DNA REPARATION
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The document summarizes two scientific studies. The first study characterizes an enzyme called Zf-GRF that is involved in detecting oxidative DNA damage and activating the DNA repair enzyme APE2. The second study finds that increasing niacin in the diet may help control early-onset Parkinson's disease caused by defects in the PINK1 gene, as niacin helps maintain healthy mitochondria. Both studies could help develop new therapeutic approaches for diseases like cancer or Parkinson's by manipulating DNA repair mechanisms or maintaining mitochondrial health.
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Pegable Biología Molecular. María Alejandra Gómez Otálvaro
Scientists have identified two key DNA repair methods. UvrD facilitates repair by pulling RNA polymerase backwards to expose DNA lesions. The Mre11 complex cuts DNA strands to initiate precise homologous recombination repair. Defects in related human proteins XPB and Mre11 have been linked to diseases like xeroderma pigmentosum and cancer. Further research on these repair proteins may help develop new therapies.
Presentation on personalised medicines
Personalized medicine uses a patient's genetic profile to determine the best medication, therapy, and dose for treating and preventing disease. It allows targeting of treatment based on an individual's genetic makeup, which can influence drug metabolism and efficacy. Pharmacogenetics studies how genetic variations affect individual responses to drugs by influencing protein functions like metabolism and transport. Genetic testing can predict treatment responses before starting therapy to optimize treatment selection and reduce adverse reactions.
DNA REPARATION ELISA OROZCO
This document summarizes research on mechanisms for repairing damaged DNA, including non-homologous end joining and homologous recombination. It discusses how enzymes act to replace lost DNA information before joining, and how further research on these enzymes may help prevent diseases like cancer via gene therapy. The document also discusses how the p53 tumor suppressor protein prevents genome mutation, and research showing statins may help prevent damage caused by mutated p53 and prevent its destruction by enzymes. Statins are said to have potential benefits for treating cancer by preventing chemotherapy resistance and metastasis. Overall, further research on DNA repair mechanisms and related proteins is said to lead to improved control of diseases through prevention, detection and treatment approaches.
Mutagens
This document discusses mutagens, which are substances that can cause mutations in genetic material by changing DNA. Common mutagens include chemicals like ethidium bromide and radiation. Mutations caused by mutagens can lead to cancer or genetic disorders. The document outlines different types of mutagens like alkylating agents, base analogs, and intercalating agents which can cause different mutation types like transitions or frameshifts. Tests like the Ames test are used to identify potential mutagens. A variety of genetic disorders caused by mutations are also described.
Physical and chemical mutagen copy
Physical and chemical mutagens can cause mutations in DNA. Physical mutagens include electromagnetic radiation like UV light and ionizing radiation such as X-rays, which can damage DNA bases and cause breaks in the DNA strands. Chemical mutagens include base analogs that get incorporated into DNA, base-altering chemicals that modify DNA bases, intercalating agents that insert between DNA bases, and agents that alter DNA structure by causing breaks or crosslinks. Many mutagens are carcinogens, but not all carcinogens are mutagens. The Ames test screens for potential mutagens. Radiation was the first known mutagen and damages DNA through free radicals or direct interaction, causing breaks, base damage, or crosslinks.
ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Ola...
This document discusses research into using PARP inhibitors like olaparib to treat colorectal cancer (CRC). The researchers found that CRC cell lines with mutations in the ATM gene, which is involved in DNA damage repair, were more sensitive to olaparib than cell lines without ATM mutations. They showed that inhibiting both ATM and PARP together was more effective at killing CRC cells than inhibiting either pathway alone. The researchers concluded that cancers involving ATM mutations, including CRC, may be good candidates for PARP inhibitor treatment. Testing patients' tumors for ATM mutations could help guide treatment decisions.
Mutation, Types and Causes, Chromosomal Variation in Number, Gene Mutation
- Mutation is a change in the nucleotide sequence of an organism's genome. There are several types of mutations including substitution, insertion, deletion, and frameshift.
