Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene that result in a defective chloride channel protein. This leads to thick, sticky mucus in the lungs and other organs. In the lungs, the mucus clogs the airways and traps bacteria, causing chronic lung infections. While treatments can help manage symptoms, the only cure would be gene therapy to replace the defective gene or provide the normal protein before damage occurs. The goal of treatment is to clear the lungs of mucus and control infections.
Bronchiectasis is a chronic, irreversible dilation of the bronchi and bronchioles. Or •Bronchiectasis is characterized by permanent, abnormal dilation of one or more large bronchBronchiectasis.
THIS PRESENTATION INCLUDES DEFINITION, OVERVIEW, PATHOLOGY, CLINICAL FEATURES, ASSESSMENT AND PT MANAGEMENT OF CYSTIC FIBROSIS. THIS PPT WILL BE VERY USEFUL FOR FINAL YEAR BPT STUDENTS. IT COVERS BASIC KNOWLEDGE REGARDING THE DISEASE AND ALLOWS BETTER UNDERSTANDING. IT IS MADE ONLY FOR LEARNING AND EXAM PURPOSE.
Bronchiectasis
A condition characterized by chronic permanent dilation & destruction of bronchi due to destructive changes in the elastic and muscular layers of bronchial walls.
The common thread in the pathogenesis of bronchiectasis consists of difficulty clearing secretions & recurrent infections with a “vicious circle” of infection and inflammation resulting in airway injury and remodelling.
PLEASE REFER TO REFERENCE TEXTBOOKS FOR CLARITY.
Bronchiectasis is a chronic, irreversible dilation of the bronchi and bronchioles. Or •Bronchiectasis is characterized by permanent, abnormal dilation of one or more large bronchBronchiectasis.
THIS PRESENTATION INCLUDES DEFINITION, OVERVIEW, PATHOLOGY, CLINICAL FEATURES, ASSESSMENT AND PT MANAGEMENT OF CYSTIC FIBROSIS. THIS PPT WILL BE VERY USEFUL FOR FINAL YEAR BPT STUDENTS. IT COVERS BASIC KNOWLEDGE REGARDING THE DISEASE AND ALLOWS BETTER UNDERSTANDING. IT IS MADE ONLY FOR LEARNING AND EXAM PURPOSE.
Bronchiectasis
A condition characterized by chronic permanent dilation & destruction of bronchi due to destructive changes in the elastic and muscular layers of bronchial walls.
The common thread in the pathogenesis of bronchiectasis consists of difficulty clearing secretions & recurrent infections with a “vicious circle” of infection and inflammation resulting in airway injury and remodelling.
PLEASE REFER TO REFERENCE TEXTBOOKS FOR CLARITY.
cystic fibrosis is a hereditary disease which can transfer from one generation to another generation. it is only effective one both of two partner contain defective gene, if only one partner contain the defective gene he/se will be carrier no an effective
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Cystic fibrosis
1. Cystic fibrosis (CF)
Definition
Cystic fibrosis (CF) is an autosomal recessive
multisytem disease characterised by altered
function of the exocrine glands affecting primarily
the lungs, pancreas and sweat glands.
Etiology
Cystic fibrosis (CF) is caused by mutations in the
CF transmembrane conductance regulator (CFTR)
gene which encodes a protein expressed in the
apical membrane of exocrine epithelial cells.
2. Autosomal recessive
Gene located on chromosome 7
Prevalence- varies with ethnic origin
1 in 3000 live births in Caucasians in
North America
and Northern Europe
1 in 17,000 live births of African
Americans
1 in 90,000 live births in Hawaiian
Asians
3. Protein Structure and Function
•
The normal CFTR protein product
is a chloride channel protein
found in membranes of cells that
line passageways of the lungs,
liver, pancreas, intestines,
reproductive tract, and skin.
•
CFTR transports chloride ions
(Cl-) ions across the membranes
of cells in the lungs, liver,
pancreas, digestive tract,
reproductive tract, and skin.
•
CFTR controls chloride ion
movement in and out of the cell.
4. CF-Pathophysiology – Primary defect
• loss of chloride ion transport.
• This upsets the sodium and chloride ion
balance needed to maintain the normal, thin
mucus layer that is easily removed by cilia
lining the lungs and other organs. The
sodium and chloride ion imbalance creates
a thick, sticky mucus layer that cannot be
removed by cilia and traps bacteria such as
S. aureus and Pseudomonas aeruginosa
resulting in chronic infections.
5. CF-Manifestations
Common presentations
Meconium ileus
Failure to thrive
Chronic cough
Recurrent pulmonary infiltrates
Respiratory tract
Chronic sinusitis
Nasal obstruction
Rhinorrhea
Nasal polyps in 25%; often
requires surgery
Chronic cough
Persistent
Viscous, purulent, green sputum
6. Respiratory tract
Lung function
Small airway disease is first functional
lung
abnormality
Progresses to reversible as well as
irreversible
changes in FEV1
Chest x-ray may show hyperinflation,
mucus impaction, bronchial cuffing,
bronchiectasis.
Complications
Pneumothorax
~10% of CF patients
Hemoptysis
Digital clubbing
Cor pulmonale
Respiratory failure
Mucous in the airways cannot be easily cleared
from the lungs.
7. Genitourinary
Late onset puberty-due to chronic lung disease and
inadequate nutrition
>95% of male patients with CF have azospermia due to
obliteration of the vas deferens
20% of female patients with CF are infertile
nevertheless >90% of completed pregnancies produce
viable infants
Gastrointestinal
Exocrine pancreatic insufficiency
Found in >90% of CF patients
Protein and fat malabsorption
Frequent bulky, foul-smelling stools
Vitamin A, D, E, K malabsorption
Sparing of pancreatic beta cells
Beta cell function decreases with age
Increased incidence of GI malignancy
8. Sweat chloride test
The sweat test measures the level of
chloride in the sweat using a small
electric current.
Pilocarpine increases sweating+ Mild
electric current.
The sweat is collected on a gauze for 30
minutes, then weighed in a
weighing jar
Chloride >60 mEq/L- Cystic Fibrosis
11. Treatment
•The only way to cure CF would be to use gene therapy to replace the
defective gene or to give the patient the normal form of the protein before
symptoms cause permanent damage.
•The major goal in treating CF is to clear the abnormal and excess
secretions and control infections in the lungs, and to prevent obstruction in
the intestines.
•For patients with advanced stages of the disease, a lung transplant
operation may be necessary.
•Although treating the symptoms does not cure the disease, it can greatly
improve the quality of life for most patients and has, over the years,
increased the average life span of CF patients to 30 years.
Gastrointestinal Treatment
• Modified diet
Due to pancreatic disorders, children with CF require a modified diet, including
vitamin supplements (vitamins A, D, E, and K) and pancreatic enzymes.
Maintaining adequate nutrition is essential. The diet calls for a high-caloric
content (twice what is considered normal for the child's age), which is typically
low in fat and high in protein. Patients or their caregivers should consult with
their health care providers to determine the most appropriate diet.
12. Gene Therapy
• Gene therapy is the use of
normal DNA to "correct" for
the damaged genes that
cause disease.
• In the case of CF, gene
therapy involves inhaling a
spray that delivers normal
DNA to the lungs.
• The goal is to replace the
defective CF gene in the
lungs to cure CF or slow
the progression of the
disease.