Recent research points to the predictive value of the oral microbiome for our overall health. Explore the science connecting the oral microbiome with autoimmune diseases such as Rheumatoid Arthritis, Sjogrens Syndrome, Crohn's Disease, and Lupus, in addition to our oral health! Click through the links to learn about: Oral vs. Gut Microbiome The Importance of Saliva Oral Microbiome and Caries & Periodontal Disease Oral Microbiome and Systemic Disease Personalized Nutrition Probiotics, Prebiotics, & Synbiotics

1. Exploring the Oral Microbiome,
Immune-Mediated Inflammatory Disease,
and Personalized Nutrition
A Curated Bibliography

2. Meet the Weatherwoman
Bonnie Feldman, DDS, MBA
DrBonnie360’s mission is to create a
digitally connected world of personalized
care for autoimmune patients.
As Your Autoimmunity Connection, we
consult with start-up companies and
entrepreneurs who are bringing new
products and services that will improve
research, diagnosis, and treatment for
autoimmunity.
Content and Visual Design by Ellie Macartney
Special thanks to Ellen M. Martin
+1.310.666.5312
drbonnie360@gmail.com
yourautoimmunityconnection.com
@DrBonnie360
facebook.com/YourAutoimmunityCon
nection
Your Autoimmunity Connection
DrBonnie360

3. Explore the scientific
resources behind the
oral microbiome
forecast…

4. Oral vs. Gut Microbiome: What is the Oral Microbiome?
Devine, Deirdre A. et al. "Modulation of host responses by oral commensal bacteria." Journal of oral microbiology 7 (2015).
http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26941.
Dewhirst, Floyd E. et al. "The human oral microbiome." Journal of bacteriology 192.19 (2010): 5002-5017.
http://jb.asm.org/content/192/19/5002.short.
Egija Zaura et al. “Acquiring and maintaining a normal oral microbiome: current perspective,” Frontiers in Cellular and Infection
Microbiology (2014): 85https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071637/.
Krzyściak, Wirginia et al. "The Role of Human Oral Microbiome in Dental Biofilm Formation." InTech. N.p., n.d.
Webhttps://www.intechopen.com/books/microbial-biofilms-importance-and-applications/the-role-of-human-oral-microbiome-in-
dental-biofilm-formation.
Lloyd-Price, Jason et al. "The healthy human microbiome." Genome medicine 8.1 (2016):
1.https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0307-y.
Zarco, Vess et al. “The Oral Microbiome in Health and Disease and the Potential Impact on Personalized Dental Medicine.” Oral
Diseases 18.2 (2012): 109–120. http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01851.x/full.

5. What is the Importance of Saliva?
Glurich, Ingrid et al. “Progress in Oral Personalized Medicine: Contribution of ‘omics.’”
Journal of Oral Microbiology 7.0 (2015):
28223.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561229/.
Yang, Fang et al. “Characterization of Saliva Microbiota’s Functional Feature Based on
Metagenomic Sequencing.” SpringerPlus 5.1 (2016): 2098. PMC. Web. 18 Jan. 2017.
http://link.springer.com/article/10.1186/s40064-016-3728-6.
Zaura, Egija et al. "On the ecosystemic network of saliva in healthy young adults." The
ISME Journal
(2017).http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej2016199a.html.

6. Oral Microbiome and Caries & Periodontal Disease
Costalonga, Massimo et al. "The oral microbiome and the immunobiology of periodontal disease and caries."
Immunology letters 162.2 (2014): 22-38.
http://www.sciencedirect.com/science/article/pii/S0165247814001874.
Dewhirst, Floyd E. “The Oral Microbiome: Critical for Understanding Oral Health and Disease.” Journal of the
California Dental Association 44.7 (2016): 409–10.https://www.ncbi.nlm.nih.gov/pubmed/27514152.
Hajishengallis, George. “Periodontitis: from microbial immune subversion to systemic inflammation,” Nature
Reviews Immunology (2015): 30–44 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276050/.
Kilian, M. et al. "The oral microbiome–an update for oral healthcare professionals." British Dental Journal
221.10 (2016): 657-666.http://www.nature.com/bdj/journal/v221/n10/abs/sj.bdj.2016.865.html.
Liu, Bo et al. "Deep sequencing of the oral microbiome reveals signatures of periodontal disease." PloS one
7.6 (2012): e37919. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037919.
Yost, Susan et al. “Potassium is a key signal in host-microbiome dysbiosis in periodontitis,” PLOS Pathogens
(2017): e1006457. https://www.ncbi.nlm.nih.gov/pubmed/28632755.

