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A PROGRESS REPORT ON THE
CONTROL OF HEPATITIS B
IN THE PHILIPPINES
Disease Burden
 >12% prevalence of chronic Hep B infection
HB Control Targets
 Hepatitis B is a priority

•
 In 2005, countries in the Western Pacific Region including

the Philippines aimed to:
 Milestone : Reduce the prevalence of chronic HBV

infection to <2% among children aged ≥5 years by 2012
 Goal: Reduce the prevalence to ≤ 1% among children ≥5

years by 2017
Strategies to Achieve the Goal
• High coverage of 3 doses of hepatitis B vaccine (HepB3),

with a birth dose given within 24 hours of birth
• Measuring the prevalence of chronic HBV infection by

conducting representative seroprevalence surveys;
• Verifying achievement of a reduced prevalence of chronic

HBV infection by submitting country-level data to be
reviewed by a regional verification panel.
Strategy 1: Hepatitis B vaccination
• ≥65% timely birth dose coverage defined as within 24H

after birth
• ≥ 85% three (3) dose of Hepatitis B vaccine coverage
Immunization Schedule for Infants
AGE
Antigen

At birth 1 ½ mo

BCG

3 ½ mo

9mo

12mo

√

HepB

2 ½ mo

√

DPT-HepB-Hib

√

√

√

OPV

√

√

√

Rota

√

√

Measles
MMR

√
√
THE MANDATE….
WHAT HAS BEEN DONE?
…..Hepatitis B immunization
in the PhilHealth Newborn
Package…

Time Band:
90minutes to 6hrs
Intervention:
Inject HepB and BCG
Strategy 2: Measure Impact-1
• Field assessment of the hepatitis b birth dose practices in health

facilities in 2011
• Done in 8/17 regions in the country
• 142 health facilities were assessed (health centers , lying-in

clinics, public & private hospitals with deliveries)
Strategy 2: Measure Impact-2
• National Hepatitis B Seroprevalence Study in 2013

• 1st Hepatitis B seroprevalence survey conducted in the Philippines

among children
• Objectives

• Primary: To determine the seroprevalence of HBsAg among 5-6
year old children.
• Secondary: To evaluate the HepB vaccination effectiveness by
reviewing the HepB vaccination coverage including timing of the
first dose along with the seroprevalence of HBsAg in the sampled
population
Strategy 2: Measure Impact-2
• National Hepatitis B Seroprevalence Study in 2013

• Sample population were children born between

January 1, 2007- December 31, 2008
• 3000 children aged 5-6 years old
•
• RESULT will be available SOON……
Strategy 3: Verification of Reduced
Prevalence of chronic Hep B Infection

• Country notify WHO readiness for the verification process
• Submits evidences that the prevalence of chronic hepatitis

reduced.
HBV prevalence among blood donors and
OFWCs* (2002-2004)
HBsAg
Number
Tested

Number
positive

%

Blood Donors
Male

59,740

2,551

4.27

5,214

153

2.93

64,954

2,704

4.16

Male

30,484

1,374

4.51

Female

49,186

1,952

3.97

All

79,670

3,326

4.17

Female
All
OFWs

* Yanase, Gill, et. al
HBsAg positivity rates among clients of Laboratories
Participating in EQAS of NRL – SACCL
(2010-2012)

Year
2012
2011
2010

HBV Total
Tested

HBV(+)

%+

#lab

2,206,310 99,184

4.49

1019

1,936,046 97,814

5.05

789

1,712,645 90,052

5.25

429

Census of Natioanl Reference Lab – STD AIDS Cooperative Laboratory
What has been done. . .
Guidelines for the Implementation of a Workplace
Policy and Program on Hepatitis B (DOLE)
All establishments are encouraged to provide mandatory HepB
vaccination to employees
– Required for healthcare workers and high-risk individuals
• Individuals with HepB should not be declared unfit to work without
medical evaluation, nor terminated on the basis of HepB status
• confidentiality, referral system in the workplace
• Screening for HepB as pre-requisite for employment shall not be
mandatory
• Those who contract HepB in the course of their duty are entitled of
Health benefits under SSS and Employees Compensation Benefits
under PD 626
• IEC on hepatitis

https://dl.dropbox.com/u/84112124/Department%2520Advisory%2520No.
%252005%2520%28Corrected%2520Copy%29%5B1%5D.pdf
What has been done. . .
• Policy on Post Exposure Management
(PEM) for HIV, Hepatitis B & C in
Healthcare Settings (DOH) – Technical
Guide
• All hospitals shall include Hepatitis B and C into existing HIV
awareness campaign by HACT or ICC
• New entrant health care personnel in clinical and ancillary
departments shall be required to undergo mandatory Hep B
vaccination
• All cases of accidental exposures should be reported to ICC
for a decision to commence PEP
• Policy on Post Exposure Management (PEM) for
HIV, Hepatitis B & C in Healthcare Settings
•

What has been done. . .

