2. Anatomy
❖ The spleen has a smooth, convex surface that
faces the diaphragm and is located beneath the
left portion of the diaphragm. The ninth, tenth,
and eleventh ribs are above it.
❖ A ridge separates the anterior gastric portion
with the posterior renal section of the other side
of the spleen. The stomach's posterior wall
comes into contact with the gastric surface,
which is large and concave and faces forward,
upward, and toward the center.
❖ It comes into contact with the pancreatic tail
below this. The direction of the renal surface is
medially and downward.
3. Anatomy
❖ It lies in proximity to the upper portion of the anterior surface of the left
kidney and, on occasion, the left adrenal gland. It is relatively
fl
attened,
signi
fi
cantly narrower than the gastric surface.
❖ The gastrosplenic ligament, splenorenal ligament, colicosplenic ligament, and
phrenocolic ligament are the four ligaments that attach to the spleen.
❖ In healthy adult humans, the spleen ranges in size from 7 centimeters (2.8 in)
to 14 centimeters (5.5 in).
4. Function
❖ The spleen is a vital organ for the immune system and red blood cells (erythrocytes).
It also recycles iron while removing old red blood cells and keeping a reserve of
blood that may be useful in the event of hemorrhagic shock. It breaks down
hemoglobin that has been taken out of senescent red blood cells as a component of
the mononuclear phagocyte system.
❖ The heme portion of hemoglobin is converted into bilirubin, which is excreted in the
liver, while the globin portion is broken down to its inherent amino acids.
❖ The spleen contains lymphocytes that produce antibodies in its white pulp as well as
monocytes that circulate through the blood and lymph nodes to clear out germs and
blood cells coated in antibodies.
5. Function
❖ When these monocytes enter wounded tissue (like the heart after a myocardial
infarction), they develop into dendritic cells and macrophages that aid in the healing
process.
❖ The spleen functions as the mononuclear phagocyte system's hub of activity and is
comparable to a big lymph node since its absence increases the risk of contracting
certain infections.
❖ White pulp (A) and red pulp (B) are the two distinct tissues that make up the spleen
(B). The white pulp has a role in the development and production of blood and
immune cells. The red pulp cleans blood by removing antigens, microbes, and
damaged or worn-out red blood cells.