the detail study of diuretics which include their drugs, use,classification of diuretics, side effect, mechanism of action, metabolism, synthesis etc. this all things are cover in this presentation.
This document discusses different classes of diuretic drugs, including their mechanisms of action and sites of action in the kidney. It covers carbonic anhydrase inhibitors which act in the proximal convoluted tubule, loop diuretics which act in the loop of Henle, thiazide diuretics which act in the distal convoluted tubule, and potassium-sparing diuretics which act in the cortical collecting duct. Adverse effects are discussed for each class. The key functions of the kidney in filtration, reabsorption and regulation of water and electrolytes are also summarized.
The document summarizes renal physiology and kidney function. It discusses:
1) The structure of the kidney including nephrons, collecting ducts, and microvasculature. Nephron number is established prenatally and cannot be replaced if lost.
2) Urine formation through selective retention and elimination of solutes and water by different nephron segments including the glomerulus, proximal tubule, loop of Henle, and collecting ducts.
3) Causes, types (prerenal, intrarenal, postrenal), phases, prevention and management of acute renal failure and end-stage renal disease where dialysis or transplantation is needed for survival.
in this presentation i have tried to briefly discuss about diuretics (water pills), their classification, mechanism of action, pharmacokinetics and pharmacodynamics of these drugs
Diuretics are drugs that promote the excretion of sodium and water from the body by acting on the kidney. They work by interfering with sodium transport mechanisms in different segments of the nephron. The main types are loop diuretics which act on the thick ascending limb of the loop of Henle, thiazide diuretics which act on the early distal tubule, and potassium-sparing diuretics which act on the late distal tubule and collecting duct. Diuretics are important drugs used to treat hypertension, heart failure, and edema.
This ppt tells us about the topics diuretics and antidiuretics.
It also indicates us about their classification, mechanism of action, side effects and many more.
Edema can be categorized as intracellular (66%), extracellular (33%) with most extracellular fluid located interstitially (75%) and a smaller amount intravascularly (25%). Edema develops when Starling forces are altered, increasing fluid movement from blood vessels into tissues. Causes of edema include capillary leakage, reduced arterial volume, renal factors activating the renin-angiotensin-aldosterone system, vasopressin, endothelin 1, and natriuretic peptides. Edema distribution provides clues to its underlying cause, such as heart failure causing leg edema worse at night, hepatic cirrhosis indicated by ascites, and hypoalbuminemia in nephrotic syndrome shown through facial swelling worse in morning
the detail study of diuretics which include their drugs, use,classification of diuretics, side effect, mechanism of action, metabolism, synthesis etc. this all things are cover in this presentation.
This document discusses different classes of diuretic drugs, including their mechanisms of action and sites of action in the kidney. It covers carbonic anhydrase inhibitors which act in the proximal convoluted tubule, loop diuretics which act in the loop of Henle, thiazide diuretics which act in the distal convoluted tubule, and potassium-sparing diuretics which act in the cortical collecting duct. Adverse effects are discussed for each class. The key functions of the kidney in filtration, reabsorption and regulation of water and electrolytes are also summarized.
The document summarizes renal physiology and kidney function. It discusses:
1) The structure of the kidney including nephrons, collecting ducts, and microvasculature. Nephron number is established prenatally and cannot be replaced if lost.
2) Urine formation through selective retention and elimination of solutes and water by different nephron segments including the glomerulus, proximal tubule, loop of Henle, and collecting ducts.
3) Causes, types (prerenal, intrarenal, postrenal), phases, prevention and management of acute renal failure and end-stage renal disease where dialysis or transplantation is needed for survival.
in this presentation i have tried to briefly discuss about diuretics (water pills), their classification, mechanism of action, pharmacokinetics and pharmacodynamics of these drugs
Diuretics are drugs that promote the excretion of sodium and water from the body by acting on the kidney. They work by interfering with sodium transport mechanisms in different segments of the nephron. The main types are loop diuretics which act on the thick ascending limb of the loop of Henle, thiazide diuretics which act on the early distal tubule, and potassium-sparing diuretics which act on the late distal tubule and collecting duct. Diuretics are important drugs used to treat hypertension, heart failure, and edema.
