CitySDK is a platform to share real-time data and making it available to developers and citizens alike. By implementing CitySDK, cities and citizens can make use of applications built elsewhere, while developers massively extend their potential reach. Opening up can lead to better services, and eventually better cities.
DSD-INT 2020 BlueEarth Data - Towards an open water data platform and communityDeltares
Presentation by Daniel Twigt, Deltares, at the BlueEarth User Day: Explain the past, explore the future, during Delft Software Days - Edition 2020. Monday, 16 November 2020.
ICT4D - the what, why and how + Digital Principles Pecha Kucha (http://digitalprinciples.org/)
Download to view the citations and references (included in the comments on each slide) as well as the GIFs.
A Roadmap for 21st Century Innovation - Global eGovernment Forum 201421cConsultancy_2012
Presentation by Dr Julia Glidden, President and Founder of 21c Consultancy Ltd, for the UN Global eGovernment Forum 2014, organised from on the 7th and 8th of October 2014.
Oct. 8th: Session 2 - Strategic Policy-Making Aspects of Implementing Smart Government
News recommenders have the potential to help users filter the enormous amount of news that is available online, and as such may play an important role in determining what information users do and do not get to see. However, current approaches to evaluating recommender systems are often focused on measuring an increase in user clicks and short-term engagement, rather than measuring the user's and society’s longer term interest in diverse and important recommendations. In this talk we aim to bridge the gap between so-called normative notions of news diversity, as it is known in social sciences and specifically democratic theory, and quantitative metrics necessary for evaluating the recommender system. We discuss a number of democratic missions a recommender system could have, together with a set of evaluation metrics stemming from these missions, and suggest ways for practical implementations of these metrics.
The talk will be about practical considerations that our team has had to make in order to bring a recommender system into production. I’ll cover the “default” tools with which we started (Batch processing in Spark) and follow that up with more recent tools like AWS Lambda and Spark Streaming.
CitySDK is a platform to share real-time data and making it available to developers and citizens alike. By implementing CitySDK, cities and citizens can make use of applications built elsewhere, while developers massively extend their potential reach. Opening up can lead to better services, and eventually better cities.
DSD-INT 2020 BlueEarth Data - Towards an open water data platform and communityDeltares
Presentation by Daniel Twigt, Deltares, at the BlueEarth User Day: Explain the past, explore the future, during Delft Software Days - Edition 2020. Monday, 16 November 2020.
ICT4D - the what, why and how + Digital Principles Pecha Kucha (http://digitalprinciples.org/)
Download to view the citations and references (included in the comments on each slide) as well as the GIFs.
A Roadmap for 21st Century Innovation - Global eGovernment Forum 201421cConsultancy_2012
Presentation by Dr Julia Glidden, President and Founder of 21c Consultancy Ltd, for the UN Global eGovernment Forum 2014, organised from on the 7th and 8th of October 2014.
Oct. 8th: Session 2 - Strategic Policy-Making Aspects of Implementing Smart Government
News recommenders have the potential to help users filter the enormous amount of news that is available online, and as such may play an important role in determining what information users do and do not get to see. However, current approaches to evaluating recommender systems are often focused on measuring an increase in user clicks and short-term engagement, rather than measuring the user's and society’s longer term interest in diverse and important recommendations. In this talk we aim to bridge the gap between so-called normative notions of news diversity, as it is known in social sciences and specifically democratic theory, and quantitative metrics necessary for evaluating the recommender system. We discuss a number of democratic missions a recommender system could have, together with a set of evaluation metrics stemming from these missions, and suggest ways for practical implementations of these metrics.
The talk will be about practical considerations that our team has had to make in order to bring a recommender system into production. I’ll cover the “default” tools with which we started (Batch processing in Spark) and follow that up with more recent tools like AWS Lambda and Spark Streaming.
