This document discusses distant hybridization in fruit crops. It begins by defining interspecific and intergeneric hybridization. It then reviews the history of important early hybrids created, such as triticale. The main features of distant hybridization are that it is used to transfer desirable genes between related species when the trait is lacking within a species. It can result in fully fertile, partially fertile, or fully sterile crosses depending on the species. Problems that can occur include cross incompatibility, hybrid inviability, hybrid sterility, and hybrid breakdown. Techniques to overcome these barriers include manipulation of ploidy levels, use of growth regulators, embryo rescue, somatic hybridization, and use of bridge species. Several case studies are presented