- Mutations can be caused by natural DNA replication errors or external mutagens like radiation, chemicals, and viruses. These mutagens can directly damage DNA or produce reactive molecules that cause mutations.
- Several genetic disorders in humans are caused by chromosomal mutations, such as Down syndrome from trisomy 21, Edward's syndrome from trisomy 18, and Patau syndrome from trisomy 13. Other disorders involve the loss or gain of whole chromosomes or chromosome segments.
DNA Repair
DNA Repair is a process that corrects a damage in the cell but not always it is good for her, sometimes this reparation is the real problem.
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Pegable Biología Molecular. María Alejandra Gómez Otálvaro
Scientists have identified two key DNA repair methods. UvrD facilitates repair by pulling RNA polymerase backwards to expose DNA lesions. The Mre11 complex cuts DNA strands to initiate precise homologous recombination repair. Defects in related human proteins XPB and Mre11 have been linked to diseases like xeroderma pigmentosum and cancer. Further research on these repair proteins may help develop new therapies.
Presentation on personalised medicines
Personalized medicine uses a patient's genetic profile to determine the best medication, therapy, and dose for treating and preventing disease. It allows targeting of treatment based on an individual's genetic makeup, which can influence drug metabolism and efficacy. Pharmacogenetics studies how genetic variations affect individual responses to drugs by influencing protein functions like metabolism and transport. Genetic testing can predict treatment responses before starting therapy to optimize treatment selection and reduce adverse reactions.
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This document summarizes research on mechanisms for repairing damaged DNA, including non-homologous end joining and homologous recombination. It discusses how enzymes act to replace lost DNA information before joining, and how further research on these enzymes may help prevent diseases like cancer via gene therapy. The document also discusses how the p53 tumor suppressor protein prevents genome mutation, and research showing statins may help prevent damage caused by mutated p53 and prevent its destruction by enzymes. Statins are said to have potential benefits for treating cancer by preventing chemotherapy resistance and metastasis. Overall, further research on DNA repair mechanisms and related proteins is said to lead to improved control of diseases through prevention, detection and treatment approaches.
Mutagens
This document discusses mutagens, which are substances that can cause mutations in genetic material by changing DNA. Common mutagens include chemicals like ethidium bromide and radiation. Mutations caused by mutagens can lead to cancer or genetic disorders. The document outlines different types of mutagens like alkylating agents, base analogs, and intercalating agents which can cause different mutation types like transitions or frameshifts. Tests like the Ames test are used to identify potential mutagens. A variety of genetic disorders caused by mutations are also described.
Physical and chemical mutagen copy
Physical and chemical mutagens can cause mutations in DNA. Physical mutagens include electromagnetic radiation like UV light and ionizing radiation such as X-rays, which can damage DNA bases and cause breaks in the DNA strands. Chemical mutagens include base analogs that get incorporated into DNA, base-altering chemicals that modify DNA bases, intercalating agents that insert between DNA bases, and agents that alter DNA structure by causing breaks or crosslinks. Many mutagens are carcinogens, but not all carcinogens are mutagens. The Ames test screens for potential mutagens. Radiation was the first known mutagen and damages DNA through free radicals or direct interaction, causing breaks, base damage, or crosslinks.
ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Ola...
This document discusses research into using PARP inhibitors like olaparib to treat colorectal cancer (CRC). The researchers found that CRC cell lines with mutations in the ATM gene, which is involved in DNA damage repair, were more sensitive to olaparib than cell lines without ATM mutations. They showed that inhibiting both ATM and PARP together was more effective at killing CRC cells than inhibiting either pathway alone. The researchers concluded that cancers involving ATM mutations, including CRC, may be good candidates for PARP inhibitor treatment. Testing patients' tumors for ATM mutations could help guide treatment decisions.