Using digital pathology to enhance a biobank portalYves Sucaet
The combination of tissue samples and online digital histopathology images can be a major asset in
the valorisation of tissue collections. At Brussels Free University (VUB), our biobank data consists of
three different datasets: clinical data, brightfield whole slide images, and fluorescence snapshots. A
single whole slide imaging (WSI) repository of microscopy slides was set up that could contain all
material. The flexibility of modern digital pathology hardware and software solutions allows bespoke
solutions to meet individual biobanking needs. A combination of commercial hardware, commercial
software, and open source software was used to get this accomplished. Custom coding to connect
interfaces was used where needed. Potential users of the tissue bank material can now choose and
inspect the tissue and patient characteristics before entering into a collaborative agreement.
Researchers can visually inspect a sample first and find out for themselves if the sample really
contains the material that they are looking for. Pathologists can gather customised collections of
virtual slide material for studying specific phenotypes. Computationally oriented scientists can
bypass the (physical) retrieval of material from the biobank, as the digital data by their very nature is
reusable by many groups around the world. Whole slide image database repositories add value to
legacy biobank and we can see that these “virtual” biorepositories will quickly spread and have the
potential to become a new ‘standard of care’ for biobanks.
The MICO Project: COgnitive MIcroscopy For Breast Cancer GradingIPALab
In close collaboration with AGFA Healthcare and La Pitié Salpêtrière Hospital, Paris, France, IPAL’s MICO (COgnitive virtual MIcroscopy)platform aims at developing a cognition-driven visual explorer for histopathology, particularly for breast cancer grading, supported by dynamic semantic annotation and medical ontology. The analysis capabilities and results are made available to the pathologist through a platform combining virtual microscopy and cognitive reasoning. This allows the medical staff to interact with the platform at the appropriate level of abstraction. The platform should combine multi-modal histopathological images, multi-scale whole slide image (WSI) exploration analysis, and medical knowledge representation inference using ontologies.
Semantic tools should be used to drive image exploration & analysis. A semantic profile should be provided to each algorithm, allowing high flexibility and good knowledge gathering. Medical knowledge should also be integrated into MICO, improving it’s abilities to interact with the histopathologist users, helping them to make the right choices.
The Troy lectures: The advent of digital microscopy (IT/ComS edition)Yves Sucaet
This is an exciting time to do microscopy with the development of digital tools. Recently, digital microscopy has centered around whole slide imaging (WSI), a term that refers to devices that can digitize (scan) an entire glass slide.
For healthcare, digital microscopy manifests itself in the pathology department (digital pathology): it is important to get the right case, to the right pathologist, at the right time, to make the right diagnosis. Digitizing data eliminates the boundaries of time and distance.
Digital microscopy can enhance efficiency and improve quality for various use cases, including teaching, research, as well as clinical settings.
TELEPATHOLOGY is the practice of pathology at a distance. It uses telecommunications technology to facilitate the transfer of image-rich pathology data between distant locations for the purposes of diagnosis, education, consultation and research.
Bio-banking and metagenomics platforms for pathogen discovery at ILRIILRI
Poster prepared by George Michuki, Absolomon Kihara, Alan Orth, Cecilia Rumberia and Steve Kemp for the 8 International Congress on Ticks and Tick-Borne Pathogens (TTP8) and 12 Biennial Conference of the Society for Tropical Veterinary Medicine (STVM 12), South Africa, 24-29 August 2014
Bridging the STEM gender gap through cultural inclusion and educational opportunity, this opportunity was granted to a selected set of women from UB to showcase their research.
Birmingham Heartlands Hospital in the U.K. has been using the Roche Digital Pathology portfolio to transform tissue diagnostics. They have streamlined collaboration, especially for their multi-disciplinary meetings and they have used digital technology in the education of new pathologists. Lab workflow has become more efficient and pathologists are now more seamlessly connected.
