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Achieving Higher States of
Consciousness with Low
Level Energy Transfer
Sanjay Manchanda PhD
Low Power Energy
Desired Change of
State
Learning/Trait
Change of State ≠ or = Learning
Transcranial Alternating Current
Stimulation (tACS)
Transcranial Direct Current Stimulation
(tDCS)
Pulsed Electromagnetic Frequency
Therapy (PEMF)
Photobiomodulation
State Change vs Learning
tDCS/tACs Adds Energy
• 10 – 500 micro amps
• Increased ATP production 500%
• Increased Protein synthesis 70%
• Increased Amino Acid transport
40%
• Increased Cell Signaling
• Activates Signal transduction
Cheng N 1982, The Effect of Electric Currents on ATP
Generation, Protein Synthesis and Membrane
Transport in Rat Skin. Clinical Orthopedics 171:
264-272
Nourishment
tDCS and Depression
Credit: Neuroelectrics Wiki page
Successful
supervised Home
Use
Accelerated Learning
Studies show that tDCS can increase both
Speed of Learning
Ceiling of Learning
Can be Stacked with Other Interventions
Threat Detection Task Learning Improves with
Simultaneous tDCS
DARWARs
Investigated at the University of New Mexico, Clark et. al.
E-Meditation Retreat
Alternating Current: The Power of
Frequency
PAIN INFLAMMATION & ENDORPHINS
Frequency Specific Current for Cervical
Trauma Fibromyalgia
When two signals were combined at
40hz / 10hz
Pain = 7.4/10 reduced to 1.3/10 in 90 min
All 54 patients experienced pain relief
58% total relief in 4 mos
Fibromyalgia Treatment with FSM
Cytokine changes with microcurrent treatment of fibromyalgia associated
with cervical spine trauma JBMT, July 2005, 9 169-176
5/11 5/14 5/17
Pre
Post
400
350
300
250
200
150
100
50
0
IL-1 levels reduced from 392.8 to 21.4 pg/ml over
a 90-minute treatment session. (Normal levels = 0 -
25 pg/ml).
Beta Endorphin Levels
10 Fold
Increase
LLLT
Near-Infrared Photobiomodulation
Infrared LightMechanism
Repair Restore and Enhance
Trans-cranial Infrared Photobiomodulation
600-1000 nm
wavelength
Infra red LEDs
MIT 40 flicker Hz Experiment
Method:
• 1 hr/day x 7 days
Results in Visual Cortex:
• Aβ load reduced by >50%
• Microglia function modified
Result in Hippocampus: No
change
Iaccarino HF, Singer AC, Martorell AJ, et al (2016). Gamma frequency entrainment
attenuates amyloid load and modifies microglia. Nature 540(7632): 230-235.
NeuroGamma 40Hz
Weeks
ChangeinADAS-cogfrombaseline
-12
-10
-8
-6
-4
-2
0
2
4
6
8
PBM
UC
PTSD: After 12 weeks, ADAS-cog scores
improved in the PBM group, but declined in
the Usual Care (UC) group.
Neurogamma Improves Learning Improved Over
tDCS
• DARWARS
Effect Size:
Investigated at the University of New Mexico
Delta Theta Alpha Beta Gamma
Frequency band
0
2
4
6
8
10
12
AbsolutePowerspectrum
Active
Sham
Double-blind RCT of
20 normal subjects
with the Neuro
Gamma
Difference between Post
and Pre in Active and
Sham
Are We Inducing
Gamma?
Increased Gamma in High-level Meditation
Experimental Unit
Sweet spots at 80 Hz,
120 Hz, 160 Hz, 200 Hz
…
High Gamma
High Frequency Stimulation
40 Hz : Increased Focus, Self-observation, Equanimity
80 Hz: Positive Emotion, Joy, Vibratory Flow
100 hz & Above: Feelings of Expansion, Deep Calm, Decrease in
thought
Above 200 Hz—?
