DIC is an acute, subacute, or chronic thrombohemorrhagic disorder characterized by systemic intravascular coagulation. It occurs as a secondary complication of various diseases and is initiated by coagulation within blood vessels, leading to thrombosis, bleeding, and potentially organ failure. The only proven treatment is stopping the triggering process and supporting therapy, as there are no specific treatments for DIC itself.

1. DISSEMINATED INTRAVASCULAR COAGULATION(DIC)AMAN MAURYAROLL NO- 1O

2. DICIt is an acute, subacute, or chronic thrombohemorrrhagicdisorder.It occurs as secondary complication of various diseases.An acquired syndrome characterized by systemicintravascularcoagulationCoagulation is always the initial event.WWW. Coumadin.com

3. DICSYSTEMIC ACTIVATION OF COAGULATIONMost morbidity and mortality depends on extent of intravascular thrombosisIntravascular deposition of fibrinDepletion of platelets and coagulation factorsThrombosis of small and midsize vesselsBleedingDEATHOrgan failure

4. D. I. C. Causes

5. Clinical Manifestations of DICIschemic Findingsare earliest!Bleeding is the most obvious clinical finding

6. Clinical Manifestations of DIC

7. Laboratory diagnosisThrombocytopeniaplatelet count <100,000 or rapidly decliningProlonged clotting times (PT, APTT)Presence of Fibrin degradation products or positive D-dimerLow levels of coagulation inhibitorsAT III, protein CLow levels of coagulation factorsFactors V,VIII,X,XIIIFibrinogen levels not useful diagnostically

8. Treatment of DICStop the triggering process .The only proven treatment!Supportive therapyNo specific treatmentsPlasma and platelet substitution therapyAnticoagulantsPhysiologic coagulation inhibitors

9. SummaryDIC is a syndrome characterized systemic intravascular coagulation.Coagulation is the initial event and the extent of intravascular thrombosis has the greatest impact on morbidity and mortality.Important link between inflammation and coagulation. Morbidity and mortality remain high.The only proven treatment is reversal or controlof the underlying cause.