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Bugs, biofilms and resistance in Cystic Fibrosis Davies et al Respiratory Care May 2009 Infectious Disease Journal Club 20 August 2009 Dr Preneshni R Naicker
Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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Why the propensity for bacterial infection? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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[object Object],[object Object],[object Object],Break down intercellular tight juctions Slow ciliary beat functions Siderophores  Inhibits phagocytosis Suppresses cell-mediated immunity Exotoxin A Cleave Immunoglobulins, complement components and cytokines Elastase Protease
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[object Object],[object Object],[object Object]
Biofilm  production
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Infection with other organisms
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Virulence factors of Burkholderia cepacia complex
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prevention ,[object Object],[object Object],[object Object]
Treatment – basic principles ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Eradication of early Pseudomonas infection in Cystic Fibrosis TWR Lee Chronic Respiratory Disease Journal, May 2009
Introduction ,[object Object],[object Object],[object Object]
Definitions
 
How to detect P.aeruginosa in CF pts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is the evidence that early eradication is effective? ,[object Object],[object Object],[object Object]
What agents should be used in eradication regimes?
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Any adverse effects of early eradication? ,[object Object],[object Object],[object Object],[object Object]
Practical aspects ,[object Object],[object Object],[object Object],[object Object]
Thank you

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Cystic Fibrosis Infections