Cystic fibrosis is a genetic disease that affects the secretory glands, including those that produce mucus and sweat. It is caused by a mutation in the CFTR gene that results in abnormal chloride transport in epithelial cells. This causes very thick, sticky mucus to build up in the lungs and pancreas. In the lungs, the mucus leads to chronic lung infections and respiratory failure, which is most common cause of death for those with cystic fibrosis. There is currently no cure for cystic fibrosis.

1. By: Cassandra Petrilla

2. It is an inherited disease of your secretory
glands, including the glands that make
mucus and sweat.

3.  Cystic fibrosis of the Pancreas
 Fibrocystic Disease of the Pancreas
 Mucoviscidosis
 Mucoviscidosis of the Pancreas
 Pancreas Fibrocystic Disease
 Pancreatic Cystic Fibrosis

4. What causes CF?
 When a mutation called delta-F508 occurs in a single gene on chromosome 7.
 The gene that is infected contains instructions for building a protein called cystic fibrosis
transmembrane (CFTR).
 The gene will there forth produce CFTR that does not work and chloride ions can not
pass through the membrane.
 In 70-80% of the cases in the US the gene is completely missing from the membrane.
 If CFTR is missing, chloride ions are not reabsorbed.

5. How is CF
inherited?
 A person gets CF when they inherit 2 mutated CFTR genes
, one from each parent.
 The parents might not have the disease because they have a
normal copy of the gene on their other chromosome.
 CF is a recessive disorder.

6. 1. Your sweat is saltier than most people.
2. The doctors then use the “sweat test”.
3. During the test, the doctors use a sweat-inducing
chemical called pilocarpine.
4. If the reading comes back that your chloride ion
is above 60 mmol/liters, then you have CF.

7. Intestines
 The digestive enzyme that your pancreas makes (breaks down your food so you can
eat) cannot reach your small intestines.
 Without this enzyme you cannot fully absorb fats and proteins.
 This can then lead to vitamin deficiency and malnutrition because nutrients leave
your body unused.
Lungs
Your mucus becomes thick and sticky.
 The mucus will eventually build up in
your lungs and block the airways.
 This buildup makes it easy for bacteria to
grow.
 This leads to serious lung infections and
over time can severely damage your lungs.

8. • CF causes your sweat to leave your body 5 times saltier.
• This leads to abnormal heart rhythms.
• Your balance of minerals in your blood becomes upset
and can cause health problems.
• Have increased risk for diabetes or osteoporosis.
• Causes infertility in men and makes it harder for
women to get pregnant.
• Most common death of people with CF is respiratory
failure.

9. NO CURE
FOR CF!!!
 You can take supplements containing enzymes to help digestion.
 You can take replacement enzymes such as pancreatin.
 You can reduce chest infections with frequent physiotherapy
and either occasional or continuous antibiotics.
 You can take physiotherapy which involves vigorous massage to
help loosen the sticky mucus.
 In severe cases a lung or heart and lung transplant operation is
necessary.

10. Prevalance Rate of CF-1 in
31,000 in U.S. get it

11.  Cystic Fibrosis Worldwide
 Canadian Cystic Fibrosis
 Cystic Fibrosis Research, Inc.
 Karen’s Climb Foundation
Pennsylvania Cystic Fibrosis, Inc.
 Reaching Out Foundation
 St. Louis Second Wind Transplant Association

12.  http://www.nhlbi.nih.gov/health/dci/Diseases/cf/cf_what.html
 http://www.yourgenesyourhealth.org/cf/have.htm
http://www.ask.com/bar?q=how+do+you+treat+cystic+fibrosis&page=1&qs
rc=0&ab=2&u=http%3A%2F%2Fhcd2.bupa.co.uk%2Ffact_sheets%2FMosb
y_factsheets%2FCystic_fibrosis.html
 http://www.nhlbi.nih.gov/health/dci/Diseases/cf/cf_what.html
http://www.lpch.org/clinicalSpecialtiesServices/COE/PulmonaryCareCF/ov
erview.html