Big Data in Healthcare: Hype and Hope at NY eHealth Collaborative

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As the author of "Big Data in Healthcare Hype and Hope," Dr Feldman has interviewed over 180 emerging tech and healthcare companies, always asking, "How can your new approach help patients?" Her research shows that data, as an enabling tool, has the power to give us critical new insights into not only what causes disease, but what comprises normal. Despite this promise, few patients have reaped the benefits of personalized medicine. A data ecosystem and how big data is being leveraged for research, discovery, clinical trials, genomics, and cancer care. Case studies and real-life examples of what's working, what's not working, and how we can help speed up progress to get patients the right care at the right time will be explored and debated.

Health & Medicine

Big Data in Healthcare: Hype and Hope
How can we find the path to precision medicine?
Bonnie Feldman, DDS, MBA | www.drbonnie360.com | @DrBonnie360 | drbonnie360@gmail.com

Medical Data
Owners: Consumers, caretakers
Sources: Patients, providers
Users: Patients, providers, R&D, payers
Examples: vitals, fitness, history
© 2014 - All rights reserved.
Patient
Clinical
Financial
R&D
Owners: Providers, patients
Sources: Patients, providers
Users: R&D, patients, providers, payers
Examples: EMRs, images, Dx, Tx
Owners: Payers,
Sources: Providers
Users: Payers, providers, regulators
Examples: claims, cost, payment, utilization
Owners: Academics, pharma
Sources: Providers, patients
Users: Researchers, developers
Examples: trials, screening libraries

Different Perspectives from:
•Andrew Kasarskis Co-director, Icahn Institute for
© 2014 - All rights reserved.
Genomics and Multiscale Biology
• Colin Hill CEO of GNS Healthcare
•William King CEO Zephyr Health
•Jonathan Hirsch Founder and President Syapse

Icahn Institute GNS Healthcare Zephyr Health Syapse
What Integrate Big Data to
build models of
biology and thus
better diagnose,
treat + prevent
disease
© 2014 - All rights reserved.
Value based Big data
analytics for
personalized
interventions that
deliver better
population health
Organizes health
information that
makes it useful and
accessible for anyone
Precision medicine
platform that
enables healthcare
providers
How Aggregation and
mining of clinical,
preclinical + basic
research data,
molecular + other
profiling tech, emr
and other data
sources
Value- based
analytics that
combine economic
and clinical models
to predict the right
interventions targets
for best outcomess
Integrates health
data from thousands
of disparate source
lets users find
insights by viewing
data in context
Semantic computing
based Precision
Medicine Platform
aggregates genomic,
molecular, outcomes
and cost data
For Whom Patients
Providers
Health Care
Innovators
Payers Life Science
Companies
Commercial team
Medical affairs team
Providers
Oncology
Cardiovascular
Genomic Medicine

Open Questions
•What has worked?
•What has not worked?
•How is your business model evolving?
•Dreams for the future?
© 2014 - All rights reserved.

+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
Bonnie Feldman
DDS, MBA
Business Development
for Digital Health

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Joining Discovery on Target 2016 in Boston, for Targeting the Microbiome, DrBonnie presents new discoveries in research, technology, and upcoming companies. Most importantly, DrBonnie360 focuses on the gut as an organ of immunity and its possible relations to autoimmune disease. Topics include: Brain-Gut Axis, Locality, The Leaky Gut, Microbial Composition, Dysbiosis, Oral Microbiome, Personalizing Nutrition, Crowdscience, and Medicines from the Microbiome. Company Summary Tables: Information in order of Indication, What, and How.

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Content and Visual Design by Tiffany Simms Presenting Tinkering, Tweaking, and Tuning: Big Data and Little Data Coming Together in Chronic Disease, DrBonnie360 shows the 4th annual Medical Informatics World Conference 2016 (Boston) the time is now for personalized prevention. DrBonnie360 discusses the invisible epidemic, advances in omics and tracking, and research in epigenetics, the microbiome, nutrigenomics. Lastly, she presents an image of what personalized prevention could look like in the near future.