RTDPC-DP-0034b 6021A-3
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Digital Pathology streamlines tissue diagnostics and helps protect patient sa...Roche Tissue Diagnostics
RZ Tienen Hospital became one of the first hospitals in Belgium, and one of the first in Europe, to implement and integrate digital pathology into daily operations. They have transformed their AP lab and are now able to manage caseloads remotely, facility MDT oncology meetings and enhance collaboration with colleagues. The benefits of digital pathology have been well recognized and RZ Tienen expects continued growth in this area.
Machine Learning in Pathology Diagnostics with Simagis Livekhvatkov
Simagis Live Digital Pathology platform employs latest generation of visual recognition technology with Deep Learning bring game changing application to pathology cancer diagnostics
Presentation of the Big Data Europe project at the EIP Water Conference 2016 ...Martin Kaltenböck
Presentation of the Big Data Europe project (http://www.big-data-europe.eu) at the EIP Water Conference 2016 in Leeuwarden, The Netherlands. Taking place on 09/02/2016 at the Wetsus Campus in Leeuwarden, the Netherlands in the course of an ICT4Water workshop.
Using digital pathology to enhance a biobank portalYves Sucaet
The combination of tissue samples and online digital histopathology images can be a major asset in
the valorisation of tissue collections. At Brussels Free University (VUB), our biobank data consists of
three different datasets: clinical data, brightfield whole slide images, and fluorescence snapshots. A
single whole slide imaging (WSI) repository of microscopy slides was set up that could contain all
material. The flexibility of modern digital pathology hardware and software solutions allows bespoke
solutions to meet individual biobanking needs. A combination of commercial hardware, commercial
software, and open source software was used to get this accomplished. Custom coding to connect
interfaces was used where needed. Potential users of the tissue bank material can now choose and
inspect the tissue and patient characteristics before entering into a collaborative agreement.
Researchers can visually inspect a sample first and find out for themselves if the sample really
contains the material that they are looking for. Pathologists can gather customised collections of
virtual slide material for studying specific phenotypes. Computationally oriented scientists can
bypass the (physical) retrieval of material from the biobank, as the digital data by their very nature is
reusable by many groups around the world. Whole slide image database repositories add value to
legacy biobank and we can see that these “virtual” biorepositories will quickly spread and have the
potential to become a new ‘standard of care’ for biobanks.
The MICO Project: COgnitive MIcroscopy For Breast Cancer GradingIPALab
In close collaboration with AGFA Healthcare and La Pitié Salpêtrière Hospital, Paris, France, IPAL’s MICO (COgnitive virtual MIcroscopy)platform aims at developing a cognition-driven visual explorer for histopathology, particularly for breast cancer grading, supported by dynamic semantic annotation and medical ontology. The analysis capabilities and results are made available to the pathologist through a platform combining virtual microscopy and cognitive reasoning. This allows the medical staff to interact with the platform at the appropriate level of abstraction. The platform should combine multi-modal histopathological images, multi-scale whole slide image (WSI) exploration analysis, and medical knowledge representation inference using ontologies.
Semantic tools should be used to drive image exploration & analysis. A semantic profile should be provided to each algorithm, allowing high flexibility and good knowledge gathering. Medical knowledge should also be integrated into MICO, improving it’s abilities to interact with the histopathologist users, helping them to make the right choices.
The Troy lectures: The advent of digital microscopy (IT/ComS edition)Yves Sucaet
This is an exciting time to do microscopy with the development of digital tools. Recently, digital microscopy has centered around whole slide imaging (WSI), a term that refers to devices that can digitize (scan) an entire glass slide.
For healthcare, digital microscopy manifests itself in the pathology department (digital pathology): it is important to get the right case, to the right pathologist, at the right time, to make the right diagnosis. Digitizing data eliminates the boundaries of time and distance.
Digital microscopy can enhance efficiency and improve quality for various use cases, including teaching, research, as well as clinical settings.
TELEPATHOLOGY is the practice of pathology at a distance. It uses telecommunications technology to facilitate the transfer of image-rich pathology data between distant locations for the purposes of diagnosis, education, consultation and research.
