BBI Solutions’ Biobank (BBI Biobank) provides bulk disease state plasma units, specialising in autoimmune, infectious diseases, pregnancy and allergy.

1. Disease State Plasma

2. “We identify rare
materials for early
disease or esoteric
markers through our
extensive screening
programme”
 Save time & optimise your success rate
- highly characterised disease state
plasma units. Large inventory stored at
our facilities
 Confidence in supply - collecting directly
from hospitals and blood banks
 Quality/traceability - materials collected
with ethics approval and/or donor consent
when relevant, storage at a HTA licenced
facility
 Global operations - Facilities in the UK
and Containment Level 3 laboratories in
South Africa to process infectious disease
state plasma
Disease state plasma and clinical specimens

3. Local sourcing in three continents
 Partnerships with local
blood banks and
hospitals
 Shipping hubs in three
continents
 Ethical & regulatory
compliance
CL2 laboratory
 Non-infectious DSP
collection at source
 Screening
 Processing
 Testing
CL3 laboratory
 Infectious DSP
collection at source
 Can be collected
liquid 2-8C
 Screening / viral
load testing
/ genotyping
 Processing
 Testing
Kent, UK
Cape Town, South Africa

4. Suggested disease phase *
Number of Units
characterised in 2013
1) HBV, Early Acute Phase 6
2) HBV, Acute Phase (Infectious & Carrier), HBcAb 3
3) HBV, Early Acute Phase (infectious), HBeAg 2
4)N HBV, Acute Phase (Infectious & Carrier), HBeAg & HBcAb 2
5) HBV, Acute Phase (Carrier), HBc IgM 3
6) HBV, Late Acute Phase 101
Hepatitis B screening program
* Suggestions based on
biomarker results interpretation,
not actual diagnosis

5. Hepatitis B
screening
programme
HCV / HIV
Recovered
Plasma
Syphilis
Recovered
Plasma
Specialty infectious disease state plasma
• Units of 250ml
• Semi-quantitative
immunological data
• Viral load &
genotyping data
• Donor consent
• Units of 250ml +
• Large range of titres
• Donor consent
• Measured MHA-TP
ratio from 1:4
through to 1:256
• Rare early acute phase
• Screened for numerous
analytes:
 HbSAg
 Hep B Core IgM Ab
 Hep B Core Total Ab
 Hep B e Ag
 Hep B e Ab

6. On-going autoimmune disease state plasma
screening programme
 Regular supply - screening programme
to characterise over 40L of autoimmune
disease state plasma every month
 High quality products - collect under
ethics approval, and carry out viral
testing
 The best results - test for numerous
markers and provide extensive
characterisation data
 Customisation for bulk - pool process
units and QC to meet defined
specifications
Current Inventory:
 A-GBM
 ANCA (Anti-PR3 / Anti-MPO)
 A-RNP / A-SS-A
 SAA / CRP
 RF
 Celiac Disease
 Crohn’s Disease
 A-Tg
 A-TPO

7. Infectious Disease Autoimmune Cardiac
 Chlamydia IgG / IgM
 Anti-GBM
 Anti-RNP / Anti-SSA
 Cholesterol
 CMV IgG / IgM / Negative  ANCA (Anti-MPO / Anti-PR3)  HDL
 EBV IgG / IgM  Celiac Disease  Hypertension
 H. Pylori  Crohn’s Disease  LDL
 HAV IgG / IgM  Gliadin Antibodies IgA / IgG  Triglyceride
 HCV IgG  HAMA
 HBsAg  Rheumatoid Factor Organ Failure / Impairment
 HBc IgM / Total Ab  SLE  Renal Failure
 HBeAg / HBeAb  Tissue Transglutaminase Abs  Kidney Transplant
 HIV 1  Liver Transplant
 HIV 2 Autoimmune Thyroid Disease
 HIV O  Anti-Tg Drugs of Abuse
 HSV 2 IgG / IgM  Anti-TPO  CDT
 HTLV-1  Graves Disease
 HTLV-2  Hashimoto’s Disease Pregnancy
 HEV  Amniotic Fluid
 Lyme IgG / IgM Diabetes  Pregnancy Serum
 Malaria  Glucose  Chronological Bulk Urine
 Parvovirus B19  HbA1c
 Rubella IgG / Negative  Diagnosis (Type I / II)
 Syphilis IgG / IgM Other Biomaterials
 Toxoplasma IgG / IgM / Negative Inflammation / Allergy  CSF
 CRP  Urine
Biochemistry  SAA  Saliva
 Vitamin D  Specific IgE (Allergy)  Cord Serum
Our capabilities | Disease State Plasma