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Content and Visual Design by Tiffany Simms Do you know why you should take steps to get healthy when you already think you are healthy? DrBonnie360 brings together Linda Avey (We Are Curious Inc.), Poonacha Machaiah (JIYO), and Nicole Guthrie (HopeLab), to present you with your #HacktoHeal. With Chronic Disease, especially autoimmune disease, slowly creeping up on us at an epidemic level, we can no longer ignore the importance of being healthy. The stage is set for personalized prevention. The science, research, data, digital health, and patients, are all ready for personalized prevention to become a reality. We Are Curious, JIYO, and Hopelab bring SXSW the steps to finding and maintaining their optimal health. The key to all this is finding the right feedback loops for each of you and maintaining balance.

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i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource. This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and Associate Division Director for Ambulatory Operations The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma. STATEMENT OF NEED Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL. Target Audience Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL). Learning Objectives 1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL 2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults 3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection

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RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0). CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.

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Non-respiratory Functions of the Lungs.pdf

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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract. Learning objectives: 1. Enlist the non-respiratory functions of the respiratory tract 2. Briefly explain how these functions are carried out 3. Discuss the significance of dead space 4. Differentiate between minute ventilation and alveolar ventilation 5. Describe the cough and sneeze reflexes Study Resources: 1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition 4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874

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The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.

Prix Galien International 2024 Forum Program

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June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels: - ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING - WOMEN’S HEALTH: FERTILITY PRESERVATION - WHAT’S NEW IN THE TREATMENT OF INFECTIOUS, ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES? - ARTIFICIAL INTELLIGENCE AND ETHICS - GENE THERAPY - BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE - ETHICAL CHALLENGES IN LIFE SCIENCES - Prix Galien International Awards Ceremony

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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.

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Big Data in Healthcare: Hype and Hope at NY eHealth Collaborative

1. Big Data in Healthcare: Hype and Hope How can we find the path to precision medicine? Bonnie Feldman, DDS, MBA | www.drbonnie360.com | @DrBonnie360 | drbonnie360@gmail.com

3. Medical Data Owners: Consumers, caretakers Sources: Patients, providers Users: Patients, providers, R&D, payers Examples: vitals, fitness, history © 2014 - All rights reserved. Patient Clinical Financial R&D Owners: Providers, patients Sources: Patients, providers Users: R&D, patients, providers, payers Examples: EMRs, images, Dx, Tx Owners: Payers, Sources: Providers Users: Payers, providers, regulators Examples: claims, cost, payment, utilization Owners: Academics, pharma Sources: Providers, patients Users: Researchers, developers Examples: trials, screening libraries

5. Different Perspectives from: •Andrew Kasarskis Co-director, Icahn Institute for © 2014 - All rights reserved. Genomics and Multiscale Biology • Colin Hill CEO of GNS Healthcare •William King CEO Zephyr Health •Jonathan Hirsch Founder and President Syapse

6. Icahn Institute GNS Healthcare Zephyr Health Syapse What Integrate Big Data to build models of biology and thus better diagnose, treat + prevent disease © 2014 - All rights reserved. Value based Big data analytics for personalized interventions that deliver better population health Organizes health information that makes it useful and accessible for anyone Precision medicine platform that enables healthcare providers How Aggregation and mining of clinical, preclinical + basic research data, molecular + other profiling tech, emr and other data sources Value- based analytics that combine economic and clinical models to predict the right interventions targets for best outcomess Integrates health data from thousands of disparate source lets users find insights by viewing data in context Semantic computing based Precision Medicine Platform aggregates genomic, molecular, outcomes and cost data For Whom Patients Providers Health Care Innovators Payers Life Science Companies Commercial team Medical affairs team Providers Oncology Cardiovascular Genomic Medicine

8. +1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360 Bonnie Feldman DDS, MBA Business Development for Digital Health

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