The document describes the HPV.edu project, which is a randomized controlled trial evaluating a complex intervention to improve uptake of the school-based human papillomavirus (HPV) vaccination program for adolescents. The trial is being conducted by researchers from several Australian universities and hospitals. The primary aim is to increase HPV vaccination uptake, while secondary aims are to improve vaccination-related psychosocial outcomes and logistical program outcomes. The project is funded by the National Health and Medical Research Council.