Bio-banking and metagenomics platforms for pathogen discovery at ILRIILRI
Poster prepared by George Michuki, Absolomon Kihara, Alan Orth, Cecilia Rumberia and Steve Kemp for the 8 International Congress on Ticks and Tick-Borne Pathogens (TTP8) and 12 Biennial Conference of the Society for Tropical Veterinary Medicine (STVM 12), South Africa, 24-29 August 2014
Bridging the STEM gender gap through cultural inclusion and educational opportunity, this opportunity was granted to a selected set of women from UB to showcase their research.
Birmingham Heartlands Hospital in the U.K. has been using the Roche Digital Pathology portfolio to transform tissue diagnostics. They have streamlined collaboration, especially for their multi-disciplinary meetings and they have used digital technology in the education of new pathologists. Lab workflow has become more efficient and pathologists are now more seamlessly connected.
RTDPC-DP-0034b 6021A-3
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Digital Pathology streamlines tissue diagnostics and helps protect patient sa...Roche Tissue Diagnostics
RZ Tienen Hospital became one of the first hospitals in Belgium, and one of the first in Europe, to implement and integrate digital pathology into daily operations. They have transformed their AP lab and are now able to manage caseloads remotely, facility MDT oncology meetings and enhance collaboration with colleagues. The benefits of digital pathology have been well recognized and RZ Tienen expects continued growth in this area.
Machine Learning in Pathology Diagnostics with Simagis Livekhvatkov
Simagis Live Digital Pathology platform employs latest generation of visual recognition technology with Deep Learning bring game changing application to pathology cancer diagnostics
Presentation of the Big Data Europe project at the EIP Water Conference 2016 ...Martin Kaltenböck
Presentation of the Big Data Europe project (http://www.big-data-europe.eu) at the EIP Water Conference 2016 in Leeuwarden, The Netherlands. Taking place on 09/02/2016 at the Wetsus Campus in Leeuwarden, the Netherlands in the course of an ICT4Water workshop.
Mapping user expectations to current climate adaptation support - Jeremy GaultweADAPT
This presentation provides a summary of a knowledge exchange event held in Dublin in October 2019 focused on "Bridging the Gap between User Requirements and Climate Adaptation Services". Read more about the event here: https://www.weadapt.org/knowledge-base/climate-change-adaptation-knowledge-platforms/bridging-the-gap-between-user-requirements-and-climate-adaptation-services
Prospects of territorial intelligence tool Catalyse according to governance
Sylvie DAMY, Jean-Jacques GIRARDOT, Bénédicte HERRMANN, Cyril MASSELOT, Pierre GERARDIN
Key Technology Trends for Big Data in EuropeEdward Curry
In this presentation we will discuss some of the results of the BIG project including analysis of foundational Big Data research technologies, technology and strategy roadmaps to enable business to understand the potential of Big Data technologies across different sectors, and the necessary collaboration and dissemination infrastructure to link technology suppliers, integrators and leading user organizations.
Edward Curry is leading the Technical Working Group of the BIG Project with over 30 committed experts along the big data value chain (Acquisition, Analysis, Curation, Storage, Usage). With the help of the other technical leads, he will elaborate on the key technology trends identified in the BIG Project and how they bring data-driven value to industrial sectors.
Opportunities and Challenges of Crowdsourcing for Smart RegionsCrowdsourcing Week
By Birgitta Bergvall-Kåreborn & Anna Ståhlbröst, Luleå University of Technology, LTU. Presented at CSW Summit Arctic Circle 2015. Learn more and join us at our next event: www.crowdsourcingweek.com
Future of land use project overview - august 2019Future Agenda
Future of Land Use
With all the challenges on the horizon, we are pleased to be exploring the future of land use via another Open Foresight major project kicking off in October and running through until next summer.
Addressing pivotal issues from food production, soil quality, water scarcity and biosphere protection to urbanisation, leisure use and land ownership, this global collaborative project is focused on the critical issues and potential solutions for the future.