Mutation, Types and Causes, Chromosomal Variation in Number, Gene Mutation
- Mutation is a change in the nucleotide sequence of an organism's genome. There are several types of mutations including substitution, insertion, deletion, and frameshift.
- Mutations can be caused by natural DNA replication errors or external mutagens like radiation, chemicals, and viruses. These mutagens can directly damage DNA or produce reactive molecules that cause mutations.
- Several genetic disorders in humans are caused by chromosomal mutations, such as Down syndrome from trisomy 21, Edward's syndrome from trisomy 18, and Patau syndrome from trisomy 13. Other disorders involve the loss or gain of whole chromosomes or chromosome segments.
DNA Repair
DNA Repair is a process that corrects a damage in the cell but not always it is good for her, sometimes this reparation is the real problem.
Mutagens and their actions
This document discusses mutagens and their actions. It defines mutagens as natural or human-made agents that can alter genetic material and induce mutation. There are three main types of mutagens: chemical mutagens, radiation, and biological mutagens. Chemical mutagens include base analogs, chemical modification agents like alkylating agents, and intercalating agents. Radiation mutagens can be ionizing or non-ionizing, such as UV radiation. Biological mutagens include viruses and transposable elements that can insert into DNA. Exposure to these mutagens may induce mutations by altering DNA structure.
Biology Form 5 Chapter 6 Variation 6.2
1. Mutations can occur at the gene or chromosomal level and can be caused by errors in DNA replication or exposure to mutagens like radiation or chemicals.
2. Gene mutations include substitutions, insertions, and deletions of DNA bases and can range from having little to no effect to causing genetic disorders, depending on where they occur.
3. Chromosomal mutations involve changes in chromosome structure or number, such as deletions, inversions, duplications, and translocations, and can also cause genetic disorders.
Gene mutations ppt
Gene mutations can occur when there is a change in the DNA code, such as a substitution, insertion, or deletion of nucleotide bases. Substitution mutations, where one base is swapped for another, typically have the smallest effect since only one amino acid may change. Insertion and deletion mutations, which add or remove bases, can have larger effects by disrupting the reading frame of the entire DNA sequence. An example is sickle cell anemia, a substitution mutation that causes red blood cells to take on a sickle shape.
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The documents discuss two scientific studies:
1) A study found an enzyme in E. coli, called UvrD, that allows RNA polymerase to backtrack along DNA to expose errors, enabling DNA repair. A similar human repair mechanism involves the XPB protein. Understanding these mechanisms could help treat diseases caused by DNA mutations.
2) A study showed that the genetic disease myotonic dystrophy disrupts the MEF2 transcription factor, affecting microRNAs and other genes, particularly in heart tissue. MicroRNAs help regulate protein expression. Understanding microRNA involvement could help minimize myotonic dystrophy symptoms and improve patient quality of life.
Molecular switch that regulates DNA replication and tracking DNA
Scientists have identified a molecular switch called TEFM that regulates DNA replication and transcription in mitochondria. TEFM acts as a switch to turn transcription and replication processes on and off, and also has an anti-termination activity. This discovery could help prevent collisions between transcription and replication processes in mitochondrial DNA. Additionally, scientists have found that tracking leftover scaffolding from DNA replication can help trace the origins of genetic errors, as these regions tend to accumulate mutations in important regulatory switches. These findings may help scientists better understand diseases and develop new drug therapies.