8. Infectious disease clinical sample panels
Our clinical sample panels are readily
available - saving you time when
validating your assay
Specifications
 Citrated plasma
 Extensive donor demographics
 Tested for HIV1 & 2 Abs, HBsAg, HCV
Ab, HIV-1/HBV/HCV PCR and Syphilis
 Individual donors (no duplicates)
 Donor consent
HIV Positive Panel
+ Genotypes B, C, D, F, K
+ Testing results for multiple
markers
+ Quantitative viral load result
HBsAg Positive Panel
+ Rare combination of HBV
markers, including early
stages
+ Testing results for multiple
markers

9. Our capabilities | Clinical Samples
Infectious Disease Autoimmune Cardiac
 Chlamydia pneumoniae IgA/IgG  ASO Cholesterol
 Chlamydia trachomatis IgA/IgG  Anti-Cardiolipin CK-MB
 CMV IgG / IgM / Negative  Anti-CCP D Dimer
 EBV  Anti-dsDNA HDL
 HCV IgG  Anti-GBM Hypertension
 HBsAg / Anti-HBs  Anti-Nuclear Antibodies (Includes: LDL
 HBc IgM / Total Ab  SS-A/Ro, SS-B/La, Sm, RNP, Scl-70, Myoglobin
 HBeAg / HBeAb  Jo-1, PM-SCL, KU, Centromere, NT proBNP
 HEV  AMA-M2, RIB-P, RO52) – NEW Triglyceride
 HIV 1  Anti-Tg Troponin I
 HIV 2  Anti-TPO
 HIV O  ANCA (Anti-MPO / Anti-PR3) Neurological
 HTLV-1  Celiac Disease Alzheimer’s Disease
 HTLV-2  Crohn’s Disease NSE
 Malaria  Gliadin Antibodies IgA / IgG
 Measles IgG  HAMA Diabetes
 Mycoplasma pneumoniae  Histone Antibodies HbA1c
 Parvovirus B19  Rheumatoid Factor Diagnosis (Type I / II)
 Rubella IgM / IgG / Negative  SLE
 Sepsis  Tissue Transglutaminase Abs Organ Failure/Impairment
 Syphilis IgG / IgM Renal Failure
 Toxoplasma IgG / IgM / Negative Oncology Hepatic Impairment
 Yersinia IgG / IgM  AFP
 CA 125 Endocrine
Pregnancy  CA 15-3 Cortisol
 hCG  CA 19-9 FSH
 Pre-eclampsia  CEA LH
 Pregnancy serum (1st/2nd/3rd trimesters)  CYFRA Oestradiol
 PSA Progesterone
Biochemistry Prolactin
 Vitamin D Thyroid SHBG
 Bilirubin (Total)  Free T3 (Triiodothyronine) Testosterone
 Calcium  Free T4 (Thyroxine)
 Potassium  Parathyroid Hormone (PTH) Drugs of Abuse
 CRP  TSH  Urine
 CDT
Allergy
 Raised Specific IgE

10.  Custom Plasma collection – Custom
anticoagulant, capabilities of >500L per
month
 “Packed” red cells available in bulk
 Access to various normal patient
samples demographics to allow
representative testing cohorts
 Custom control of the pre-analytical
phase available
“Looking for something
specific? We offer custom
collections to meet your
inclusion/exclusion criteria”
Our capabilities | Normal Blood Products