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Dinoprostone Drug Presentation
Dinoprostone is a naturally occurring prostaglandin E2 used as a vaginal suppository for cervical ripening and labor induction. It stimulates uterine contractions and has various side effects, including upset stomach, vomiting, and dizziness. The drug has contraindications such as acute pelvic inflammatory disease and unexplained vaginal bleeding, and management involves careful monitoring during administration.
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Dinoprostone Drug Presentation
- 1. DRUG PRESENTATION “DINOPROSTONE” Presented By: Sandhya Kumari MScNursing, 3rd Sem ACON, AUH
- 2. INTRODUCTION- Dinoprostone isa naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimulates bone re-absorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
- 3. PHARMACODYNAMICS Dinoprostone is equivalentto prostaglandin E2 (PGE2). It stimulates labor and delivery by stimulating the uterine, and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.
- 4. MECHANISM OF ACTION:- Dinoprostoneadministered intravaginally stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions seen in the term uterus during labor, resulting in the evacuation of the products of conception from the uterus. Dinoprostone exerts its uterine effects via direct myometrial stimulation. Other suggested mechanisms include the regulation of cellular membrane calcium transport and of intracellular concentrations of cyclic 3',5'-adenosine monophosphate. Dinoprostone also appears to produce local cervical effects including softening, effacement, and dilation. The exact mechanism of action for this effect is also unknown, but it has been suggested that this effect may be associated with collagen degradation caused by secretion of the enzyme collagenase as a partial response to locally administered dinoprostone.
- 5. SIDE EFFECT OFDRUG “DINOPROSTONE Upset stomach. Vomiting. Diarrhea. Dizziness. Flushing of the skin. Headache. Fever
- 6. INDICATION OF DRUG“DINOPROSTONE”.:- Evacuation of the uterine contents. Amniotic fluid embolism Termination of pregnancy Labor induction/cervical ripening
- 7. CONTRA INDICATION OFDRUG“DINOPROSTONE” Acute pelvic inflammatory disease (PID) Placenta previa Unexplained vaginal bleeding Vasaprevia or genital herpes infection. Pregnancy termination Breast-feeding Hypersensitivity reactions
- 8. MANAGEMENT OF DRUG‘DINOPROSTONE’:- CERVIPRIME GEL - is commonly used for cervical ripening is available in a 2.5-mL syringe for an intracervical application of 0.5 mg of dinoprostone. With the woman supine, the tip of a pre-filled syringe is placed intracervically, and the gel is deposited just below the internal cervical os. After application she remains reclined for at least 30 minutes. Doses may be repeated every 6 hours, with a maximum of three doses recommended in 24 hours. Dinoprostone should only be administered at hospital.Continuous Uterine activity & FHR monitoring. If optimal response is not achieved by 6 hours, another dose can be administered. The maximum allowed dose is 3 doses be administered per 24 hours. Oxytocin should not be initiated until 6 to12 hours after the last dose because of the potential for uterine hyperstimulation with concurrent oxytocin and prostaglandin administration. Vaginal insert containing 10 mg of dinoprostone in a timed-release formulation. The vaginal insert administers the medication at 0.3 mg/h and may be left in place for up to 12 hours.
- 9. SUMMARY:- Introduction ofDrug “Dinoprostone” Pharmaceutical action of Drug “Dinoprostone”. Mechanism of Action. Side Effect of Drug “Dinoprostone” Indication of drug “Dinoprostone” Contra-indication of drug “Dinoprostone” Management of Drug “Dinoprostone”
- 10. CONCLUSION:- Dinoprostone is anaturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimulates bone re-absorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
- 11. BIBLIOGRAPHY:- https://www.google.com/search?q=dinoprostone+ma nagement&sxsrf=ALeKk03HpcpEuo_XsiAJdig43y wdnR7iw:1600519533036&source=lnms&tbm=isch &sa=X&ved=2ahUKEwioyuPxn_XrAhVD63MBHc NhBAEQ_AUoAXoECA0QAw&biw=1366&bih=65 7#imgrc=h53LlWRHOAgRRM https://www.slideshare.net/sravanthi_1786/cervical- ripening-and-labour-induction https://www.pdr.net/drug-summary/Cervidil- dinoprostone-2192
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