The onset of cancer
Investigators discovered that the DNA methyltransferase 1 (DNMT1) enzyme is more efficient at adding methyl groups in cancer cells than in normal cells. They studied two types of cells and used a mathematical model to determine the correlation between methylation levels and DNMT1 levels. Researchers are developing combination therapies using epigenetic drugs and traditional drugs to make cancer cells more susceptible to treatment and potentially kill cancer stem cells and drug-resistant cells. A separate study identified an alternative DNA repair mechanism in neuroblastoma tumor cells that may be targeted for new treatment approaches, as most children with high-risk neuroblastoma do not survive. Further research on molecular mechanisms influencing gene expression and DNA repair pathways could provide insights into developing new cancer
The onset of cancer
Investigators discovered that the DNA methyltransferase 1 (DNMT1) enzyme is more efficient in cancer cells compared to normal cells, contributing to increased methylation tags in cancer genomes. They studied two cell types and used a mathematical model to correlate methylation status with DNMT1 levels. Researchers are developing combination therapies using epigenetic and traditional drugs to make cancer cells more susceptible to treatment and potentially kill cancer stem cells and overcome drug resistance. A separate study identified an alternative DNA repair mechanism in neuroblastoma tumors that may be a new treatment target for high-risk childhood neuroblastoma.
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The document discusses two studies related to DNA methylation. The first study found that cancer incidence increases with age due to age-related methylation across the human genome, which can negatively impact gene expression and increase cancer risk. The second study discovered a new type of non-CpG methylation in brain cells that is more dynamic and potentially reversible, challenging the idea that methylation changes are permanent. This has implications for better understanding diseases like Rett syndrome that involve methylation enzymes. Both studies provide insights with potential medical applications like new cancer prevention or treatment strategies.
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This document summarizes and comments on three scientific articles about recent discoveries related to DNA regulation and replication. The first article discusses a discovery about how metabolism is linked to epigenetic regulation of DNA through an enzyme that transfers acetyl groups. The second article discusses reconstituting the DNA replication fork to study its process and regulation. The third discusses the medical importance of understanding DNA replication and regulation to develop new disease treatments.
New Approach to Protecting Prion from Altering and 'Cowcatcher' Enzyme Fixes ...
Researchers made two discoveries about proteins involved in DNA replication and prion diseases:
1) Scientists at UTMB found that the protein NEIL1 acts as a "cowcatcher" by scanning DNA for errors ahead of the replication machinery and signaling it to stop so repairs can be made. This revealed NEIL1's previously unknown role in replication error correction.
2) Researchers at Case Western modified a prion protein to stabilize its normal shape and prevent conversion to the abnormal form that causes diseases. Mice with this variant were resistant to prion infection, demonstrating this approach could block prion disease progression.
These studies provide new insights into DNA repair mechanisms and potential treatments for prion diseases.
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The document discusses two studies: 1) A study showing that the RNF20 protein is required for amplification of MLL-rearranged leukemia. 2) A study describing how multiple RNA binding proteins cooperatively control genetic splicing codes.
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Mutagens and their actions
This document discusses mutagens and their actions. It defines mutagens as natural or human-made agents that can alter genetic material and induce mutation. There are three main types of mutagens: chemical mutagens, radiation, and biological mutagens. Chemical mutagens include base analogs, chemical modification agents like alkylating agents, and intercalating agents. Radiation mutagens can be ionizing or non-ionizing, such as UV radiation. Biological mutagens include viruses and transposable elements that can insert into DNA. Exposure to these mutagens may induce mutations by altering DNA structure.
Biology Form 5 Chapter 6 Variation 6.2
1. Mutations can occur at the gene or chromosomal level and can be caused by errors in DNA replication or exposure to mutagens like radiation or chemicals.
2. Gene mutations include substitutions, insertions, and deletions of DNA bases and can range from having little to no effect to causing genetic disorders, depending on where they occur.
3. Chromosomal mutations involve changes in chromosome structure or number, such as deletions, inversions, duplications, and translocations, and can also cause genetic disorders.
Gene mutations ppt
Gene mutations can occur when there is a change in the DNA code, such as a substitution, insertion, or deletion of nucleotide bases. Substitution mutations, where one base is swapped for another, typically have the smallest effect since only one amino acid may change. Insertion and deletion mutations, which add or remove bases, can have larger effects by disrupting the reading frame of the entire DNA sequence. An example is sickle cell anemia, a substitution mutation that causes red blood cells to take on a sickle shape.