Frequencies as Indices to Mind-
Body States
Increase Depth, Breadth and Flexibility of
access to Mind States
100+
Body
Instinct
Unconscious
Pre-personal
Spirit
Intuition
Superconscious
Transpersonal
Mind
Intellect

Conscious

Personal
0
Awareness
Meditation
Tranquility/Calmness Energy
Equanimity Joy/Bliss
Concentration Investigation
Optimal States Protocol
Sequential or Simultaneous
stimulation at various frequencies
Awakened Mind
Simultaneous synchrony in multiple eeg
bands
Asynchronous
Synchronous
Flash 1st
Flash 2ndTiming
Self-Observation—Closing the Loop
Cross-Frequency Coupling
Hippocampal Theta-Gamma Coupling
Balanced Mind
Shinzen Photo
Ultra Low Training
Cygnet/Othmer system
No training of Amplitude Up or Down
• Meditative Process: Self-observation of waveform envelope
Strong effects on balancing Arousal
• Frequency may need to be optimized
Extremely helpful for kids/people stuck in high Arousal
Mechanism of training is Controversial
Ultra Low Freq Stimulation
•Release of deep tension
•Reduction in “Sympathetic Drive”
•Around 0.5 Hz across mastoids
•Effects similar to EMDR
• Side-Effects: Regression, Spaciness, Tiredness
Frequency As Index to States of
Awareness/Experience of Self
0 100…
Body
Instinct
Unconscious
Prepersonal
Pre-rational
Spirit
Intuition
Superconscious
Transpersonal
Post Rational
Mind
Intellect

Conscious

Personal
Rational
Frequency As Index to States of
Awareness/Experience of Self
0 100…
Depth
Breadth
Flexibility
tACS at Ultra Low Frequencies
• Affects Glial Cell Activity, Thalamic excitability
•Releases deep tension
• Reduction in “Sympathetic Drive”
• Around 0.5 Hz across mastoids similar to EMDR
• Can be used to improve Autonomic Regulation
It Takes A Village (62)
45
Learn From Liz
• Non-invasive form of brain stimulation
• Low, safe dose of electrical current (2mA)
delivered via saline soaked sponges
• Sessions last about 20min
• Generally, the anode electrode excites, cathode
electrode inhibits cortex
Transcranial Direct Current Stimulation (tDCS)
tDCS
•Reduced threshold for
firing
•Does not make neurons
fire
• Affects Potential for Neurons
to Fire
• Repeated Stimulation—Long
Term Potentiation
• Synaptic Plasticity (BDNF)
Transcranial Alternating Current
Stimulation (tACS)
Current: 0.1 ma to 2 ma
9 volt Nirvana,
Radiolab & Sally Adee
of New Scientist
Pulsed Electromagnetic Frequency
Therapy (PEMF)
• Non-invasive form of brain stimulation
• Low dose of pulsing magnetic fields delivered
through coils (1-500 microtesla)
Photobiomodulation
Stepping Through The frequencies
1-12 15-40 Hz12-15 Hz
Arousal
s Delta, Theta Alpha LoBeta/SMR Beta, HiBeta
LOGamma
Focus Internal/Low Balanced/Medium External/High
Energy Low Medium High
Body Awareness High Medium Low
State Relaxed Alert Activated
Emotions Peaceful/Sad Neutral/Present Joyful/Agitated
Sinusoidal tACS High Frequency Entrainment
Effects
•40 Hz and above: Increased self-observation,
Equanimity
•80 Hz: Positive Emotion, Joy, Feelings of
Expansion
•100 hz & Above: Expansion of feeling/concept
of Self
•Agitation, Dissociation, Discomfort, Sleep issues
Frequency As Index to States of
Awareness/Experience of Self
0 100…
Body
Instinct
Unconscious
Prepersonal
Pre-rational
Spirit
Intuition
Superconscious
Transpersonal
Post Rational
Mind
Intellect

Conscious

Personal
Rational
Fibromyalgia Treatment with FSM
54 Fibromyalgia patients with history of trauma
9.5yrs (1-50 years) Chronicity
Blood sample data for 6 patients analyzed by NIH
Control = myofascial trigger points
Characteristic Pain Pattern – Pain 7.3 /10
Resistant to narcotics
Modulating Consciousness with AC
frequencies?
• What does a 13 Hz square wave at very low power do the body
tissues?
• 10 Hz, 94 Hz, 18 Hz….??
