The document discusses two studies: 1) A study showing that the RNF20 protein is required for amplification of MLL-rearranged leukemia. 2) A study describing how multiple RNA binding proteins cooperatively control genetic splicing codes.

1. RNF20 protein required for MLL-
rearranged leukemia amplification
and
Study describes how multiple RNA
binding proteins cooperatively control
genetic splicing code.
Nataly Giraldo Duque
Medicine Student
3° semestre
U.P.B

4. AML has symptoms like fatigue,
difficulty to coagulate and
high-risk infections. Now the
medical treatment to patients
who suffer this kind of cancer
is about chemotherapy and
bone-marrow transplant.
This process happens inside cell
nucleus, and during transcription
processes and translation can
happen alterations and it can
produce cancer.

5. RNFE20 protein required for
MLL-rearranged leukemia
amplification
Proceedings of the National
Academy of Sciences
Published on February 12, 2013

6. CSHL Cold Spring Harbor Laboratory is
a private, non-profit institution with research
programs focusing on:
• Cancer
• Neurobiology
• plant genetics
that have studied the molecular cause of AML
and its possible solution.

9. OPINION
I think this research work is so much
important, because it provided outstanding
advances to develop the medical care to LMA.
Besides, I think the medical cure discovery is
coming up soon and it benefits enormously to
the cancer patients, because they would
avoid chemotherapy that is highly
degenerative method to organism

10. Study describes how multiple RNA
binding proteins cooperatively
control genetic splicing code.
Cell Reports
Published on february 16, 2013

11. • Some kind of cancer and neurodegenerative upsets can be
caused by upsets in the joint process of the RNA.
• Heterogeneous nuclear ribonucleoparticle (hnRNP) proteins are
proteins groups
• they join the RNA and help to regulate the expression of other
proteins through the control in the alternative splicing process
of gene.

13. hnRNP regulate by their self
and they also regulate to other
RNA binding proteins.
Most of changes that happen in cancer
are on introns, and as before it was
mentioned, they are eliminated by
splicing, although the intronic regions
often join with hnRNB proteins.

14. OPINION
I think this discovery about the link between
the hnRNP proteins and the splicing
regulation is so much useful to science,
because this discovery approximates us
treatments to frequent diseases around the
world like cancer y neurodegenerative upsets,
therefore I think scientists should continue
with the research, because it would bring a lot
of positive impacts to society.

15. Medical utility
This study could radically change
the prognosis of person who get
LMA

16. • LMA • No LMA
cromatina
Cromatina
RNF20
drug

17. Medical utility
Attack the specific cause
of cancer

18. The study is very important not only for
people with cancer, but also for those who
suffer from diseases that are caused by
introns that were not eliminated.

19. REFERENCES
• News medical “RNF20 protein required for MLL-rearranged leukemia amplification”
February 12, 2013, Proceedings of the National Academy of Sciences
[http://www.news-medical.net/news/20130212/RNF20-protein-required-for-MLL-
rearranged-leukemia-amplification.aspx?page=2]
• News Medical “Study describes how multiple RNA binding proteins cooperatively control
genetic splicing code”
February 17,2013, Cell Press' new
[http://www.news-medical.net/news/20120217/Study-describes-how-multiple-RNA-binding-
proteins-cooperatively-control-genetic-splicing-code.aspx]
• Wikipedia “Cold Spring Harbor Laboratory “ February 28, 2013
[http://en.wikipedia.org/wiki/Cold_Spring_Harbor_Laboratory]

20. THANKS