Undertaken in collaboration with a wide range of major organisations, including the WWF as our global knowledge partner, the locations and schedule for the programme are now being detailed.
This is the project overview.
If you would like to be involved in this major and important topic and host one or more of the expert workshops around the world, do let us know.
Being open, accessible, and understandable by Jonathan Challener, OECD - #ima...Jonathan Challener
With the recent introduction of Open Data APIs, namely SDMX-JSON, and other web services planned, the OECD is moving from a pure ‘browser centric’ architecture towards a more ‘web service oriented’ architecture, with powerful and scalable data delivery capabilities in machine-to-machine exchanges, enabling a much wider use of our data by third parties. This focus has, and will further enable more and more users to assemble content and data themselves, compare or integrate data, or collaborate with each other to produce new content.
This also allowed for and has led to a number of new and accessible data experiences, now targeting those who do not understand, or have the desire to understand, specialised formats of a statistical nature. This is where the real value will be found in being ‘open, accessible, and understandable”.
See the Whole Story: The Case for a Visualization PlatformEric Kavanagh
Seeing is believing, which is why data visualization continues to play a major role in helping businesses understand their data. But there's more than meets the eye. Underneath that stimulating surface layer, some data environments are much more organized -- and thus reliable -- than others. The key to success? Taking a platform approach to address the entire end-to-end process of delivering governed, scalable analytics.
Register for this episode of The Briefing Room to hear veteran Analyst Dr. Robin Bloor explain why a platform approach to visual analytics enables the kind of governance that today's organizations need. He'll be briefed by Dan Brault of Qlik, who will showcase his company's analytics platform which was built from the ground up with the design point of delivering analytics to everyone in an organization. He'll stress the importance of governance, trust and scalability.
Data ecosystems: turning data into public valueSlim Turki, Dr.
Africa Information Highway Live Exchange #Session 7
8 October 2021
The AIH Live Exchange between the Africa Information Highway Team, partners and countries is a free monthly webinar hosted by the African Development Bank to discuss topics related to government data and statistics. This webinar series is the main platform for countries to share their experiences and best practices around open data including using their Open Data Platform of the AIH.
This session is co-organized with the Luxembourg Institute of Science and Technology (LIST) which is a mission-driven Research and Technology Organization (RTO) that develops advanced technologies and delivers innovative products and services to industry and society. These innovations can also be used to solve several societal challenges, particularly in the areas of the environment, security, education and culture, sustainable development, as well as the efficient use of resources.
Official statistical data are recognized as high-value datasets for the society and economy, to enrich research, inform decision making or develop new products and services. The use of these authoritative data sources contributes to building a society with more empowered people, better policies, more effective and accountable decision-making, greater participation and stronger democratic mechanisms.
Official statistics are produced to be used and re-used to make an impact on society through a higher degree of openness and transparency while ensuring confidentiality and, at the same time, providing equal access to information to citizens.
The value of data lies in its use and re-use. In this interactive webinar, you will learn new techniques to improve the use and re-use of your statistical data, going beyond the provision logic and adopting the ecosystem mindset. You will:
● Sharpen your capacity at identifying and engaging users and re-users and stakeholders (data ecosystem mapping)?
● Effectively tackle technical and organizational barriers to stimulate data use and re-use?
● Smartly orchestrate a self-sustainable data ecosystem to increase the impact of statistical data.
This session is an opportunity for Regional members countries to '' Sharpen their skills in making data used and re-used by developing an ecosystem mindset to effectively build sustainable community of users around their Open Data Platform thus promoting transparency and better decision-making”
Easy SPARQLing for the Building Performance ProfessionalMartin Kaltenböck
Slides of Martin Kaltenböcks (SWC) presentation at SEMANTiCS2014 conference in Leipzig on 5th of September 2014 about the 'Tool for Building Energy Performance Scenarios' of GBPN (Global Buildings Performance Network, http://gbpn.org) that provides a prediction tool for buildings performance worldwide by making use of Linked Open Data (LOD).