• Guidelines and packages which help assist service
providers and managers including safety, quality
and availability of blood are available
• Infection control guideline -prevention of hepa B
and other diseases in the health care setting
• Persons with active chronic Hep B and HIV can
now benefit new treatment with anti-retrovirals
Action Points
Action Points
Action Points
• Increase awareness and knowledge on hepatitis
including that of health care workers integrated
with other health promotion activities
• Enhance Planning and working with partners
•

Challenges

• surveillance systems for HepB – basis for
evidence-based policy actions
• People Who Inject Drugs - horizontal and vertical
transmission
• Many chronically infected individuals are unaware
of their Hep B status
• Behavior change
Support Healthy Lifestyle Programs
•Enforce restrictions on smoking in public places and near schools based on the Tobacco
Regulations Act
•Enforce restrictions on selling tobacco products based on the Tobacco Regulations Act

• Grant access to lands that the community can use as pocket farms to grow fruits and
vegetables
• Hold community feeding programs to teach children the value of nutritious food
• Hold lectures for mothers to teach them how to prepare healthy yet inexpensive food

• Provide courts and facilities that can serve as venue for physical activities
• Host sports fests that will foster healthy competition and sportsmanship
• Hold a community exercise program to in partnership with local gym or fitness center
instructors?

• Enforce restrictions on selling alcohol to minors
Thank you for your attention. . .

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Dr irma asuncion hb liver ca summit

  • 1. A PROGRESS REPORT ON THE CONTROL OF HEPATITIS B IN THE PHILIPPINES
  • 2. Disease Burden  >12% prevalence of chronic Hep B infection
  • 3. HB Control Targets  Hepatitis B is a priority •  In 2005, countries in the Western Pacific Region including the Philippines aimed to:  Milestone : Reduce the prevalence of chronic HBV infection to <2% among children aged ≥5 years by 2012  Goal: Reduce the prevalence to ≤ 1% among children ≥5 years by 2017
  • 4. Strategies to Achieve the Goal • High coverage of 3 doses of hepatitis B vaccine (HepB3), with a birth dose given within 24 hours of birth • Measuring the prevalence of chronic HBV infection by conducting representative seroprevalence surveys; • Verifying achievement of a reduced prevalence of chronic HBV infection by submitting country-level data to be reviewed by a regional verification panel.
  • 5. Strategy 1: Hepatitis B vaccination • ≥65% timely birth dose coverage defined as within 24H after birth • ≥ 85% three (3) dose of Hepatitis B vaccine coverage
  • 6. Immunization Schedule for Infants AGE Antigen At birth 1 ½ mo BCG 3 ½ mo 9mo 12mo √ HepB 2 ½ mo √ DPT-HepB-Hib √ √ √ OPV √ √ √ Rota √ √ Measles MMR √ √
  • 7.
  • 9. WHAT HAS BEEN DONE? …..Hepatitis B immunization in the PhilHealth Newborn Package… Time Band: 90minutes to 6hrs Intervention: Inject HepB and BCG
  • 10. Strategy 2: Measure Impact-1 • Field assessment of the hepatitis b birth dose practices in health facilities in 2011 • Done in 8/17 regions in the country • 142 health facilities were assessed (health centers , lying-in clinics, public & private hospitals with deliveries)
  • 11.
  • 12. Strategy 2: Measure Impact-2 • National Hepatitis B Seroprevalence Study in 2013 • 1st Hepatitis B seroprevalence survey conducted in the Philippines among children • Objectives • Primary: To determine the seroprevalence of HBsAg among 5-6 year old children. • Secondary: To evaluate the HepB vaccination effectiveness by reviewing the HepB vaccination coverage including timing of the first dose along with the seroprevalence of HBsAg in the sampled population
  • 13. Strategy 2: Measure Impact-2 • National Hepatitis B Seroprevalence Study in 2013 • Sample population were children born between January 1, 2007- December 31, 2008 • 3000 children aged 5-6 years old • • RESULT will be available SOON……
  • 14. Strategy 3: Verification of Reduced Prevalence of chronic Hep B Infection • Country notify WHO readiness for the verification process • Submits evidences that the prevalence of chronic hepatitis reduced.
  • 15. HBV prevalence among blood donors and OFWCs* (2002-2004) HBsAg Number Tested Number positive % Blood Donors Male 59,740 2,551 4.27 5,214 153 2.93 64,954 2,704 4.16 Male 30,484 1,374 4.51 Female 49,186 1,952 3.97 All 79,670 3,326 4.17 Female All OFWs * Yanase, Gill, et. al
  • 16. HBsAg positivity rates among clients of Laboratories Participating in EQAS of NRL – SACCL (2010-2012) Year 2012 2011 2010 HBV Total Tested HBV(+) %+ #lab 2,206,310 99,184 4.49 1019 1,936,046 97,814 5.05 789 1,712,645 90,052 5.25 429 Census of Natioanl Reference Lab – STD AIDS Cooperative Laboratory
  • 17. What has been done. . . Guidelines for the Implementation of a Workplace Policy and Program on Hepatitis B (DOLE) All establishments are encouraged to provide mandatory HepB vaccination to employees – Required for healthcare workers and high-risk individuals • Individuals with HepB should not be declared unfit to work without medical evaluation, nor terminated on the basis of HepB status • confidentiality, referral system in the workplace • Screening for HepB as pre-requisite for employment shall not be mandatory • Those who contract HepB in the course of their duty are entitled of Health benefits under SSS and Employees Compensation Benefits under PD 626 • IEC on hepatitis https://dl.dropbox.com/u/84112124/Department%2520Advisory%2520No. %252005%2520%28Corrected%2520Copy%29%5B1%5D.pdf
  • 18. What has been done. . . • Policy on Post Exposure Management (PEM) for HIV, Hepatitis B & C in Healthcare Settings (DOH) – Technical Guide • All hospitals shall include Hepatitis B and C into existing HIV awareness campaign by HACT or ICC • New entrant health care personnel in clinical and ancillary departments shall be required to undergo mandatory Hep B vaccination • All cases of accidental exposures should be reported to ICC for a decision to commence PEP
  • 19. • Policy on Post Exposure Management (PEM) for HIV, Hepatitis B & C in Healthcare Settings
  • 20. • What has been done. . . • Guidelines and packages which help assist service providers and managers including safety, quality and availability of blood are available • Infection control guideline -prevention of hepa B and other diseases in the health care setting • Persons with active chronic Hep B and HIV can now benefit new treatment with anti-retrovirals
  • 23. Action Points • Increase awareness and knowledge on hepatitis including that of health care workers integrated with other health promotion activities • Enhance Planning and working with partners
  • 24. • Challenges • surveillance systems for HepB – basis for evidence-based policy actions • People Who Inject Drugs - horizontal and vertical transmission • Many chronically infected individuals are unaware of their Hep B status • Behavior change
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30. Support Healthy Lifestyle Programs •Enforce restrictions on smoking in public places and near schools based on the Tobacco Regulations Act •Enforce restrictions on selling tobacco products based on the Tobacco Regulations Act • Grant access to lands that the community can use as pocket farms to grow fruits and vegetables • Hold community feeding programs to teach children the value of nutritious food • Hold lectures for mothers to teach them how to prepare healthy yet inexpensive food • Provide courts and facilities that can serve as venue for physical activities • Host sports fests that will foster healthy competition and sportsmanship • Hold a community exercise program to in partnership with local gym or fitness center instructors? • Enforce restrictions on selling alcohol to minors
  • 31. Thank you for your attention. . .