This ppt tells us about the topics diuretics and antidiuretics.
It also indicates us about their classification, mechanism of action, side effects and many more.
Edema can be categorized as intracellular (66%), extracellular (33%) with most extracellular fluid located interstitially (75%) and a smaller amount intravascularly (25%). Edema develops when Starling forces are altered, increasing fluid movement from blood vessels into tissues. Causes of edema include capillary leakage, reduced arterial volume, renal factors activating the renin-angiotensin-aldosterone system, vasopressin, endothelin 1, and natriuretic peptides. Edema distribution provides clues to its underlying cause, such as heart failure causing leg edema worse at night, hepatic cirrhosis indicated by ascites, and hypoalbuminemia in nephrotic syndrome shown through facial swelling worse in morning
Diuretics work by interfering with electrolyte reabsorption in the kidney to promote excretion of sodium and water. They are classified based on where in the nephron they act: carbonic anhydrase inhibitors act in the proximal convoluted tubule; loop diuretics act on the ascending loop of Henle; thiazide diuretics act in the distal convoluted tubule; and aldosterone inhibitors act on the collecting tubule. Common diuretics include acetazolamide, furosemide, hydrochlorothiazide, and spironolactone. They are used to treat conditions like hypertension, heart failure, and edema. Adverse effects can include electrolyte imbalances like hyp
The document summarizes kidney structure and function, the pathophysiology of acute renal failure, and approaches to diagnosing and managing acute renal failure. It describes how the nephron filters blood to form urine and maintains electrolyte balance. Acute renal failure is often caused by reduced blood flow and oxidative damage to the kidneys. Diagnosis involves assessing for pre-renal versus renal causes. Management focuses on fluid balance, electrolytes, nutrition, and potentially renal replacement therapies like hemodialysis or hemofiltration.
Loop diuretics, thiazides, and other diuretic classes are summarized. Loop diuretics act in the thick ascending limb of Henle's loop by inhibiting the Na-K-2Cl transporter. Thiazides act in the distal convoluted tubule by blocking coupled Na and Cl reabsorption. Carbonic anhydrase inhibitors inhibit bicarbonate absorption in the proximal tubule. Osmotic diuretics like mannitol are filtered but not reabsorbed, drawing water out of cells. Potassium-sparing diuretics like amiloride act late in the distal nephron to inhibit Na reabsorption. Diuretic combinations can have synergistic effects.
This document discusses different classes of diuretic drugs, including their sites of action in the nephron, mechanisms of action, therapeutic uses, and side effects. It covers osmotic diuretics, carbonic anhydrase inhibitors, thiazide diuretics, loop diuretics, and potassium-sparing diuretics. The main points are that diuretics work by inhibiting transport in different parts of the nephron like the proximal tubule, loop of Henle, or distal convoluted tubule. They are used to treat conditions like edema, hypertension, and heart failure. Common side effects among the classes include electrolyte imbalances and metabolic alterations.
This document provides information about different types of diuretic drugs, including their mechanisms of action, therapeutic uses, and side effects. It discusses loop diuretics like furosemide that act in the thick ascending limb of the loop of Henle, thiazide diuretics like hydrochlorothiazide that act in the distal convoluted tubule, potassium-sparing diuretics like spironolactone that act in the collecting duct, and carbonic anhydrase inhibitors like acetazolamide. The document explains how each class of diuretic increases urine output and outlines their applications in conditions like heart failure, hypertension, and edema. It also notes common adverse effects like hypokalemia, hy
This document provides an overview of heart failure and its treatment. It discusses how heart failure occurs when the heart can no longer meet the body's demand due to compromised ventricular contraction. It describes different classes of drugs used to treat heart failure by increasing contraction force and reducing blood volume. These include diuretics, vasodilators, ACE inhibitors, and drugs that increase contractility like cardiac glycosides. The document also examines the pathophysiology of ventricular dysfunction and the body's homeostatic response to heart failure through activation of neurohormonal systems.
