The document discusses the connection between the oral microbiome and systemic health. It explores how the hundreds of bacteria in the mouth, known as the oral microbiome, could impact overall health and disease. Recent research shows the oral microbiome may play overlooked roles and could be linked to conditions like cardiovascular disease, rheumatoid arthritis, and more. Personalizing care based on each person's unique oral microbiome is an area that startups are exploring to improve diagnosis and treatment of autoimmune diseases.

1. Your Autoimmunity Connection
Our Body’s Immune System
Starts in the Mouth
Exploring the Link between the Oral Microbiome and Systemic Disease

2. Bonnie Feldman, DDS, MBA
DrBonnie360’s mission is to create a digitally
connected world of personalized care for autoimmune
patients.
We consult with start-up companies and entrepreneurs
who are bringing new products and services that will
improve research, diagnosis, and treatment for
autoimmunity
Bibliography for The Gateway to Health and
Disease
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
www.facebook.com/YourAutoimmunityConnection
Content and Visual Design by Tiffany Simms

3. The mouth is home to hundreds of
bacteria. Recent research shows
that the ecosystem in your mouth –
the oral microbiome – could be
significantly connected to one’s
health.
The following slides explore the
overlooked roles the oral
microbiome plays, the potential for
personalization, and the connection
to systemic diseases.

4. Devine, Deirdre A., Philip D. Marsh, and Josephine Meade. "Modulation of host responses by oral commensal bacteria."
Journal of oral microbiology 7 (2015). <http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26941>.
The Overlooked Microbes in Your Mouth
What is the Oral Microbiome?
Oral vs Gut Microbiome
Dewhirst, Floyd E., et al. "The human oral microbiome." Journal of bacteriology 192.19 (2010): 5002-5017.
<http://jb.asm.org/content/192/19/5002.short>.
Krzyściak, Wirginia, Anna Jurczak, and Jakub Piątkowski. "The Role of Human Oral Microbiome in Dental Biofilm Formation."
InTech. N.p., n.d. Web. <http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/the-role-of-human-
oral-microbiome-in-dental-biofilm-formation>.
Lloyd-Price, Jason, Galeb Abu-Ali, and Curtis Huttenhower. "The healthy human microbiome." Genome medicine 8.1 (2016): 1.
<https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0307-y>.
Nelson-Dooley, Cass. "The Mouth, the Oral Microbiome, and Systemic Inflammation." Institute for Functional Medicine. N.p.,
n.d. Web. 18 Jan. 2017. <https://www.functionalmedicine.org/home/focus_on/oral_microbiome/>.
What is the Oral Microbiome

5. Nelson-Dooley, Cass, and Stephen F. Olmstead. "The Microbiome and Overall Health Part 5: The Oropharyngeal Microbiota's
Far-Reaching Role in Immunity, Gut Health, and Cardiovascular Disease." Complementary Prescriptions. N.p., n.d. Web. 19
Jan. 2017. <http://www.cpmedical.net/newsletter/the-microbiome-and-overall-health-part-5-the-oropharyngeal>.
Zarco, Vess, and Ginsburg. “The Oral Microbiome in Health and Disease and the Potential Impact on Personalized Dental
Medicine.” Oral Diseases 18.2 (2012): 109–120. <http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01851.x/full>.
The Hidden Gold Mine: Saliva’s Importance
Glurich, Ingrid et al. “Progress in Oral Personalized Medicine: Contribution of ‘omics.’” Journal of Oral Microbiology 7.0 (2015):
28223. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561229/>.
Yang, Fang et al. “Characterization of Saliva Microbiota’s Functional Feature Based on Metagenomic Sequencing.”
SpringerPlus 5.1 (2016): 2098. PMC. Web. 18 Jan. 2017. <http://link.springer.com/article/10.1186/s40064-016-3728-6>.
Zaura, Egija, et al. "On the ecosystemic network of saliva in healthy young adults." The ISME Journal (2017).
<http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej2016199a.html>.

6. Costalonga, Massimo, and Mark C. Herzberg. "The oral microbiome and the immunobiology of periodontal disease and caries."
Immunology letters 162.2 (2014): 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>.
Dewhirst, Floyd E. “The Oral Microbiome: Critical for Understanding Oral Health and Disease.” Journal of the California Dental
Association 44.7 (2016): 409–10. <https://www.ncbi.nlm.nih.gov/pubmed/27514152>.
Kilian, M., et al. "The oral microbiome–an update for oral healthcare professionals." British Dental Journal 221.10 (2016): 657-666.
<http://www.nature.com/bdj/journal/v221/n10/abs/sj.bdj.2016.865.html>.
Liu, Bo, et al. "Deep sequencing of the oral microbiome reveals signatures of periodontal disease." PloS one 7.6 (2012): e37919.
<http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037919>.
Our Disease Barometer: The Oral Microbiome in Caries & Periodontal Disease
Chicken or the Egg? The Oral Microbiome & Systemic Disease
Nikitakis, N. G., et al. "The autoimmunity–oral microbiome connection." Oral diseases (2016).
<http://onlinelibrary.wiley.com/doi/10.1111/odi.12589/full>.
Scher, Jose U., et al. "Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis."
Arthritis & Rheumatism 64.10 (2012): 3083-3094. <http://onlinelibrary.wiley.com/doi/10.1002/art.34539/full>.
Zhang, Xuan et al. “The Oral and Gut Microbiomes Are Perturbed in Rheumatoid Arthritis and Partly
Normalized after Treatment.” Nature Medicine 21.8 (2015): 895–905.
<http://www.nature.com/nm/journal/v21/n8/abs/nm.3914.html>.

7. Biesalski, Hans K. “Nutrition Meets the Microbiome: Micronutrients and the Microbiota.” Annals of the New York Academy of
Sciences 1372.1 (2016): 53–64. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.13145/full>.
Marshall, Lisa. "The Personalized-Nutrition Boom." Nutrition Business Journal XX.4 (2015): 1-4. PLM Institute. Apr. 2015. Web.
21 Jan. 2017. <http://plminstitute.org/wp-content/uploads/2015/05/NBJ-Personalized-Nutrition_final_April-2015-_Pages-1-
4.pdf>.
Shoaie, Saeed et al. “Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.” Cell metabolism 22.2
(2015): 320–331. <http://www.sciencedirect.com/science/article/pii/S1550413115003307>.
vel Szic, Katarzyna Szarc, et al. "From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to
personalized nutrition?." Clinical epigenetics 7.1 (2015): 33.
<https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-015-0068-2>.
Wasielewski, Helen, Joe Alcock, and Athena Aktipis. “Resource Conflict and Cooperation between Human Host and Gut
Microbiota: Implications for Nutrition and Health.” Annals of the New York Academy of Sciences 1372.1 (2016): 20–8.
<http://onlinelibrary.wiley.com/doi/10.1111/nyas.13118/full>.
Zeevi, David, et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5 (2015): 1079-1094.
<http://www.sciencedirect.com/science/article/pii/S0092867415014816>.
Zmora, Niv, et al. "Taking it personally: personalized utilization of the human microbiome in health and disease." Cell host &
microbe 19.1 (2016): 12-20. <http://www.sciencedirect.com/science/article/pii/S1931312815005089>.
Dinnertime! The Personalized Nutrition Boom