Health and Sustainability of Open Source Software from a Public Sector Perspe...Johan Linåker
Open Source Software (OSS) makes up a critical part of today's digital infrastructure. As with physical infrastructure, its robustness and security depend on how well it is maintained. But how do you know how "well-maintained" and secure an OSS project is? Or what you can do to help? This presentation will shed light on the concept of health and sustainability of OSS projects, how to analyze it, and how to act on it. We will also discuss how this can help public as well as private entities in decisions related to OSS adoption and contributions, and consider how it may, and should, be part of a continuous and proactive security mindset and risk management process.
Explaining "pathology" in digital pathologyYves Sucaet
Digital pathology is a recent hybrid field. It involves expertise from computer science and medicine alike. This presentation targets ICT staff and software development that wants to understand more of the background on where whole slide images originate from and what unique challenges this represents.
Explaining "digital" in digital pathologyYves Sucaet
Digital pathology is a recent hybrid field. It involves expertise from computer science and medicine alike. This presentation targets medially trained personnel that wants to understand more of the background on how the whole slide images are rendered on the screen and what unique challenges this represents.
Do you want to build digital pathology software.pptxYves Sucaet
Find out what advantages can be the Pathomation software platform for digital pathology can offer newcomers to the market. Get started adding digital pathology capabilities to your own software FAST!
A gallery of implementation with our Javascript-based PMA.UI framework for custom digital pathology applications and workflows. Adapt the most versatile PMA.core tile server for brightfield, fluorescence, and z-stacked data. Then, add microscopy, data, whole slide images and virtual slides to your own (web-)applications with PMA.UI.
An in-depth technical look at the different interfaces and components that our platform for digital pathology and virtual microscopy is made of. Pathomation software comes together to offer a comprehensive suite of various tools. We don't just sell you individual programs, we allow you to gradually scale components to develop your own virtual and digital microscopy
Using a novel whole slide imaging software platform for an international mult...Yves Sucaet
An old presentation from IADP 2014 in Boston, MA, but still relevent, now that the paper has been published at https://pubmed.ncbi.nlm.nih.gov/28982110/ . The presentation is a good illustration of how digital pathology can facilitate international collaboration efficiently.
An overview of the various components in Pathomation's API-enabled software platform for digital pathology. Includes PMA.start, PMA.core, PMA.view, PMA.studio, and PMA.control.
Digital Pathology Information Web Services (DPIWS): Convergence in Digital Pa...Yves Sucaet
A standard recommendation for Digital Pathology Information Web-Services. A novel recommendation for the Digital Pathology Information Web-Services (DPIWS) standard is presented, with respect to specific characteristics of the informative content of discourse. The recommendation establishes a common software interface for the exchange of digital pathology (DP)images and related metadata over the web, independently of storage, encoding, and internal handling details. Thepro-posed structure is implemented and tested in a “Pathomation”software environment.
Digital pathology and its importance as an omics data layerYves Sucaet
Bioinformatics and pathology are obvious scientific partners. Bioinformatics often takes places at the most basic (almost chemical, or even physical) level of life, but much of its procedures to obtain data are destructive. Pathology on the other hand takes place at a much more coarse level of data acquisition (usually where the physical properties of visible light end), but has the advantage of being rooted in the tradition of medicine. The traditional paradigm of pathology is "tissue is the issue". Morphology (exactly the component that often gets overlooked in bioinformatics) plays a large role and helps millions of patients each year around the world. Pathology is proven technology, bioinformatics is limited to niche applications.
With the development of whole slide imaging technology some twenty years ago, digital pathology became possible. Observations that used to be for the eyes of the pathologist only, could now be captured and translated into high-resolution pixels, and studied by and communicated to many. Many began to dream of automated tissue evaluation systems and AI-pathology, some even going as far as to suggest the replacement of the pathologist by intelligent computer systems.