The document discusses kidney function and urine formation processes. It then summarizes the key functions of the kidneys, which include regulating electrolyte and fluid balance and removing waste from the blood. It describes the three main processes involved in urine formation - filtration, reabsorption, and secretion. The document then focuses on hypertension, describing classifications of blood pressure and types of hypertension. It outlines mechanisms for blood pressure control and discusses non-pharmacological and pharmacological approaches to hypertension management.
This document discusses diuretics, with a special focus on hydrochlorothiazide. It provides details on renal physiology and pharmacology. It describes the main types of diuretics and their mechanisms of action. It discusses thiazide diuretics in depth, including common examples like hydrochlorothiazide, their effects, kinetics, side effects, and clinical uses, especially for hypertension.
Diuretics
Pharmacology
Katzung
Abnormalities in fluid volume and electrolyte composition are common and important clinical disorders. Drugs that block specific transport functions of the renal tubules are valuable clinical tools in the treatment of these disorders. Although various agents that increase urine volume (diuretics) have been described since antiquity, it was not until 1937 that carbonic anhydrase inhibitors were first described and not until 1957 that a much more useful and powerful diuretic agent (chlorothiazide) became available. Technically, a “diuretic” is an agent that increases urine volume, whereas a “natriuretic” causes an increase in renal sodium excretion and an “aquaretic” increases excretion of solute-free water. Because natriuretics almost always also increase water excretion, they are usually called diuretics. Osmotic diuretics and antidiuretic hormone antagonists (see Agents That Alter Water Excretion) are aquaretics that are not directly natriuretic.
This document provides information on diuretic drugs, including their mechanisms and sites of action, indications for use, and adverse effects. It discusses loop diuretics like furosemide and bumetanide that act in the thick ascending loop of Henle, thiazide diuretics like hydrochlorothiazide that act in the distal tubule, and potassium-sparing diuretics like amiloride and spironolactone that act in the collecting ducts. It also covers carbonic anhydrase inhibitors and osmotic diuretics. Non-diuretic uses and combinations with other drugs are mentioned. Resistance, interactions, and specific adverse effects are summarized for each drug class.
Diuretics and antidiuretics detail STUDYNittalVekaria
diuretics and antidiuretics detail study
-diuretic are the drug which increase the urine formation and excretion.
- antidiuretic work by decrease the urine formation.
classification, mechanism of action, use ,pharmacokinetic, pharmacodynamic,adverse effect
-newer drug
-banned diuretic and antidiuretic drug
This document discusses different classes of diuretic medications, their mechanisms of action, indications, and side effects. It describes:
1) Loop diuretics which inhibit sodium reabsorption in the loop of Henle, causing increased excretion of sodium, chloride, and water. Their main indications include heart failure and edema.
2) Thiazide diuretics which inhibit sodium reabsorption in the distal convoluted tubule. They are used to treat hypertension and have fewer side effects than loop diuretics.
3) Carbonic anhydrase inhibitors which inhibit bicarbonate reabsorption in the proximal tubule, causing a metabolic acidosis. Their main use is for glaucoma.
Diuretics are a class of drugs that cause the kidneys to produce more urine. They help the body eliminate excess fluid and salt. The main types are loop diuretics, thiazide diuretics, carbonic anhydrase inhibitors, potassium-sparing diuretics, and osmotic diuretics. Diuretics are used to treat conditions like heart failure, liver cirrhosis, and hypertension by removing extra fluid from the body. Common side effects include impotence, rashes, nausea, dizziness and fatigue.
Diuretics are drugs that increase urine output by interfering with sodium reabsorption in the kidneys. They are commonly used to treat hypertension by lowering blood volume and pressure. The main classes of diuretics act on different parts of the kidney tubule: loop diuretics act on the ascending loop of Henle; thiazide diuretics act on the distal tubule; and potassium-sparing diuretics act on the late distal tubule or collecting duct. While all diuretics lower blood pressure, their specific sites of action determine their degree of natriuresis and potassium retention or loss.