Microcurrent: Physiological Effects on
Body Tissues
•Frequency Specific
Microcurrent
•Carol Mcmakin DC
•Resonance Effect: How Frequency
Specific Microcurrent Is Changing
Medicine
•Frequency Specific Microcurrent in
Pain Management
Effective Fibromyalgia Treatment with FSM
FSM with Cervical Trauma Fibro
•Only one frequency combination reduced pain
• 40hz / 10hz
•P = 7.4/10 reduced to 1.3/10 in 90 min
• Lasts 2 hours to two weeks
•All 54 patients experienced pain relief
•58% experienced resolution of fibromyalgia within
4 months
Fibromyalgia Treatment with FSM
• 54 Fibromyalgia patients with history of trauma
• 9.5yrs (1-50 years) Chronicity
• Blood sample data for 6 patients analyzed by NIH
•Control = myofascial trigger points
•Characteristic Pain Pattern – Pain 7.3 /10
• Resistant to narcotics
Fibromyalgia Treatment with FSM
Cytokine changes with microcurrent treatment of fibromyalgia associated
with cervical spine trauma JBMT, July 2005, 9 169-176
5/11 5/14
5/17
Pre
Post
400
350
300
250
200
150
100
50
0
IL-1 levels reduced from 392.8 to 21.4 pg/ml over a
90-minute treatment session. (Normal levels = 0 - 25
pg/ml).
Substance P
normal=0-30pg/ml
± 31 reduced to ± 28 pg/ml , t-test
22
“Smoosh” Effect – Beta-Endorphins
•Beta-Endorphin levels can increase
dramatically during FSM treatment
Suggested Mechanism
• Electromagnetic frequencies change membrane protein
configuration through
• Biological Resonance
• Turning receptors on or off
• Modifying cell function
• After insult, Cell Memory is maintained until reset
Other Applications
•Burns
•Shingles
•Nerve Pain
•Neuropathy
McMakin, C, Non-pharmacologic treatment of shingles,
Practical Pain Management, 2010, Vol 10; 4; 24-29
The Use of Microcurrent and Autocatalytic Silver Plated
Dressings in Burn Patients : A Feasibility Study
Infraslow oscillations < 0.1 Hz (EEG)(Hughes 2011)
Discovered in 1957 by Aladjalova
Coincide with long lasting hyperpolarization
Based on K+ channels
Hyperpolarization in thalamus (part of rich
club) results in bursting
Which requires ca influx through T channels
Cross-frequency couples with alpha in thalamus
Alpha consists of tonic and burst firing
Burst at 4Hz @130-200 Hz spike mode
Awakened Mind
•Maxwell Cade, Anna Wise, Judith
Pennington
•Simultaneous synchrony in multiple
eeg bands
Neurofeedback
Transcranial Alternating Current
Stimulation (tACS)
•Almost Infinite Parameter Space
•Location –Head, Neck, Spine, Body
•Frequency—1-1000 Hz
•Shape of Waveform
• Limited research
What are the Entrainment
Effects of tACS?
Subjective Effects of Sinusoidal tACS
• Mastoids Montage
• Is there a consistent response at different
frequencies?
tACS vs Neurofeedback
• Simpler to use and wider applicability
• Consistent responses/Efficient Response
• Targeting Specificity is an issue
Does it train the brain? The effects last?
tACS vs Neurofeedback
tACS is good for stimulating large areas of the brain across a
wide range of frequencies
Fehmi Analog trainer: whole brain synchrony
tACS good Ultra Low and Ultra High
Ultra Low Frequencies
.0001 to 0.9 Hz
• Glial Cell Activity, particularly Astrocytes
• Manage thalamic excitability, energy and firing tone
• Autonomic Regulation
• Rest/Digest (PNS) vs Flight/Fight (SNS)
Brain Wave Entrainment with tACS
• Does sinusoidal or square wave stimulation at 1or 10 Hz increase
power at 1 or 10 Hz?
• Is it similar to uptraining EEG Neurofeedback at the same band?
Frequency As Index to States of
Awareness/Experience of Self
0 100…
Body
Instinct
Unconscious
Prepersonal
Pre-rational
Spirit
Intuition
Superconscious
Transpersonal
Post Rational
Mind
Intellect

Conscious

Personal
Rational
tACS Balanced Mind Protocol
• Can we create high functioning
mind with high mindfulness?