Meanwhile in several areas of bioinformatics, new limits are being hit. Yes, we can do high-throughput experiments, but noisy datasets are often the results, (inter- and even intra-observer) replicability is difficult, and statistics only offer limited relief.
The goal of this introductory lecture is to highlight the problems as well as opportunities for both fields of study, and how exchange of experiences, and (in a later stadium) integration of techniques close the scientific gap that still exists in a great many areas.
There is no lack of pathology-centric workshops that offer insights into the world of algorithms. With the CPW event however, we take another approach. We want to bring together the most advanced groups in digital pathology, with the bioinformatics community, to explore the opportunities that exist on both sides of the fence.
We start by explaining the basic data types that are introduced by digital pathology. We also explain where they come from, and why this presents unique challenges when it comes to data mining and image analysis. Finally, we introduce PMA.start, a free software environment that can be used to universally gain access to digital pathology (imaging) data.
Bioinformatics groups can help quantify, model, and reduce morphological whole tissue data. Pathologists can help interpret and explain heterogeneous high-throughput datasets. And the first seeds of such collaboration can be planted right here, in Athens.
A global integrative ecosystem for digital pathology: how can we get there?Yves Sucaet
Digital pathology has many faces. Its stakeholders can roughly be classified into four categories: education, research, clinical, and clinical research. We come together at events like Pathology Informatics or Pathology Visions, and discuss the evolution of the field.
While progression is being made, it sometimes appears that around every corner are more challenges and forks in the road. New applications and scenarios emerge at a rapid pace, and it is clear that a single one-size-fits-all type of software is unlikely to satisfy most participants in this space, if any.
At the institutional level, ecosystems of digital pathology have already been established. At a national level, attempts are being made. At a global level, this is still a wide open question, but one very much worth exploring.
Digital pathology comes with some unique properties, like the data it generates and the pace at which this happens. This guest lecture then will examine the solutions that already exist, and what an inclusive global scalable digital pathology ecosystem may look like in the future.
Whole slide imaging technology has matured to the point where it can now facilitate many applications outside the pathology field. The flexibility of today's hardware and software solutions allows one to create a custom and scalable solution to meet individual project needs. In a biobank, large collections of high-quality samples can help researchers identify clinically useful markers of disease and develop novel drugs. But in order to fulfil this role, however, it is essential that the samples are well-documented with up-to-date epidemiological, clinical and molecular data. The vast numbers of patients and controls contained in these biobanks needs to be easy to browse and search, too. At Brussels Free University (VUB), an online histopathology platform was built that presents a catalogue of tissues available in the biobank. This was done to contribute to the valorisation of the biobank, and to lead to new collaborations between academia and industry. In this guest lecture, this project is presented a hybrid solution that consists of commercial hardware and software, as well as open source packages. We further demonstrate how this new technology has significantly enhanced our research and education activities, beyond the "traditional" pathology applications.
The Troy lectures: The advent of digital microscopy (biology edition)Yves Sucaet
This is an exciting time to do microscopy with the development of digital tools. Recently, digital microscopy has centered around whole slide imaging (WSI), a term that refers to devices that can digitize (scan) an entire glass slide.
For healthcare, digital microscopy manifests itself in the pathology department (digital pathology): it is important to get the right case, to the right pathologist, at the right time, to make the right diagnosis. Digitizing data eliminates the boundaries of time and distance.
Digital microscopy can enhance efficiency and improve quality for various use cases, including teaching, research, as well as clinical settings.
Prepared to scale: experiences with building a department-wide digital pathol...Yves Sucaet
At Brussels Free University (VUB), we wanted to build a core digital pathology infrastructure to support a range of different use cases. Various images platforms needed to be accessible through a single access point, while still supporting different user profiles. We wanted a scalable solution that would allow interaction between equipment from different research groups intra- and extra- muros. A combination of commercial hardware, commercial software, and open source software was used to get this accomplished. Custom coding to connect interfaces was used where needed.