This document discusses the approach to hyponatremia. It defines hyponatremia as a plasma sodium concentration below 135 mEq/L. Hyponatremia is usually caused by a failure to excrete water normally. The severity ranges from severe (<120 mEq/L) to moderate (120-129 mEq/L) to mild (130-134 mEq/L). Treatment involves slowly correcting the sodium level to avoid complications and is dependent on the underlying cause, such as treating volume depletion or the underlying disease in cases of SIADH or heart failure.
HORMONAL CONTROL OF TUBULAR REABSORPTION (The Guyton and Hall physiology)Maryam Fida
REGULATION OF SODIUM AND WATER BALANCE
by hormones
• Aldosterone
• Angiotensin II
• Atrial natriuretic Peptide
• Parathyroid Hormone
• Antidiuretic hormone (ADH) or vasopressin
ALDOSTERONE
Release: Aldosterone is secreted by the zona glomerulosa cells of the adrenal cortex in response to
Increased extracellular potassium concentration
Increased angiotensin II levels in conditions associated with sodium and volume depletion or low blood pressure.
Site of Action: Major renal tubular site of aldosterone action is on the principal cells of the cortical collecting tubule.
Effects on the Renal Tubules
Aldosterone increases sodium reabsorption and potassium secretion by stimulating the sodium-potassium ATPase pump on the basolateral side of the cortical collecting tubule membrane.
Aldosterone also increases the sodium permeability of the luminal side of the membrane.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
More Related Content
Similar to Diuretics its classification and Pharmacology.ppt
Diuretics work by interfering with electrolyte reabsorption in the kidney to promote excretion of sodium and water. They are classified based on where in the nephron they act: carbonic anhydrase inhibitors act in the proximal convoluted tubule; loop diuretics act on the ascending loop of Henle; thiazide diuretics act in the distal convoluted tubule; and aldosterone inhibitors act on the collecting tubule. Common diuretics include acetazolamide, furosemide, hydrochlorothiazide, and spironolactone. They are used to treat conditions like hypertension, heart failure, and edema. Adverse effects can include electrolyte imbalances like hyp
The document summarizes kidney structure and function, the pathophysiology of acute renal failure, and approaches to diagnosing and managing acute renal failure. It describes how the nephron filters blood to form urine and maintains electrolyte balance. Acute renal failure is often caused by reduced blood flow and oxidative damage to the kidneys. Diagnosis involves assessing for pre-renal versus renal causes. Management focuses on fluid balance, electrolytes, nutrition, and potentially renal replacement therapies like hemodialysis or hemofiltration.
Loop diuretics, thiazides, and other diuretic classes are summarized. Loop diuretics act in the thick ascending limb of Henle's loop by inhibiting the Na-K-2Cl transporter. Thiazides act in the distal convoluted tubule by blocking coupled Na and Cl reabsorption. Carbonic anhydrase inhibitors inhibit bicarbonate absorption in the proximal tubule. Osmotic diuretics like mannitol are filtered but not reabsorbed, drawing water out of cells. Potassium-sparing diuretics like amiloride act late in the distal nephron to inhibit Na reabsorption. Diuretic combinations can have synergistic effects.
This document discusses different classes of diuretic drugs, including their sites of action in the nephron, mechanisms of action, therapeutic uses, and side effects. It covers osmotic diuretics, carbonic anhydrase inhibitors, thiazide diuretics, loop diuretics, and potassium-sparing diuretics. The main points are that diuretics work by inhibiting transport in different parts of the nephron like the proximal tubule, loop of Henle, or distal convoluted tubule. They are used to treat conditions like edema, hypertension, and heart failure. Common side effects among the classes include electrolyte imbalances and metabolic alterations.
