Pistoia Alliance US Conference 2015 - 1.1.3 Innovation in Pharma - Robert Boland

1. Robert Boland
Translational Informatics & External Innovation
13-Oct-2015
The Digital Patient: Innovation in
Leveraging Digital Biomarker and Sensor
Technology
1

2. Business Context
Janssen is engaged on a number of fronts in exploring
opportunities to use commercially available and emerging
technologies (chiefly biosensors and mobile technologies) to
create new services, develop higher degrees of engagement
with healthcare stakeholders and to improve effectiveness/
adherence of medicines.
The nature of these engagements are decidedly cross-
discipline, bringing together researchers, healthcare
professionals, care-givers, technologists, human factors
research, designers and the patients themselves to develop
these solutions.
210/19/2015Digital Patient COP

3. Digital Patient Challenges
 Collecting and making meaningful assessments of streaming
data
 Consumer Grade Data not good enough
 API’s are required to extract granular data
 Disparate Devices and Manufacturer landscape as it relates to
Health IT
 Many Devices Manufactures with ‘An App for That!”
 Garmin
 Fitbit
 Apple
 Intel
 Google
 How to evaluate and who’s to select?
 What JNJ is doing to accelerate the pace of Innovation the pace
related to the Digital Patient
310/19/2015Digital Patient COP

4. 4
Health &
wellness
Early
Diagnostics
Interception
Therapy/
Adherence
Relapse Risk
mitigation
Patient-Centric Care Continuum

5. 5
Web / Mobile
Smart Packaging
Sensors
Digital Diagnostics
Behavior Tracking
Health &
wellness
Early
Diagnostics
Interception
Therapy/
Adherence
Relapse Risk
mitigation
Digital Patient-Centric Care Continuum

6. Observational/Clinical Trial
Symptom monitoring via sensors and
apps to support Clinical Trial compliance
and data collection efforts
Pharma Development Process
Create
Confirm
Integrate
Consumer
Helpful recommendations
and self-assessment tools to
improve patient experience and
outcomes while generating
“Real World” data to improve
product outcomes
Clinical
Objective measures via
sensors, combines with
messaging and assessment tools
to improve patient-HCP
communication and visibility of
issues/ tracking outcomes
Explore

7. Information Technology 710/19/2015
Digital Patient Technology Use Cases
Qualification Study
Is “this” digitally collected data
better, faster or cheaper than an
existing diagnostic?
Exploratory / POC
Identify what data can we obtain digitally, and what are the gaps/challenges to harness it.
Lower Development Barriers
Development of capabilities that can
de-risk future trials with better data
and better clinical end-points.
Rx Support
Evidence based methods to inform
clinicians decision to start/change
therapies.
Disease Management
Solutions to provide patients and caregivers with better tools
to manage their condition.
Disease Interception
Solution to provide patients and caregivers with actionable
information to prevent (or limit impact of) disease onset
Clinical Trial Execution
Capabilities that allow digitally
gathered data to serve as surrogate
endpoints to accelerate trials.
Adherence
Solutions that measure adherence and provide feedback to patients,
caregivers and HCPs
Subject Selection
Capabilities that create engagement, deliver digital assessments and allow
digital patient data to be combined with other data (e.g. RWE) to identify
and recruit target patients/subjects.
Observational/Clinical Trials Integrated Solutions Consumer Health
Self Directed Health
Data and algorithms
that provide insight to
a patient (or their
caregiver) on their
current health status,
presented with content
and comparative data
that allows the
consumer to make
better health decisions.

8. Mobile/Web
Applications
Continuous
Biosensor
Monitoring
Objective
Diagnostic
Testing
Behavior
Tracking
Smart
Packaging
Digital Patient Technology Use Cases
Self-
Administered
Diagnostics &
Questionnaires Voice Analysis
Gaming /
Gamification
Haptic
Feedback
Blood Markers
Galvanic Skin
Response
Weight / BMI
Sleep Quality /
Duration
Texting / Email
Frequency
Social Media Location
Motion
Diary/Journal
Eye Tracking
Joint Range of
Motion
Task Speed
EKG / EEG
Tracking /
Serialization
Blister Pack
Monitoring
Medicinal Bottle
Monitoring
2D/3D Image &
Video Analysis
Blood Pressure
/Heartrate
Content
Delivery
Repetitive
behaviors
Alerts /
Messaging
Electrochemical