• One that releases the grip of the
narrative self?
• Preliminary Work
Mindfulness
Tranquility/Calmness Energy
Equanimity Joy/Bliss
Concentration Investigation
Applying tDCS
• Find Brain Area associated
with expert task
performance
• Stimulate Task Significant
Area while Performing Task

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Dr. Sanjay Manchanda. Achieving Higher States of Consciousness with Low Level Energy Transfer to the Brain

  • 1. Achieving Higher States of Consciousness with Low Level Energy Transfer Sanjay Manchanda PhD
  • 2. Low Power Energy Desired Change of State Learning/Trait Change of State ≠ or = Learning
  • 3. Transcranial Alternating Current Stimulation (tACS) Transcranial Direct Current Stimulation (tDCS) Pulsed Electromagnetic Frequency Therapy (PEMF) Photobiomodulation
  • 4. State Change vs Learning
  • 5. tDCS/tACs Adds Energy • 10 – 500 micro amps • Increased ATP production 500% • Increased Protein synthesis 70% • Increased Amino Acid transport 40% • Increased Cell Signaling • Activates Signal transduction Cheng N 1982, The Effect of Electric Currents on ATP Generation, Protein Synthesis and Membrane Transport in Rat Skin. Clinical Orthopedics 171: 264-272 Nourishment
  • 6. tDCS and Depression Credit: Neuroelectrics Wiki page Successful supervised Home Use
  • 7. Accelerated Learning Studies show that tDCS can increase both Speed of Learning Ceiling of Learning Can be Stacked with Other Interventions
  • 8. Threat Detection Task Learning Improves with Simultaneous tDCS DARWARs Investigated at the University of New Mexico, Clark et. al.
  • 10. Alternating Current: The Power of Frequency PAIN INFLAMMATION & ENDORPHINS
  • 11. Frequency Specific Current for Cervical Trauma Fibromyalgia When two signals were combined at 40hz / 10hz Pain = 7.4/10 reduced to 1.3/10 in 90 min All 54 patients experienced pain relief 58% total relief in 4 mos
  • 12. Fibromyalgia Treatment with FSM Cytokine changes with microcurrent treatment of fibromyalgia associated with cervical spine trauma JBMT, July 2005, 9 169-176 5/11 5/14 5/17 Pre Post 400 350 300 250 200 150 100 50 0 IL-1 levels reduced from 392.8 to 21.4 pg/ml over a 90-minute treatment session. (Normal levels = 0 - 25 pg/ml).
  • 13. Beta Endorphin Levels 10 Fold Increase
  • 14. LLLT
  • 19. MIT 40 flicker Hz Experiment Method: • 1 hr/day x 7 days Results in Visual Cortex: • Aβ load reduced by >50% • Microglia function modified Result in Hippocampus: No change Iaccarino HF, Singer AC, Martorell AJ, et al (2016). Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature 540(7632): 230-235.
  • 20. NeuroGamma 40Hz Weeks ChangeinADAS-cogfrombaseline -12 -10 -8 -6 -4 -2 0 2 4 6 8 PBM UC PTSD: After 12 weeks, ADAS-cog scores improved in the PBM group, but declined in the Usual Care (UC) group.
  • 21. Neurogamma Improves Learning Improved Over tDCS • DARWARS Effect Size: Investigated at the University of New Mexico
  • 22. Delta Theta Alpha Beta Gamma Frequency band 0 2 4 6 8 10 12 AbsolutePowerspectrum Active Sham Double-blind RCT of 20 normal subjects with the Neuro Gamma Difference between Post and Pre in Active and Sham Are We Inducing Gamma?
  • 23. Increased Gamma in High-level Meditation
  • 25. Sweet spots at 80 Hz, 120 Hz, 160 Hz, 200 Hz … High Gamma
  • 26.
  • 27. High Frequency Stimulation 40 Hz : Increased Focus, Self-observation, Equanimity 80 Hz: Positive Emotion, Joy, Vibratory Flow 100 hz & Above: Feelings of Expansion, Deep Calm, Decrease in thought Above 200 Hz—?