This document provides information about different types of diuretic drugs, including their mechanisms of action, therapeutic uses, and side effects. It discusses loop diuretics like furosemide that act in the thick ascending limb of the loop of Henle, thiazide diuretics like hydrochlorothiazide that act in the distal convoluted tubule, potassium-sparing diuretics like spironolactone that act in the collecting duct, and carbonic anhydrase inhibitors like acetazolamide. The document explains how each class of diuretic increases urine output and outlines their applications in conditions like heart failure, hypertension, and edema. It also notes common adverse effects like hypokalemia, hy
This document provides an overview of heart failure and its treatment. It discusses how heart failure occurs when the heart can no longer meet the body's demand due to compromised ventricular contraction. It describes different classes of drugs used to treat heart failure by increasing contraction force and reducing blood volume. These include diuretics, vasodilators, ACE inhibitors, and drugs that increase contractility like cardiac glycosides. The document also examines the pathophysiology of ventricular dysfunction and the body's homeostatic response to heart failure through activation of neurohormonal systems.
The document discusses kidney function and urine formation processes. It then summarizes the key functions of the kidneys, which include regulating electrolyte and fluid balance and removing waste from the blood. It describes the three main processes involved in urine formation - filtration, reabsorption, and secretion. The document then focuses on hypertension, describing classifications of blood pressure and types of hypertension. It outlines mechanisms for blood pressure control and discusses non-pharmacological and pharmacological approaches to hypertension management.
This document discusses diuretics, with a special focus on hydrochlorothiazide. It provides details on renal physiology and pharmacology. It describes the main types of diuretics and their mechanisms of action. It discusses thiazide diuretics in depth, including common examples like hydrochlorothiazide, their effects, kinetics, side effects, and clinical uses, especially for hypertension.
Diuretics
Pharmacology
Katzung
Abnormalities in fluid volume and electrolyte composition are common and important clinical disorders. Drugs that block specific transport functions of the renal tubules are valuable clinical tools in the treatment of these disorders. Although various agents that increase urine volume (diuretics) have been described since antiquity, it was not until 1937 that carbonic anhydrase inhibitors were first described and not until 1957 that a much more useful and powerful diuretic agent (chlorothiazide) became available. Technically, a “diuretic” is an agent that increases urine volume, whereas a “natriuretic” causes an increase in renal sodium excretion and an “aquaretic” increases excretion of solute-free water. Because natriuretics almost always also increase water excretion, they are usually called diuretics. Osmotic diuretics and antidiuretic hormone antagonists (see Agents That Alter Water Excretion) are aquaretics that are not directly natriuretic.
This document provides information on diuretic drugs, including their mechanisms and sites of action, indications for use, and adverse effects. It discusses loop diuretics like furosemide and bumetanide that act in the thick ascending loop of Henle, thiazide diuretics like hydrochlorothiazide that act in the distal tubule, and potassium-sparing diuretics like amiloride and spironolactone that act in the collecting ducts. It also covers carbonic anhydrase inhibitors and osmotic diuretics. Non-diuretic uses and combinations with other drugs are mentioned. Resistance, interactions, and specific adverse effects are summarized for each drug class.
Diuretics and antidiuretics detail STUDYNittalVekaria
diuretics and antidiuretics detail study
-diuretic are the drug which increase the urine formation and excretion.
- antidiuretic work by decrease the urine formation.
classification, mechanism of action, use ,pharmacokinetic, pharmacodynamic,adverse effect
-newer drug
-banned diuretic and antidiuretic drug
This document discusses different classes of diuretic medications, their mechanisms of action, indications, and side effects. It describes:
1) Loop diuretics which inhibit sodium reabsorption in the loop of Henle, causing increased excretion of sodium, chloride, and water. Their main indications include heart failure and edema.
2) Thiazide diuretics which inhibit sodium reabsorption in the distal convoluted tubule. They are used to treat hypertension and have fewer side effects than loop diuretics.
3) Carbonic anhydrase inhibitors which inhibit bicarbonate reabsorption in the proximal tubule, causing a metabolic acidosis. Their main use is for glaucoma.
Diuretics are a class of drugs that cause the kidneys to produce more urine. They help the body eliminate excess fluid and salt. The main types are loop diuretics, thiazide diuretics, carbonic anhydrase inhibitors, potassium-sparing diuretics, and osmotic diuretics. Diuretics are used to treat conditions like heart failure, liver cirrhosis, and hypertension by removing extra fluid from the body. Common side effects include impotence, rashes, nausea, dizziness and fatigue.