Manual de Gerencia Estratégica de la Arquitectura 2014
La sociedad actual necesita de profesionales que tengan la capacidad y disposición para trabajar interdisciplinariamente de manera efectiva. Que hayan adquirido una actitud responsable, ética y productiva que les augure éxitos futuros para colaborar con el desarrollo económico y social del país. Profesionales, capaces de responder a un mundo que es cada vez más competitivo pero que también necesita de esfuerzos integrados para obtener resultados trascendentes que contribuyan con una sociedad más justa. Este documento intenta brindar algunas herramientas para iniciar el desarrollo de esta visión.
TecnologíAs (Chistes)
El documento contiene varias historias cortas sobre personas que tienen dificultades para entender la tecnología moderna. Un hombre cambió su nombre a DVD, otro le pregunta a su hijo si puede grabar y enviar una película a través de varios dispositivos, y otro intenta dejar la computadora usando un CD en lugar de un parche de nicotina.
Final project ppt
Udit Shah has created a marketing plan for ooVoo, a video chat and instant messaging app. The plan aims to address problems with traditional texting by promoting ooVoo as an engaging platform for video calling. Over the next 3 years, the plan aims to launch the app in regions with strong internet connectivity, define its target markets of personal and business users, and scale up internationally to reach 5 million normal users and 200,000 business users. The key tactics include optimizing the app, promoting on social media, and getting existing users to spread the word.
Solstice
The document outlines a marketing plan for Seoul Sausage food truck to increase awareness and become the go-to catering option in Southern California. The plan includes creating awareness through email marketing, social media, and a website with scheduling. It also proposes hosting a catering event near innovative companies to gain exposure. Finally, providing food samples to additional companies will allow them to experience the brand. The plan aims to acquire and retain customers through various channels while expanding the consumer base with vegetarian options.
Boletin informativo nº 22
Este boletín informativo del Parque Nacional Los Alerces presenta varios temas, incluyendo el 73o aniversario del parque, el Día Internacional del Combatiente de Incendios Forestales, una evaluación de la salud de mamíferos exóticos, una encuesta a prestadores de servicios turísticos, la reapertura de un sendero, y convenios como el Tratado Interjurisdiccional para el funcionamiento del Centro de Investigación y Extensión Forestal Andino Patagónico.
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Similar to DNA REPARATION
Plegable biologia molecular Maria Isabel Perez Palacio
The documents discuss two scientific studies:
1) A study found an enzyme in E. coli, called UvrD, that allows RNA polymerase to backtrack along DNA to expose errors, enabling DNA repair. A similar human repair mechanism involves the XPB protein. Understanding these mechanisms could help treat diseases caused by DNA mutations.
2) A study showed that the genetic disease myotonic dystrophy disrupts the MEF2 transcription factor, affecting microRNAs and other genes, particularly in heart tissue. MicroRNAs help regulate protein expression. Understanding microRNA involvement could help minimize myotonic dystrophy symptoms and improve patient quality of life.
Molecular switch that regulates DNA replication and tracking DNA
Scientists have identified a molecular switch called TEFM that regulates DNA replication and transcription in mitochondria. TEFM acts as a switch to turn transcription and replication processes on and off, and also has an anti-termination activity. This discovery could help prevent collisions between transcription and replication processes in mitochondrial DNA. Additionally, scientists have found that tracking leftover scaffolding from DNA replication can help trace the origins of genetic errors, as these regions tend to accumulate mutations in important regulatory switches. These findings may help scientists better understand diseases and develop new drug therapies.