  • 28. Frequencies as Indices to Mind- Body States Increase Depth, Breadth and Flexibility of access to Mind States 100+ Body Instinct Unconscious Pre-personal Spirit Intuition Superconscious Transpersonal Mind Intellect
 Conscious
 Personal 0 Awareness
  • 30. Optimal States Protocol Sequential or Simultaneous stimulation at various frequencies
  • 31. Awakened Mind Simultaneous synchrony in multiple eeg bands
  • 33.
  • 34.
  • 39. Ultra Low Training Cygnet/Othmer system No training of Amplitude Up or Down • Meditative Process: Self-observation of waveform envelope Strong effects on balancing Arousal • Frequency may need to be optimized Extremely helpful for kids/people stuck in high Arousal Mechanism of training is Controversial
  • 40.
  • 41. Ultra Low Freq Stimulation •Release of deep tension •Reduction in “Sympathetic Drive” •Around 0.5 Hz across mastoids •Effects similar to EMDR • Side-Effects: Regression, Spaciness, Tiredness
  • 42. Frequency As Index to States of Awareness/Experience of Self 0 100… Body Instinct Unconscious Prepersonal Pre-rational Spirit Intuition Superconscious Transpersonal Post Rational Mind Intellect
 Conscious
 Personal Rational
  • 43. Frequency As Index to States of Awareness/Experience of Self 0 100… Depth Breadth Flexibility
  • 44. tACS at Ultra Low Frequencies • Affects Glial Cell Activity, Thalamic excitability •Releases deep tension • Reduction in “Sympathetic Drive” • Around 0.5 Hz across mastoids similar to EMDR • Can be used to improve Autonomic Regulation
  • 45. It Takes A Village (62) 45 Learn From Liz • Non-invasive form of brain stimulation • Low, safe dose of electrical current (2mA) delivered via saline soaked sponges • Sessions last about 20min • Generally, the anode electrode excites, cathode electrode inhibits cortex Transcranial Direct Current Stimulation (tDCS)
  • 46. tDCS •Reduced threshold for firing •Does not make neurons fire • Affects Potential for Neurons to Fire • Repeated Stimulation—Long Term Potentiation • Synaptic Plasticity (BDNF)
  • 47. Transcranial Alternating Current Stimulation (tACS) Current: 0.1 ma to 2 ma
  • 48. 9 volt Nirvana, Radiolab & Sally Adee of New Scientist
  • 49. Pulsed Electromagnetic Frequency Therapy (PEMF) • Non-invasive form of brain stimulation • Low dose of pulsing magnetic fields delivered through coils (1-500 microtesla)
  • 51. Stepping Through The frequencies 1-12 15-40 Hz12-15 Hz Arousal s Delta, Theta Alpha LoBeta/SMR Beta, HiBeta LOGamma Focus Internal/Low Balanced/Medium External/High Energy Low Medium High Body Awareness High Medium Low State Relaxed Alert Activated Emotions Peaceful/Sad Neutral/Present Joyful/Agitated
  • 52. Sinusoidal tACS High Frequency Entrainment Effects •40 Hz and above: Increased self-observation, Equanimity •80 Hz: Positive Emotion, Joy, Feelings of Expansion •100 hz & Above: Expansion of feeling/concept of Self •Agitation, Dissociation, Discomfort, Sleep issues
  • 53. Frequency As Index to States of Awareness/Experience of Self 0 100… Body Instinct Unconscious Prepersonal Pre-rational Spirit Intuition Superconscious Transpersonal Post Rational Mind Intellect
 Conscious
 Personal Rational
  • 54.
  • 55. Fibromyalgia Treatment with FSM 54 Fibromyalgia patients with history of trauma 9.5yrs (1-50 years) Chronicity Blood sample data for 6 patients analyzed by NIH Control = myofascial trigger points Characteristic Pain Pattern – Pain 7.3 /10 Resistant to narcotics
  • 56. Modulating Consciousness with AC frequencies? • What does a 13 Hz square wave at very low power do the body tissues? • 10 Hz, 94 Hz, 18 Hz….??
