other tropical diseases, before this study little was known about the antimicrobial potentials of its roots, stem and leaves against three candidate microorganisms namely; Candida albicans, staphylococcus aureus and E. coli. This study was thus initiated to investigate (1) the antimicrobial effects of slenderleaf on Candida albicans, staphylococcus aureus and E. coli, and (2) establish the presence of phenols, steroids, glycosides, saponins, quinones, tannins, terpenoids and flavonoids in its crude leaf and root extracts. The plant roots and leaves used during these studies were collected, shade dried and blended to obtain a fine powder. Ethanol was used as the solvent to extract the pure components by dissolving 25g of leaves and 6g of roots separately in 150ml of ethanol in each case. After seven days, the extract was filtered and the filtrate put in a rotary evaporator to obtain a pure solid sample of the extract. A stock solution was made with 3g of the leaf extract that resulted by dissolving in 40ml distilled water making a concentration of 75mg/ml. the stock was diluted to 3.75mg/ml, 11.25mg/ml, 18.75mg/ml and 37.5mg/ml as 5%, 15%, 25% and 50% respectively. A control with distilled water (0%) was used. This was then replicated thrice to minimize variability and arranged in a completely randomized design. The screening of antimicrobial activity of crude extracts was done by measuring the zone of inhibition using agar diffusion method. Data obtained were subjected to analysis of variance (ANOVA) and means separated and compared using least significance difference (LSD) at (p<0.05). There was a clear zone observed around the discs impregnated in the extract and transferred to the inoculated petri dishes. High inhibition was observed on Escherichia coli at a concentration of 37.5mg/ml. phytochemical screening showed presence of flavonoids, tannins, saponins, anthraquinones, phenols, terpenoids and cardiac glycosides as secondary metabolites. The crude extracts obtained in these studies clearly indicated antimicrobial properties against the three tested microorganisms, and therefore there is need to determine the main active components for studies that may lead to the discovery of new natural drugs.
Therapeutic Properties and Nutritive Values of Some Fruit Bearing Medicinal P...Ram Sahu
The medicinal plants imparts chief role in protecting our health from various disease. It is nature’s gift to human being to live healthy life. Medicinal plants are believed to be much safer and proved as elixir in the treatment of various ailments. Medicinal plants used in Indian system of medicine from Rajasthan state have been surveyed and categorized systematically. The manuscript incorporated the therapeutic properties and nutritive values of medicinal plants of Rajasthan. The paper deals with 11 medicinal plants, thoroughly indexed along with their important traditional application for the cure of various ailments. This study also incorporates the ethno-botany and biological activities of these important plants
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Biochemical and Therapeutic Properties of Withania Somnifera in Traditional M...ijtsrd
Withania somnifera Ashwagandha is a very important medicinal plant of Ayurveda. Roots are used as Rejuvenating drug, tonic, Alternative pungent, astringent, Aphrodisiac, anti inflammatory agent. Root powder has been found to be effective against Asthma, bronchitis, leucoderma, Arthritis, emenagogue cold, asthma, Tuberculosis, fever. Leaves are effective against Ulcers, painful swelling Fever, chest pain, sores, swelling. Seeds contains Diuretic, narcotic and hypnotic properties. Ashwagandha contains anti Diabetic, anti cancer, anti oxidant Effects, anti inflammatory, antimicrobial, Anti stress, Aphrodisiac, anti arthritic, Cardiovascular and Immunomodulatory effects. Biotechnological, and Modern Genomics tools may play an important role in the field of discovery of other secondary metabolites and development of improved plant varieties. Neha Singh | Dr. Anita R. J. Singh ""Biochemical and Therapeutic Properties of Withania Somnifera in Traditional Medicinal System"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd21715.pdf
Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/21715/biochemical-and-therapeutic-properties-of-withania-somnifera-in-traditional-medicinal-system/neha-singh
Abstract
In recent times, there is an extensive interest in these Alcoholic extracts due to the emergence and spread of new drugresistant human pathogens to existing antimicrobials. The emergence of medicine opposing pathogens is one of the mostcritical threats to booming treatment of bacterial diseases. Mode of action of Methanolic extracts likely involves fairly a lotof targets in the cell due to huge number of active components and also their hydroplillicity helps them to screen in the cellmembrane, rendering them permeable , leading to leakage of cell contents. This calls for a transformed effort to identifyagents efficient against disease causing bacteria to present antimicrobials. Seed extracts of two different plants viz. Phoenixdactylifera and Annona squamosa, were prepared by methanol extraction method at the ratio of 1:2 using 100ml volume of methanol and stock concentration of 50mg/ml in dimethyl sulfoxide (DMSO) of each extract was made.The extracts and fractions were tested for antimicrobial activity against standard microbial strains of Klebsiella pneumoniae (gramnegative), Staphylococcus aureus (gram-positive), Escherichia.coli (gram-negative), Salmonella typhi (gram-negative) , Enterococcus faecalis (grampositive), Pseudomon aerugenosa (gram-negative),and Salmonella paratyphi (gram-negative)by means of Agar-Disc Diffusion Method and minimal inhibitory concentration (MIC) was noted .. The test culture of standard microbial cultures was 3 X 105 CFU/ml, and standard antibiotic used is Ampicillin with clavulanic acid. In this context, two extract from traditional plants, Custard Apple (Annona squamosa) and Dates (Phoenix dactylifera) were used alone or in combination to assess their antimicrobial efficacy against both Gram negative and Gram positive bacterial clinical isolates .Antimicrobial test was completed by agar disc diffusion method. Although, both extract were found to be effective in inhibiting pathogens to varying degrees to the tested organisms, the Annona squamosa extract is found to be more effective than Phoenix dactylifera.When both extracts were used in combination, they have shown strong synergistic effect against all the pathogens tested in the present studyexcept for the P.aerugenosa and S. Para typhi. Bactericidal abilities displayed by the seed extracts signified their remarkable potential for exploration for effective natural antimicrobial agents against standard pathogenic bacteria. The extracts have shown the synergistic effects even at their MIC against E.fecalis, indicating that with further researches these extracts can be used for treating enteric diseases.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
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The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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Macroeconomics- Movie Location
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Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2. DEFINITIONS :
DRUG – Any chemical substance which is used in
treatment, cure, prevention, or diagnosis of disease
is known as drug.