The onset of cancer
Investigators discovered that the DNA methyltransferase 1 (DNMT1) enzyme is more efficient at adding methyl groups in cancer cells than in normal cells. They studied two types of cells and used a mathematical model to determine the correlation between methylation levels and DNMT1 levels. Researchers are developing combination therapies using epigenetic drugs and traditional drugs to make cancer cells more susceptible to treatment and potentially kill cancer stem cells and drug-resistant cells. A separate study identified an alternative DNA repair mechanism in neuroblastoma tumor cells that may be targeted for new treatment approaches, as most children with high-risk neuroblastoma do not survive. Further research on molecular mechanisms influencing gene expression and DNA repair pathways could provide insights into developing new cancer
The onset of cancer
Investigators discovered that the DNA methyltransferase 1 (DNMT1) enzyme is more efficient in cancer cells compared to normal cells, contributing to increased methylation tags in cancer genomes. They studied two cell types and used a mathematical model to correlate methylation status with DNMT1 levels. Researchers are developing combination therapies using epigenetic and traditional drugs to make cancer cells more susceptible to treatment and potentially kill cancer stem cells and overcome drug resistance. A separate study identified an alternative DNA repair mechanism in neuroblastoma tumors that may be a new treatment target for high-risk childhood neuroblastoma.
“Dna topoisomerases in mt dna maintenance and ageing” and “dna damage checkpo...
“DNA topoisomerases in mtDNA maintenance and ageing” and “DNA damage checkpoints in nasopharyngeal carcinoma”
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The document discusses two studies related to DNA methylation. The first study found that cancer incidence increases with age due to age-related methylation across the human genome, which can negatively impact gene expression and increase cancer risk. The second study discovered a new type of non-CpG methylation in brain cells that is more dynamic and potentially reversible, challenging the idea that methylation changes are permanent. This has implications for better understanding diseases like Rett syndrome that involve methylation enzymes. Both studies provide insights with potential medical applications like new cancer prevention or treatment strategies.
The evolution of medicine: DNA
This document summarizes and comments on three scientific articles about recent discoveries related to DNA regulation and replication. The first article discusses a discovery about how metabolism is linked to epigenetic regulation of DNA through an enzyme that transfers acetyl groups. The second article discusses reconstituting the DNA replication fork to study its process and regulation. The third discusses the medical importance of understanding DNA replication and regulation to develop new disease treatments.
New Approach to Protecting Prion from Altering and 'Cowcatcher' Enzyme Fixes ...
Researchers made two discoveries about proteins involved in DNA replication and prion diseases:
1) Scientists at UTMB found that the protein NEIL1 acts as a "cowcatcher" by scanning DNA for errors ahead of the replication machinery and signaling it to stop so repairs can be made. This revealed NEIL1's previously unknown role in replication error correction.
2) Researchers at Case Western modified a prion protein to stabilize its normal shape and prevent conversion to the abnormal form that causes diseases. Mice with this variant were resistant to prion infection, demonstrating this approach could block prion disease progression.
These studies provide new insights into DNA repair mechanisms and potential treatments for prion diseases.
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The document discusses two studies: 1) A study showing that the RNF20 protein is required for amplification of MLL-rearranged leukemia. 2) A study describing how multiple RNA binding proteins cooperatively control genetic splicing codes.
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P53 protein can repair DNA damage before cell replication. Studies found higher rates of germline DNA repair mutations in men with metastatic prostate cancer, such as with the BRCA1, BRCA2, MHSH2, and HOXB13 genes. These mutations were independent of family history and age of diagnosis. A limitation is that the studies only focused on specific genes and not how multiple genes may interact to influence disease. The student notes that identifying DNA mutations could help various cancer types and that education is needed on tobacco and UV radiation risks.
Plegable biomol
Researchers at the UT Southwestern Medical Center and the University of Geneva studied how certain genes and proteins involved in maintaining genetic stability can sometimes contribute to cancer development. They found:
1) Mutations in the p53 tumor suppressor gene, which normally restrains mobile genetic elements, were prevalent in cancer samples. This leads to genomic instability by allowing increased movement of these elements within chromosomes.
2) The APOBEC protein, intended to fight viruses by modifying single-stranded DNA, can exploit weaknesses during human DNA replication to introduce mutations, as detected in tumor cells. It acts on the single strands present during replication fork separation.