Diuretics are drugs that increase urine output by interfering with sodium reabsorption in the kidneys. They are commonly used to treat hypertension by lowering blood volume and pressure. The main classes of diuretics act on different parts of the kidney tubule: loop diuretics act on the ascending loop of Henle; thiazide diuretics act on the distal tubule; and potassium-sparing diuretics act on the late distal tubule or collecting duct. While all diuretics lower blood pressure, their specific sites of action determine their degree of natriuresis and potassium retention or loss.
This document discusses the approach to hyponatremia. It defines hyponatremia as a plasma sodium concentration below 135 mEq/L. Hyponatremia is usually caused by a failure to excrete water normally. The severity ranges from severe (<120 mEq/L) to moderate (120-129 mEq/L) to mild (130-134 mEq/L). Treatment involves slowly correcting the sodium level to avoid complications and is dependent on the underlying cause, such as treating volume depletion or the underlying disease in cases of SIADH or heart failure.
HORMONAL CONTROL OF TUBULAR REABSORPTION (The Guyton and Hall physiology)Maryam Fida
REGULATION OF SODIUM AND WATER BALANCE
by hormones
• Aldosterone
• Angiotensin II
• Atrial natriuretic Peptide
• Parathyroid Hormone
• Antidiuretic hormone (ADH) or vasopressin
ALDOSTERONE
Release: Aldosterone is secreted by the zona glomerulosa cells of the adrenal cortex in response to
Increased extracellular potassium concentration
Increased angiotensin II levels in conditions associated with sodium and volume depletion or low blood pressure.
Site of Action: Major renal tubular site of aldosterone action is on the principal cells of the cortical collecting tubule.
Effects on the Renal Tubules
Aldosterone increases sodium reabsorption and potassium secretion by stimulating the sodium-potassium ATPase pump on the basolateral side of the cortical collecting tubule membrane.
Aldosterone also increases the sodium permeability of the luminal side of the membrane.
Similar to Diuretics its classification and Pharmacology.ppt (20)
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
Reimagining Your Library Space: How to Increase the Vibes in Your Library No ...Diana Rendina
Librarians are leading the way in creating future-ready citizens – now we need to update our spaces to match. In this session, attendees will get inspiration for transforming their library spaces. You’ll learn how to survey students and patrons, create a focus group, and use design thinking to brainstorm ideas for your space. We’ll discuss budget friendly ways to change your space as well as how to find funding. No matter where you’re at, you’ll find ideas for reimagining your space in this session.
Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
How to Fix the Import Error in the Odoo 17Celine George
An import error occurs when a program fails to import a module or library, disrupting its execution. In languages like Python, this issue arises when the specified module cannot be found or accessed, hindering the program's functionality. Resolving import errors is crucial for maintaining smooth software operation and uninterrupted development processes.
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
How to Manage Your Lost Opportunities in Odoo 17 CRMCeline George
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
How to Setup Warehouse & Location in Odoo 17 InventoryCeline George
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
2. Anatomy and Physiology of Renal
system
► Remember the nephron is the most
important part of the kidney that regulates
fluid and electrolytes.
► Urine formation:
1. Glomerular filtration rate = 180L/day
2. Tubular re-absorption (around 98%)
3. Tubular secretion
3. ► How could urine output be increased ?
↑ Glomerular filtration Vs ↓ Tubular reabsorption
(the most important clinically)
o If you increase the glomerular filtriation increase
tubular reabsorption (so you cant use glomerular
filtiration)
► Purpose of Using Diuretics
1. To maintain urine volume ( e.g.: renal failure)
2. To mobilize edema fluid (e.g.: heart failure,liver
failure, nephrotic syndrome)
3. To control high blood pressure.
4. ►Percentage of reabsorption in each
segment:
Proximal convoluted tubule 60-70%
Thick portion of ascending limb of the loop of
Henle. 25%
Distal convoluted tubule 5-10%
Cortical collecting tubule 5% (Aldosterone and
ADH)
5. Physiology of tubular reabsorption
The filtirate
here is
isotonic
The filtirate
here is
hypertonic
6.
