The document discusses bacterial infections in cystic fibrosis (CF), focusing on Pseudomonas aeruginosa. Key points: 1) P. aeruginosa is well-adapted to the CF lung environment and uses several mechanisms to establish chronic infection, including biofilm production and antibiotic resistance. 2) Early eradication of P. aeruginosa with combinations of antibiotics like ciprofloxacin and colistin can delay or prevent chronic infection in 74% of cases. 3) Once chronic P. aeruginosa infection is established, eradication is almost impossible so preventing its establishment is important for lung health outcomes in CF patients.