3) Understanding how p53 and APOBEC influence genetic
DNA repair mechanisms
This document discusses two recent studies on DNA repair mechanisms and their implications for cancer research and treatment. The first study found a higher incidence of germline mutations in DNA repair genes in men with metastatic prostate cancer compared to localized disease, which could enable more personalized cancer therapies. The second study was able to film the enzymes involved in DNA repair, providing insights into the repair process that may help counter cancer's resistance to chemotherapy and develop new treatments. Both studies increase understanding of cancer at the molecular level and open doors to improved early detection and more targeted therapies.
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Trabajo plegable biomol
Researchers have discovered two new mechanisms related to DNA replication and gene expression. First, they found an enzyme called NEIL1 that repairs damaged DNA and could enhance cancer treatments if inhibited in cancer cells. Second, they uncovered a new mechanism where a fragment of the CACNA1A gene causes spinocerebellar ataxia type-6 by producing toxic proteins, offering potential treatment by inhibiting production of the mutant fragment. The discoveries provide insights into cellular processes that could be targeted to develop new disease treatments.
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This document summarizes two scientific articles about DNA damage and repair mechanisms. The first article describes a discovery by University of Pennsylvania researchers about how DNA damage activates the immune system to target cancer cells. They propose using this knowledge to design new combination treatments. The second article discusses a new technique by University of North Carolina scientists to map DNA damage caused by cigarette smoking across the genome. This mapping revealed specific sites where repair was initiated following damage from cigarette carcinogens. Both advances could lead to improved cancer treatments and prevention strategies by deepening understanding of DNA replication and repair failures involved in disease.
MOLECULAR BASES OF THE GENOME
This document discusses DNA, RNA, and the molecular bases of the genome. It covers how tracking DNA helps scientists trace the origins of genetic errors. RNA plays a role in genetic expression and manipulation of genetic material. Understanding the genome could allow it to function like a computer receiving orders from RNA. Studying the genome increases scientific understanding, but more remains to be learned about maintaining the genetic code and enzymes responsible for genetic processes. Understanding genetics could improve medical treatments and steer medicine towards prevention by addressing genetic predispositions.
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A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
By harnessing the power of High Flux Vacuum Membrane Distillation, Travis Hills from MN envisions a future where clean and safe drinking water is accessible to all, regardless of geographical location or economic status.
Micronuclei test.M.sc.zoology.fisheries.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
The debris of the ‘last major merger’ is dynamically young
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
学校原件一模一样【微信：741003700 】《(UAM毕业证书)马德里自治大学毕业证学位证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
【主营项目】
一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
Pests of Storage_Identification_Dr.UPR.pdf
InIndia-post-harvestlosses-unscientificstorage,insects,rodents,micro-organismsetc.,accountforabout10percentoftotalfoodgrains
Graininfestation
Directdamage
Indirectly
•theexuviae,skin,deadinsects
•theirexcretawhichmakefoodunfitforhumanconsumption
About600speciesofinsectshavebeenassociatedwithstoredgrainproducts
100speciesofinsectpestsofstoredproductscauseeconomiclosses
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...Scintica Instrumentation
Targeting Hsp90 and its pathogen Orthologs with Tethered Inhibitors as a Diagnostic and Therapeutic Strategy for cancer and infectious diseases with Dr. Timothy Haystead.The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Ozturkcan, S., Berndt, A., & Angelakis, A. (2024). Mending clothing to support sustainable fashion. Presented at the 31st Annual Conference by the Consortium for International Marketing Research (CIMaR), 10-13 Jun 2024, University of Gävle, Sweden.
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ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
The cost of acquiring information by natural selection
The cost of acquiring information by natural selection
Basics of crystallography, crystal systems, classes and different forms
Basics of crystallography, crystal systems, classes and different forms
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
The debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically young
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...
The binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defects
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
DNA REPARATION
- 1. DNA REPARATION MARIA CATALINA SOTO LOPEZ MEDICINE STUDENT
- 4. INTRODUCTION
- 5. STUDY CHARACTERIZES KEY MOLECULAR TOOL IN DNA REPAIR ENZYMES University of North Carolina at Charlotte. (2017,january 6).
- 6. STUDY CHARACTERIZES KEY MOLECULAR TOOL IN DNA REPAIR ENZYMES The DNA needs constant maintenance for it have found a set of molecules that detect oxidative damage to sections of DNA molecules
- 7. STUDY CHARACTERIZES KEY MOLECULAR TOOL IN DNA REPAIR ENZYMES • The Zf-GRF is found in several molecules that work for the maintenance of DNA including APE2 which is an enzyme that is activated when DNA damage occurs and subsequently generate its repair
- 8. STUDY CHARACTERIZES KEY MOLECULAR TOOL IN DNA REPAIR ENZYMES If DNA repair is not generated after suffering oxidative damage this can contribute to the appearance of various diseases such as cancer
- 9. STUDENT´S OPINION • It seems to me very important because having knowledge on this subject could be of great help to intervene in the progression of cancer or other diseases related to oxidative stress and possible solutions would be obtained on the therapeutic measures of these diseases in the near future.
- 10. PEOPLE WITH FORMS OF EARLY-ONSET PARKINSON'S DISEASE MAY BENEFIT FROM BOOSTING NIACIN IN DIET University of Leicester. (2017,January 10).
- 11. PEOPLE WITH FORMS OF EARLY-ONSET PARKINSON'S DISEASE MAY BENEFIT FROM BOOSTING NIACIN IN DIET Niacin is necessary for the proper functioning of the brain since it intervenes in the process of synthesis of certain neurotransmitters such as serotonin being thus partly responsible for our good mood. In addition to being very useful in cases of schizophrenia, psychosis ...
- 12. PEOPLE WITH FORMS OF EARLY-ONSET PARKINSON'S DISEASE MAY BENEFIT FROM BOOSTING NIACIN IN DIET • In some cases Parkinson's disease may occur due to a defect in the PINK1 gene, which is found on the outer membrane of the mitochondria, and this is where the researchers' effect of niacin
- 13. PEOPLE WITH FORMS OF EARLY-ONSET PARKINSON'S DISEASE MAY BENEFIT FROM BOOSTING NIACIN IN DIET • After the study it can be determined that niacin would allow the mitochondria to be maintained in a good state and with it the more controlled family parkinson's disease
- 14. STUDENT´S OPNINION • It seems to me a very good research since although it is not the cure for the disease, it is an improvement for the quality of life that these patients lead mainly because of the easy obtaining of the NAD since it would not be at the hand of some Few, but the therapeutic effect would be available to all.
- 15. MEDICAL UTILITY
- 16. MEDICAL UTILITY • Finding therapeutic pathways in a disease such as Parkinson's is very useful because it would have a great impact on the deteriorated quality of life that these patients carry.
- 17. MEDICAL UTILITY Discovering this type of enzymes such as Zf GRf can be very useful as they can be manipulated to intervene in the evolution of some disease such as cancer
- 18. MEDICAL UTILITY • Both investigations, especially that of the enzyme, may have an impact on morbidity rates, increase the half-life in a patient suffering from cancer or other disease related to oxidative damage
- 19. BIBLIOGRAPHY University of North Carolina at Charlotte. (2017 January 6) "Study characterizes key molecular tool in DNA repair enzymes." ScienceDaily. Retrieved february 5, 2017 from <www.sciencedaily.com/releases/2017/01/170106150915.htm>. University of Leicester.(2017 January 10) "People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, research suggests.". ScienceDaily. Retrieved February 5,2017 from <www.sciencedaily.com/releases/2017/01/170110092059.htm>.