7. Classification of Diuretics
► The best way to classify diuretics is to look for their Site of
action in the nephron
A) Diuretics that inhibit transport in the Proximal
Convoluted Tubule ( Osmotic diuretics, Carbonic
Anhydrase Inhibitors)
B) Diuretics that inhibit transport in the Medullary
Ascending Limb of the Loop of Henle( Loop diuretics)
C) Diuretics that inhibit transport in the Distal Convoluted
Tubule( Thiazides : Indapamide , Metolazone)
D) Diuretics that inhibit transport in the Cortical Collecting
Tubule (Potassium sparing diuretics)
8.
9.
10. A. Diuretics that inhibit transport in the
Convoluted Proximal Tubule
1. Osmotic Diuretics (e.g.: Mannitol)
Mechanism of action: They are hydrophilic compounds that are easily
filtered through the glomerulus with little re-absorption and thus increase
urinary output via osmosis.
PK: Given parentrally. If given orally it will cause osmotic diarrhea.
Indications:
- to decrease intracranial pressure in neurological condition
- to decrease intraocular pressure in acute glaucoma
- to maintain high urine flow in acute renal failure during shock
Adverse Reactions:
- Extracellular water expansion may complicate heart failure and produce
pulmonary edema.
- Dehydration
- Hypernatremia due to loss more water than sodium
contraindication:
1- heart failure
2- renal failure
11. 2. Carbonic Anhydrase Inhibitors (Acetazolamide (Oral) ;
Dorzolamide (Ocular) ; Brinzolamide (Ocular)
Mechanism of action Simply inhibit reabsorption of sodium
and bicarbonate.
It prevents the
reabsorption of
HCO3 and Na
•Inhibition of HCO3 reabsorption metabolic acidosis.
•HCO3 depletion enhance reabsorption of Na and Cl hyperchloremea.
•Reabsorption of Na ↑ negative charge inside the lumen ↑K secretion
12. •Weak diuretic : because depletion of HCO3 enhance reabsorption of Na and Cl
•In glaucoma :
The ciliary process absorbs HCO3 from the blood.
↑HCO3 ↑aqueous humor.
Carbonic anhydrase inhibitors prevent absorption of HCO3 from the blood.
•Urinary alkalinization : to increase renal excretion of weak acids e.g.cystin and uric acid.
•In metabolic alkalosis.
•Epilepsy : because acidosis results in ↓seizures.
•Acute mountain sickness.
•Benign intracranial hyper tension.
Dorzolamde and brinzolamide are mixed with β blockers
(Timolol) to treat glaucoma (as topical drops)
13. ►Side Effects of Acetazolamide:
Sedation and drowsiness; Hypersensitivity
reaction (because it contains sulfur)
Acidosis (because of decreased absorption
of HCO3 ) ; Renal stone (because of alkaline
urine); Hyperchloremia, hyponatremia and
hypokalemia
14. B. Diuretics Acting on the Thick Ascending Loop
of Henle (loop diuretics) High ceiling (most efficacious)
► e.g. Furosemide (LasixR), Torsemide, Bumetanide
(BumexR), Ethacrynic acid.
► Phrmacodynamics:
1) Mechanism of Action : Simply inhibit the coupled
Na/K/2Cl cotransporter in the loop of Henle. Also,
they have potent pulmonary vasodilating effects (via
prostaglandins).
2) They eliminate more water than Na.
3) They induce the synthesis of prostaglandins in kidney
and NSAIDs interfere with this action.
They are the best diuretics for 2 reasons:
1- they act on thick ascending limb which has large capacity of reabsorption.
2- action of these drugs is not limited by acidosis
15.
16. In loop diuretics and
thiazides :
The body senses the loss of
Na in the tubule.
This lead to compensatory
mechanism (the body will try
to reabsorb Na as much as
possible)
So the body will
increase synthesis of
aldosterone leading to
:
1- increase Na
absorption
2- hypokalemia
3- alkalosis
17. 2. Side effects:.