  • 57. Microcurrent: Physiological Effects on Body Tissues •Frequency Specific Microcurrent •Carol Mcmakin DC •Resonance Effect: How Frequency Specific Microcurrent Is Changing Medicine •Frequency Specific Microcurrent in Pain Management
  • 59. FSM with Cervical Trauma Fibro •Only one frequency combination reduced pain • 40hz / 10hz •P = 7.4/10 reduced to 1.3/10 in 90 min • Lasts 2 hours to two weeks •All 54 patients experienced pain relief •58% experienced resolution of fibromyalgia within 4 months
  • 60. Fibromyalgia Treatment with FSM • 54 Fibromyalgia patients with history of trauma • 9.5yrs (1-50 years) Chronicity • Blood sample data for 6 patients analyzed by NIH •Control = myofascial trigger points •Characteristic Pain Pattern – Pain 7.3 /10 • Resistant to narcotics
  • 61. Fibromyalgia Treatment with FSM Cytokine changes with microcurrent treatment of fibromyalgia associated with cervical spine trauma JBMT, July 2005, 9 169-176 5/11 5/14 5/17 Pre Post 400 350 300 250 200 150 100 50 0 IL-1 levels reduced from 392.8 to 21.4 pg/ml over a 90-minute treatment session. (Normal levels = 0 - 25 pg/ml).
  • 62. Substance P normal=0-30pg/ml ± 31 reduced to ± 28 pg/ml , t-test 22
  • 63. “Smoosh” Effect – Beta-Endorphins •Beta-Endorphin levels can increase dramatically during FSM treatment
  • 64. Suggested Mechanism • Electromagnetic frequencies change membrane protein configuration through • Biological Resonance • Turning receptors on or off • Modifying cell function • After insult, Cell Memory is maintained until reset
  • 65. Other Applications •Burns •Shingles •Nerve Pain •Neuropathy McMakin, C, Non-pharmacologic treatment of shingles, Practical Pain Management, 2010, Vol 10; 4; 24-29 The Use of Microcurrent and Autocatalytic Silver Plated Dressings in Burn Patients : A Feasibility Study
  • 66. Infraslow oscillations < 0.1 Hz (EEG)(Hughes 2011) Discovered in 1957 by Aladjalova Coincide with long lasting hyperpolarization Based on K+ channels Hyperpolarization in thalamus (part of rich club) results in bursting Which requires ca influx through T channels Cross-frequency couples with alpha in thalamus Alpha consists of tonic and burst firing Burst at 4Hz @130-200 Hz spike mode
  • 67.
  • 68. Awakened Mind •Maxwell Cade, Anna Wise, Judith Pennington •Simultaneous synchrony in multiple eeg bands Neurofeedback
  • 69. Transcranial Alternating Current Stimulation (tACS) •Almost Infinite Parameter Space •Location –Head, Neck, Spine, Body •Frequency—1-1000 Hz •Shape of Waveform • Limited research
  • 70. What are the Entrainment Effects of tACS?
  • 71. Subjective Effects of Sinusoidal tACS • Mastoids Montage • Is there a consistent response at different frequencies?
  • 72. tACS vs Neurofeedback • Simpler to use and wider applicability • Consistent responses/Efficient Response • Targeting Specificity is an issue Does it train the brain? The effects last?
  • 73. tACS vs Neurofeedback tACS is good for stimulating large areas of the brain across a wide range of frequencies Fehmi Analog trainer: whole brain synchrony tACS good Ultra Low and Ultra High
  • 74. Ultra Low Frequencies .0001 to 0.9 Hz • Glial Cell Activity, particularly Astrocytes • Manage thalamic excitability, energy and firing tone • Autonomic Regulation • Rest/Digest (PNS) vs Flight/Fight (SNS)
  • 75. Brain Wave Entrainment with tACS • Does sinusoidal or square wave stimulation at 1or 10 Hz increase power at 1 or 10 Hz? • Is it similar to uptraining EEG Neurofeedback at the same band?
  • 76. Frequency As Index to States of Awareness/Experience of Self 0 100… Body Instinct Unconscious Prepersonal Pre-rational Spirit Intuition Superconscious Transpersonal Post Rational Mind Intellect
 Conscious
 Personal Rational
  • 77. tACS Balanced Mind Protocol • Can we create high functioning mind with high mindfulness? • One that releases the grip of the narrative self? • Preliminary Work
  • 79. Applying tDCS • Find Brain Area associated with expert task performance • Stimulate Task Significant Area while Performing Task