Editor's Notes

  1. Read Slide ,,,, Presentation focus on the primary hepatitis b immunization during infancy.
  2. Hepatitis B vaccine introduced in the Philippines in 1992 in a phased manner. Nationwide implementation of the Hepatitis B vaccination achieved in 2006 Birth dose incorporated in the country’s Expanded Programme of Immunization (EPI) in 2007.
  3. Since 2007, this has been the current immunization schedule for infants. For hepatitis b vaccination, an infant will receive 4 doses of hepatitis b vaccines, at birth with the monovalent vaccine and additional 3 doses at 1.5 months , 2.5 months and 3.5 months. All EPI vaccines are procured by the government. And all vaccines procured are WHO pre=qualified. This is the current immunization schedule for Infants. The monovalent Hepatitis B vaccination is given at birth within 24 hours after birth, and the combination DPT-HepB-Hib (known us Pentavalent vaccine) is given at 6W, 10W and 14W. Therefore, an infant should receive a total of 4 doses of Hepatitis B before reaching 1 year old. Ay sori…senior moments. Monovalent HepB only for HepB birth dose (HepB BD). Pentavalent vaccines refers to DPT-HepB-Hepatitis B vaccines. So an infant will receive a total of 4 doses of HepB (Birth Dose, 3 penta at 6W, 10W, 14W). Vaccines are procured by national and distributed nationwide. Vaccination is free of charge.
  4. Maam di ko ma-update. 2011 hepb birth dose 42 % ;hepb3 80% 2012 birthdose 35, hepb3 70%. Stock-out of hepb vaccine
  5. Republic Act No. 10152 has been signed. It is otherwise known as the “Mandatory Infants and Children Health Immunization Act of 2011, which requires that all children under five years old be given basic immunization against vaccine-preventable diseases. Specifically, this bill provides for all infants to be given the birth dose of the Hepatitis-B vaccine within 24 hours of birth.
  6. In the Philippines one strategy to strengthen Hepatitis B coverage, administration of birth dose is integration of Hep B birth dose administration in the Essential Intrapartum and Newborn Care Package (EINC). In 2011 11 tertiary hospitals are already EINC compliant. And In the inclusion of the hepatitis B immunization in the Philhealth’s insurance newborn package.
  7. Sample selection: 3-stage cluster used probability proportional to size calculation First stage is province – 25 provinces or highly urbanized centers chosen using probability-proportional-to-size-sampling (PPS) Second stage is barangay - Within each province, 12 barangays Third stage is children - Within each barangay, 10 children born in 2007-8