Ototoxicity; Hypokalemic metabolic
alkalosis; hypocalcemia and
hypomagnesemia; hypochloremia;
Hypovolemia; hyperuricemia (the drugs are
secreted in proximal convoluted tubule so
they compete with uric acid’s secretion)
hypersensitivity reactions(contain sulfur)
3. Therapeutic Uses
a) Edema (in heart failure, liver cirrhosis,
nephrotic syndrome)
b) Acute renal failure
c) Hyperkalemia
d) Hypercalcemia
18. Dosage of loop diuretics:
Furosemide 20-80 mg
Torsemide 2.5-20 mg
Bumetanide 0.5-2.0 mg
Loop
diuretics
Furosemide:
Taken orally or i.v
If taken orally only 50
% is absorbed
Torsemide:
Taken orally.
Better absorption
Fast onset of action
↑t1/2
Bumetanide (Bumex®)
Taken orally
40 times potent than
furosemide.
Fast onset
Short duration of action
19.
20.
21. C. Diuretics that Inhibit Transport in the Distal
Convoluted Tubule (e.g.: Thiazides and
Thiazide-like (Indapamide; Metolazone)
►Pharmacodynamics:
Mechanism of action: Inhibit Na+ via inhibition
of Na+/Cl- cotransporter.
They have natriuretic action.
Side effects:
► No ototoxicity; hypercalcemia due to ↑PTH, more
hyponatremia; hyperglycemia (due to both impaired
pancreatic release of insulin and diminished utilization of
glucose) hyperlipidemia and hyperurecemia ; hypokalemic
metabloic alkalosis
22.
23. ► Clinical uses:
a) Hypertension Drug of Choice
(Hydrochlorthiazide; Indapamide (NatrilexR)
b) Refractory Edema(doesn’t respond well to
ordinary treatment) together with the Loop
diuretics (Metolazone).
c) Nephrolithiasis (Renal stone) due to idiopathic
hypercalciuria .
d) hypocalcemia.
e) Nephrogenic Diabetes Insipidus. (it decreases
flow of urine more reabsorption)
Indapamide is a potent vasodilator
لق اللي الوحيد التفسير هذا
يته
الستخدام
thiazides
24.
25. ►D. Diuretics that inhibit transport in the
Cortical Collecting Tubule (e.g. potassium
sparing diuretics).
Classification of Potassium Sparing Diuretics:
A) Direct antagonist of mineralocorticoid
receptors (Aldosterone Antagonists e.g
spironolactone (AldactoneR) or
B) Indirect via inhibition of Na+ influx in the
luminal membrane (e.g. Amiloride, Triametrene)
26. Spironolactone (AldactoneR)
►Synthetic steroid acts as a competitive
antagonist of aldosterone with a slow onset of
action.
► Mechanism of action: Aldosterone cause
↑K and H+ secretion and ↑Na reabsorption.
►The action of spironolactone is the opposite
27. Clinical Uses of K+ sparing Diuretics:
In states of primary aldosteronism (e.g. Conn’s
syndrome, ectopic ACTH production) of secondary
aldosteronism (e.g. heart failure, hepatic cirrhosis,
nephrotic syndrome)
To overcome the hypokalemic action of diuretics
Hirsutism (the condensation and elongation of
female facial hair) because it is an
antiandrogenic drug.
28. Side effects:
► Hyperkalemia (some times it’s useful other wise it’s a
side effect).
► Hyperchloremic (it has nothing to do with Cl)
metabolic acidosis
► Antiandrognic effects (e.g. gynecomastia: breast
enlargement in males, impotence) by spironolactone.
► Triametrene causes kidney stones.
► Diuretics Combination preparations
these are anti-hypertensive drugs:
DyazideR = Triametrene 50 mg + Hydrochlorothiazide HCT 25 mg
AldactazideR= Spironolactone 25 mg + HCT 25 mg
ModureticR = Amiloride 5 mg + HCT 50 mg
► Note : HCT to decrease hypertension and K sparing
diuretics to overcome the hypokalemic effect of HCT
► Contraindications: Oral K administration and using of ACE