DRUG DISCOVERY PROCESS – It is a process by
which new candidate medications is/are discovered.
DRUG DEVELOPMENT PROCESS– It is a process of
bringing a new pharmaceutical drug to the market
once a lead compound has been identified through
the process of drug discovery.
3. STAGES OF NEW DRUG DEVELOPMENT PROCESS
DRUG DISCOVERY- Candidate molecules are
chosen on the basis of their pharmacological
properties.
PRECLINICAL DEVELOMENT- Non-human studies
(e.g.- toxicity testing, pharmacokinetic analysis and
formulations) are performed.
CLINICAL DEVELOPMENT- The selected compound
is tested for efficacy, side-effects and potential
dangers.
4.
5.
6. INTRODUCTION
PREDISCOVERY –
o It includes understanding the disease.
o Identify cellular and genetic factors.
o Need to know which gene(s) are involved and
how they interact.
11. HOW DRUGS ARE DISCOVERED ?
• Choose a disease
• Choose a drug target
• Identify a “bioassay”
bioassay = A test used to
determine biological activity.
12. • Find a “lead compound”
“lead compound” = structure that
has some activity against the chosen
target, but not yet good enough to be
the drug itself.
• If not known, determine the
structure of the “lead compound”.
• Synthesize analogs of the lead.
13. • Identify Structure-Activity-
Relationships (SAR’s).
• Identify the “pharmacophore”
pharmacophore = the structural
features directly responsible for
activity.
• Optimize structure to improve
interactions with target.
14. • Determine toxicity and efficacy in animal
models.
• Determine pharmacodynamics and
pharmacokinetics of the drug.
15. • Continue to study drug metabolism
• Carry out clinical trials
• Market the drug
16. ARTEMISININ
Artemisinin (also known as qinghao su)
and its derivatives are a new class of
Antimalarials, derived from the sweet
wormwood plant Artemisia annua L.,
which belongs to the family
Asteraceae.
Artemisinin was discovered in 1972 by Tu Youyou, a Chinese scientist,
who was co-recipient of the 2015 Nobel Prize in Medicine for her
discovery of artemisinin.
17. Extracts from different parts of plant (leaves, branches, main stem
and roots) were analyzed, artemisinin content was higher in the leaf
extract and no artemisinin was detected in root extract.
The first effective antimalarial drug was quinine; since then, malaria
has been treated with quinoline-based drugs like chloroquine,
mefloquine, and pyrimethamine, but malaria parasite developed
resistance to these drugs [1–3].
Artemisinin and its derivatives have played a key role in malaria
related mortality.
Due to the problem of resistance, artemisinin and its semisynthetic
derivatives artemether, arteether, dihydroartemisinin and artesunate
are considered to be the most effective for the treatment of malaria.
18. Physicochemical properties
• Artemisinin is white needle-like crystals.
• M.P. = 151–153 °C
• Molecular formula = C15H22O5
• Insoluble in water but dissolves in acetone,
ethanol, ether, petroleum ether and alkali solution.
• It reacts with triphenylphosphine to give
triphenylphosphine oxide. This reaction indicate
existence of an oxidative group in the molecule.
22. ANDROGRAPHOLIDE
Andrographolide is a potential cancer therapeutic agent
isolated from the leaves and roots of Andrographis
paniculata Nees. It belongs to the family Acanthaceae.
Ethnobotanically used for the treatment of snake bite,
bug bite, fever, and malaria [4].
Because of its extreme bitterness, it is also called
“king of bitters.”
The primary bioactive compound of andrographolide is
responsible for antimalarial activity.
The principal constituents are 14-deoxy-11-
dehydroandrographolide, 14-deoxy-11-
oxoandrographolide, andrographolide,
andrographine, neoandrographolide, panicoline,
paniculide-A, paniculide-B, and paniculide-C , a
plant originating from Southeast Asian countries.
23. Andrographis paniculata have a broad range of pharmacological
effects including –
anticancer [5–12]
antidiarrheal [13, 14]
antihepatitis [15, 16]
anti-HIV [17]
antihyperglycemic [18–21]
anti-inflammatory [22–26]
antimicrobial, antimalarial [27, 28]
antioxidant [29–31]
cardiovascular [32, 33]
cytotoxic
hepatoprotective [34–45]
immunostimulatory
sexual dysfunctions.
24. Biosynthesis
• Andrographolide is a simple diterpene lactone.
• Andrographolide is a member of the isoprenoid family of natural products.
• The precursors to isoprenoid biosynthesis, isopentenyl pyrophosphate (IPP)
and dimethylally pyrophosphate (DMAPP), can be synthesized through either
the mevalonic acid pathway (MVA) or deoxyxylulose pathway (DXP).
• Majority of the andrographolide precursors are synthesized through the DXP
pathway.
• The biosynthesis of andrographolide begins with the addition of IPP to DMAPP,
which forms geranyl pyrophosphate.
• Another molecule of IPP is then added, yielding farnesyl pyrophosphate (FPP).
• The final IPP molecule is added to the FPP to complete the backbone of the
diterpene.
• The double bond originating from DMAPP is oxidized to an epoxide prior to the ring
closing cascade that forms two six-membered rings.
25.
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