7. Oral Microbiome and Systemic Disease
Bars, Pierre et al. “The oral cavity microbiota: between health, oral disease and cancers of the aerodigestive tract,”
Canadian Journal of Microbiology (2017): 475–492. https://www.ncbi.nlm.nih.gov/pubmed/28257583
Curatola, Gerald P. et al., “The Mouth-Body Connection: a 28-Day Program to Create a Healthy Mouth, Reduce Inflammation, and
Prevent Disease throughout the Body,” Center Street, (2017).
https://books.google.com/books/about/The_Mouth_Body_Connection.html?id=TCQavgAACAAJ
Nikitakis, N. G., et al. "The autoimmunity–oral microbiome connection." Oral diseases (2016).
http://onlinelibrary.wiley.com/doi/10.1111/odi.12589/full.
Scher, Jose U. et al. "Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis." Arthritis &
Rheumatism 64.10 (2012): 3083-3094. http://onlinelibrary.wiley.com/doi/10.1002/art.34539/full.
Zhang, Xuan et al. “The Oral and Gut Microbiomes Are Perturbed in Rheumatoid Arthritis and Partly Normalized after
Treatment.” Nature Medicine 21.8 (2015): 895–905. http://www.nature.com/nm/journal/v21/n8/abs/nm.3914.html.

8. How Can Personalized Nutrition Impact the Oral
Microbiome?
Biesalski, Hans K. “Nutrition Meets the Microbiome: Micronutrients and the Microbiota.” Annals of the New York
Academy of Sciences 1372.1 (2016): 53–64. http://onlinelibrary.wiley.com/doi/10.1111/nyas.13145/full.
Marshall, Lisa. "The Personalized-Nutrition Boom." Nutrition Business Journal XX.4 (2015): 1-4. PLM Institute. Apr.
2015. Web. 21 Jan. 2017. http://plminstitute.org/wp-content/uploads/2015/05/NBJ-Personalized-Nutrition_final_April-
2015-_Pages-1-4.pdf.
Shoaie, Saeed et al. “Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.” Cell metabolism
22.2 (2015): 320–331. http://www.sciencedirect.com/science/article/pii/S1550413115003307.
van Ommen, Ben et al. “Systems biology of personalized nutrition,” International Life Sciences Institute (2017).
https://www.researchgate.net/publication/8940020_Nutrigenomics_Exploiting_systems_biology_in_the_nutrition_and_h
ealth_arenas.
vel Szic, Katarzyna Szarc et al. "From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key
to personalized nutrition?." Clinical epigenetics 7.1 (2015): 33.
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-015-0068-2.

9. How Can Personalized Nutrition Impact the Oral
Microbiome? (Continued)
Wasielewski, Helen et al. “Resource Conflict and Cooperation between Human Host and Gut
Microbiota: Implications for Nutrition and Health.” Annals of the New York Academy of Sciences
1372.1 (2016): 20–8. http://onlinelibrary.wiley.com/doi/10.1111/nyas.13118/full.
Woelber et al. “An oral health optimized diet can reduce gingival and periodontal inflammation
in humans - a randomized controlled pilot study,” BMC Oral Health (2016): 28.
https://www.ncbi.nlm.nih.gov/pubmed/27460471
Zeevi, David et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5
(2015): 1079-1094. http://www.sciencedirect.com/science/article/pii/S0092867415014816.
Zmora, Niv et al. "Taking it personally: personalized utilization of the human microbiome in
health and disease." Cell host & microbe 19.1 (2016): 12-20.
http://www.sciencedirect.com/science/article/pii/S1931312815005089.

10. Prebiotics, Probiotics, & Synbiotics for Oral Health
Evans, Joseph. “Think outside the gut: Probiotics for oral health,” Agro Food Industry Hi Tech.
(2016): 27. 48-53.
https://www.researchgate.net/publication/303462030_Think_outside_the_gut_Probiotics_for_or
al_health.
Ohshima T et al. “Therapeutic Application of Synbiotics, a Fusion of Probiotics and Prebiotics,
and Biogenics as a New Concept for Oral Candida Infections: A Mini Review,” Front Microbiol.
(2016): 7:10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724717/.
Reddy, R. Sudhakar et al. “Bacteria in Oral Health – Probiotics and Prebiotics A Review,” Int J
Biol Med Res. (2011): 2(4): 1226-
1233.https://www.biomedscidirect.com/261/bacteria_in_oral_health_probiotics_and_prebiotics_
a_review/articlescategories.