We built a centralized infrastructure that integrates a variety of imaging platforms (brightfield, fluorescence, z-stacking), and we now have an interconnected network of heterogeneous and scalable information silos.
Image analysis and data/image mining projects can remain stuck in microenvironments due to limits artificially imposed by vendor-specific solutions. We have shown this need not be the case, and have integrated five different imaging platforms onto one architecture. We are storing data from all modalities in a single storage facility, and can manage it through a single access point. We support 40+ users, working on different use cases, including education, biobanking, and telepathology.
Technical implementation details of a biobank portal enhanced with digital pa...Yves Sucaet
Facilitating biobanks are a novel application for digital pathology. The Brussels Free University (VUB) and its teaching hospital UZ Brussel, together with the Belgian Diabetes Registry have developed one of the world’s largest biobanks in the domain of type 1 diabetes. The digital pathology platform of Pathomation was deployed to facilitate access to the tissue collection and promote basic and clinical research. Clinical data is available side by side to whole slide image data in a seamless and transparent interface, assisting the researcher to make an optimal selection of material of interest for a particular study. Digital pathology is thus presented as a natural add-on to a biobank query interface.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Digital pathology landscape 2016
1. 30-12-2015 pag. 1
The landscape for digital
pathology anno 2016
Yves Sucaet, PhD
Diabetes Research Center
2. 30-12-2015 pag. 2
Why this presentation?
• Successful roll-out of digital pathology requires
more than a whole slide scanner.
• Different end-users require customized user
interfaces.
• Various datastores and image repositories need to
integrate.
• We wish we would have had this presentation
available as we embarked upon our digital
pathology adventure though.
• It’s worthwhile to map the different stakeholders,
and we hope you can now benefit from our
experience
3. 30-12-2015 pag. 3
Different stakeholders
Digital
Pathology
and Whole
Slide Imaging
Scanner
vendors
(AP)LI(M)S
vendors
PACS vendors
Regulators,
standards,
and
governments
Universal
viewing and
sharing
Image
analysis
Other users
and
stakeholders
Conference
organizers
5. 30-12-2015 pag. 5
Stakeholder: scanner vendor
• What do they do?
• Build the hardware to convert glass slides to pixels
• Capture brightfield, fluorescence, z-stacking, time-lapse…
6. 30-12-2015 pag. 6
Stakeholder: (AP)LI(M)S vendor
• What do they do?
• Organize the workflow around the glass slide;
• Present the right slide to the right person at the right time
7. 30-12-2015 pag. 7
Stakeholder: PACS vendor
• What do they do?
• Manage the (imaging) data
• Store, retrieve, archive, distribute
8. 30-12-2015 pag. 8
Stakeholder: Regulators, standards, and
governments
• What do they do?
• Direct market and technology developments
• Make sure everybody is well-behaved and plays nice
9. 30-12-2015 pag. 9
Stakeholder: Universal viewers
• What do they do?
• Distribute content in a uniform manner to multiple devices
• Let end-users focus on what to do, rather than how to do it.
10. 30-12-2015 pag. 10
Stakeholder: Image analysis software
• What do they do?
– Big data, data mining, decision support
– Automate manual process flows for large collections
11. 30-12-2015 pag. 11
Stakeholder: conference organizer
• What do they do?
– Present content to as many people as possible
– Present content in a user-friendly environment
12. 30-12-2015 pag. 12
Other stakeholders
• What do they do?
– Operate in different geographical locales
– Organize and represent people with common goals
13. 30-12-2015 pag. 13
Digital pathology at the VUB
• A subset of VUB-specific applications are available to the
public via http://www.diabetesbiobank.org.
• Integrates five different imaging platforms onto a single
architecture.
– Stores data from all modalities in a single storage
facility
– Manage it through a single access point
– Render content to any type of display device
• No need for extra software or background information
concerning the content’s origin
– Present web-accessible interfaces to the right end-
users at the right time